Network medicine :: complex systems in human disease and therapeutics /
"Network medicine, a new field which developed from the application of systems biology approaches to human disease, embraces the complexity of multifactorial influences on disease, which can be driven by non-linear effects and molecular and statistical interactions. The development of comprehen...
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, Massachusetts :
Harvard University Press,
2017.
|
| Schlagworte: | |
| Online-Zugang: | DE-862 DE-863 |
| Zusammenfassung: | "Network medicine, a new field which developed from the application of systems biology approaches to human disease, embraces the complexity of multifactorial influences on disease, which can be driven by non-linear effects and molecular and statistical interactions. The development of comprehensive and affordable Omics platforms provides the data types for network medicine, and graph theory and statistical physics provide the theoretical framework to analyze networks. While network medicine provides a fundamentally different approach to understanding disease etiology, it will also lead to key differences in how diseases are treated--with multiple molecular targets that may require manipulation in a coordinated, dynamic fashion. Much remains to be learned regarding the optimal approaches to integrate different Omics data types and to perform network analyses; this book provides an overview of the progress that has been made and the challenges that remain."-- |
| Beschreibung: | Includes index. |
| Beschreibung: | 1 online resource (xi, 436 pages) : illustrations (chiefly color) |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9780674545533 0674545532 9780674545526 0674545524 |
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| 245 | 0 | 0 | |a Network medicine : |b complex systems in human disease and therapeutics / |c edited by Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman. |
| 264 | 1 | |a Cambridge, Massachusetts : |b Harvard University Press, |c 2017. | |
| 300 | |a 1 online resource (xi, 436 pages) : |b illustrations (chiefly color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 520 | |a "Network medicine, a new field which developed from the application of systems biology approaches to human disease, embraces the complexity of multifactorial influences on disease, which can be driven by non-linear effects and molecular and statistical interactions. The development of comprehensive and affordable Omics platforms provides the data types for network medicine, and graph theory and statistical physics provide the theoretical framework to analyze networks. While network medicine provides a fundamentally different approach to understanding disease etiology, it will also lead to key differences in how diseases are treated--with multiple molecular targets that may require manipulation in a coordinated, dynamic fashion. Much remains to be learned regarding the optimal approaches to integrate different Omics data types and to perform network analyses; this book provides an overview of the progress that has been made and the challenges that remain."-- |c Provided by publisher | ||
| 500 | |a Includes index. | ||
| 505 | 0 | |a Scientific basis of network medicine / Edwin K. Silverman and Joseph Loscalzo -- Introduction to network analysis / Jorg Menche and Albert-Laszlo Barabasi -- Human interactomes in network medicine / Michael E. Cusick, Benoit Charloteaux, Thomas Rolland, Michael A. Calderwood, David E. Hill, and Marc Vidal -- Social networks in human disease / Martin W. Schoen and Douglas Luke -- Phenotype, pathophenotype and endo(patho)phenotype in network medicine / Calum A. MacRae -- A new paradigm for defining human disease and therapy / Joseph Loscalzo -- Complex disease genetics and network medicine / Edwin K. Silverman -- Transcriptomics and network medicine / Kimberly Glass and John Quackenbush -- Post-translational modifications of the proteome: the example of Tau in the neuron and the brain / Guy Lippens, Jeremy Gunawardena, Isabelle Landrieu, Caroline Smet-Nocca, Sudhakaran Prabakaran, Benjamin Parent, Arnaud Leroy, and I. Huvent -- Epigenetics and network medicine / Dawn L. DeMeo and Scott T. Weiss -- Metabolomics and network medicine / Jessica Lasky-Su and Clary B. Clish -- Using integrative Omics approaches in network medicine / Shuyi Ma, John C. Earls, James A. Eddy, and Nathan D. Price -- Cancer network medicine / Takeshi Hase, Samik Ghosh, Sucheendra K Palaniappan, and Hiroaki Kitano -- Systems pharmacology in network medicine / Edwin K. Silverman and Joseph Loscalzo -- Systems approaches to clinical trials / Elliott M. Antman -- Microbiomics in network medicine / Joanne E. Sordillo, George M. Weinstock, and Augusto A. Litonjua. | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 611 | 2 | 7 | |a Medizinische Informatik |g Veranstaltung |2 gnd |0 http://d-nb.info/gnd/1091911096 |
| 650 | 0 | |a Medical informatics. |0 http://id.loc.gov/authorities/subjects/sh89005069 | |
| 650 | 0 | |a Data integration (Computer science) |0 http://id.loc.gov/authorities/subjects/sh2010014388 | |
| 650 | 0 | |a Diseases |x Causes and theories of causation |x Data processing. | |
| 650 | 0 | |a Therapeutics |x Data processing. | |
| 650 | 0 | |a Medicine |x Data processing. |0 http://id.loc.gov/authorities/subjects/sh85083074 | |
| 650 | 1 | 2 | |a Systems Biology |x methods |
| 650 | 1 | 2 | |a Molecular Biology |x methods |
| 650 | 2 | 2 | |a Gene Regulatory Networks |x genetics |
| 650 | 2 | 2 | |a Medical Informatics Computing |0 https://id.nlm.nih.gov/mesh/D008492 |
| 650 | 2 | 2 | |a Disease |x genetics |
| 650 | 2 | |a Medical Informatics Applications |0 https://id.nlm.nih.gov/mesh/D008491 | |
| 650 | 2 | |a Medical Informatics |0 https://id.nlm.nih.gov/mesh/D008490 | |
| 650 | 6 | |a Médecine |x Informatique. | |
| 650 | 6 | |a Intégration de données (Informatique) | |
| 650 | 6 | |a Étiologie |x Informatique. | |
| 650 | 6 | |a Thérapeutique |x Informatique. | |
| 650 | 7 | |a HEALTH & FITNESS |x Holism. |2 bisacsh | |
| 650 | 7 | |a HEALTH & FITNESS |x Reference. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Alternative Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Atlases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Essays. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Family & General Practice. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Holistic Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Osteopathy. |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Research |2 bisacsh | |
| 650 | 7 | |a Medicine |x Data processing |2 fast | |
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| 650 | 7 | |a Therapeutics |x Data processing |2 fast | |
| 700 | 1 | |a Loscalzo, Joseph, |e editor. | |
| 700 | 1 | |a Barabási, Albert-László, |e editor. | |
| 700 | 1 | |a Silverman, Edwin K., |e editor. | |
| 758 | |i has work: |a Network medicine (Text) |1 https://id.oclc.org/worldcat/entity/E39PCG3Pmk7fDgTxXqpRj8tvXm |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
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Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-on1085349450 |
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| _version_ | 1829095295865061376 |
| adam_text | |
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| author2 | Loscalzo, Joseph Barabási, Albert-László Silverman, Edwin K. |
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| author_facet | Loscalzo, Joseph Barabási, Albert-László Silverman, Edwin K. |
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| callnumber-first | R - Medicine |
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| callnumber-search | R858 .N48 2017eb |
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| contents | Scientific basis of network medicine / Edwin K. Silverman and Joseph Loscalzo -- Introduction to network analysis / Jorg Menche and Albert-Laszlo Barabasi -- Human interactomes in network medicine / Michael E. Cusick, Benoit Charloteaux, Thomas Rolland, Michael A. Calderwood, David E. Hill, and Marc Vidal -- Social networks in human disease / Martin W. Schoen and Douglas Luke -- Phenotype, pathophenotype and endo(patho)phenotype in network medicine / Calum A. MacRae -- A new paradigm for defining human disease and therapy / Joseph Loscalzo -- Complex disease genetics and network medicine / Edwin K. Silverman -- Transcriptomics and network medicine / Kimberly Glass and John Quackenbush -- Post-translational modifications of the proteome: the example of Tau in the neuron and the brain / Guy Lippens, Jeremy Gunawardena, Isabelle Landrieu, Caroline Smet-Nocca, Sudhakaran Prabakaran, Benjamin Parent, Arnaud Leroy, and I. Huvent -- Epigenetics and network medicine / Dawn L. DeMeo and Scott T. Weiss -- Metabolomics and network medicine / Jessica Lasky-Su and Clary B. Clish -- Using integrative Omics approaches in network medicine / Shuyi Ma, John C. Earls, James A. Eddy, and Nathan D. Price -- Cancer network medicine / Takeshi Hase, Samik Ghosh, Sucheendra K Palaniappan, and Hiroaki Kitano -- Systems pharmacology in network medicine / Edwin K. Silverman and Joseph Loscalzo -- Systems approaches to clinical trials / Elliott M. Antman -- Microbiomics in network medicine / Joanne E. Sordillo, George M. Weinstock, and Augusto A. Litonjua. |
| ctrlnum | (OCoLC)1085349450 |
| dewey-full | 610.285 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610.285 |
| dewey-search | 610.285 |
| dewey-sort | 3610.285 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | ZDB-4-EBA-on1085349450 |
| illustrated | Illustrated |
| indexdate | 2025-04-11T08:46:45Z |
| institution | BVB |
| isbn | 9780674545533 0674545532 9780674545526 0674545524 |
| language | English |
| oclc_num | 1085349450 |
| open_access_boolean | |
| owner | MAIN DE-862 DE-BY-FWS DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-862 DE-BY-FWS DE-863 DE-BY-FWS |
| physical | 1 online resource (xi, 436 pages) : illustrations (chiefly color) |
| psigel | ZDB-4-EBA FWS_PDA_EBA ZDB-4-EBA |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Harvard University Press, |
| record_format | marc |
| spelling | Network medicine : complex systems in human disease and therapeutics / edited by Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman. Cambridge, Massachusetts : Harvard University Press, 2017. 1 online resource (xi, 436 pages) : illustrations (chiefly color) text txt rdacontent computer c rdamedia online resource cr rdacarrier "Network medicine, a new field which developed from the application of systems biology approaches to human disease, embraces the complexity of multifactorial influences on disease, which can be driven by non-linear effects and molecular and statistical interactions. The development of comprehensive and affordable Omics platforms provides the data types for network medicine, and graph theory and statistical physics provide the theoretical framework to analyze networks. While network medicine provides a fundamentally different approach to understanding disease etiology, it will also lead to key differences in how diseases are treated--with multiple molecular targets that may require manipulation in a coordinated, dynamic fashion. Much remains to be learned regarding the optimal approaches to integrate different Omics data types and to perform network analyses; this book provides an overview of the progress that has been made and the challenges that remain."-- Provided by publisher Includes index. Scientific basis of network medicine / Edwin K. Silverman and Joseph Loscalzo -- Introduction to network analysis / Jorg Menche and Albert-Laszlo Barabasi -- Human interactomes in network medicine / Michael E. Cusick, Benoit Charloteaux, Thomas Rolland, Michael A. Calderwood, David E. Hill, and Marc Vidal -- Social networks in human disease / Martin W. Schoen and Douglas Luke -- Phenotype, pathophenotype and endo(patho)phenotype in network medicine / Calum A. MacRae -- A new paradigm for defining human disease and therapy / Joseph Loscalzo -- Complex disease genetics and network medicine / Edwin K. Silverman -- Transcriptomics and network medicine / Kimberly Glass and John Quackenbush -- Post-translational modifications of the proteome: the example of Tau in the neuron and the brain / Guy Lippens, Jeremy Gunawardena, Isabelle Landrieu, Caroline Smet-Nocca, Sudhakaran Prabakaran, Benjamin Parent, Arnaud Leroy, and I. Huvent -- Epigenetics and network medicine / Dawn L. DeMeo and Scott T. Weiss -- Metabolomics and network medicine / Jessica Lasky-Su and Clary B. Clish -- Using integrative Omics approaches in network medicine / Shuyi Ma, John C. Earls, James A. Eddy, and Nathan D. Price -- Cancer network medicine / Takeshi Hase, Samik Ghosh, Sucheendra K Palaniappan, and Hiroaki Kitano -- Systems pharmacology in network medicine / Edwin K. Silverman and Joseph Loscalzo -- Systems approaches to clinical trials / Elliott M. Antman -- Microbiomics in network medicine / Joanne E. Sordillo, George M. Weinstock, and Augusto A. Litonjua. Includes bibliographical references and index. Print version record. Medizinische Informatik Veranstaltung gnd http://d-nb.info/gnd/1091911096 Medical informatics. http://id.loc.gov/authorities/subjects/sh89005069 Data integration (Computer science) http://id.loc.gov/authorities/subjects/sh2010014388 Diseases Causes and theories of causation Data processing. Therapeutics Data processing. Medicine Data processing. http://id.loc.gov/authorities/subjects/sh85083074 Systems Biology methods Molecular Biology methods Gene Regulatory Networks genetics Medical Informatics Computing https://id.nlm.nih.gov/mesh/D008492 Disease genetics Medical Informatics Applications https://id.nlm.nih.gov/mesh/D008491 Medical Informatics https://id.nlm.nih.gov/mesh/D008490 Médecine Informatique. Intégration de données (Informatique) Étiologie Informatique. Thérapeutique Informatique. HEALTH & FITNESS Holism. bisacsh HEALTH & FITNESS Reference. bisacsh MEDICAL Alternative Medicine. bisacsh MEDICAL Atlases. bisacsh MEDICAL Essays. bisacsh MEDICAL Family & General Practice. bisacsh MEDICAL Holistic Medicine. bisacsh MEDICAL Osteopathy. bisacsh MEDICAL / Research bisacsh Medicine Data processing fast Data integration (Computer science) fast Medical informatics fast Therapeutics Data processing fast Loscalzo, Joseph, editor. Barabási, Albert-László, editor. Silverman, Edwin K., editor. has work: Network medicine (Text) https://id.oclc.org/worldcat/entity/E39PCG3Pmk7fDgTxXqpRj8tvXm https://id.oclc.org/worldcat/ontology/hasWork Print version: Network medicine. Cambridge, Massachusetts : Harvard University Press, 2017 9780674436534 (DLC) 2016006644 (OCoLC)939597214 |
| spellingShingle | Network medicine : complex systems in human disease and therapeutics / Scientific basis of network medicine / Edwin K. Silverman and Joseph Loscalzo -- Introduction to network analysis / Jorg Menche and Albert-Laszlo Barabasi -- Human interactomes in network medicine / Michael E. Cusick, Benoit Charloteaux, Thomas Rolland, Michael A. Calderwood, David E. Hill, and Marc Vidal -- Social networks in human disease / Martin W. Schoen and Douglas Luke -- Phenotype, pathophenotype and endo(patho)phenotype in network medicine / Calum A. MacRae -- A new paradigm for defining human disease and therapy / Joseph Loscalzo -- Complex disease genetics and network medicine / Edwin K. Silverman -- Transcriptomics and network medicine / Kimberly Glass and John Quackenbush -- Post-translational modifications of the proteome: the example of Tau in the neuron and the brain / Guy Lippens, Jeremy Gunawardena, Isabelle Landrieu, Caroline Smet-Nocca, Sudhakaran Prabakaran, Benjamin Parent, Arnaud Leroy, and I. Huvent -- Epigenetics and network medicine / Dawn L. DeMeo and Scott T. Weiss -- Metabolomics and network medicine / Jessica Lasky-Su and Clary B. Clish -- Using integrative Omics approaches in network medicine / Shuyi Ma, John C. Earls, James A. Eddy, and Nathan D. Price -- Cancer network medicine / Takeshi Hase, Samik Ghosh, Sucheendra K Palaniappan, and Hiroaki Kitano -- Systems pharmacology in network medicine / Edwin K. Silverman and Joseph Loscalzo -- Systems approaches to clinical trials / Elliott M. Antman -- Microbiomics in network medicine / Joanne E. Sordillo, George M. Weinstock, and Augusto A. Litonjua. Medizinische Informatik Veranstaltung gnd http://d-nb.info/gnd/1091911096 Medical informatics. http://id.loc.gov/authorities/subjects/sh89005069 Data integration (Computer science) http://id.loc.gov/authorities/subjects/sh2010014388 Diseases Causes and theories of causation Data processing. Therapeutics Data processing. Medicine Data processing. http://id.loc.gov/authorities/subjects/sh85083074 Systems Biology methods Molecular Biology methods Gene Regulatory Networks genetics Medical Informatics Computing https://id.nlm.nih.gov/mesh/D008492 Disease genetics Medical Informatics Applications https://id.nlm.nih.gov/mesh/D008491 Medical Informatics https://id.nlm.nih.gov/mesh/D008490 Médecine Informatique. Intégration de données (Informatique) Étiologie Informatique. Thérapeutique Informatique. HEALTH & FITNESS Holism. bisacsh HEALTH & FITNESS Reference. bisacsh MEDICAL Alternative Medicine. bisacsh MEDICAL Atlases. bisacsh MEDICAL Essays. bisacsh MEDICAL Family & General Practice. bisacsh MEDICAL Holistic Medicine. bisacsh MEDICAL Osteopathy. bisacsh MEDICAL / Research bisacsh Medicine Data processing fast Data integration (Computer science) fast Medical informatics fast Therapeutics Data processing fast |
| subject_GND | http://d-nb.info/gnd/1091911096 http://id.loc.gov/authorities/subjects/sh89005069 http://id.loc.gov/authorities/subjects/sh2010014388 http://id.loc.gov/authorities/subjects/sh85083074 https://id.nlm.nih.gov/mesh/D008492 https://id.nlm.nih.gov/mesh/D008491 https://id.nlm.nih.gov/mesh/D008490 |
| title | Network medicine : complex systems in human disease and therapeutics / |
| title_auth | Network medicine : complex systems in human disease and therapeutics / |
| title_exact_search | Network medicine : complex systems in human disease and therapeutics / |
| title_full | Network medicine : complex systems in human disease and therapeutics / edited by Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman. |
| title_fullStr | Network medicine : complex systems in human disease and therapeutics / edited by Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman. |
| title_full_unstemmed | Network medicine : complex systems in human disease and therapeutics / edited by Joseph Loscalzo, Albert-László Barabási, Edwin K. Silverman. |
| title_short | Network medicine : |
| title_sort | network medicine complex systems in human disease and therapeutics |
| title_sub | complex systems in human disease and therapeutics / |
| topic | Medizinische Informatik Veranstaltung gnd http://d-nb.info/gnd/1091911096 Medical informatics. http://id.loc.gov/authorities/subjects/sh89005069 Data integration (Computer science) http://id.loc.gov/authorities/subjects/sh2010014388 Diseases Causes and theories of causation Data processing. Therapeutics Data processing. Medicine Data processing. http://id.loc.gov/authorities/subjects/sh85083074 Systems Biology methods Molecular Biology methods Gene Regulatory Networks genetics Medical Informatics Computing https://id.nlm.nih.gov/mesh/D008492 Disease genetics Medical Informatics Applications https://id.nlm.nih.gov/mesh/D008491 Medical Informatics https://id.nlm.nih.gov/mesh/D008490 Médecine Informatique. Intégration de données (Informatique) Étiologie Informatique. Thérapeutique Informatique. HEALTH & FITNESS Holism. bisacsh HEALTH & FITNESS Reference. bisacsh MEDICAL Alternative Medicine. bisacsh MEDICAL Atlases. bisacsh MEDICAL Essays. bisacsh MEDICAL Family & General Practice. bisacsh MEDICAL Holistic Medicine. bisacsh MEDICAL Osteopathy. bisacsh MEDICAL / Research bisacsh Medicine Data processing fast Data integration (Computer science) fast Medical informatics fast Therapeutics Data processing fast |
| topic_facet | Medizinische Informatik Veranstaltung Medical informatics. Data integration (Computer science) Diseases Causes and theories of causation Data processing. Therapeutics Data processing. Medicine Data processing. Systems Biology methods Molecular Biology methods Gene Regulatory Networks genetics Medical Informatics Computing Disease genetics Medical Informatics Applications Medical Informatics Médecine Informatique. Intégration de données (Informatique) Étiologie Informatique. Thérapeutique Informatique. HEALTH & FITNESS Holism. HEALTH & FITNESS Reference. MEDICAL Alternative Medicine. MEDICAL Atlases. MEDICAL Essays. MEDICAL Family & General Practice. MEDICAL Holistic Medicine. MEDICAL Osteopathy. MEDICAL / Research Medicine Data processing Medical informatics Therapeutics Data processing |
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