Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic /:
Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin ; Boston :
De Gruyter,
[2019]
|
| Schriftenreihe: | Metal ions in life sciences ;
v. 19. |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching. |
| Beschreibung: | 1 online resource (455 pages) |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9783110527872 3110527871 |
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| 505 | 0 | 0 | |t Frontmatter -- |t About the Editors -- |t Historical Development and Perspectives of the Series Metal Ions in Life Sciences -- |t Preface to Volume 19. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic -- |t Contents -- |t Contributors to Volume 19 -- |t Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- |t Contents of Volumes in the Metal Ions in Life Sciences Series -- |t 1. Metals in Medicine: The Therapeutic Use of Metal Ions in the Clinic / |r Carver, Peggy L. -- |t 2. Small Molecules: The Past or the Future in Drug Innovation? / |r Robert, Anne / Benoit-Vical, Françoise / Liu, Yan / Meunier, Bernard -- |t 3. Iron Chelation for Iron Overload in Thalassemia / |r Crisponi, Guido / Nurchi, Valeria M. / Lachowicz, Joanna I. -- |t 4. Ironing out the Brain / |r Ward, Roberta J. / Crichton, Robert R. -- |t 5. Infections Associated with Iron Administration / |r Nairz, Manfred / Weiss, Guenter -- |t 6. Iron Oxide Nanoparticle Formulations for Supplementation / |r Pai, Amy Barton -- |t 7. Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases / |r Gumienna-Kontecka, Elzbieta / Carver, Peggy L. -- |t 8. Developing Vanadium as an Antidiabetic or Anticancer Drug: A Clinical and Historical Perspective / |r Crans, Debbie C. / Henry, LaRee / Cardiff, Gabriel / Posner, Barry I. -- |t 9. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes / |r Maret, Wolfgang -- |t 10. Manganese: Its Role in Disease and Health / |r Erikson, Keith M. / Aschner, Michael -- |t 11. Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses / |r Bajema, Elizabeth A. / Roberts, Kaleigh F. / Meade, Thomas J. -- |t 12. Copper Depletion as a Therapeutic Strategy in Cancer / |r Lopez, Jay / Ramchandani, Divya / Vahdat, Linda -- |t 13. Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic / |r Gambino, Dinorah / Otero Á, Lucía -- |t 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide / |r Suman, Sigridur G. / Gretarsdottir, Johanna M. -- |t Subject Index |
| 520 | |a Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching. | ||
| 546 | |a In English. | ||
| 588 | 0 | |a Online resource; title from PDF title page (publisher's Web site, viewed 23. Jan 2019). | |
| 504 | |a Includes bibliographical references and index. | ||
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| adam_text | |
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| author2 | Carver, Peggy L. |
| author2_role | edt |
| author2_variant | p l c pl plc |
| author_GND | http://id.loc.gov/authorities/names/n2019182800 |
| author_additional | Carver, Peggy L. -- Robert, Anne / Benoit-Vical, Françoise / Liu, Yan / Meunier, Bernard -- Crisponi, Guido / Nurchi, Valeria M. / Lachowicz, Joanna I. -- Ward, Roberta J. / Crichton, Robert R. -- Nairz, Manfred / Weiss, Guenter -- Pai, Amy Barton -- Gumienna-Kontecka, Elzbieta / Carver, Peggy L. -- Crans, Debbie C. / Henry, LaRee / Cardiff, Gabriel / Posner, Barry I. -- Maret, Wolfgang -- Erikson, Keith M. / Aschner, Michael -- Bajema, Elizabeth A. / Roberts, Kaleigh F. / Meade, Thomas J. -- Lopez, Jay / Ramchandani, Divya / Vahdat, Linda -- Gambino, Dinorah / Otero Á, Lucía -- Suman, Sigridur G. / Gretarsdottir, Johanna M. -- |
| author_facet | Carver, Peggy L. |
| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | R - Medicine |
| callnumber-label | RM666 |
| callnumber-raw | RM666.M513 E87 2019 |
| callnumber-search | RM666.M513 E87 2019 |
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| callnumber-subject | RM - Therapeutics and Pharmacology |
| collection | ZDB-4-EBA |
| contents | Frontmatter -- About the Editors -- Historical Development and Perspectives of the Series Metal Ions in Life Sciences -- Preface to Volume 19. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic -- Contents -- Contributors to Volume 19 -- Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- Contents of Volumes in the Metal Ions in Life Sciences Series -- 1. Metals in Medicine: The Therapeutic Use of Metal Ions in the Clinic / 2. Small Molecules: The Past or the Future in Drug Innovation? / 3. Iron Chelation for Iron Overload in Thalassemia / 4. Ironing out the Brain / 5. Infections Associated with Iron Administration / 6. Iron Oxide Nanoparticle Formulations for Supplementation / 7. Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases / 8. Developing Vanadium as an Antidiabetic or Anticancer Drug: A Clinical and Historical Perspective / 9. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes / 10. Manganese: Its Role in Disease and Health / 11. Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses / 12. Copper Depletion as a Therapeutic Strategy in Cancer / 13. Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic / 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide / Subject Index |
| ctrlnum | (OCoLC)1083584136 |
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| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.231 |
| dewey-search | 615/.231 |
| dewey-sort | 3615 3231 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes /</subfield><subfield code="r">Maret, Wolfgang --</subfield><subfield code="t">10. Manganese: Its Role in Disease and Health /</subfield><subfield code="r">Erikson, Keith M. / Aschner, Michael --</subfield><subfield code="t">11. Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses /</subfield><subfield code="r">Bajema, Elizabeth A. / Roberts, Kaleigh F. / Meade, Thomas J. --</subfield><subfield code="t">12. Copper Depletion as a Therapeutic Strategy in Cancer /</subfield><subfield code="r">Lopez, Jay / Ramchandani, Divya / Vahdat, Linda --</subfield><subfield code="t">13. Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic /</subfield><subfield code="r">Gambino, Dinorah / Otero Á, Lucía --</subfield><subfield code="t">14. 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Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. 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| id | ZDB-4-EBA-on1083584136 |
| illustrated | Not Illustrated |
| indexdate | 2024-10-25T15:50:07Z |
| institution | BVB |
| isbn | 9783110527872 3110527871 |
| language | English |
| oclc_num | 1083584136 |
| open_access_boolean | |
| owner | MAIN |
| owner_facet | MAIN |
| physical | 1 online resource (455 pages) |
| psigel | ZDB-4-EBA |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| publisher | De Gruyter, |
| record_format | marc |
| series | Metal ions in life sciences ; |
| series2 | Metal Ions in Life Sciences ; |
| spelling | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / Peggy L. Carver. Berlin ; Boston : De Gruyter, [2019] ©2019 1 online resource (455 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Metal Ions in Life Sciences ; Volume 19 Frontmatter -- About the Editors -- Historical Development and Perspectives of the Series Metal Ions in Life Sciences -- Preface to Volume 19. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic -- Contents -- Contributors to Volume 19 -- Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- Contents of Volumes in the Metal Ions in Life Sciences Series -- 1. Metals in Medicine: The Therapeutic Use of Metal Ions in the Clinic / Carver, Peggy L. -- 2. Small Molecules: The Past or the Future in Drug Innovation? / Robert, Anne / Benoit-Vical, Françoise / Liu, Yan / Meunier, Bernard -- 3. Iron Chelation for Iron Overload in Thalassemia / Crisponi, Guido / Nurchi, Valeria M. / Lachowicz, Joanna I. -- 4. Ironing out the Brain / Ward, Roberta J. / Crichton, Robert R. -- 5. Infections Associated with Iron Administration / Nairz, Manfred / Weiss, Guenter -- 6. Iron Oxide Nanoparticle Formulations for Supplementation / Pai, Amy Barton -- 7. Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases / Gumienna-Kontecka, Elzbieta / Carver, Peggy L. -- 8. Developing Vanadium as an Antidiabetic or Anticancer Drug: A Clinical and Historical Perspective / Crans, Debbie C. / Henry, LaRee / Cardiff, Gabriel / Posner, Barry I. -- 9. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes / Maret, Wolfgang -- 10. Manganese: Its Role in Disease and Health / Erikson, Keith M. / Aschner, Michael -- 11. Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses / Bajema, Elizabeth A. / Roberts, Kaleigh F. / Meade, Thomas J. -- 12. Copper Depletion as a Therapeutic Strategy in Cancer / Lopez, Jay / Ramchandani, Divya / Vahdat, Linda -- 13. Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic / Gambino, Dinorah / Otero Á, Lucía -- 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide / Suman, Sigridur G. / Gretarsdottir, Johanna M. -- Subject Index Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching. In English. Online resource; title from PDF title page (publisher's Web site, viewed 23. Jan 2019). Includes bibliographical references and index. Metals in medicine. http://id.loc.gov/authorities/subjects/sh85084264 Metals Therapeutic use. http://id.loc.gov/authorities/subjects/sh85084250 Metals therapeutic use Metals pharmacokinetics Métaux en médecine. Métallothérapie. MEDICAL Pharmacology. bisacsh Metals in medicine fast Metals Therapeutic use fast Carver, Peggy L., editor. http://id.loc.gov/authorities/names/n2019182800 has work: Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic (Text) https://id.oclc.org/worldcat/entity/E39PCFrGVTkkGBqrcJQqdXgBT3 https://id.oclc.org/worldcat/ontology/hasWork EPUB 9783110526981 print 9783110526912 Metal ions in life sciences ; v. 19. http://id.loc.gov/authorities/names/n2005184640 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=2004789 Volltext CBO01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=2004789 Volltext |
| spellingShingle | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / Metal ions in life sciences ; Frontmatter -- About the Editors -- Historical Development and Perspectives of the Series Metal Ions in Life Sciences -- Preface to Volume 19. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic -- Contents -- Contributors to Volume 19 -- Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- Contents of Volumes in the Metal Ions in Life Sciences Series -- 1. Metals in Medicine: The Therapeutic Use of Metal Ions in the Clinic / 2. Small Molecules: The Past or the Future in Drug Innovation? / 3. Iron Chelation for Iron Overload in Thalassemia / 4. Ironing out the Brain / 5. Infections Associated with Iron Administration / 6. Iron Oxide Nanoparticle Formulations for Supplementation / 7. Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases / 8. Developing Vanadium as an Antidiabetic or Anticancer Drug: A Clinical and Historical Perspective / 9. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes / 10. Manganese: Its Role in Disease and Health / 11. Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses / 12. Copper Depletion as a Therapeutic Strategy in Cancer / 13. Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic / 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide / Subject Index Metals in medicine. http://id.loc.gov/authorities/subjects/sh85084264 Metals Therapeutic use. http://id.loc.gov/authorities/subjects/sh85084250 Metals therapeutic use Metals pharmacokinetics Métaux en médecine. Métallothérapie. MEDICAL Pharmacology. bisacsh Metals in medicine fast Metals Therapeutic use fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85084264 http://id.loc.gov/authorities/subjects/sh85084250 |
| title | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / |
| title_alt | Frontmatter -- About the Editors -- Historical Development and Perspectives of the Series Metal Ions in Life Sciences -- Preface to Volume 19. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic -- Contents -- Contributors to Volume 19 -- Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- Contents of Volumes in the Metal Ions in Life Sciences Series -- 1. Metals in Medicine: The Therapeutic Use of Metal Ions in the Clinic / 2. Small Molecules: The Past or the Future in Drug Innovation? / 3. Iron Chelation for Iron Overload in Thalassemia / 4. Ironing out the Brain / 5. Infections Associated with Iron Administration / 6. Iron Oxide Nanoparticle Formulations for Supplementation / 7. Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases / 8. Developing Vanadium as an Antidiabetic or Anticancer Drug: A Clinical and Historical Perspective / 9. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes / 10. Manganese: Its Role in Disease and Health / 11. Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses / 12. Copper Depletion as a Therapeutic Strategy in Cancer / 13. Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic / 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide / Subject Index |
| title_auth | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / |
| title_exact_search | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / |
| title_full | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / Peggy L. Carver. |
| title_fullStr | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / Peggy L. Carver. |
| title_full_unstemmed | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / Peggy L. Carver. |
| title_short | Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic / |
| title_sort | essential metals in medicine therapeutic use and toxicity of metal ions in the clinic |
| topic | Metals in medicine. http://id.loc.gov/authorities/subjects/sh85084264 Metals Therapeutic use. http://id.loc.gov/authorities/subjects/sh85084250 Metals therapeutic use Metals pharmacokinetics Métaux en médecine. Métallothérapie. MEDICAL Pharmacology. bisacsh Metals in medicine fast Metals Therapeutic use fast |
| topic_facet | Metals in medicine. Metals Therapeutic use. Metals therapeutic use Metals pharmacokinetics Métaux en médecine. Métallothérapie. MEDICAL Pharmacology. Metals in medicine Metals Therapeutic use |
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