The Construction of Analogy-Based Research Programs :: the Lock-and-Key Analogy in 20th Century Biochemistry.
When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical struc...
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Format: | Elektronisch E-Book |
Sprache: | English |
Veröffentlicht: |
Bielefeld :
Transcipt Verlag,
2019.
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Schriftenreihe: | Science studies.
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Schlagworte: | |
Online-Zugang: | Volltext |
Zusammenfassung: | When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. |
Beschreibung: | 1 online resource (225 pages) |
ISBN: | 383944442X 9783839444429 |
Zugangseinschränkungen: | Legal Deposit; |
Internformat
MARC
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520 | |a When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. | ||
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author | Mertens, Rebecca |
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contents | Cover; Table of contents; Preface; 1 The lock-and-key analogy and its influence on 20th century biochemistry; 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907; 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930; 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960; 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs; 6 Concluding remarks on the construction of analogy-based research programs; Literature |
ctrlnum | (OCoLC)1096231434 |
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dewey-ones | 570 - Biology |
dewey-raw | 570 |
dewey-search | 570 |
dewey-sort | 3570 |
dewey-tens | 570 - Biology |
discipline | Biologie |
era | 1700-1799 fast |
era_facet | 1700-1799 |
format | Electronic eBook |
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genre | History fast |
genre_facet | History |
id | ZDB-4-EBA-on1096231434 |
illustrated | Not Illustrated |
indexdate | 2024-11-27T13:29:26Z |
institution | BVB |
isbn | 383944442X 9783839444429 |
language | English |
oclc_num | 1096231434 |
open_access_boolean | |
owner | MAIN DE-863 DE-BY-FWS |
owner_facet | MAIN DE-863 DE-BY-FWS |
physical | 1 online resource (225 pages) |
psigel | ZDB-4-EBA |
publishDate | 2019 |
publishDateSearch | 2019 |
publishDateSort | 2019 |
publisher | Transcipt Verlag, |
record_format | marc |
series | Science studies. |
series2 | Science Studies |
spelling | Mertens, Rebecca. The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. Bielefeld : Transcipt Verlag, 2019. 1 online resource (225 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Science Studies Print version record. Cover; Table of contents; Preface; 1 The lock-and-key analogy and its influence on 20th century biochemistry; 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907; 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930; 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960; 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs; 6 Concluding remarks on the construction of analogy-based research programs; Literature When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK). WlAbNL In English. History. http://id.loc.gov/authorities/subjects/sh85061212 History of Science. Medicine. http://id.loc.gov/authorities/subjects/sh85083064 Science Social aspects. http://id.loc.gov/authorities/subjects/sh85118585 Life sciences. http://id.loc.gov/authorities/subjects/sh85076841 Science Philosophy. http://id.loc.gov/authorities/subjects/sh85118582 Biochemistry. http://id.loc.gov/authorities/subjects/sh85014171 Analogy. http://id.loc.gov/authorities/subjects/sh85004775 Research Program. Molecular biology. http://id.loc.gov/authorities/subjects/sh85086577 Mathematical models. http://id.loc.gov/authorities/subjects/sh85082124 Medicine History 18th century. http://id.loc.gov/authorities/subjects/sh94001714 Biochemical Phenomena https://id.nlm.nih.gov/mesh/D001669 Research history https://id.nlm.nih.gov/mesh/D012106Q000266 Models, Theoretical https://id.nlm.nih.gov/mesh/D008962 History, 19th Century https://id.nlm.nih.gov/mesh/D049672 History, 18th Century https://id.nlm.nih.gov/mesh/D049671 History https://id.nlm.nih.gov/mesh/D006664 Medicine https://id.nlm.nih.gov/mesh/D008511 Biological Science Disciplines https://id.nlm.nih.gov/mesh/D001690 Biochemistry https://id.nlm.nih.gov/mesh/D001671 Molecular Biology https://id.nlm.nih.gov/mesh/D008967 Histoire. Médecine. Sciences Aspect social. Sciences de la vie. Biochimie. Analogie (Philosophie) Biologie moléculaire. Modèles mathématiques. Médecine Histoire 19e siècle. Médecine Histoire 18e siècle. history (discipline) aat medicines (material) aat biological sciences. aat biochemistry. aat analogy. aat molecular biology. aat mathematical models. aat medicine (discipline) aat HISTORY General. bisacsh HISTORY / General bisacsh Mathematical models fast Analogy fast Biochemistry fast History fast Life sciences fast Medicine fast Molecular biology fast Science Philosophy fast Science Social aspects fast 1700-1799 fast Analogy. Biochemistry. History. Life Sciences. Medicine. Molecular Biology. Philosophy of Science. Science. Sociology of Science. has work: The construction of analogy-based research programs (Text) https://id.oclc.org/worldcat/entity/E39PCFqxxpyr3kYyCBmwC3dwBX https://id.oclc.org/worldcat/ontology/hasWork Print version: Mertens, Rebecca. Construction of Analogy-Based Research Programs : The Lock-and-Key Analogy in 20th Century Biochemistry. Bielefeld : Transcipt Verlag, ©2019 9783837644425 Science studies. http://id.loc.gov/authorities/names/n90675942 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=2091561 Volltext |
spellingShingle | Mertens, Rebecca The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. Science studies. Cover; Table of contents; Preface; 1 The lock-and-key analogy and its influence on 20th century biochemistry; 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907; 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930; 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960; 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs; 6 Concluding remarks on the construction of analogy-based research programs; Literature History. http://id.loc.gov/authorities/subjects/sh85061212 History of Science. Medicine. http://id.loc.gov/authorities/subjects/sh85083064 Science Social aspects. http://id.loc.gov/authorities/subjects/sh85118585 Life sciences. http://id.loc.gov/authorities/subjects/sh85076841 Science Philosophy. http://id.loc.gov/authorities/subjects/sh85118582 Biochemistry. http://id.loc.gov/authorities/subjects/sh85014171 Analogy. http://id.loc.gov/authorities/subjects/sh85004775 Research Program. Molecular biology. http://id.loc.gov/authorities/subjects/sh85086577 Mathematical models. http://id.loc.gov/authorities/subjects/sh85082124 Medicine History 18th century. http://id.loc.gov/authorities/subjects/sh94001714 Biochemical Phenomena https://id.nlm.nih.gov/mesh/D001669 Research history https://id.nlm.nih.gov/mesh/D012106Q000266 Models, Theoretical https://id.nlm.nih.gov/mesh/D008962 History, 19th Century https://id.nlm.nih.gov/mesh/D049672 History, 18th Century https://id.nlm.nih.gov/mesh/D049671 History https://id.nlm.nih.gov/mesh/D006664 Medicine https://id.nlm.nih.gov/mesh/D008511 Biological Science Disciplines https://id.nlm.nih.gov/mesh/D001690 Biochemistry https://id.nlm.nih.gov/mesh/D001671 Molecular Biology https://id.nlm.nih.gov/mesh/D008967 Histoire. Médecine. Sciences Aspect social. Sciences de la vie. Biochimie. Analogie (Philosophie) Biologie moléculaire. Modèles mathématiques. Médecine Histoire 19e siècle. Médecine Histoire 18e siècle. history (discipline) aat medicines (material) aat biological sciences. aat biochemistry. aat analogy. aat molecular biology. aat mathematical models. aat medicine (discipline) aat HISTORY General. bisacsh HISTORY / General bisacsh Mathematical models fast Analogy fast Biochemistry fast History fast Life sciences fast Medicine fast Molecular biology fast Science Philosophy fast Science Social aspects fast |
subject_GND | http://id.loc.gov/authorities/subjects/sh85061212 http://id.loc.gov/authorities/subjects/sh85083064 http://id.loc.gov/authorities/subjects/sh85118585 http://id.loc.gov/authorities/subjects/sh85076841 http://id.loc.gov/authorities/subjects/sh85118582 http://id.loc.gov/authorities/subjects/sh85014171 http://id.loc.gov/authorities/subjects/sh85004775 http://id.loc.gov/authorities/subjects/sh85086577 http://id.loc.gov/authorities/subjects/sh85082124 http://id.loc.gov/authorities/subjects/sh94001714 https://id.nlm.nih.gov/mesh/D001669 https://id.nlm.nih.gov/mesh/D012106Q000266 https://id.nlm.nih.gov/mesh/D008962 https://id.nlm.nih.gov/mesh/D049672 https://id.nlm.nih.gov/mesh/D049671 https://id.nlm.nih.gov/mesh/D006664 https://id.nlm.nih.gov/mesh/D008511 https://id.nlm.nih.gov/mesh/D001690 https://id.nlm.nih.gov/mesh/D001671 https://id.nlm.nih.gov/mesh/D008967 |
title | The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. |
title_auth | The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. |
title_exact_search | The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. |
title_full | The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. |
title_fullStr | The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. |
title_full_unstemmed | The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry. |
title_short | The Construction of Analogy-Based Research Programs : |
title_sort | construction of analogy based research programs the lock and key analogy in 20th century biochemistry |
title_sub | the Lock-and-Key Analogy in 20th Century Biochemistry. |
topic | History. http://id.loc.gov/authorities/subjects/sh85061212 History of Science. Medicine. http://id.loc.gov/authorities/subjects/sh85083064 Science Social aspects. http://id.loc.gov/authorities/subjects/sh85118585 Life sciences. http://id.loc.gov/authorities/subjects/sh85076841 Science Philosophy. http://id.loc.gov/authorities/subjects/sh85118582 Biochemistry. http://id.loc.gov/authorities/subjects/sh85014171 Analogy. http://id.loc.gov/authorities/subjects/sh85004775 Research Program. Molecular biology. http://id.loc.gov/authorities/subjects/sh85086577 Mathematical models. http://id.loc.gov/authorities/subjects/sh85082124 Medicine History 18th century. http://id.loc.gov/authorities/subjects/sh94001714 Biochemical Phenomena https://id.nlm.nih.gov/mesh/D001669 Research history https://id.nlm.nih.gov/mesh/D012106Q000266 Models, Theoretical https://id.nlm.nih.gov/mesh/D008962 History, 19th Century https://id.nlm.nih.gov/mesh/D049672 History, 18th Century https://id.nlm.nih.gov/mesh/D049671 History https://id.nlm.nih.gov/mesh/D006664 Medicine https://id.nlm.nih.gov/mesh/D008511 Biological Science Disciplines https://id.nlm.nih.gov/mesh/D001690 Biochemistry https://id.nlm.nih.gov/mesh/D001671 Molecular Biology https://id.nlm.nih.gov/mesh/D008967 Histoire. Médecine. Sciences Aspect social. Sciences de la vie. Biochimie. Analogie (Philosophie) Biologie moléculaire. Modèles mathématiques. Médecine Histoire 19e siècle. Médecine Histoire 18e siècle. history (discipline) aat medicines (material) aat biological sciences. aat biochemistry. aat analogy. aat molecular biology. aat mathematical models. aat medicine (discipline) aat HISTORY General. bisacsh HISTORY / General bisacsh Mathematical models fast Analogy fast Biochemistry fast History fast Life sciences fast Medicine fast Molecular biology fast Science Philosophy fast Science Social aspects fast |
topic_facet | History. History of Science. Medicine. Science Social aspects. Life sciences. Science Philosophy. Biochemistry. Analogy. Research Program. Molecular biology. Mathematical models. Medicine History 18th century. Biochemical Phenomena Research history Models, Theoretical History, 19th Century History, 18th Century History Medicine Biological Science Disciplines Biochemistry Molecular Biology Histoire. Médecine. Sciences Aspect social. Sciences de la vie. Biochimie. Analogie (Philosophie) Biologie moléculaire. Modèles mathématiques. Médecine Histoire 19e siècle. Médecine Histoire 18e siècle. history (discipline) medicines (material) biological sciences. biochemistry. analogy. molecular biology. mathematical models. medicine (discipline) HISTORY General. HISTORY / General Mathematical models Analogy Life sciences Molecular biology Science Philosophy Science Social aspects |
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