Theta oscillations in a model of temporal lobe epilepsy:
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1. Verfasser: | |
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Format: | Abschlussarbeit Buch |
Sprache: | English |
Veröffentlicht: |
Freiburg im Breisgau
2018
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Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
Beschreibung: | Enthält Sonderabdrucke |
Beschreibung: | XI, 157 Seiten Illustrationen, Diagramme 30 cm |
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245 | 1 | 0 | |a Theta oscillations in a model of temporal lobe epilepsy |c vorgelegt von Antje Kilias |
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Datensatz im Suchindex
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adam_text | C ONTENTS
1 INTRODUCTION 1
1.1 MESIAL TEMPORAL LOBE E P ILE P S Y
...............................................................
2
1.2 THETA OSCILLATIONS
.....................................................................................
4
1.2.1 HISTOPATHOLOGY OF THETA GENERATORS IN EPILEPTIC BRAINS .... 5
1.2.1.1 EXTRAHIPPOCAMPAL THETA P A CE M A K ERS
......................
7
1.2.1.2 INTRAHIPPOCAMPAL THETA OS C ILLA TO RS
...........................
10
1.2.2 ALTERED PROPERTIES OF THETA OSCILLATIONS IN EPILEPTIC RODENTS . 15
1.3 OPTOGENETIC ENTRAINMENT OF NETWORK OSCILLATIONS
.
...............................
20
1.3.1 OPTOGENETIC S TIM U LA TIO N
........................................................ 22
1.3.2 SINUSOIDAL OPTOGENETIC STIM ULATION
........................................
23
1.4 OBJECTIVES AND STRUCTURE OF THIS TH
ESIS................................................... 25
2 T HETA OSCILLATIONS IN TH E D G AND M EC 27
2.1 SYNAPTIC REMODELING OF ENTORHINAL INPUT CONTRIBUTES TO AN ABERRANT
HIPPOCAMPAL NETWORK IN TEMPORAL LOBE E P ILE P S Y
................................ 29
2.2 THETA FREQUENCY DECREASES THROUGHOUT THE HIPPOCAMPAL FORMATION
IN A FOCAL EPILEPSY M O D E
L.........................................................................
48
2.3 MAINTAINED PHASE-COUPLING OF NEURONAL FIRING TO THETA OSCILLATIONS .
67
2.3.1 METHODS: THETA PHASE-COUPLED F I R I N G
.................................. 68
2.3.2 RESULTS: THETA PHASE-COUPLED FIRIN G
.....................................
71
2.3.3 DISCUSSIONS: THETA PHASE-COUPLED FIRIN G
............................... 74
2.4 STRUCTURAL INTEGRITY OF THE MEDIAL SEPTUM AFTER INTRAHIPPOCAMPAL
KA INJECTION
..................
78
2.4.1 METHODS: INTEGRITY OF THE MEDIAL S E P TU M
............................ 78
2.4.2 RESULTS: INTEGRITY OF THE MEDIAL S E P TU M
............................... 80
3 T H ETA OSCILLATIONS IN TH E CA2 REGION 85
3.1 MOSSY FIBER SPROUTING AND PYRAMIDAL CELL DISPERSION IN THE HIP
POCAMPAL CA2 REGION IN A MOUSE MODEL OF TEMPORAL LOBE EPILEPSY . 86
3.2 THETA OSCILLATIONS PERSIST BUT AT DECREASED FREQUENCY IN THE DIS
PERSED CA2 REGION
.....................................................................................
100
3.2.1 METHODS: THETA OSCILLATIONS IN THE DISPERSED CA2 REGION . . 101
3.2.2 RESULTS: THETA OSCILLATIONS IN THE DISPERSED CA2 REGION . . . 102
4 O PTOGENETIC ENTRAINM ENT OF NEURAL OSCILLATIONS W ITH HYBRID FIBER
PROBES 105
5 D ISCUSSION 120
5.1 THETA OSCILLATIONS ARE PRESERVED THROUGHOUT THE HIPPOCAMPAL FOR
MATION
...........................................................................................................
120
5.2 ALTERED PROPERTIES OF THETA O S C ILLA TIO N S
.................................................. 123
5.2.1 POSSIBLE MECHANISMS OF THETA FREQUENCY DECREASE
...................
124
5.2.1.1 ALTERED COUPLING OF HIPPOCAMPAL OSCILLATORS .... 126
5.2.1.2 IMPAIRED THETA P A C E M A K E RS
.........................................127
5.2.2 FUNCTIONAL IMPLICATION OF CHANGES IN THETA RH Y TH M
..................
130
5.3 LOCAL STIMULATION TO INDUCE THETA OSCILLATIONS
........................................
133
5.3.1 OPTICAL STIMULATION INDUCED THETA O S C ILLA TIO N S
.........................133
5.3.2 OPTICAL CONTROL OF FREQUENCY AND PHASE OF THETA OSCILLATIONS . 137
5.4 O U TLO O K
........................................................................................................139
LIST OF FIGURES 140
BIBLIOGRAPHY 141
|
any_adam_object | 1 |
author | Kilias, Antje |
author_GND | (DE-588)1128174898 |
author_facet | Kilias, Antje |
author_role | aut |
author_sort | Kilias, Antje |
author_variant | a k ak |
building | Verbundindex |
bvnumber | BV045485757 |
ctrlnum | (OCoLC)1136386496 (DE-599)DNB1172031819 |
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format | Thesis Book |
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genre_facet | Hochschulschrift |
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illustrated | Illustrated |
indexdate | 2024-07-10T08:19:22Z |
institution | BVB |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030870712 |
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physical | XI, 157 Seiten Illustrationen, Diagramme 30 cm |
publishDate | 2018 |
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spelling | Kilias, Antje Verfasser (DE-588)1128174898 aut Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias Freiburg im Breisgau 2018 XI, 157 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation Albert-Ludwigs-Universität, Freiburg im Breisgau 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1172031819/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030870712&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Kilias, Antje Theta oscillations in a model of temporal lobe epilepsy |
subject_GND | (DE-588)4113937-9 |
title | Theta oscillations in a model of temporal lobe epilepsy |
title_auth | Theta oscillations in a model of temporal lobe epilepsy |
title_exact_search | Theta oscillations in a model of temporal lobe epilepsy |
title_full | Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias |
title_fullStr | Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias |
title_full_unstemmed | Theta oscillations in a model of temporal lobe epilepsy vorgelegt von Antje Kilias |
title_short | Theta oscillations in a model of temporal lobe epilepsy |
title_sort | theta oscillations in a model of temporal lobe epilepsy |
topic_facet | Hochschulschrift |
url | http://d-nb.info/1172031819/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030870712&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT kiliasantje thetaoscillationsinamodeloftemporallobeepilepsy |
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