Polyomaviruses and human diseases:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York, NY
Springer Science + Business Media [u.a.]
2006
|
| Series: | Advances in experimental medicine and biology
577 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXIV, 360 S. Ill., graph. Darst. |
| ISBN: | 0387292330 |
Staff View
MARC
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| 245 | 1 | 0 | |a Polyomaviruses and human diseases |c ed. by Nasimul Ahsan |
| 264 | 1 | |a New York, NY |b Springer Science + Business Media [u.a.] |c 2006 | |
| 300 | |a XXIV, 360 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in experimental medicine and biology |v 577 | |
| 650 | 4 | |a Infections à polyomavirus | |
| 650 | 4 | |a Polyomavirus | |
| 650 | 4 | |a BK Virus | |
| 650 | 4 | |a JC Virus | |
| 650 | 4 | |a Polyomavirus Infections | |
| 650 | 4 | |a Polyomavirus infections | |
| 650 | 4 | |a Polyomaviruses | |
| 650 | 0 | 7 | |a Polyoma-Virus |0 (DE-588)4175270-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Virusinfektion |0 (DE-588)4188401-2 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Polyoma-Virus |0 (DE-588)4175270-3 |D s |
| 689 | 0 | 1 | |a Virusinfektion |0 (DE-588)4188401-2 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Ahsan, Nasimul |e Sonstige |0 (DE-588)133506282 |4 oth | |
| 830 | 0 | |a Advances in experimental medicine and biology |v 577 |w (DE-604)BV000003102 |9 577 | |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014775398&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-014775398 | ||
Record in the Search Index
| _version_ | 1804135319885316096 |
|---|---|
| adam_text | CONTENTS
1. POLYOMAVIRUSES AND HUMAN
DISEASES
______________________1
Nasimul Ahsan and Keerti
V. Shah
Abstract
............................................................................................................................... 1
History
..M......«..«.....-«..-..-«-..·-..-··.-·.-..«.-....««·.·.·-....-·..-..«.·-».««.··.·«.· .·.«.··..—.-.«.·.-.«-·- -
1
2. DISCOVERY
AND EPIDEMIOLOGY OF THE HUMAN
POLYOMAVIRUSES BK VIRUS
(BKV)
AND JC VIRUS (JCV)
... 19
Wendy A. Knowles
Abstract
______________________-___________·________________·___________19
nf
BKV
and JCV
................................................—.19
.. . .. ..............................
..m....
.......................
,
......».........20
3.
PHYLOGENOMICS
AND MOLECULAR EVOLUTION
OF POLYOMAVIRUSES
_____________________________________46
Keith A. Crandall, Marcos
Ρ
rez-Losada, Ryan G. Christensen,
David A. McClellan and Raphael P.
Viscidi
„»....».......u..
46
t.M.ttl44ttMl*»Tt46
Population
Variation of SV40
..„...„.««-..».......„-»..„..„«-««..«»«»»»«..»«—.„-.«.......„.. 56
Ciimtnirv
»·»«*■»·**■·>■·■■···■·
a«·.*
·■«···■■····*»■· ··■·■·«·■»·■··
■••»•»•«.»»■a
■···»»·*■■·■■■■■■·■··■.■■ 56
ЛІШІІКІ
j
„»■»··■*··*■·»··■■*· ·····«■··■«■■ ■■■■«■·«■««■«« ■■«■ »·«■ ■■ ■ ■ ■ · ■ ■■»■« ■■■» «■ ■··■«·«·■■ ·- »»
4.
VIRUS RECEPTORS AND
TROPISM
______________________________60
Aarthi Ashok and Walter J. Atwood
tntrnHiiftinn
„„„.„.„„..«««..«..»..«..«......«..«..........„..................«..„..„..„......„..„ „.....60
Mouse Polyonmvinis (PyV)
---------------------------------------------------------------------61
JC
VÍrOS
(JCV)
.1.
I.I I .
_____..............................._____....... ............
Ч
.......
II II.
........................63
B-Lymphotropk Papovavirus (LPV)
------.------------.---------_------.______._____.__. 66
Conclusions
..................................
~
-----------—---------------------
~~™„
—„..-----------„. 68
xvü
xviii
Contents
5. SEROLOGICAL
CROSS REACTIVITY BETWEEN
POLYOMAVIRUS CAPSIDS
__________________________________73
Raphael P.
Viscidi
and Barbara dayman
Abstract
._______._____________________________________________....___.____73
Introduction
................................................................—■.......—■■■■■■■■—■-—···■...............-■— 73
Virus-Like Particle-Based Polyomavirus Enzyme Immunoassays
_______________74
Reactivity of Rhesus Macaque Sera in VLP-Based Polyomavirus
Enzyme Immunoassays
______.________________________________________76
Reactivity of Human Sera in VLP-Based Polyomavirus Enzyme Immunoassays
..— 78
Reactivity of Human Sera in LPV VLP-Based Enzyme Immunoassay
____._______81
Conclusions
.■•......•.•.•...•.••...•..............••.«•..•.•..•.».■•...••..••••.......••••..•..•••.■•..•..•••..»••».••••..»•»81
6.
MOLECULAR GENETICS OF THE BK VIRUS
......................................85
Christopher L. Cubitt
Abstract.
___._________.____________________.________________-..__________85
Introduction
....................................................................................................... 85
Genotyping
BKV
...________________......_____...._________._______________....90
Association of Mutations and Genotypes with Disease
_____„___________________90
BKV
Molecular Genetics: Future Research
._________________________________92
7.
SEROLOGICAL DIAGNOSIS OF HUMAN POLYOMAVIRUS
INFECTION
_______________________................................................96
Annika
Lundstig
and
Joakim
Dillner
Abstract
.......___________.__________.____».______________._____.„.._____..__96
Introduction
.».......„»„.„...„..»„....„....„„..„..„......„.„.„„..».„...„...„.»..„......„.._„„.„...»... 96
Simian Virus
40_________.____._______„___„.__._______..___________........__».. 97
Antibody Stability
__....__..„..__»....__..____..........._______________.„___»...___„..98
Serological Methods
..__._________.„____..___________.__________________........98
EIA
Serological Method
__________.„„____.____..._____.____.....___.»._______99
Preparation of Virus-Like Particles
................................................................................. 99
Expression Systems
..___.__.»___»________________._____...»________________100
8.
HUMAN POLYOMAVIRUS JC AND BK PERSISTENT
INFECTION
________________________________________________102
Kristína
Doerries
Abstract.»
___».__
^.
____________________.________„„___________________102
Introduction
.».»»..—».«...»..»..»..„..»..„..»„„......»..»..„„„„„.„„„..„.„..„..»„„.._.._..». 102
Urogenital
Persistent
BKV
Infection
____________»-..__._______»____
„„„»...„.™
105
Active
BKV
Infection in the Kidney
._____„„.___.__
™
_____..»___».,».______„„ 105
JCVin the
Urogenital
Tract
______„»„»..„..„.._...„™._________„...____
„™~.
__.» 106
Activation of
Urogenital
JCV Infection..»..»
__„»__.._.„.»_________
~_
___„„„__107
Neurotropism of Human Polyomaviruses
____».__»·„»»__
™.
_____.______
»™.™
108
JCV in the Central Nervous System
____________________.__________________108
Activity of Asymptomatic JCV Infection in the CNS
_________________________110
Human Polyomaviruses in the Hematopoietic System
..„..„._„.____„.„„.„.„_..„__
111
Contents
x¡x
Association
of
BKV
with Cells of the Immune System
___________......______..... 112
JCV in Lymphoid Organs and Blood Cells
________________________.....____.__
ИЗ
Activation of JCV Infection in Hematopoietic Cells
_________________________114
9.
IMMUNITY AND AUTOIMMUNITY INDUCED BY
POLYOMAVIRUSES: CLINICAL, EXPERIMENTAL
AND THEORETICAL ASPECTS
....................................................117
Ole
Petter Rekvig, Signy Bendiksen and
Ugo
Moens
Abstract
...................................................................................................................... 117
Introduction
......................»..................................................................................^......... 117
Immunology
of Polyomaviruses
..................................................................................... 119
Polyomaviruses and
T
Cell Responses
........................................................................... 126
Polyomaviruses, SLE and Autoimmunity to Nucleosomes and dsDNA
____....__... 130
Concluding Remarks.......................................................................................................
139
10.
THE PATHOBIOLOGY OF POLYOMAVIRUS
INFECTION IN MAN
.......................................................................148
Parmjeet Randhawa, Abhay Vats and Ron Shapiro
Abstract
..____...__.___.______________________.__.........................__...____......148
Biology of Polyomaviruses
________________________...___................__..___..... 148
Historical Aspects
............................................ ..............„....................................... 149
Modes of Natural Transmission
__.____.____.__.........________„___..____............ 149
Transmission of Polyomavirus via Organ Transplantation
—.....___....................... 150
Viral Interactions with Host Cell Receptors
___________________________.____150
Entry of Virus into Host Cells
____________.___________.___________________151
Cytoplasmic Trafficking......
________________......__....._____.__............................ 152
Nuclear Targeting
...,.·.·..·.·....·....·.··.·..»...·........·..·.....··.......·...··..·.·..·.·....·.·...·.····..-.··...·..··
153
Clinical Sequelae of Primary Infection in Man
___.____.________.-----.------.......... 153
Sites of Viral Latency
___________________________________.---------------------153
Reactivation of Latent Virus
_________________________________________.„.. 154
Pathogenesis of Tissue Damage in Polyomavirus Infected Tissues
.------.................. 154
Concluding Remarks
______«__________________.-------------------------------——155
11.
POLYOMAVmUS-ASSOCIATED NEPHROPATHY IN RENAL
TRANSPLANTATION: CRITICAL ISSUES OF SCREENING
AND MANAGEMENT
_____________________________________160
Hans H.
Hirsch,
Cinthia B.
Drachenberg, Jueig Steiger
and
Emilio
Ramos
Abstract
......................................,..........,,......,,
.........г.,
.........._____——
~—.~~-~~—
—. 160
Introduction
________„________________________________________________160
Infection, Replication and Disease
________.„„„..„._—.„..„.„._.„..„.„.—._..-..... 161
Epidemiology
-------------------------------_„___________
,_.™~~..™~~
--------.„„_.—163
Risk Factors
_________________________________________________________164
Diagnose
..................................-------___—
~~.~~~~~~
—..............................
»~
—«— 166
Intervention
.........................._____„_„........................_____.------„......_......„.„„....„„ 169
RetransplMtatioB
-------------------------------------------------------------------------------170
Conclusion
ι,·
......
.ι.
-,...,..
1.1,
......,....,,.,,„,,,,-■.......■--·.........______________________________
І
70
xx
Contents
12.
BK
VIRUS AND IMMUNOSUPPRESSIVE AGENTS
_____________174
Irfan Agha and Daniel C. Brennan
Abstract
________________________________________________________174
Biology of
BKV
Infection: From Primary Infection to Manifest Disease
.__.._____174
The Second Hit Hypothesis
________________________________________175
Clinical Correlates of
BKV
Infection in Renal Transplant Recipients
__________176
Impact of Immunosuppression: Net State or Asymmetric Predisposition?
___......... 176
Prospective Look at BKVN: Role of Immunosuppression
.___.-----.------------.—178
Reflections on the Biologic Behavior of the Virus
_______....-----------------------. 180
Risks of Alteration of Immunosuppression
__.-----------------.__________._____181
Immunosuppression Management for
BKV
Infection
____._______.________.. 181
13.
BK VIRUS INFECTION AFTER NON-RENAL
TRANSPLANTATION
___________________________________185
Martha Pavlakis, Abdolreza Haririan and David K.
Klassen
Abstract
__________________________________________________.___...... 185
BKV-BMT-Hemorrhagic Cystitis
_____________________________________185
BKV-Non-Renal Solid Organ Transplant
_______________________________188
14.
LATENT AND PRODUCTIVE POLYOMAVIRUS INFECTIONS
OF RENAL ALLOGRAFTS: MORPHOLOGICAL,
CLINICAL, AND
Ρ
ATHOPHYSIOLOGICAL ASPECTS
______190
Volker
Nickeleit, Harsharan K. Singh and Michael J. Mihatsch
Abstract
..........__„____.____„..„_______.________.___......______._____._____190
Introduction
..............-..............................«..................................-.............._................. 190
Morphologic Characterization of BK Virus Allograft Nephropathy (BKN)
______191
Ultrastructural
Features
........____.__......___.___.______„..___.___.„..____.__193
Ancillary Diagnostic Techniaues
................................................................................. 193
Histologie
Stages/Patterns of BKN
___.._______________.___..___________...... 196
Latent
BK Virus
Infections
............................................................................................. 198
15.
URINE
CYTOLOGY FINDINGS OF POLYOMAVIRUS
INFECTIONS
__________________________________________201
Harsharan K. Singh,
Lukas Bubendorf,
Michael
J. Mihatsch,
Cinthia B.
Drachenberg and Volker
Nickeleit
Abstract
____._____.-__,.„__._..___.._______________._______„______„__201
Introduction ..—....«—«»■.»..-..—..».»...»..««—.—.—»«..»..»....««.»..»..«..«..„.«...„«m..«»«.
201
Polyomavirus Inclusion Bearing Decoy Cells
...._...._.._.....».._._..„.....„..„..„..„... 202
Urine
Analyste
for Risk Assessment and Management of BK-Virus
Nephropathy (BKN)
..„-_.._.«..____
..~....„„„_..„.
___....____—.„.„.__
„,.™.™
209
Appendix Immunohistochemical Staining Protocols to Detect Polyomavirus
Antigens in Urine Cytology Specimens (Decoy Cells)
..__„..„__
,„™~._„™
__210
Contents xxi
16.
DIAGNOSIS AND TREATMENT OF BK
VIRUS-ASSOCIATED TRANSPLANT
NEPHROPATHY
...............................................................................213
Abhay Vats, Parmjeet S. Randhawa and Ron Shapiro
Abstract
_________________.........................................................................................213
Introduction
.....................................................................................................................213
Clinical Presentation of BKVAN
___________._____._____....________.....___.__„214
Diagnosis of BKVAN
______.___________...____._____..___..______.___....____214
Risk Factors for BKVAN
_______________.__________________________...____219
Clinical Management of BKVAN
..............................„_____._____.„„„......_____....... 220
Conclusion
...........—...■........■.......................„....................................................................224
17.
PHARMACOTHERAPEUTIC OPTIONS
FOR THE MANAGEMENT OF HUMAN
POLYOMAVIRUSES
_________________________...........................228
Julie Roskopf, Jennifer Trofe, Robert J.
Stratta
and Nasimul Ahsan
Abstract
.............................................................................................................228
Introduction
. _..„................................................................................................ 228
JC
Virus
_______„______.....__........_____..........__._____...___.............____.........229
Progressive Multifocal Leukoencephalopathy
......._____.___._______...................... 229
BK Virus
......................................................................................................... .„..„„....„...230
BKV-
Associated Hemorrnagic Cystitis
------------------------------------------------------230
Polyomavirus-Associated Nephropathy in Transplant Recipients
...___....___„___230
Targets for Pharmacotherapeutic Intervention
...........______......_____...__...„.__..234
Specific Pharmacotherapeutic Intervention
.........___..._______.....___........___..... 235
Algorithms for Clinical Interventions
______._______.........................__„.„....„..„„.246
{ ΏηρΙικΐηη
.»..„.„.■«..„„„„«„·■„„■·„■■„...■■■„■.„..„■.„..„.■„..„..„„·...„..„.■„■.„..„„»■„■ 248
18.
LEFLUNOMIDE
IN SOLID ORGAN
TRANSPLANTATION AND POLYOM A
VIRUS INFECTION
____________________________________255
Michelle
A. Josephson,
Basit
Javaid,
Pradeep V. Kadambi,
Shane M. Meehan and James W. Williams
IntrnHiirtinn
______._.._.
.„.„„„.^...~.„.
.„.._..„..........„..„..„..„..........„..„......„..„..„.„. 255
f
Ііпігяі
PliarmftcekKry
..........».»■«.......................
,...............^...
......
x»...^.,..!......
................. 255
Immunosuppressive
Properties: Mechanisms of Immunosuppression
.„..„..__„___256
Anti-Viral Properties: la Vitro Activity of A77
1726-------------------------------------259
Reconciliation of Immune Suppression and Anti-Viral Activity
.__„.„___..__......260
I .»flnnnmWI» in BKN
._„„>»...»».»„_.„.
.....~..~.„..„.
....._..„......„.„......„..........».„.„ 261
Conclusion.™~
-----------
„„^„
—
.„~~.
—~™.^.™...„„..^~™„™...™------„..„_.„„ 262
xrii Contents
19.
JC VIRUS CAN INFECT HUMAN IMMUNE AND NERVOUS
SYSTEM PROGENITOR CELLS: IMPLICATIONS
FOR PATHOGENESIS
.....................................................................266
Jean
Hou,
Pankaj Seth and Eugene O. Major
Abstract
______________________________________________________________266
Introduction
..·..·.........,........···.·...........·..·.......·..·■...·.·.·.....·.·.·.■.,·..·.......·■....■...····■·■..···.··..· 266
JCV in the Immune System
______________________________________________268
JCV in the CNS
________________________________________________________269
Therapeutic Purposes
...................................................................................................271
Conclusion
...................................................................................................................... 272
20.
THE POLYOMAVIRUS, JCV, AND ITS INVOLVEMENT
IN HUMAN DISEASE
_______________________________________274
Kamel
Khalili, Jennifer Gordon and
Martyn
К.
White
Abstract
______________._____________.__.______.______._________________274
An Introduction to JC Virus
_____________________________________________274
The Life Cycle of JCV
„______._________.__________.______________________275
Tropism
of JCV
_____________________________________________________..... 276
The Spread of JCV
_____.________________.__._______...__._______._________276
JCV and PML
________________________________________.________________277
JCV and Cancer: Experimental Tumorigenesis
_______________________.____... 278
JCV and Cancer: Clinical Tumors
________________________________________279
JCV Molecular Biology
..............____.________.____.___...»___________..__.__.__281
Future Studies of JCV
...._______________„________________.______________-. 282
21.
TRANSFORMING ACTIVITIES OF JC VIRUS
EARLY PROTEINS
_________________________________________288
Richard J. Frisque, Catherine Hofstetter and Shiva K. Tyagarajan
Abstract
__....„_____.______.....__.__....___..„..__...___„.._____.________.___„288
Introduction
............................................................................................................. 288
JCV TAg Functions
........................___.......__...........___
™._
____....__«..________„. 292
JCV tAg Functions
____„________.___,_..-___-__»-______
..~
___.....__.__«..„..300
JCV T Protein Functions
..__.......__.....__..„__.__._______.__....—__.......______„301
Summary of JCV Early Protein Function
__________________________________304
22.
POLYOMAVIRUS IN HUMAN CANCER DEVELOPMENT
_______310
Winston Lee and
Erik Langhoff
Abstract
__
~
__.._..„.._..._____.„____-___............__..„__„.____
^.^
___..«..._ 310
Viral Life Cycle
.„__„__„______.._____.........__„.._.________.___.____„________310
Mechanisms of Oncogenesis
..„.„..„..„......„..........„..............„..„......„......„..„„„......„.„ 311
Evidence of Poiyoma-Cancer Association
..__......-----
~
____.___________________312
Conclusion
·* ·*■■>··
.,ttt
„
шлл
. ···*«··♦·«··«···■*.............,...........
ttMł
315
Contents
xxüi
23.
BK
VIRUS, JC VIRUS AND SIMIAN VIRUS
40
INFECTION IN
HUMANS, AND ASSOCIATION WITH HUMAN TUMORS
.___319
Giuseppe Barbanti-Brodano, Silvia
Sabbioni,
Femanda
Martini,
Massimo Negrini, Alfredo
Corallini
and
Mauro Tognon
Abstract
...........................................................................................................................319
Introduction
..................................................................................................................... 319
General Characteristics of
BKV,
JCV and SV40
____________________________320
BKV,
JCV and SV40 Infection in Humans
_________________.................................320
BKV,
JCV and SV40 Cell Transformation and Experimental Oncogenicity
______322
Association of
BKV,
JCV and SV40 with Human Tumors
____________________325
Conclusions and Future Perspectives
...........................................................................332
24.
EPIDEMIOLOGIC STUDIES OF POLYOMAVIRUSES AND
CANCER: PREVIOUS FINDINGS, METHODOLOGIC
CHALLENGES AND FUTURE DIRECTIONS
.............................342
Dana E.M. Rollison
Abstract
............................................................................................................. 342
Introduction
..................„..................................................................„..............■■■■■.......·.. 342
Previous Findings
..«..«..«..».».««...•..«...«.„......«..»•.........«...•..»..«•.........«....•■.••...■•»••.•343
Methodologie
Challenges
__.».-»___«_____».„...«-.„..„...........■.,....„.,,..„..^..«..»..»....353
Future Directions
,._..._..»...._........_„..»_..._..._.........»..„..»......«.......»...»..»..»..»...«.·»..»...». 354
.»...«*.«..»..»...·■....»...«·»....».·...**«*·».·······.» 355
INDEX
-----------------------------------------------.....--------------------.................................357
|
| adam_txt |
CONTENTS
1. POLYOMAVIRUSES AND HUMAN
DISEASES
_1
Nasimul Ahsan and Keerti
V. Shah
Abstract
. 1
History
.M.«.«.-«.-.-«-.·-.-··.-·.-.«.-.««·.·.·-.-·.-.«.·-».««.··.·«.·".·.«.··.—.-.«.·.-.«-·-"-
1
2. DISCOVERY
AND EPIDEMIOLOGY OF THE HUMAN
POLYOMAVIRUSES BK VIRUS
(BKV)
AND JC VIRUS (JCV)
. 19
Wendy A. Knowles
Abstract
_-_·_·_19
nf
BKV
and JCV
.—.19
. . . .
.m.
.
,
.».20
3.
PHYLOGENOMICS
AND MOLECULAR EVOLUTION
OF POLYOMAVIRUSES
_46
Keith A. Crandall, Marcos
Ρ
rez-Losada, Ryan G. Christensen,
David A. McClellan and Raphael P.
Viscidi
„».».u.
46
t.M.ttl44ttMl*»Tt46
Population
Variation of SV40
.„.„.««-.».„-».„.„«-««.«»«»»»«.»«—.„-.«.„. 56
Ciimtnirv
»·»«*■»·**■·>■·■■···■·
a«·.*
·■«···■■····*»■· ··■·■·«·■»·■··
■••»•»•«.»»■a
■···»»·*■■·■■■■■■·■··■.■■ 56
ЛІШІІКІ
j
„»■»··■*··*■·»··■■*·'·····«■··■«■■'■■■■«■·«■««■««''■■«■'»·«■'''■■'■'■''■''·'■'■■»■«'■■■»'«■'■··■«·«·■■ ·-'»»
4.
VIRUS RECEPTORS AND
TROPISM
_60
Aarthi Ashok and Walter J. Atwood
tntrnHiiftinn
„„„.„.„„.«««.«.».«.«.«.«.„.«.„.„.„.„.„ „.60
Mouse Polyonmvinis (PyV)
---------------------------------------------------------------------61
JC
VÍrOS
(JCV)
.1.
I.I I".
_._. .
Ч
.
II II.
.63
B-Lymphotropk Papovavirus (LPV)
------.------------.---------_------._._._. 66
Conclusions
.
~
-----------—---------------------
~~™„
—„.-----------„. 68
xvü
xviii
Contents
5. SEROLOGICAL
CROSS REACTIVITY BETWEEN
POLYOMAVIRUS CAPSIDS
_73
Raphael P.
Viscidi
and Barbara dayman
Abstract
._._._._73
Introduction
.—■.—■■■■■■■■—■-—···■.-■— 73
Virus-Like Particle-Based Polyomavirus Enzyme Immunoassays
_74
Reactivity of Rhesus Macaque Sera in VLP-Based Polyomavirus
Enzyme Immunoassays
_._76
Reactivity of Human Sera in VLP-Based Polyomavirus Enzyme Immunoassays
.— 78
Reactivity of Human Sera in LPV VLP-Based Enzyme Immunoassay
_._81
Conclusions
.■•.•.•.•.•.••.•.••.«•.•.•.•.».■•.••.••••.••••.•.•••.■•.•.•••.»••».••••.»•»81
6.
MOLECULAR GENETICS OF THE BK VIRUS
.85
Christopher L. Cubitt
Abstract.
_._._._-._85
Introduction
. 85
Genotyping
BKV
._._._._.90
Association of Mutations and Genotypes with Disease
_„_90
BKV
Molecular Genetics: Future Research
._92
7.
SEROLOGICAL DIAGNOSIS OF HUMAN POLYOMAVIRUS
INFECTION
_.96
Annika
Lundstig
and
Joakim
Dillner
Abstract
._._._»._._.„._._96
Introduction
.».„»„.„.„.»„.„.„„.„.„.„.„.„„.».„.„.„.».„.„._„„.„.». 96
Simian Virus
40_._._„_„._._._._». 97
Antibody Stability
_._.„._»._._._.„_»._„.98
Serological Methods
._._.„_._._.98
EIA
Serological Method
_.„„_._._._._.»._99
Preparation of Virus-Like Particles
. 99
Expression Systems
._._.»_»_._.»_100
8.
HUMAN POLYOMAVIRUS JC AND BK PERSISTENT
INFECTION
_102
Kristína
Doerries
Abstract.»
_»._
^.
_._„„_102
Introduction
.».»».—».«.».».».„.».„.»„„.».».„„„„„.„„„.„.„.„.»„„._._.». 102
Urogenital
Persistent
BKV
Infection
_»-._._»_
„„„».„.™
105
Active
BKV
Infection in the Kidney
._„„._._
™
_.»_».,»._„„ 105
JCVin the
Urogenital
Tract
_„»„».„.„._.„™._„._
„™~.
_.» 106
Activation of
Urogenital
JCV Infection.».»
_„»_._.„.»_
~_
_„„„_107
Neurotropism of Human Polyomaviruses
_»._»·„»»_
™.
_._
»™.™
108
JCV in the Central Nervous System
_._108
Activity of Asymptomatic JCV Infection in the CNS
_110
Human Polyomaviruses in the Hematopoietic System
.„.„._„._„.„„.„.„_.„_
111
Contents
x¡x
Association
of
BKV
with Cells of the Immune System
_._. 112
JCV in Lymphoid Organs and Blood Cells
_._._
ИЗ
Activation of JCV Infection in Hematopoietic Cells
_114
9.
IMMUNITY AND AUTOIMMUNITY INDUCED BY
POLYOMAVIRUSES: CLINICAL, EXPERIMENTAL
AND THEORETICAL ASPECTS
.117
Ole
Petter Rekvig, Signy Bendiksen and
Ugo
Moens
Abstract
. 117
Introduction
.».^. 117
Immunology
of Polyomaviruses
. 119
Polyomaviruses and
T
Cell Responses
. 126
Polyomaviruses, SLE and Autoimmunity to Nucleosomes and dsDNA
_._. 130
Concluding Remarks.
139
10.
THE PATHOBIOLOGY OF POLYOMAVIRUS
INFECTION IN MAN
.148
Parmjeet Randhawa, Abhay Vats and Ron Shapiro
Abstract
._._._._._._._.148
Biology of Polyomaviruses
_._._._. 148
Historical Aspects
. .„. 149
Modes of Natural Transmission
_._._._._„_._. 149
Transmission of Polyomavirus via Organ Transplantation
—._. 150
Viral Interactions with Host Cell Receptors
_._150
Entry of Virus into Host Cells
_._._151
Cytoplasmic Trafficking.
_._._._. 152
Nuclear Targeting
.,.·.·.·.·.·.·.··.·.».·.·.·.··.·.··.·.·.·.·.·.·.·.····.-.··.·.··
153
Clinical Sequelae of Primary Infection in Man
_._._.-----.------. 153
Sites of Viral Latency
_.---------------------153
Reactivation of Latent Virus
_.„. 154
Pathogenesis of Tissue Damage in Polyomavirus Infected Tissues
.------. 154
Concluding Remarks
_«_.-------------------------------——155
11.
POLYOMAVmUS-ASSOCIATED NEPHROPATHY IN RENAL
TRANSPLANTATION: CRITICAL ISSUES OF SCREENING
AND MANAGEMENT
_160
Hans H.
Hirsch,
Cinthia B.
Drachenberg, Jueig Steiger
and
Emilio
Ramos
Abstract
.,.,,.,,
.г.,
._——
~—.~~-~~—
—. 160
Introduction
_„_160
Infection, Replication and Disease
_.„„„.„._—.„.„.„._.„.„.„.—._.-. 161
Epidemiology
-------------------------------_„_
,_.™~~.™~~
--------.„„_.—163
Risk Factors
_164
Diagnose
.-------_—
~~.~~~~~~
—.
»~
—«— 166
Intervention
._„_„._.------„._.„.„„.„„ 169
RetransplMtatioB
-------------------------------------------------------------------------------170
Conclusion
ι,·
.
.ι.
-,.,.
1.1,
.,.,,.,,„,,,,-■.■--·._
І
70
xx
Contents
12.
BK
VIRUS AND IMMUNOSUPPRESSIVE AGENTS
_174
Irfan Agha and Daniel C. Brennan
Abstract
_174
Biology of
BKV
Infection: From Primary Infection to Manifest Disease
._._174
The Second Hit Hypothesis
_175
Clinical Correlates of
BKV
Infection in Renal Transplant Recipients
_176
Impact of Immunosuppression: Net State or Asymmetric Predisposition?
_. 176
Prospective Look at BKVN: Role of Immunosuppression
._.-----.------------.—178
Reflections on the Biologic Behavior of the Virus
_.-----------------------. 180
Risks of Alteration of Immunosuppression
_.-----------------._._181
Immunosuppression Management for
BKV
Infection
_._._. 181
13.
BK VIRUS INFECTION AFTER NON-RENAL
TRANSPLANTATION
_185
Martha Pavlakis, Abdolreza Haririan and David K.
Klassen
Abstract
_._. 185
BKV-BMT-Hemorrhagic Cystitis
_185
BKV-Non-Renal Solid Organ Transplant
_188
14.
LATENT AND PRODUCTIVE POLYOMAVIRUS INFECTIONS
OF RENAL ALLOGRAFTS: MORPHOLOGICAL,
CLINICAL, AND
Ρ
ATHOPHYSIOLOGICAL ASPECTS
_190
Volker
Nickeleit, Harsharan K. Singh and Michael J. Mihatsch
Abstract
._„_._„.„_._._._._._190
Introduction
.-.«.-._. 190
Morphologic Characterization of BK Virus Allograft Nephropathy (BKN)
_191
Ultrastructural
Features
._._._._._„._._.„._._193
Ancillary Diagnostic Techniaues
. 193
Histologie
Stages/Patterns of BKN
_._._._. 196
Latent
BK Virus
Infections
. 198
15.
URINE
CYTOLOGY FINDINGS OF POLYOMAVIRUS
INFECTIONS
_201
Harsharan K. Singh,
Lukas Bubendorf,
Michael
J. Mihatsch,
Cinthia B.
Drachenberg and Volker
Nickeleit
Abstract
_._.-_,.„_._._._._„_„_201
Introduction .—.«—«»■.».-.—.».».».««—.—.—»«.».».««.».».«.«.„.«.„«m.«»«.
201
Polyomavirus Inclusion Bearing Decoy Cells
._._._.»._._.„.„.„.„.„. 202
Urine
Analyste
for Risk Assessment and Management of BK-Virus
Nephropathy (BKN)
.„-_._.«._
.~.„„„_.„.
_._—.„.„._
„,.™.™
209
Appendix Immunohistochemical Staining Protocols to Detect Polyomavirus
Antigens in Urine Cytology Specimens (Decoy Cells)
._„.„_
,„™~._„™
_210
Contents xxi
16.
DIAGNOSIS AND TREATMENT OF BK
VIRUS-ASSOCIATED TRANSPLANT
NEPHROPATHY
.213
Abhay Vats, Parmjeet S. Randhawa and Ron Shapiro
Abstract
_.213
Introduction
.213
Clinical Presentation of BKVAN
_._._._._._„214
Diagnosis of BKVAN
_._._._._._._._214
Risk Factors for BKVAN
_._._219
Clinical Management of BKVAN
.„_._.„„„._. 220
Conclusion
.—.■.■.„.224
17.
PHARMACOTHERAPEUTIC OPTIONS
FOR THE MANAGEMENT OF HUMAN
POLYOMAVIRUSES
_.228
Julie Roskopf, Jennifer Trofe, Robert J.
Stratta
and Nasimul Ahsan
Abstract
.228
Introduction
. _.„. 228
JC
Virus
_„_._._._._._._.229
Progressive Multifocal Leukoencephalopathy
._._._. 229
BK Virus
. .„.„„.„.230
BKV-
Associated Hemorrnagic Cystitis
------------------------------------------------------230
Polyomavirus-Associated Nephropathy in Transplant Recipients
._._„_230
Targets for Pharmacotherapeutic Intervention
._._._.„._.234
Specific Pharmacotherapeutic Intervention
._._._._. 235
Algorithms for Clinical Interventions
_._._„.„.„.„„.246
{"ΏηρΙικΐηη
.».„.„.■«.„„„„«„·■„„■·„■■„.■■■„■.„.„■.„.„.■„.„.„„·.„.„.■„■.„.„„»■„■ 248
18.
LEFLUNOMIDE
IN SOLID ORGAN
TRANSPLANTATION AND POLYOM A
VIRUS INFECTION
_255
Michelle
A. Josephson,
Basit
Javaid,
Pradeep V. Kadambi,
Shane M. Meehan and James W. Williams
IntrnHiirtinn
_._._.
.„.„„„.^.~.„.
.„._.„.„.„.„.„.„.„.„.„.„.„. 255
f
Ііпігяі
PliarmftcekKry
.».»■«.
,.^.
.
x».^.,.!.
. 255
Immunosuppressive
Properties: Mechanisms of Immunosuppression
.„.„._„_256
Anti-Viral Properties: la Vitro Activity of A77
1726-------------------------------------259
Reconciliation of Immune Suppression and Anti-Viral Activity
._„.„_._.260
I .»flnnnmWI» in BKN
._„„>».»».»„_.„.
.~.~.„.„.
._.„.„.„.„.».„.„ 261
Conclusion.™~
-----------
„„^„
—
.„~~.
—~™.^.™.„„.^~™„™.™------„.„_.„„ 262
xrii Contents
19.
JC VIRUS CAN INFECT HUMAN IMMUNE AND NERVOUS
SYSTEM PROGENITOR CELLS: IMPLICATIONS
FOR PATHOGENESIS
.266
Jean
Hou,
Pankaj Seth and Eugene O. Major
Abstract
_266
Introduction
.·.·.,.···.·.·.·.·.·■.·.·.·.·.·.·.■.,·.·.·■.■.····■·■.···.··.· 266
JCV in the Immune System
_268
JCV in the CNS
_269
Therapeutic Purposes
.271
Conclusion
. 272
20.
THE POLYOMAVIRUS, JCV, AND ITS INVOLVEMENT
IN HUMAN DISEASE
_274
Kamel
Khalili, Jennifer Gordon and
Martyn
К.
White
Abstract
_._._._._._274
An Introduction to JC Virus
_274
The Life Cycle of JCV
„_._._._275
Tropism
of JCV
_. 276
The Spread of JCV
_._._._._._._276
JCV and PML
_._277
JCV and Cancer: Experimental Tumorigenesis
_._. 278
JCV and Cancer: Clinical Tumors
_279
JCV Molecular Biology
._._._._.»_._._._281
Future Studies of JCV
._„_._-. 282
21.
TRANSFORMING ACTIVITIES OF JC VIRUS
EARLY PROTEINS
_288
Richard J. Frisque, Catherine Hofstetter and Shiva K. Tyagarajan
Abstract
_.„_._._._._.„._._„._._._„288
Introduction
. 288
JCV TAg Functions
._._._
™._
_._«._„. 292
JCV tAg Functions
_„_._,_.-_-_»-_
.~
_._._«.„.300
JCV T' Protein Functions
._._._.„_._._._.—_._„301
Summary of JCV Early Protein Function
_304
22.
POLYOMAVIRUS IN HUMAN CANCER DEVELOPMENT
_310
Winston Lee and
Erik Langhoff
Abstract
_
~
_._.„._._.„_-_._.„_„._
^.^
_.«._ 310
Viral Life Cycle
.„_„_„_._._„._._._._„_310
Mechanisms of Oncogenesis
.„.„.„.„.„.„.„.„.„.„.„„„.„.„ 311
Evidence of Poiyoma-Cancer Association
._.-----
~
_._312
Conclusion
·* ·*■■>··
.,ttt
„
шлл
. ···*«··♦·«··«···■*.,.
ttMł
315
Contents
xxüi
23.
BK
VIRUS, JC VIRUS AND SIMIAN VIRUS
40
INFECTION IN
HUMANS, AND ASSOCIATION WITH HUMAN TUMORS
._319
Giuseppe Barbanti-Brodano, Silvia
Sabbioni,
Femanda
Martini,
Massimo Negrini, Alfredo
Corallini
and
Mauro Tognon
Abstract
.319
Introduction
. 319
General Characteristics of
BKV,
JCV and SV40
_320
BKV,
JCV and SV40 Infection in Humans
_.320
BKV,
JCV and SV40 Cell Transformation and Experimental Oncogenicity
_322
Association of
BKV,
JCV and SV40 with Human Tumors
_325
Conclusions and Future Perspectives
.332
24.
EPIDEMIOLOGIC STUDIES OF POLYOMAVIRUSES AND
CANCER: PREVIOUS FINDINGS, METHODOLOGIC
CHALLENGES AND FUTURE DIRECTIONS
.342
Dana E.M. Rollison
Abstract
. 342
Introduction
.„.„.■■■■■.·. 342
Previous Findings
.«.«.«.».».««.•.«.«.„.«.»•.«.•.».«•.«.•■.••.■•»••.•343
Methodologie
Challenges
_.».-»_«_».„.«-.„.„.■.,.„.,,.„.^.«.».».353
Future Directions
,._._.»._._„.»_._._.».„.».«.».».».».».«.·».».». 354
.».«*.«.».».·■.».«·».».·.**«*·».·······.» 355
INDEX
-----------------------------------------------.--------------------.357 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author_GND | (DE-588)133506282 |
| building | Verbundindex |
| bvnumber | BV021559431 |
| callnumber-first | Q - Science |
| callnumber-label | QR201 |
| callnumber-raw | QR201.P732 |
| callnumber-search | QR201.P732 |
| callnumber-sort | QR 3201 P732 |
| callnumber-subject | QR - Microbiology |
| classification_rvk | XD 7700 |
| ctrlnum | (OCoLC)61459360 (DE-599)BVBBV021559431 |
| dewey-full | 616.9/1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.9/1 |
| dewey-search | 616.9/1 |
| dewey-sort | 3616.9 11 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| discipline_str_mv | Biologie Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV021559431 |
| illustrated | Illustrated |
| index_date | 2024-07-02T14:34:16Z |
| indexdate | 2024-07-09T20:38:37Z |
| institution | BVB |
| isbn | 0387292330 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014775398 |
| oclc_num | 61459360 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR DE-20 |
| owner_facet | DE-12 DE-355 DE-BY-UBR DE-20 |
| physical | XXIV, 360 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Springer Science + Business Media [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Polyomaviruses and human diseases ed. by Nasimul Ahsan New York, NY Springer Science + Business Media [u.a.] 2006 XXIV, 360 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 577 Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus (DE-588)4175270-3 gnd rswk-swf Virusinfektion (DE-588)4188401-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Polyoma-Virus (DE-588)4175270-3 s Virusinfektion (DE-588)4188401-2 s b DE-604 Ahsan, Nasimul Sonstige (DE-588)133506282 oth Advances in experimental medicine and biology 577 (DE-604)BV000003102 577 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014775398&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Polyomaviruses and human diseases Advances in experimental medicine and biology Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus (DE-588)4175270-3 gnd Virusinfektion (DE-588)4188401-2 gnd |
| subject_GND | (DE-588)4175270-3 (DE-588)4188401-2 (DE-588)4143413-4 |
| title | Polyomaviruses and human diseases |
| title_auth | Polyomaviruses and human diseases |
| title_exact_search | Polyomaviruses and human diseases |
| title_exact_search_txtP | Polyomaviruses and human diseases |
| title_full | Polyomaviruses and human diseases ed. by Nasimul Ahsan |
| title_fullStr | Polyomaviruses and human diseases ed. by Nasimul Ahsan |
| title_full_unstemmed | Polyomaviruses and human diseases ed. by Nasimul Ahsan |
| title_short | Polyomaviruses and human diseases |
| title_sort | polyomaviruses and human diseases |
| topic | Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus (DE-588)4175270-3 gnd Virusinfektion (DE-588)4188401-2 gnd |
| topic_facet | Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus Virusinfektion Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014775398&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT ahsannasimul polyomavirusesandhumandiseases |