Holdings: Theta oscillations in a model of temporal lobe epilepsy

Theta oscillations in a model of temporal lobe epilepsy:

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Bibliographic Details
Main Author:	Kilias, Antje (Author)
Format:	Thesis Book
Language:	English
Published:	Freiburg im Breisgau 2018
Subjects:	Hochschulschrift
Online Access:	Inhaltsverzeichnis Inhaltsverzeichnis
Item Description:	Enthält Sonderabdrucke
Physical Description:	XI, 157 Seiten Illustrationen, Diagramme 30 cm

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Record in the Search Index

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adam_text	C ONTENTS 1 INTRODUCTION 1 1.1 MESIAL TEMPORAL LOBE E P ILE P S Y ............................................................... 2 1.2 THETA OSCILLATIONS ..................................................................................... 4 1.2.1 HISTOPATHOLOGY OF THETA GENERATORS IN EPILEPTIC BRAINS .... 5 1.2.1.1 EXTRAHIPPOCAMPAL THETA P A CE M A K ERS ...................... 7 1.2.1.2 INTRAHIPPOCAMPAL THETA OS C ILLA TO RS ........................... 10 1.2.2 ALTERED PROPERTIES OF THETA OSCILLATIONS IN EPILEPTIC RODENTS . 15 1.3 OPTOGENETIC ENTRAINMENT OF NETWORK OSCILLATIONS . ............................... 20 1.3.1 OPTOGENETIC S TIM U LA TIO N ........................................................ 22 1.3.2 SINUSOIDAL OPTOGENETIC STIM ULATION ........................................ 23 1.4 OBJECTIVES AND STRUCTURE OF THIS TH ESIS................................................... 25 2 T HETA OSCILLATIONS IN TH E D G AND M EC 27 2.1 SYNAPTIC REMODELING OF ENTORHINAL INPUT CONTRIBUTES TO AN ABERRANT HIPPOCAMPAL NETWORK IN TEMPORAL LOBE E P ILE P S Y ................................ 29 2.2 THETA FREQUENCY DECREASES THROUGHOUT THE HIPPOCAMPAL FORMATION IN A FOCAL EPILEPSY M O D E L......................................................................... 48 2.3 MAINTAINED PHASE-COUPLING OF NEURONAL FIRING TO THETA OSCILLATIONS . 67 2.3.1 METHODS: THETA PHASE-COUPLED F I R I N G .................................. 68 2.3.2 RESULTS: THETA PHASE-COUPLED FIRIN G ..................................... 71 2.3.3 DISCUSSIONS: THETA PHASE-COUPLED FIRIN G ............................... 74 2.4 STRUCTURAL INTEGRITY OF THE MEDIAL SEPTUM AFTER INTRAHIPPOCAMPAL KA INJECTION .................. 78 2.4.1 METHODS: INTEGRITY OF THE MEDIAL S E P TU M ............................ 78 2.4.2 RESULTS: INTEGRITY OF THE MEDIAL S E P TU M ............................... 80 3 T H ETA OSCILLATIONS IN TH E CA2 REGION 85 3.1 MOSSY FIBER SPROUTING AND PYRAMIDAL CELL DISPERSION IN THE HIP POCAMPAL CA2 REGION IN A MOUSE MODEL OF TEMPORAL LOBE EPILEPSY . 86 3.2 THETA OSCILLATIONS PERSIST BUT AT DECREASED FREQUENCY IN THE DIS PERSED CA2 REGION ..................................................................................... 100 3.2.1 METHODS: THETA OSCILLATIONS IN THE DISPERSED CA2 REGION . . 101 3.2.2 RESULTS: THETA OSCILLATIONS IN THE DISPERSED CA2 REGION . . . 102 4 O PTOGENETIC ENTRAINM ENT OF NEURAL OSCILLATIONS W ITH HYBRID FIBER PROBES 105 5 D ISCUSSION 120 5.1 THETA OSCILLATIONS ARE PRESERVED THROUGHOUT THE HIPPOCAMPAL FOR MATION ........................................................................................................... 120 5.2 ALTERED PROPERTIES OF THETA O S C ILLA TIO N S .................................................. 123 5.2.1 POSSIBLE MECHANISMS OF THETA FREQUENCY DECREASE ................... 124 5.2.1.1 ALTERED COUPLING OF HIPPOCAMPAL OSCILLATORS .... 126 5.2.1.2 IMPAIRED THETA P A C E M A K E RS .........................................127 5.2.2 FUNCTIONAL IMPLICATION OF CHANGES IN THETA RH Y TH M .................. 130 5.3 LOCAL STIMULATION TO INDUCE THETA OSCILLATIONS ........................................ 133 5.3.1 OPTICAL STIMULATION INDUCED THETA O S C ILLA TIO N S .........................133 5.3.2 OPTICAL CONTROL OF FREQUENCY AND PHASE OF THETA OSCILLATIONS . 137 5.4 O U TLO O K ........................................................................................................139 LIST OF FIGURES 140 BIBLIOGRAPHY 141
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author	Kilias, Antje
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spelling	Kilias, Antje Verfasser (DE-588)1128174898 aut Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias Freiburg im Breisgau 2018 XI, 157 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation Albert-Ludwigs-Universität, Freiburg im Breisgau 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1172031819/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030870712&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Kilias, Antje Theta oscillations in a model of temporal lobe epilepsy
subject_GND	(DE-588)4113937-9
title	Theta oscillations in a model of temporal lobe epilepsy
title_auth	Theta oscillations in a model of temporal lobe epilepsy
title_exact_search	Theta oscillations in a model of temporal lobe epilepsy
title_full	Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias
title_fullStr	Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias
title_full_unstemmed	Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias
title_short	Theta oscillations in a model of temporal lobe epilepsy
title_sort	theta oscillations in a model of temporal lobe epilepsy
topic_facet	Hochschulschrift
url	http://d-nb.info/1172031819/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030870712&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT kiliasantje thetaoscillationsinamodeloftemporallobeepilepsy

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