Verfügbarkeit: Polyomaviruses and human diseases

Polyomaviruses and human diseases:

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Format:	Buch
Sprache:	English
Veröffentlicht:	New York, NY Springer Science + Business Media [u.a.] 2006
Schriftenreihe:	Advances in experimental medicine and biology 577
Schlagworte:	Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus Virusinfektion Aufsatzsammlung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XXIV, 360 S. Ill., graph. Darst.
ISBN:	0387292330

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245	1	0	\|a Polyomaviruses and human diseases \|c ed. by Nasimul Ahsan
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Datensatz im Suchindex

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adam_text	CONTENTS 1. POLYOMAVIRUSES AND HUMAN DISEASES ______________________1 Nasimul Ahsan and Keerti V. Shah Abstract ............................................................................................................................... 1 History ..M......«..«.....-«..-..-«-..·-..-··.-·.-..«.-....««·.·.·-....-·..-..«.·-».««.··.·«.· .·.«.··..—.-.«.·.-.«-·- - 1 2. DISCOVERY AND EPIDEMIOLOGY OF THE HUMAN POLYOMAVIRUSES BK VIRUS (BKV) AND JC VIRUS (JCV) ... 19 Wendy A. Knowles Abstract ______________________-___________·________________·___________19 nf BKV and JCV ................................................—.19 .. . .. .............................. ..m.... ....................... , ......».........20 3. PHYLOGENOMICS AND MOLECULAR EVOLUTION OF POLYOMAVIRUSES _____________________________________46 Keith A. Crandall, Marcos Ρ rez-Losada, Ryan G. Christensen, David A. McClellan and Raphael P. Viscidi „»....».......u.. 46 t.M.ttl44ttMl»Tt46 Population Variation of SV40 ..„...„.««-..».......„-»..„..„«-««..«»«»»»«..»«—.„-.«.......„.. 56 Ciimtnirv »·»«■»·*■·>■·■■···■· a«·. ·■«···■■····»■· ··■·■·«·■»·■·· ■••»•»•«.»»■a ■···»»·■■·■■■■■■·■··■.■■ 56 ЛІШІІКІ j „»■»··■··■·»··■■· ·····«■··■«■■ ■■■■«■·«■««■«« ■■«■ »·«■ ■■ ■ ■ ■ · ■ ■■»■« ■■■» «■ ■··■«·«·■■ ·- »» 4. VIRUS RECEPTORS AND TROPISM ______________________________60 Aarthi Ashok and Walter J. Atwood tntrnHiiftinn „„„.„.„„..«««..«..»..«..«......«..«..........„..................«..„..„..„......„..„ „.....60 Mouse Polyonmvinis (PyV) ---------------------------------------------------------------------61 JC VÍrOS (JCV) .1. I.I I . _____..............................._____....... ............ Ч ....... II II. ........................63 B-Lymphotropk Papovavirus (LPV) ------.------------.---------_------.______._____.__. 66 Conclusions .................................. ~ -----------—--------------------- ~~™„ —„..-----------„. 68 xvü xviii Contents 5. SEROLOGICAL CROSS REACTIVITY BETWEEN POLYOMAVIRUS CAPSIDS __________________________________73 Raphael P. Viscidi and Barbara dayman Abstract ._______._____________________________________________....___.____73 Introduction ................................................................—■.......—■■■■■■■■—■-—···■...............-■— 73 Virus-Like Particle-Based Polyomavirus Enzyme Immunoassays _______________74 Reactivity of Rhesus Macaque Sera in VLP-Based Polyomavirus Enzyme Immunoassays ______.________________________________________76 Reactivity of Human Sera in VLP-Based Polyomavirus Enzyme Immunoassays ..— 78 Reactivity of Human Sera in LPV VLP-Based Enzyme Immunoassay ____._______81 Conclusions .■•......•.•.•...•.••...•..............••.«•..•.•..•.».■•...••..••••.......••••..•..•••.■•..•..•••..»••».••••..»•»81 6. MOLECULAR GENETICS OF THE BK VIRUS ......................................85 Christopher L. Cubitt Abstract. ___._________.____________________.________________-..__________85 Introduction ....................................................................................................... 85 Genotyping BKV ...________________......_____...._________._______________....90 Association of Mutations and Genotypes with Disease _____„___________________90 BKV Molecular Genetics: Future Research ._________________________________92 7. SEROLOGICAL DIAGNOSIS OF HUMAN POLYOMAVIRUS INFECTION _______________________................................................96 Annika Lundstig and Joakim Dillner Abstract .......___________.__________.____».______________._____.„.._____..__96 Introduction .».......„»„.„...„..»„....„....„„..„..„......„.„.„„..».„...„...„.»..„......„.._„„.„...»... 96 Simian Virus 40_________.____._______„___„.__._______..___________........__».. 97 Antibody Stability __....__..„..__»....__..____..........._______________.„___»...___„..98 Serological Methods ..__._________.„____..___________.__________________........98 EIA Serological Method __________.„„____.____..._____.____.....___.»._______99 Preparation of Virus-Like Particles ................................................................................. 99 Expression Systems ..___.__.»___»________________._____...»________________100 8. HUMAN POLYOMAVIRUS JC AND BK PERSISTENT INFECTION ________________________________________________102 Kristína Doerries Abstract.» ___».__ ^. ____________________.________„„___________________102 Introduction .».»»..—».«...»..»..»..„..»..„..»„„......»..»..„„„„„.„„„..„.„..„..»„„.._.._..». 102 Urogenital Persistent BKV Infection ____________»-..__._______»____ „„„»...„.™ 105 Active BKV Infection in the Kidney ._____„„.___.__ ™ _____..»___».,».______„„ 105 JCVin the Urogenital Tract ______„»„»..„..„.._...„™._________„...____ „™~. __.» 106 Activation of Urogenital JCV Infection..»..» __„»__.._.„.»_________ ~_ ___„„„__107 Neurotropism of Human Polyomaviruses ____».__»·„»»__ ™. _____.______ »™.™ 108 JCV in the Central Nervous System ____________________.__________________108 Activity of Asymptomatic JCV Infection in the CNS _________________________110 Human Polyomaviruses in the Hematopoietic System ..„..„._„.____„.„„.„.„_..„__ 111 Contents x¡x Association of BKV with Cells of the Immune System ___________......______..... 112 JCV in Lymphoid Organs and Blood Cells ________________________.....____.__ ИЗ Activation of JCV Infection in Hematopoietic Cells _________________________114 9. IMMUNITY AND AUTOIMMUNITY INDUCED BY POLYOMAVIRUSES: CLINICAL, EXPERIMENTAL AND THEORETICAL ASPECTS ....................................................117 Ole Petter Rekvig, Signy Bendiksen and Ugo Moens Abstract ...................................................................................................................... 117 Introduction ......................»..................................................................................^......... 117 Immunology of Polyomaviruses ..................................................................................... 119 Polyomaviruses and T Cell Responses ........................................................................... 126 Polyomaviruses, SLE and Autoimmunity to Nucleosomes and dsDNA ____....__... 130 Concluding Remarks....................................................................................................... 139 10. THE PATHOBIOLOGY OF POLYOMAVIRUS INFECTION IN MAN .......................................................................148 Parmjeet Randhawa, Abhay Vats and Ron Shapiro Abstract ..____...__.___.______________________.__.........................__...____......148 Biology of Polyomaviruses ________________________...___................__..___..... 148 Historical Aspects ............................................ ..............„....................................... 149 Modes of Natural Transmission __.____.____.__.........________„___..____............ 149 Transmission of Polyomavirus via Organ Transplantation —.....___....................... 150 Viral Interactions with Host Cell Receptors ___________________________.____150 Entry of Virus into Host Cells ____________.___________.___________________151 Cytoplasmic Trafficking...... ________________......__....._____.__............................ 152 Nuclear Targeting ...,.·.·..·.·....·....·.··.·..»...·........·..·.....··.......·...··..·.·..·.·....·.·...·.····..-.··...·..·· 153 Clinical Sequelae of Primary Infection in Man ___.____.________.-----.------.......... 153 Sites of Viral Latency ___________________________________.---------------------153 Reactivation of Latent Virus _________________________________________.„.. 154 Pathogenesis of Tissue Damage in Polyomavirus Infected Tissues .------.................. 154 Concluding Remarks ______«__________________.-------------------------------——155 11. POLYOMAVmUS-ASSOCIATED NEPHROPATHY IN RENAL TRANSPLANTATION: CRITICAL ISSUES OF SCREENING AND MANAGEMENT _____________________________________160 Hans H. Hirsch, Cinthia B. Drachenberg, Jueig Steiger and Emilio Ramos Abstract ......................................,..........,,......,, .........г., .........._____—— ~—.~~-~~— —. 160 Introduction ________„________________________________________________160 Infection, Replication and Disease ________.„„„..„._—.„..„.„._.„..„.„.—._..-..... 161 Epidemiology -------------------------------_„___________ ,_.™~~..™~~ --------.„„_.—163 Risk Factors _________________________________________________________164 Diagnose ..................................-------___— ~~.~~~~~~ —.............................. »~ —«— 166 Intervention .........................._____„_„........................_____.------„......_......„.„„....„„ 169 RetransplMtatioB -------------------------------------------------------------------------------170 Conclusion ι,· ...... .ι. -,...,.. 1.1, ......,....,,.,,„,,,,-■.......■--·.........______________________________ І 70 xx Contents 12. BK VIRUS AND IMMUNOSUPPRESSIVE AGENTS _____________174 Irfan Agha and Daniel C. Brennan Abstract ________________________________________________________174 Biology of BKV Infection: From Primary Infection to Manifest Disease .__.._____174 The Second Hit Hypothesis ________________________________________175 Clinical Correlates of BKV Infection in Renal Transplant Recipients __________176 Impact of Immunosuppression: Net State or Asymmetric Predisposition? ___......... 176 Prospective Look at BKVN: Role of Immunosuppression .___.-----.------------.—178 Reflections on the Biologic Behavior of the Virus _______....-----------------------. 180 Risks of Alteration of Immunosuppression __.-----------------.__________._____181 Immunosuppression Management for BKV Infection ____._______.________.. 181 13. BK VIRUS INFECTION AFTER NON-RENAL TRANSPLANTATION ___________________________________185 Martha Pavlakis, Abdolreza Haririan and David K. Klassen Abstract __________________________________________________.___...... 185 BKV-BMT-Hemorrhagic Cystitis _____________________________________185 BKV-Non-Renal Solid Organ Transplant _______________________________188 14. LATENT AND PRODUCTIVE POLYOMAVIRUS INFECTIONS OF RENAL ALLOGRAFTS: MORPHOLOGICAL, CLINICAL, AND Ρ ATHOPHYSIOLOGICAL ASPECTS ______190 Volker Nickeleit, Harsharan K. Singh and Michael J. Mihatsch Abstract ..........__„____.____„..„_______.________.___......______._____._____190 Introduction ..............-..............................«..................................-.............._................. 190 Morphologic Characterization of BK Virus Allograft Nephropathy (BKN) ______191 Ultrastructural Features ........____.__......___.___.______„..___.___.„..____.__193 Ancillary Diagnostic Techniaues ................................................................................. 193 Histologie Stages/Patterns of BKN ___.._______________.___..___________...... 196 Latent BK Virus Infections ............................................................................................. 198 15. URINE CYTOLOGY FINDINGS OF POLYOMAVIRUS INFECTIONS __________________________________________201 Harsharan K. Singh, Lukas Bubendorf, Michael J. Mihatsch, Cinthia B. Drachenberg and Volker Nickeleit Abstract ____._____.-__,.„__._..___.._______________._______„______„__201 Introduction ..—....«—«»■.»..-..—..».»...»..««—.—.—»«..»..»....««.»..»..«..«..„.«...„«m..«»«. 201 Polyomavirus Inclusion Bearing Decoy Cells ...._...._.._.....».._._..„.....„..„..„..„... 202 Urine Analyste for Risk Assessment and Management of BK-Virus Nephropathy (BKN) ..„-_.._.«..____ ..~....„„„_..„. ___....____—.„.„.__ „,.™.™ 209 Appendix Immunohistochemical Staining Protocols to Detect Polyomavirus Antigens in Urine Cytology Specimens (Decoy Cells) ..__„..„__ ,„™~._„™ __210 Contents xxi 16. DIAGNOSIS AND TREATMENT OF BK VIRUS-ASSOCIATED TRANSPLANT NEPHROPATHY ...............................................................................213 Abhay Vats, Parmjeet S. Randhawa and Ron Shapiro Abstract _________________.........................................................................................213 Introduction .....................................................................................................................213 Clinical Presentation of BKVAN ___________._____._____....________.....___.__„214 Diagnosis of BKVAN ______.___________...____._____..___..______.___....____214 Risk Factors for BKVAN _______________.__________________________...____219 Clinical Management of BKVAN ..............................„_____._____.„„„......_____....... 220 Conclusion ...........—...■........■.......................„....................................................................224 17. PHARMACOTHERAPEUTIC OPTIONS FOR THE MANAGEMENT OF HUMAN POLYOMAVIRUSES _________________________...........................228 Julie Roskopf, Jennifer Trofe, Robert J. Stratta and Nasimul Ahsan Abstract .............................................................................................................228 Introduction . _..„................................................................................................ 228 JC Virus _______„______.....__........_____..........__._____...___.............____.........229 Progressive Multifocal Leukoencephalopathy ......._____.___._______...................... 229 BK Virus ......................................................................................................... .„..„„....„...230 BKV- Associated Hemorrnagic Cystitis ------------------------------------------------------230 Polyomavirus-Associated Nephropathy in Transplant Recipients ...___....___„___230 Targets for Pharmacotherapeutic Intervention ...........______......_____...__...„.__..234 Specific Pharmacotherapeutic Intervention .........___..._______.....___........___..... 235 Algorithms for Clinical Interventions ______._______.........................__„.„....„..„„.246 { ΏηρΙικΐηη .»..„.„.■«..„„„„«„·■„„■·„■■„...■■■„■.„..„■.„..„.■„..„..„„·...„..„.■„■.„..„„»■„■ 248 18. LEFLUNOMIDE IN SOLID ORGAN TRANSPLANTATION AND POLYOM A VIRUS INFECTION ____________________________________255 Michelle A. Josephson, Basit Javaid, Pradeep V. Kadambi, Shane M. Meehan and James W. Williams IntrnHiirtinn ______._.._. .„.„„„.^...~.„. .„.._..„..........„..„..„..„..........„..„......„..„..„.„. 255 f Ііпігяі PliarmftcekKry ..........».»■«....................... ,...............^... ...... x»...^.,..!...... ................. 255 Immunosuppressive Properties: Mechanisms of Immunosuppression .„..„..__„___256 Anti-Viral Properties: la Vitro Activity of A77 1726-------------------------------------259 Reconciliation of Immune Suppression and Anti-Viral Activity .__„.„___..__......260 I .»flnnnmWI» in BKN ._„„>»...»».»„_.„. .....~..~.„..„. ....._..„......„.„......„..........».„.„ 261 Conclusion.™~ ----------- „„^„ — .„~~. —~™.^.™...„„..^~™„™...™------„..„_.„„ 262 xrii Contents 19. JC VIRUS CAN INFECT HUMAN IMMUNE AND NERVOUS SYSTEM PROGENITOR CELLS: IMPLICATIONS FOR PATHOGENESIS .....................................................................266 Jean Hou, Pankaj Seth and Eugene O. Major Abstract ______________________________________________________________266 Introduction ..·..·.........,........···.·...........·..·.......·..·■...·.·.·.....·.·.·.■.,·..·.......·■....■...····■·■..···.··..· 266 JCV in the Immune System ______________________________________________268 JCV in the CNS ________________________________________________________269 Therapeutic Purposes ...................................................................................................271 Conclusion ...................................................................................................................... 272 20. THE POLYOMAVIRUS, JCV, AND ITS INVOLVEMENT IN HUMAN DISEASE _______________________________________274 Kamel Khalili, Jennifer Gordon and Martyn К. White Abstract ______________._____________.__.______.______._________________274 An Introduction to JC Virus _____________________________________________274 The Life Cycle of JCV „______._________.__________.______________________275 Tropism of JCV _____________________________________________________..... 276 The Spread of JCV _____.________________.__._______...__._______._________276 JCV and PML ________________________________________.________________277 JCV and Cancer: Experimental Tumorigenesis _______________________.____... 278 JCV and Cancer: Clinical Tumors ________________________________________279 JCV Molecular Biology ..............____.________.____.___...»___________..__.__.__281 Future Studies of JCV ...._______________„________________.______________-. 282 21. TRANSFORMING ACTIVITIES OF JC VIRUS EARLY PROTEINS _________________________________________288 Richard J. Frisque, Catherine Hofstetter and Shiva K. Tyagarajan Abstract __....„_____.______.....__.__....___..„..__...___„.._____.________.___„288 Introduction ............................................................................................................. 288 JCV TAg Functions ........................___.......__...........___ ™._ ____....__«..________„. 292 JCV tAg Functions ____„________.___,_..-___-__»-______ ..~ ___.....__.__«..„..300 JCV T Protein Functions ..__.......__.....__..„__.__._______.__....—__.......______„301 Summary of JCV Early Protein Function __________________________________304 22. POLYOMAVIRUS IN HUMAN CANCER DEVELOPMENT _______310 Winston Lee and Erik Langhoff Abstract __ ~ __.._..„.._..._____.„____-___............__..„__„.____ ^.^ ___..«..._ 310 Viral Life Cycle .„__„__„______.._____.........__„.._.________.___.____„________310 Mechanisms of Oncogenesis ..„.„..„..„......„..........„..............„..„......„......„..„„„......„.„ 311 Evidence of Poiyoma-Cancer Association ..__......----- ~ ____.___________________312 Conclusion · ·■■>·· .,ttt „ шлл . ···«··♦·«··«···■.............,........... ttMł 315 Contents xxüi 23. BK VIRUS, JC VIRUS AND SIMIAN VIRUS 40 INFECTION IN HUMANS, AND ASSOCIATION WITH HUMAN TUMORS .___319 Giuseppe Barbanti-Brodano, Silvia Sabbioni, Femanda Martini, Massimo Negrini, Alfredo Corallini and Mauro Tognon Abstract ...........................................................................................................................319 Introduction ..................................................................................................................... 319 General Characteristics of BKV, JCV and SV40 ____________________________320 BKV, JCV and SV40 Infection in Humans _________________.................................320 BKV, JCV and SV40 Cell Transformation and Experimental Oncogenicity ______322 Association of BKV, JCV and SV40 with Human Tumors ____________________325 Conclusions and Future Perspectives ...........................................................................332 24. EPIDEMIOLOGIC STUDIES OF POLYOMAVIRUSES AND CANCER: PREVIOUS FINDINGS, METHODOLOGIC CHALLENGES AND FUTURE DIRECTIONS .............................342 Dana E.M. Rollison Abstract ............................................................................................................. 342 Introduction ..................„..................................................................„..............■■■■■.......·.. 342 Previous Findings ..«..«..«..».».««...•..«...«.„......«..»•.........«...•..»..«•.........«....•■.••...■•»••.•343 Methodologie Challenges __.».-»___«_____».„...«-.„..„...........■.,....„.,,..„..^..«..»..»....353 Future Directions ,._..._..»...._........_„..»_..._..._.........»..„..»......«.......»...»..»..»..»...«.·»..»...». 354 .»...«.«..»..»...·■....»...«·»....».·...*«·».·······.» 355 INDEX -----------------------------------------------.....--------------------.................................357
adam_txt	CONTENTS 1. POLYOMAVIRUSES AND HUMAN DISEASES _1 Nasimul Ahsan and Keerti V. Shah Abstract . 1 History .M.«.«.-«.-.-«-.·-.-··.-·.-.«.-.««·.·.·-.-·.-.«.·-».««.··.·«.·".·.«.··.—.-.«.·.-.«-·-"- 1 2. DISCOVERY AND EPIDEMIOLOGY OF THE HUMAN POLYOMAVIRUSES BK VIRUS (BKV) AND JC VIRUS (JCV) . 19 Wendy A. Knowles Abstract _-_·_·_19 nf BKV and JCV .—.19 . . . . .m. . , .».20 3. PHYLOGENOMICS AND MOLECULAR EVOLUTION OF POLYOMAVIRUSES _46 Keith A. Crandall, Marcos Ρ rez-Losada, Ryan G. Christensen, David A. McClellan and Raphael P. Viscidi „».».u. 46 t.M.ttl44ttMl»Tt46 Population Variation of SV40 .„.„.««-.».„-».„.„«-««.«»«»»»«.»«—.„-.«.„. 56 Ciimtnirv »·»«■»·*■·>■·■■···■· a«·. ·■«···■■····»■· ··■·■·«·■»·■·· ■••»•»•«.»»■a ■···»»·■■·■■■■■■·■··■.■■ 56 ЛІШІІКІ j „»■»··■··■·»··■■·'·····«■··■«■■'■■■■«■·«■««■««''■■«■'»·«■'''■■'■'■''■''·'■'■■»■«'■■■»'«■'■··■«·«·■■ ·-'»» 4. VIRUS RECEPTORS AND TROPISM _60 Aarthi Ashok and Walter J. Atwood tntrnHiiftinn „„„.„.„„.«««.«.».«.«.«.«.„.«.„.„.„.„.„ „.60 Mouse Polyonmvinis (PyV) ---------------------------------------------------------------------61 JC VÍrOS (JCV) .1. I.I I". _._. . Ч . II II. .63 B-Lymphotropk Papovavirus (LPV) ------.------------.---------_------._._._. 66 Conclusions . ~ -----------—--------------------- ~~™„ —„.-----------„. 68 xvü xviii Contents 5. SEROLOGICAL CROSS REACTIVITY BETWEEN POLYOMAVIRUS CAPSIDS _73 Raphael P. Viscidi and Barbara dayman Abstract ._._._._73 Introduction .—■.—■■■■■■■■—■-—···■.-■— 73 Virus-Like Particle-Based Polyomavirus Enzyme Immunoassays _74 Reactivity of Rhesus Macaque Sera in VLP-Based Polyomavirus Enzyme Immunoassays _._76 Reactivity of Human Sera in VLP-Based Polyomavirus Enzyme Immunoassays .— 78 Reactivity of Human Sera in LPV VLP-Based Enzyme Immunoassay _._81 Conclusions .■•.•.•.•.•.••.•.••.«•.•.•.•.».■•.••.••••.••••.•.•••.■•.•.•••.»••».••••.»•»81 6. MOLECULAR GENETICS OF THE BK VIRUS .85 Christopher L. Cubitt Abstract. _._._._-._85 Introduction . 85 Genotyping BKV ._._._._.90 Association of Mutations and Genotypes with Disease _„_90 BKV Molecular Genetics: Future Research ._92 7. SEROLOGICAL DIAGNOSIS OF HUMAN POLYOMAVIRUS INFECTION _.96 Annika Lundstig and Joakim Dillner Abstract ._._._»._._.„._._96 Introduction .».„»„.„.„.»„.„.„„.„.„.„.„.„„.».„.„.„.».„.„._„„.„.». 96 Simian Virus 40_._._„_„._._._._». 97 Antibody Stability _._.„._»._._._.„_»._„.98 Serological Methods ._._.„_._._.98 EIA Serological Method _.„„_._._._._.»._99 Preparation of Virus-Like Particles . 99 Expression Systems ._._.»_»_._.»_100 8. HUMAN POLYOMAVIRUS JC AND BK PERSISTENT INFECTION _102 Kristína Doerries Abstract.» _»._ ^. _._„„_102 Introduction .».»».—».«.».».».„.».„.»„„.».».„„„„„.„„„.„.„.„.»„„._._.». 102 Urogenital Persistent BKV Infection _»-._._»_ „„„».„.™ 105 Active BKV Infection in the Kidney ._„„._._ ™ _.»_».,»._„„ 105 JCVin the Urogenital Tract _„»„».„.„._.„™._„._ „™~. _.» 106 Activation of Urogenital JCV Infection.».» _„»_._.„.»_ ~_ _„„„_107 Neurotropism of Human Polyomaviruses _»._»·„»»_ ™. _._ »™.™ 108 JCV in the Central Nervous System _._108 Activity of Asymptomatic JCV Infection in the CNS _110 Human Polyomaviruses in the Hematopoietic System .„.„._„._„.„„.„.„_.„_ 111 Contents x¡x Association of BKV with Cells of the Immune System _._. 112 JCV in Lymphoid Organs and Blood Cells _._._ ИЗ Activation of JCV Infection in Hematopoietic Cells _114 9. IMMUNITY AND AUTOIMMUNITY INDUCED BY POLYOMAVIRUSES: CLINICAL, EXPERIMENTAL AND THEORETICAL ASPECTS .117 Ole Petter Rekvig, Signy Bendiksen and Ugo Moens Abstract . 117 Introduction .».^. 117 Immunology of Polyomaviruses . 119 Polyomaviruses and T Cell Responses . 126 Polyomaviruses, SLE and Autoimmunity to Nucleosomes and dsDNA _._. 130 Concluding Remarks. 139 10. THE PATHOBIOLOGY OF POLYOMAVIRUS INFECTION IN MAN .148 Parmjeet Randhawa, Abhay Vats and Ron Shapiro Abstract ._._._._._._._.148 Biology of Polyomaviruses _._._._. 148 Historical Aspects . .„. 149 Modes of Natural Transmission _._._._._„_._. 149 Transmission of Polyomavirus via Organ Transplantation —._. 150 Viral Interactions with Host Cell Receptors _._150 Entry of Virus into Host Cells _._._151 Cytoplasmic Trafficking. _._._._. 152 Nuclear Targeting .,.·.·.·.·.·.·.··.·.».·.·.·.··.·.··.·.·.·.·.·.·.·.····.-.··.·.·· 153 Clinical Sequelae of Primary Infection in Man _._._.-----.------. 153 Sites of Viral Latency _.---------------------153 Reactivation of Latent Virus _.„. 154 Pathogenesis of Tissue Damage in Polyomavirus Infected Tissues .------. 154 Concluding Remarks _«_.-------------------------------——155 11. POLYOMAVmUS-ASSOCIATED NEPHROPATHY IN RENAL TRANSPLANTATION: CRITICAL ISSUES OF SCREENING AND MANAGEMENT _160 Hans H. Hirsch, Cinthia B. Drachenberg, Jueig Steiger and Emilio Ramos Abstract .,.,,.,, .г., ._—— ~—.~~-~~— —. 160 Introduction _„_160 Infection, Replication and Disease _.„„„.„._—.„.„.„._.„.„.„.—._.-. 161 Epidemiology -------------------------------_„_ ,_.™~~.™~~ --------.„„_.—163 Risk Factors _164 Diagnose .-------_— ~~.~~~~~~ —. »~ —«— 166 Intervention ._„_„._.------„._.„.„„.„„ 169 RetransplMtatioB -------------------------------------------------------------------------------170 Conclusion ι,· . .ι. -,.,. 1.1, .,.,,.,,„,,,,-■.■--·._ І 70 xx Contents 12. BK VIRUS AND IMMUNOSUPPRESSIVE AGENTS _174 Irfan Agha and Daniel C. Brennan Abstract _174 Biology of BKV Infection: From Primary Infection to Manifest Disease ._._174 The Second Hit Hypothesis _175 Clinical Correlates of BKV Infection in Renal Transplant Recipients _176 Impact of Immunosuppression: Net State or Asymmetric Predisposition? _. 176 Prospective Look at BKVN: Role of Immunosuppression ._.-----.------------.—178 Reflections on the Biologic Behavior of the Virus _.-----------------------. 180 Risks of Alteration of Immunosuppression _.-----------------._._181 Immunosuppression Management for BKV Infection _._._. 181 13. BK VIRUS INFECTION AFTER NON-RENAL TRANSPLANTATION _185 Martha Pavlakis, Abdolreza Haririan and David K. Klassen Abstract _._. 185 BKV-BMT-Hemorrhagic Cystitis _185 BKV-Non-Renal Solid Organ Transplant _188 14. LATENT AND PRODUCTIVE POLYOMAVIRUS INFECTIONS OF RENAL ALLOGRAFTS: MORPHOLOGICAL, CLINICAL, AND Ρ ATHOPHYSIOLOGICAL ASPECTS _190 Volker Nickeleit, Harsharan K. Singh and Michael J. Mihatsch Abstract ._„_._„.„_._._._._._190 Introduction .-.«.-._. 190 Morphologic Characterization of BK Virus Allograft Nephropathy (BKN) _191 Ultrastructural Features ._._._._._„._._.„._._193 Ancillary Diagnostic Techniaues . 193 Histologie Stages/Patterns of BKN _._._._. 196 Latent BK Virus Infections . 198 15. URINE CYTOLOGY FINDINGS OF POLYOMAVIRUS INFECTIONS _201 Harsharan K. Singh, Lukas Bubendorf, Michael J. Mihatsch, Cinthia B. Drachenberg and Volker Nickeleit Abstract _._.-_,.„_._._._._„_„_201 Introduction .—.«—«»■.».-.—.».».».««—.—.—»«.».».««.».».«.«.„.«.„«m.«»«. 201 Polyomavirus Inclusion Bearing Decoy Cells ._._._.»._._.„.„.„.„.„. 202 Urine Analyste for Risk Assessment and Management of BK-Virus Nephropathy (BKN) .„-_._.«._ .~.„„„_.„. _._—.„.„._ „,.™.™ 209 Appendix Immunohistochemical Staining Protocols to Detect Polyomavirus Antigens in Urine Cytology Specimens (Decoy Cells) ._„.„_ ,„™~._„™ _210 Contents xxi 16. DIAGNOSIS AND TREATMENT OF BK VIRUS-ASSOCIATED TRANSPLANT NEPHROPATHY .213 Abhay Vats, Parmjeet S. Randhawa and Ron Shapiro Abstract _.213 Introduction .213 Clinical Presentation of BKVAN _._._._._._„214 Diagnosis of BKVAN _._._._._._._._214 Risk Factors for BKVAN _._._219 Clinical Management of BKVAN .„_._.„„„._. 220 Conclusion .—.■.■.„.224 17. PHARMACOTHERAPEUTIC OPTIONS FOR THE MANAGEMENT OF HUMAN POLYOMAVIRUSES _.228 Julie Roskopf, Jennifer Trofe, Robert J. Stratta and Nasimul Ahsan Abstract .228 Introduction . _.„. 228 JC Virus _„_._._._._._._.229 Progressive Multifocal Leukoencephalopathy ._._._. 229 BK Virus . .„.„„.„.230 BKV- Associated Hemorrnagic Cystitis ------------------------------------------------------230 Polyomavirus-Associated Nephropathy in Transplant Recipients ._._„_230 Targets for Pharmacotherapeutic Intervention ._._._.„._.234 Specific Pharmacotherapeutic Intervention ._._._._. 235 Algorithms for Clinical Interventions _._._„.„.„.„„.246 {"ΏηρΙικΐηη .».„.„.■«.„„„„«„·■„„■·„■■„.■■■„■.„.„■.„.„.■„.„.„„·.„.„.■„■.„.„„»■„■ 248 18. LEFLUNOMIDE IN SOLID ORGAN TRANSPLANTATION AND POLYOM A VIRUS INFECTION _255 Michelle A. Josephson, Basit Javaid, Pradeep V. Kadambi, Shane M. Meehan and James W. Williams IntrnHiirtinn _._._. .„.„„„.^.~.„. .„._.„.„.„.„.„.„.„.„.„.„.„. 255 f Ііпігяі PliarmftcekKry .».»■«. ,.^. . x».^.,.!. . 255 Immunosuppressive Properties: Mechanisms of Immunosuppression .„.„._„_256 Anti-Viral Properties: la Vitro Activity of A77 1726-------------------------------------259 Reconciliation of Immune Suppression and Anti-Viral Activity ._„.„_._.260 I .»flnnnmWI» in BKN ._„„>».»».»„_.„. .~.~.„.„. ._.„.„.„.„.».„.„ 261 Conclusion.™~ ----------- „„^„ — .„~~. —~™.^.™.„„.^~™„™.™------„.„_.„„ 262 xrii Contents 19. JC VIRUS CAN INFECT HUMAN IMMUNE AND NERVOUS SYSTEM PROGENITOR CELLS: IMPLICATIONS FOR PATHOGENESIS .266 Jean Hou, Pankaj Seth and Eugene O. Major Abstract _266 Introduction .·.·.,.···.·.·.·.·.·■.·.·.·.·.·.·.■.,·.·.·■.■.····■·■.···.··.· 266 JCV in the Immune System _268 JCV in the CNS _269 Therapeutic Purposes .271 Conclusion . 272 20. THE POLYOMAVIRUS, JCV, AND ITS INVOLVEMENT IN HUMAN DISEASE _274 Kamel Khalili, Jennifer Gordon and Martyn К. White Abstract _._._._._._274 An Introduction to JC Virus _274 The Life Cycle of JCV „_._._._275 Tropism of JCV _. 276 The Spread of JCV _._._._._._._276 JCV and PML _._277 JCV and Cancer: Experimental Tumorigenesis _._. 278 JCV and Cancer: Clinical Tumors _279 JCV Molecular Biology ._._._._.»_._._._281 Future Studies of JCV ._„_._-. 282 21. TRANSFORMING ACTIVITIES OF JC VIRUS EARLY PROTEINS _288 Richard J. Frisque, Catherine Hofstetter and Shiva K. Tyagarajan Abstract _.„_._._._._.„._._„._._._„288 Introduction . 288 JCV TAg Functions ._._._ ™._ _._«._„. 292 JCV tAg Functions _„_._,_.-_-_»-_ .~ _._._«.„.300 JCV T' Protein Functions ._._._.„_._._._.—_._„301 Summary of JCV Early Protein Function _304 22. POLYOMAVIRUS IN HUMAN CANCER DEVELOPMENT _310 Winston Lee and Erik Langhoff Abstract _ ~ _._.„._._.„_-_._.„_„._ ^.^ _.«._ 310 Viral Life Cycle .„_„_„_._._„._._._._„_310 Mechanisms of Oncogenesis .„.„.„.„.„.„.„.„.„.„.„„„.„.„ 311 Evidence of Poiyoma-Cancer Association ._.----- ~ _._312 Conclusion · ·■■>·· .,ttt „ шлл . ···«··♦·«··«···■.,. ttMł 315 Contents xxüi 23. BK VIRUS, JC VIRUS AND SIMIAN VIRUS 40 INFECTION IN HUMANS, AND ASSOCIATION WITH HUMAN TUMORS ._319 Giuseppe Barbanti-Brodano, Silvia Sabbioni, Femanda Martini, Massimo Negrini, Alfredo Corallini and Mauro Tognon Abstract .319 Introduction . 319 General Characteristics of BKV, JCV and SV40 _320 BKV, JCV and SV40 Infection in Humans _.320 BKV, JCV and SV40 Cell Transformation and Experimental Oncogenicity _322 Association of BKV, JCV and SV40 with Human Tumors _325 Conclusions and Future Perspectives .332 24. EPIDEMIOLOGIC STUDIES OF POLYOMAVIRUSES AND CANCER: PREVIOUS FINDINGS, METHODOLOGIC CHALLENGES AND FUTURE DIRECTIONS .342 Dana E.M. Rollison Abstract . 342 Introduction .„.„.■■■■■.·. 342 Previous Findings .«.«.«.».».««.•.«.«.„.«.»•.«.•.».«•.«.•■.••.■•»••.•343 Methodologie Challenges _.».-»_«_».„.«-.„.„.■.,.„.,,.„.^.«.».».353 Future Directions ,._._.»._._„.»_._._.».„.».«.».».».».».«.·».».». 354 .».«.«.».».·■.».«·».».·.*«·».·······.» 355 INDEX -----------------------------------------------.--------------------.357
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spelling	Polyomaviruses and human diseases ed. by Nasimul Ahsan New York, NY Springer Science + Business Media [u.a.] 2006 XXIV, 360 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 577 Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus (DE-588)4175270-3 gnd rswk-swf Virusinfektion (DE-588)4188401-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Polyoma-Virus (DE-588)4175270-3 s Virusinfektion (DE-588)4188401-2 s b DE-604 Ahsan, Nasimul Sonstige (DE-588)133506282 oth Advances in experimental medicine and biology 577 (DE-604)BV000003102 577 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014775398&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Polyomaviruses and human diseases Advances in experimental medicine and biology Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus (DE-588)4175270-3 gnd Virusinfektion (DE-588)4188401-2 gnd
subject_GND	(DE-588)4175270-3 (DE-588)4188401-2 (DE-588)4143413-4
title	Polyomaviruses and human diseases
title_auth	Polyomaviruses and human diseases
title_exact_search	Polyomaviruses and human diseases
title_exact_search_txtP	Polyomaviruses and human diseases
title_full	Polyomaviruses and human diseases ed. by Nasimul Ahsan
title_fullStr	Polyomaviruses and human diseases ed. by Nasimul Ahsan
title_full_unstemmed	Polyomaviruses and human diseases ed. by Nasimul Ahsan
title_short	Polyomaviruses and human diseases
title_sort	polyomaviruses and human diseases
topic	Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus (DE-588)4175270-3 gnd Virusinfektion (DE-588)4188401-2 gnd
topic_facet	Infections à polyomavirus Polyomavirus BK Virus JC Virus Polyomavirus Infections Polyomavirus infections Polyomaviruses Polyoma-Virus Virusinfektion Aufsatzsammlung
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