The Construction of Analogy-Based Research Programs :: the Lock-and-Key Analogy in 20th Century Biochemistry.

When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical struc...

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1. Verfasser: Mertens, Rebecca
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Bielefeld : Transcipt Verlag, 2019.
Schriftenreihe:Science studies.
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Zusammenfassung:When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling.
Beschreibung:1 online resource (225 pages)
ISBN:383944442X
9783839444429
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