Vitamin D.: Volume 1, Biochemistry, physiology and diagnostics /
"Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehe...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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London ; San Diego, CA :
Academic Press is an imprint of Elsevier,
[2018]
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| Ausgabe: | Fourth edition. |
| Schlagworte: | |
| Online-Zugang: | Volltext Volltext |
| Zusammenfassung: | "Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description |
| Beschreibung: | Revised edition of: Vitamin D / editor-in-chief, David Feldman; associate editors, J. Wesley Pike, John S. Adams. 3rd ed. 2011. |
| Beschreibung: | 1 online resource (xxxvii, pages) : illustrations (chiefly color), color portraits |
| Bibliographie: | Includes bibliographical references. |
| ISBN: | 9780128099667 0128099666 |
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| 245 | 0 | 0 | |a Vitamin D. |n Volume 1, |p Biochemistry, physiology and diagnostics / |c editor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon [and 3 others]. |
| 246 | 3 | 0 | |a Biochemistry, physiology and diagnostics |
| 250 | |a Fourth edition. | ||
| 264 | 1 | |a London ; |a San Diego, CA : |b Academic Press is an imprint of Elsevier, |c [2018] | |
| 264 | 4 | |c ©2018 | |
| 300 | |a 1 online resource (xxxvii, pages) : |b illustrations (chiefly color), color portraits | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Revised edition of: Vitamin D / editor-in-chief, David Feldman; associate editors, J. Wesley Pike, John S. Adams. 3rd ed. 2011. | ||
| 504 | |a Includes bibliographical references. | ||
| 505 | 0 | |6 880-01 |a Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d -- Evolutionary biology: mysteries of vitamin D in fish -- Evolution of human skin color and vitamin D -- Photobiology of vitamin D -- The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases) -- CYP24A1: structure, function, and physiological role -- The vitamin D binding protein DBP -- Regulation of renal and extra-renal 1[alpha]-hydroxylase -- Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells -- Diverse mechanisms of transcriptional regulation by the vitamin D receptor -- Structural basis for ligand activity in VDR -- Ligand independent actions of vitamin D receptor -- Vitamin D and chromatin -- Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR -- Vitamin D and microRNAs -- Vitamin D sterol/VDR conformational dynamics and nongenomic actions -- Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function -- Osteoclastogenesis and vitamin D -- Vitamin D activities in osteocytes -- Regulation of intestinal calcium and phosphate absorption -- Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6 -- Calcium homeostasis and eggshell biomineralization in female chicken -- Mineralization in mammals -- Cartilage -- Vitamin D and bone: an integrated approach -- Section IV. Extra-skeletal targets. Vitamin D and the kidney -- Vitamin D and the parathyroids -- The calcium-sensing receptor and vitamin d -- Vitamin D in dentoalveolar and oral health -- The role of vitamin D and its receptor in hair follicle biology -- Vitamin D, calcium and the epidermis -- Vitamin D and the cardiovascular system -- Vitamin D brain development and function -- Vitamin D, VDR and adipose tissue: focus on cellular mechanisms -- Vitamin D and skeletal muscle -- Understanding vitamin D from mouse knockout models -- Section V. Human physiology. Pharmacology and pharmacokinetics -- Vitamin D role in the calcium and phosphorus economies -- Fetus, neonate and infant -- Consequences of perinatal vitamin D deficiency on later bone health -- Adolescence and acquisition of peak bone mass -- Pregnancy, lactation, and post-weaning recovery -- Role in reproductive biology and reproductive dysfunction in women -- Vitamin d, reproductive biology, and dysfunction in men -- Vitamin D and the renin-angiotensin system -- Parathyroid hormone, parathyroid hormone-related protein, and calcitonin -- FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity -- Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease -- Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology -- Mass spectrometry assays of vitamin D metabolites -- Free vitamin d: concepts, assays, outcomes and prospects -- 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation -- Bone histomorphometry -- Radiology of rickets and osteomalcia -- High-resolution imaging techniques for bone quality assessment -- The role of vitamin D in orthopedic surgery -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position. | |
| 520 | |a "Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description | ||
| 588 | 0 | |a Online resource; title from electronic title page (ClinicalKey, viewed December 14, 2017). | |
| 650 | 0 | |a Vitamin D. |0 http://id.loc.gov/authorities/subjects/sh85143982 | |
| 650 | 1 | 2 | |a Vitamin D |
| 650 | 4 | |a Vitamin D. | |
| 650 | 6 | |a Vitamine D. | |
| 650 | 7 | |a MEDICAL |x Physiology. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Human Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Vitamin D |2 fast | |
| 700 | 1 | |a Feldman, David, |d 1939- |e editor. | |
| 700 | 1 | |a Pike, J. Wesley, |e editor. | |
| 700 | 1 | |a Bouillon, R., |e editor. | |
| 730 | 0 | |i Companion to: |a Vitamin D. |n Volume 2, |p Health, disease and therapeutics. | |
| 730 | 0 | |i Preceded by: |a Vitamin D. |s 3rd ed. | |
| 776 | 0 | 8 | |i Print version: |t Vitamin D. |
| 856 | 4 | 0 | |l FWS01 |p ZDB-4-EBA |q FWS_PDA_EBA |u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1483177 |3 Volltext |
| 856 | 4 | 0 | |l FWS01 |p ZDB-4-EBA |q FWS_PDA_EBA |u https://www.sciencedirect.com/science/book/9780128099650 |3 Volltext |
| 880 | 0 | 0 | |6 505-00/(S |t Van Der Eerden -- |t Introduction -- |t Properties of Mature Osteoblasts and Osteocytes -- |t Major Regulatory Functions of Osteoblasts and Osteocytes and Control by the Vitamin D Endocrine System -- |t Effects of 1,25(OH)2D3 on Osteoblast Differentiation -- |t Regulation of Intracellular Signaling Pathways by 1,25(OH)2D3 -- |t Summary and Conclusions -- |t References -- |g 18. |t Osteoclastogenesis and Vitamin D / |r Tatsuo Suda -- |t Introduction -- |t Regulation of Mineral Metabolism by Vitamin D, Parathyroid Hormone, and Fibroblast Growth Factor 23 -- |t Phenotypes of Vitamin D Receptor Knockout Mice -- |t Regulation of Osteoclastogenesis by the Receptor Activator of Nuclear Factor-κ B Ligand/Receptor Activator of Nuclear Factor-κ B/Osteoprotegerin System -- |t In Vitro Regulation of Osteoclastogenesis by Vitamin D -- |t In Vivo Regulation of Osteoclastogenesis by Vitamin D Compounds -- |t Conclusion -- |t References -- |g 19. |t Vitamin D Activities in Osteocytes / |r David M. Findlay -- |t Introduction -- |t Cell Biology of Osteocytes -- |t Direct Actions of 1,25-Dihydroxyvitamin D on Osteocyte Maturation and Activities -- |t Receptor Activator of Nuclear Factor κ B Ligand -- |t Vitamin D Metabolism Within Osteocytes -- |t Role of Osteocytes and Vitamin D in Bone Turnover -- |t Role of Vitamin D and Osteocytes in Endocrine Feedback -- |t Conclusions -- |t References -- |g 20. |t Regulation of Intestinal Calcium and Phosphate Absorption / |r James C. Fleet -- |t Overview of Intestinal Calcium Absorption -- |t Overview of Intestinal Phosphate Absorption -- |t References -- |g 21. |t Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 / |r Puneet Dhawan -- |t Introduction and General Considerations, the Calbindins -- |t Localization and Proposed Functional Significance of the Calbindins -- |t Regulation of Calbindin Gene Expression -- |t Epithelial Calcium Channels -- |t Conclusion -- |t References -- |g 22. |t Calcium Homeostasis and Eggshell Biomineralization in Female Chicken / |r Nathalie Le Roy -- |t Introduction -- |t Mineralization Associated With Laying Hen Reproduction -- |t Transepithelial Transfer of Calcium -- |t Regulation of Calcium Metabolism in Hens -- |t Acknowledgments -- |t References. |
| 880 | 0 | 0 | |6 505-00/(S |g Contents note continued: |g 23. |t Mineralization in Mammals / |r Adele L. Boskey -- |t Introduction -- |t Direct and Indirect Effects of Vitamin D and Vitamin D Metabolites on Mineralization -- |t Methods for Quantifying Tissue Mineralization -- |t Mechanism of Effects of Vitamin D on Mineralization -- |t Mineralization and Mineral Properties in Systems With Vitamin D Alterations -- |t Conclusions -- |t Acknowledgments -- |t References -- |t Further Reading -- |g 24. |t Cartilage / |r Zvi Schwartz -- |t Properties of Cartilage Tissues -- |t Regulation by Vitamin D -- |t Rapid Actions of Vitamin D and Nongenomic Mechanisms -- |t Summary -- |t References -- |g 25. |t Vitamin D and Bone: An Integrated Approach / |r Geert Carmeliet -- |t Link Between Bone Metabolism, Calcium Homeostasis, and 1,25(OH)2D3 Activity -- |t 1,25(OH)2D3 and Bone Metabolism During a Positive Calcium Balance -- |t Negative Calcium Balance Resulting From Insufficient Vitamin D Action -- |t Negative Calcium Balance With Sufficient Vitamin D -- |t Vitamin D and Fibroblast Growth Factor 23 -- |t Conclusion -- |t References -- |g IV. |t EXTRA-SKELETAL TARGETS -- |g 26. |t Vitamin D and the Kidney / |r Rajiv Kumar -- |t Introduction -- |t Role of the Kidney in the Metabolism of 25-Hydroxyvitamin D -- |t Effects of Vitamin D, 25(OH)D3 and 1α, 25(OH)2D3 on the Renal Handling of Calcium and Phosphorus -- |t Distribution and Regulation of Vitamin D-Dependent Proteins in the Kidney -- |t Conclusion -- |t References -- |g 27. |t Vitamin D and the Parathyroids / |r Tally Naveh-Many -- |t Introduction -- |t Parathyroid Hormone Biosynthesis -- |t Parathyroid Hormone Gene -- |t Development of the Parathyroid and Tissue-Specific Expression of the Parathyroid Hormone Gene -- |t Regulation of Parathyroid Hormone Gene Expression -- |t Summary -- |t References -- |g 28. |t Calcium-Sensing Receptor and Vitamin D / |r Geoffrey N. Hendy -- |t Introduction -- |t Calcium-Sensing Receptor -- |t Overview of Extracellular Ca2+ Homeostasis: Roles of Calcium-Sensing Receptor and Vitamin D Receptor -- |t Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Involved in Ca2+ Homeostasis -- |t Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Uninvolved in Extracellular Ca2+ Homeostasis -- |t Mouse Models of Calcium-Sensing Receptor Deletion Relative to Presentation in Humans -- |t Conclusions -- |t References -- |g 29. |t Vitamin D in Dentoalveolar and Oral Health / |r Philippe P. Hujoel -- |t Introduction -- |t Brief Primer on Dentoalveolar Cells and Tissues -- |t Vitamin D Metabolism and Mechanisms of Action on Dental Cells -- |t Vitamin D, Rickets, and the Oral Tissues -- |t Hereditary Vitamin D-Related Diseases and Dentoalveolar Tissues -- |t Vitamin D and Oral Health -- |t Conclusions -- |t Acknowledgments -- |t References -- |g 30. |t Role of Vitamin D and Its Receptor in Hair Follicle Biology / |r Marie B. Demay -- |t Introduction -- |t Hair Cycle -- |t Keratinocyte Stem Cells -- |t Pathways Important for Keratinocyte Stem Cell Function -- |t Vitamin D Receptor Suppresses PPARγ Signaling in Keratinocyte Stem Cells -- |t Conclusions -- |t References -- |g 31. |t Vitamin D, Calcium, and the Epidermis / |r Daniel D. Bikle -- |t Introduction -- |t Cutaneous Production of Vitamin D and Its Biologically Active Metabolites -- |t Regulation of Keratinocyte Differentiation -- |t Role of Vitamin D Signaling in Skin Cancer -- |t Role of Vitamin D Signaling in Epidermal Wound Repair -- |t References -- |g 32. |t Vitamin D and the Cardiovascular System / |r Carlos Bernal-Mizrachi -- |t Introduction -- |t Vascular Physiology -- |t Identification of the Vitamin D Receptor in the Vascular System -- |t Vascular Relaxation -- |t Structural Vascular Changes -- |t Vascular Inflammation -- |t Angiogenesis -- |t Blood Coagulation and Fibrinolysis -- |t Animal Models -- |t Clinical Studies in Cardiovascular Disease -- |t Conclusion -- |t Acknowledgments -- |t References -- |g 33. |t Vitamin D Brain Development and Function / |r John J. Mcgrath -- |t Introduction -- |t Vitamin D Signaling in the Brain -- |t Dietary Vitamin D Deficiency, Effect on Brain Development and Function -- |t Effects of Excess Vitamin D on Brain Development and Function -- |t Vitamin D Regulates Essential Processes in Normal Brain Development -- |t Possible Neuroprotective Mechanisms of Vitamin D in the Developing Brain -- |t Developmental Vitamin D Deficiency and Neuropsychiatric Disorders -- |t Conclusions -- |t References -- |g 34. |t Vitamin D, Vitamin D Receptor, and Adipose Tissue: Focus on Cellular Mechanisms / |r Joellen Welsh -- |t Adipose Tissue: Storage Depot and Target for Vitamin D -- |t Effect of Vitamin D on Adipogenesis at the Cellular Level -- |t Impact of Vitamin D Signaling on Adiposity in Mouse Models -- |t Translational Considerations -- |t Conclusions and Future Directions -- |t References -- |g 35. |t Vitamin D and Skeletal Muscle / |r Christian M. Girgis -- |t Skeletal Muscle Physiology -- |t Vitamin D Receptor in Muscle -- |t Vitamin D and Calcium Signaling in Muscle -- |t Vitamin D and Phosphate Signaling in Muscle -- |t Vitamin D and Insulin Signaling in Muscle -- |t Vitamin D, Muscle Contraction, and Strength -- |t Vitamin D, Muscle Development, and Mass -- |t Vitamin D, Muscle Injury, and Repair -- |t Vitamin D and Age-Related Changes in Muscle -- |t Vitamin D and Bone Muscle Cross-Talk -- |t Conclusions and Future Directions -- |t References -- |g 36. |t Understanding Vitamin D From Mouse Knockout Models / |r Denshun Miao -- |t Vitamin D Metabolism -- |t 1,25 Dihydroxyvitamin D/Vitamin D Receptor System and Mineral and Skeletal Homeostasis -- |t Extraskeletal Actions of 1,25 dihydroxyvitamin D -- |t Conclusion -- |t References -- |t Further Reading -- |g V. |t HUMAN PHYSIOLOGY -- |g 37. |t Pharmacology and Pharmacokinetics / |r Kerry S. Jones -- |t Overview -- |t Vitamin D Absorption -- |t Kinetics of Cutaneous Synthesis -- |t Tissue Distribution -- |t Metabolism and Determinants of Metabolic Fate of Vitamin D -- |t Half-Lives of Vitamin D Metabolites -- |t Factors Influencing Vitamin D Half-Life -- |t Pharmacokinetics of Bound and Free Vitamin D Metabolites -- |t Influence of Vitamin D-Binding Protein Genotype and Concentration on Vitamin D Metabolism and 25(OH)D Half-Life -- |t Dose-Response to Vitamin D Supplementation -- |t 3-Epimer of 25(OH)D and 1,25(OH)2D -- |t Catabolism and Excretion -- |t Vitamin D Toxicity -- |t Acknowledgments -- |t References -- |g 38. |t Vitamin D Role in the Calcium and Phosphorus Economies / |r Laura A. Graeff-Armas -- |t Introduction -- |t Overview of the Calcium Economy -- |t Overview of the Phosphorus Economy -- |t Calcium and Phosphorus Absorptive Inputs -- |t Physiological Sources of Vitamin D Activity -- |t Optimal Vitamin D Status -- |t Summary and Conclusions -- |t References -- |g 39. |t Fetus, Neonate, and Infant / |r Christopher S. Kovacs -- |t Overview of Calcium Metabolism in the Fetus -- |t Animal Data Relevant to Vitamin D and the Fetus -- |t Human Data Relevant to Vitamin D and the Fetus -- |t Overview of Calcium Metabolism in the Neonate and Infant -- |t Animal Data Relevant to Vitamin D and the Neonate and Infant -- |t Human Data Relevant to Vitamin D and the Neonate and Infant -- |t Conclusions -- |t References -- |g 40. |t Consequences of Perinatal Vitamin D Deficiency on Later Bone Health / |r Nicholas C. Harvey -- |t Introduction -- |t Vitamin D Physiology and Epidemiology in Pregnancy -- |t Lifecourse Determinants of Osteoporosis -- |t Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health -- |t Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health: The MAVIDOS Trial -- |t Conclusion -- |t Acknowledgment -- |t References -- |g 41. |t Adolescence and Acquisition of Peak Bone Mass / |r Connie Weaver -- |t Introduction -- |t Pubertal Bone Acquisition -- |t Sex and Race Differences -- |t Serum 25(OH)D in Children and Adolescents -- |t Vitamin D and Intermediate Endpoints of Vitamin D and Bone Metabolism -- |t Vitamin D and Other Predictors of Calcium Retention -- |t Vitamin D and Bone -- |t Vitamin D and Muscle -- |t Vitamin D Requirements in Children and Adolescents -- |t Summary and Conclusions -- |t References -- |g 42. |t Pregnancy, Lactation, and Postweaning Recovery / |r Christopher S. |
| 880 | 0 | 0 | |6 505-00/(S |g Machine generated contents note: |t VOLUME I -- |g I. |t HISTORY, CHEMISTRY METABOLISM, CIRCULATION & REGULATION -- |g 1. |t Historical Overview of Vitamin D / |r Hector F. Deluca -- |t Discovery of the Vitamins -- |t Discovery of the Physiological Functions of Vitamin D -- |t Discovery of the Hormonal Form of Vitamin D -- |t Acknowledgment -- |t References -- |g 2. |t Evolutionary Biology: Mysteries of Vitamin D in Fish / |r David R. Fraser -- |t Biological Distribution of Vitamin D -- |t Evolutionary Origins of Vitamin D -- |t Evolution of Vitamin D Function -- |t Origin of Vitamin D in Fish -- |t Functional Metabolism of Vitamin D in Fish -- |t Possible Role for Sunlight in the Origin of Vitamin D in Fish -- |t Vitamin D Function in Fish -- |t Transport of Vitamin D and Its Metabolites -- |t Vitamin D Toxicity From Oral Ingestion -- |t References -- |g 3. |t Evolution of Human Skin Color and Vitamin D / |r Nina G. Jablonski -- |t Introduction -- |t Solar Context of Human Skin Color Evolution -- |t Nature of the Selective Factors Leading to the Evolution of Skin Pigmentation in Early Homo -- |t Folate Conservation and the Evolution of Permanent Protective Pigmentation -- |t Early Hominin Dispersal Out of the Tropics and Vitamin D Production -- |t Evolution of Skin Pigmentation in Homo sapiens -- |t Effects of Cultural Buffering, Rapid Migrations, and Modern Lifestyles on Skin Color and Vitamin D -- |t References -- |t Further Reading -- |g 4. |t Photobiology of Vitamin D / |r Michael F. Holick -- |t Introduction -- |t Historical Perspective -- |t Photobiology of Vitamin D -- |t Role of Sunlight and Dietary Vitamin D in Bone Health, Overall Health, and Well-being -- |t Sunlight, Vitamin D, and Skin Cancer -- |t Conclusions -- |t References -- |t Further Reading -- |g 5. |t Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases) / |r Martin Kaufmann -- |t Introduction -- |t General Information Regarding Vitamin D Hydroxylases -- |t Vitamin D3-25-Hydroxylases -- |t 25-Hydroxyvitamin D-1α-hydroxylase -- |t Additional Topics -- |t References -- |g 6. |t CYP24A1: Structure, Function, and Physiological Role / |r Glenville Jones -- |t Introduction -- |t CYP24A1-Catalyzed Pathways -- |t C24-Oxidation Pathway -- |t C23-Hydroxylation Pathway -- |t CYP24A1, a Multifunctional Enzyme -- |t Biological Relevance of the C24-Oxidation Pathway -- |t Structure-Function Relationships -- |t Mutations of CYP24A1 and Idiopathic Infantile Hypercalcemia -- |t Preclinical Models of Idiopathic Infantile Hypercalcemia -- |t Putative CYP24A1 Involvement in Other Systems -- |t CYP24A1 in Chronic Kidney Disease -- |t Role of 24,25(OH)2D in Chondrocyte Maturation -- |t 24,25(OH)2D and Fracture Repair -- |t Perspectives -- |t References -- |g 7. |t Vitamin D-Binding Protein / |r Steven Pauwels -- |t Summary -- |t Introduction -- |t Vitamin D-Binding Protein: Gene and Protein Structure -- |t Functions of Vitamin D-Binding Protein -- |t Vitamin D-Binding Protein-Actin Complex -- |t Conclusions and Perspectives -- |t References -- |g 8. |t Regulation of Renal and Extrarenal 1α-Hydroxylase / |r Martin Hewison -- |t Introduction -- |t Renal la-Hydroxylase -- |t Extrarenal Expression of 1α-Hydroxylase -- |t Conclusions and Future Prospects -- |t References -- |g II. |t MECHANISM OF ACTION -- |g 9. |t Genome-Wide Perspectives on Vitamin D Receptor--Mediated Control of Gene Expression in Target Cells / |r Nancy A. Benkusky -- |t Introduction -- |t Biology of Vitamin D -- |t Metabolic Activation of Vitamin D -- |t Overview of the Vitamin D Receptor: The Protein, Its Structure, and Function -- |t Recent Advances in the Mechanisms of Action of Vitamin D -- |t Advances in Understanding the Regulation of the Vitamin D Receptor Gene -- |t Exploiting Humanized VDR Transgenic Mice to Understand Expression, Regulation, and VDR Protein Function In Vivo -- |t Establishing a Humanized Mouse Model for the Study of Human Disease -- |t Summary and Conclusions -- |t Acknowledgments -- |t References -- |g 10. |t Diverse Mechanisms of Transcriptional Regulation by the Vitamin D Receptor / |r Manuella Bouttier -- |t Introduction -- |t Interplay Between Transforming Growth Factor β and Vitamin D Receptor Signaling -- |t Vitamin D Receptor and Transcription Factor Activator Protein-1 -- |t Interplay Between VDR and JAK/STAT Signaling in Immunity -- |t Regulation of Wnt Signaling by the Vitamin D Receptor: A Molecular Basis for Cancer Prevention -- |t Control of FoxO Protein Function by the Vitamin D Receptor -- |t Regulation of the c-MYC/MXD1 Network by the Hormone-Bound Vitamin D Receptor -- |t Multiple Mechanisms of Regulation of NF-κ B Signaling by the Hormone-Bound Vitamin D Receptor -- |t Insights Into Transcriptional Regulation by the Vitamin D Receptor from Genomics Studies -- |t Conclusions -- |t References -- |g 11. |t Structural Basis for Ligand Activity in Vitamin D Receptor / |r Natacha Rochel -- |t Introduction -- |t 1α, 25-Dihydroxyvitamin D3 Recognition by Vitamin D Receptor -- |t Natural Metabolites -- |t Other Vitamin D Receptor Natural Ligands -- |t Secosteroidal Analogs of 1α, 25-Dihydroxyvitamin D3 -- |t Structures of Vitamin D Receptor With Analogs That Induce Structural Rearrangements -- |t Synthetic Mimics of 1α,25-Dihydroxyvitamin D3 -- |t Conclusions and Perspectives -- |t Acknowledgments -- |t References -- |g 12. |t Ligand-Independent Actions of Vitamin D Receptor / |r Daniel Metzger -- |t Vitamin D Receptor -- |t Skeletal Defects Induced by Impaired Vitamin D Receptor Signaling -- |t Ligand-Independent Role of Vitamin D Receptor in Hair Cycle -- |t Unliganded Vitamin D Receptor Repressive Activities Induce Severe Skeletal Defects -- |t Toward Improved Diagnosis and Treatments of Hereditary Vitamin D Resistant Rickets Patients -- |t Conclusion and Perspectives -- |t Acknowledgments -- |t References -- |g 13. |t Vitamin D and Chromatin / |r Carsten Carlberg -- |t Introduction -- |t Nuclear Receptor Superfamily Member Vitamin D Receptor -- |t Genome-Wide Location of Vitamin D Receptor-Binding Sites -- |t CTCF as Organizer of Vitamin D-Dependent Chromatin Domains -- |t Impact of Epigenomics -- |t Vitamin D-Triggered Epigenome Changes -- |t Chromatin Model of Vitamin D Signaling Emerges -- |t Vitamin D Signaling In Vivo -- |t Conclusion -- |t Acknowledgments -- |t References -- |g 14. |t Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions With VDR / |r J. Wesley Pike -- |t Genetic Control of Mesenchymal Lineage Cells -- |t Epigenetic Fate Determination -- |t Osteoblast Enhancer Complex: Consolidated and Dispersed -- |t Dynamics of Transdifferentiation -- |t Conclusions -- |t Conflict of Interest -- |t References -- |g 15. |t Vitamin D and MicroRNAs / |r Thomas S. Lisse -- |t Introduction -- |t MicroRNAs: The Posttranscriptional Age -- |t Complexity of MicroRNA Regulation, Biogenesis, and Posttranscriptional Regulatory Actions -- |t Nuclear Receptors and MicroRNAs -- |t Duality Among MicroRNAs and the Vitamin D Synthesis, Metabolism, and Signaling Systems -- |t Interplay Between Vitamin D and MicroRNAs in Biological Systems -- |t Strategies for MicroRNA and Target Identification for Vitamin D Research -- |t Concluding Remarks -- |t Acknowledgments -- |t References -- |g 16. |t Vitamin D Sterol/Vitamin D Receptor Conformational Dynamics and Nongenomic Actions / |r Anthony W. Norman -- |t Introduction -- |t 1α, 25(OH)2 Vitamin D3 Regulation of Genomic Versus Nongenomic Signaling -- |t Vitamin D3 Sterol Chemistry -- |t 1,25(OH)2D3-Mediated Rapid, Nongenomic Responses -- |t Plasma Membrane Vitamin D Receptor -- |t Vitamin D Receptor Conformational Ensemble Model -- |t Vitamin D Receptor Ligand Specificity: Does an Unliganded Vitamin D Receptor Ever Exist In Vivo-- |t References -- |g III. |t MINERAL AND BONE HOMEOSTASIS -- |g 17. |t Vitamin D Regulation of Osteoblast Function / |r Bram C.J. |
| 880 | 0 | 0 | |6 505-01/(S |g Contents note continued: |t Renin-Angiotensin System -- |t Vitamin D Regulation of the Renin-Angiotensin System -- |t Vitamin D and the Renin-Angiotensin System in Disease -- |t Conclusion -- |t References -- |g 46. |t Parathyroid Hormone, Parathyroid Hormone--Related Protein, and Calcitonin / |r John J. Wysolmerski -- |t Parathyroid Hormone -- |t Parathyroid Hormone--Related Protein -- |t Calcitonin -- |t References -- |g 47. |t FGF23 Counter-Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity / |r L. Darryl Quarles -- |t Introduction -- |t Parathyroid Hormone--Vitamin D Axis: Key Regulator of Calcium Homeostasis -- |t Fibroblast Growth Factor-23/α-Klotho -- |t Fibroblast Growth Factor-23 Endocrine Networks -- |t Noncanonical α-Klotho and Fibroblast Growth Factor-23 Signaling -- |t Conclusions -- |t References -- |g VI. |t DIAGNOSIS AND MANAGEMENT -- |g 48. |t Approach to the Patient With Metabolic Bone Disease / |r Michael P. Whyte -- |t Introduction -- |t Diagnostic Evaluation -- |t Biochemical Investigation -- |t Histopathological Assessment -- |t Treatment -- |t Conclusions -- |t Acknowledgments -- |t References -- |g 49. |t Detection of 1,25-Dihydroxyvitamin D in Human Serum Using Receptor Assisted Chemiluminescent Hormone Assay Technology / |r Bruce W. Hollis -- |t Introduction -- |t Methodology -- |t Identification of the DNA Consensus Sequence of the Immunoglobulin G VH and VL Gene, Expressed by Hybridoma Clone 11B4 -- |t Preparation of the Assay Reagents -- |t Assay Format and Performance -- |t Discussion -- |t References -- |g 50. |t Mass Spectrometry Assays of Vitamin D Metabolites / |r Ravinder J. Singh -- |t Introduction -- |t Approaches and Utility of Vitamin D Metabolite Measurements in the Clinical Laboratory Setting -- |t Overview of Methodology for Analysis of Circulating Vitamin D Metabolites by LC-MS/MS -- |t Application of LC-MS/MS to the Study of Vitamin D Metabolism in Animal Models -- |t Future Directions -- |t References -- |g 51. |t Free Vitamin D: Concepts, Assays, Outcomes, and Prospects / |r Carrie M. Nielson -- |t Introduction -- |t Metabolism -- |t Transportation and Internalization: Free Hormone Hypothesis and Bioavailable Ligand -- |t Vitamin D-Binding Protein Genotype -- |t Free Vitamin D: Mathematical Estimation -- |t Free Vitamin D: Direct Physical Measurement -- |t Potential Utility of Free 25(OH)D for Clinical- and Population-Based Detection of Vitamin D Deficiency -- |t Conclusions and Knowledge Gaps -- |t References -- |g 52. |t 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems, and Interpretation / |r Neil C. Binkley -- |t Introduction -- |t Vitamin D Standardization Program Objectives -- |t Standardization and Traceability -- |t Vitamin D Standardization Program Standardization Protocols -- |t Performance Testing/Quality Assessment of Assays for Vitamin D Metabolites -- |t Vitamin D Standardization Program Efforts Going Into the Future -- |t Summary and Conclusions -- |t References -- |g 53. |t Bone Histomorphometry / |r David W. Dempster -- |t Introduction -- |t Bone Biopsy -- |t Histomorphometry -- |t Assessment of Mineralization -- |t Histological Diagnosis of Osteomalacia -- |t Assessment of Bone Turnover -- |t Assessment of Remodeling Balance -- |t Assessment of Bone Structure -- |t Influence of Vitamin D Status on Bone Histomorphometry -- |t Future Developments -- |t References -- |g 54. |t Radiology of Rickets and Osteomalacia / |r Judith E. Adams -- |t Introduction and Historical Aspects -- |t Vitamin D Deficiency -- |t Renal Osteodystrophy -- |t Renal Tubular Defects and Hypophosphatemia -- |t Differential Diagnoses -- |t Vitamin D Intoxication -- |t Conclusions -- |t References -- |g 55. |t High-Resolution Imaging Techniques for Bone Quality Assessment / |r Sharmila Majumdar -- |t Introduction -- |t X-ray Computed Tomography -- |t Magnetic Resonance Imaging -- |t References -- |g 56. |t Role of Vitamin D in Orthopedic Surgery / |r Joseph M. Lane -- |t Introduction -- |t Impact on Orthopedic Trauma -- |t Impact on Pediatric Orthopedics -- |t Impact on Total Joint Arthroplasty -- |t References -- |t Introduction to Chapters 57A and 57B References -- |g 57A. |t IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position / |r Cliff Rosen -- |t Introduction -- |t Vitamin D Status and Bone Health in Adults and the Elderly -- |t Vitamin D and Extraskeletal Health -- |t Lessons From Recently Updated Guidelines on Vitamin D Supplementation -- |t Vitamin D and Human Health: What is the Optimal Vitamin D Status -- |t Summary of Recommendations -- |t Highlights -- |t References -- |g 57B. |t IOM---Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position / |r Michael F. Holick -- |g Section I |t Defining the Disagreement Between IOM and Endocrine Society -- |g Section II |t Scientific Basis for Why IOM Versus Endocrine Society Values Differ in Terms of Bone Health -- |g Section III |t Toxicity and Perceptions of Risk of Higher Vitamin D Intakes: Higher-Dose Clinical Trials and Epidemiology U-Shaped Risk Findings -- |g Section IV |t Extraskeletal Effects of Vitamin D -- |g Section V |t Extraskeletal Effects: Cross-Sectional Observations Versus the Findings of Double-Blind, Randomized Clinical Trials -- |g Section VI |t Emerging Benefits of Higher Vitamin D: Life Expectancy -- |g Section VII |t New Evidence That Vitamin D Lowers Risk of Preterm Birth -- |g Section VIII |t Conclusion. |
| 938 | |a YBP Library Services |b YANK |n 15012197 | ||
| 938 | |a ProQuest MyiLibrary Digital eBook Collection |b IDEB |n cis39532288 | ||
| 938 | |a EBSCOhost |b EBSC |n 1483177 | ||
| 994 | |a 92 |b GEBAY | ||
| 912 | |a ZDB-4-EBA | ||
| 049 | |a DE-863 | ||
Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-on1013541228 |
|---|---|
| _version_ | 1816882407389790208 |
| adam_text | |
| any_adam_object | |
| author2 | Feldman, David, 1939- Pike, J. Wesley Bouillon, R. |
| author2_role | edt edt edt |
| author2_variant | d f df j w p jw jwp r b rb |
| author_facet | Feldman, David, 1939- Pike, J. Wesley Bouillon, R. |
| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | Q - Science |
| callnumber-label | QP772 |
| callnumber-raw | QP772.V53 |
| callnumber-search | QP772.V53 |
| callnumber-sort | QP 3772 V53 |
| callnumber-subject | QP - Physiology |
| collection | ZDB-4-EBA |
| contents | Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d -- Evolutionary biology: mysteries of vitamin D in fish -- Evolution of human skin color and vitamin D -- Photobiology of vitamin D -- The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases) -- CYP24A1: structure, function, and physiological role -- The vitamin D binding protein DBP -- Regulation of renal and extra-renal 1[alpha]-hydroxylase -- Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells -- Diverse mechanisms of transcriptional regulation by the vitamin D receptor -- Structural basis for ligand activity in VDR -- Ligand independent actions of vitamin D receptor -- Vitamin D and chromatin -- Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR -- Vitamin D and microRNAs -- Vitamin D sterol/VDR conformational dynamics and nongenomic actions -- Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function -- Osteoclastogenesis and vitamin D -- Vitamin D activities in osteocytes -- Regulation of intestinal calcium and phosphate absorption -- Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6 -- Calcium homeostasis and eggshell biomineralization in female chicken -- Mineralization in mammals -- Cartilage -- Vitamin D and bone: an integrated approach -- Section IV. Extra-skeletal targets. Vitamin D and the kidney -- Vitamin D and the parathyroids -- The calcium-sensing receptor and vitamin d -- Vitamin D in dentoalveolar and oral health -- The role of vitamin D and its receptor in hair follicle biology -- Vitamin D, calcium and the epidermis -- Vitamin D and the cardiovascular system -- Vitamin D brain development and function -- Vitamin D, VDR and adipose tissue: focus on cellular mechanisms -- Vitamin D and skeletal muscle -- Understanding vitamin D from mouse knockout models -- Section V. Human physiology. Pharmacology and pharmacokinetics -- Vitamin D role in the calcium and phosphorus economies -- Fetus, neonate and infant -- Consequences of perinatal vitamin D deficiency on later bone health -- Adolescence and acquisition of peak bone mass -- Pregnancy, lactation, and post-weaning recovery -- Role in reproductive biology and reproductive dysfunction in women -- Vitamin d, reproductive biology, and dysfunction in men -- Vitamin D and the renin-angiotensin system -- Parathyroid hormone, parathyroid hormone-related protein, and calcitonin -- FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity -- Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease -- Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology -- Mass spectrometry assays of vitamin D metabolites -- Free vitamin d: concepts, assays, outcomes and prospects -- 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation -- Bone histomorphometry -- Radiology of rickets and osteomalcia -- High-resolution imaging techniques for bone quality assessment -- The role of vitamin D in orthopedic surgery -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position. |
| ctrlnum | (OCoLC)1013541228 |
| dewey-full | 612.3/99 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.3/99 |
| dewey-search | 612.3/99 |
| dewey-sort | 3612.3 299 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | Fourth edition. |
| format | Electronic eBook |
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Wesley Pike, associate editors, Roger Bouillon [and 3 others].</subfield></datafield><datafield tag="246" ind1="3" ind2="0"><subfield code="a">Biochemistry, physiology and diagnostics</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">Fourth edition.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">London ;</subfield><subfield code="a">San Diego, CA :</subfield><subfield code="b">Academic Press is an imprint of Elsevier,</subfield><subfield code="c">[2018]</subfield></datafield><datafield tag="264" ind1=" " ind2="4"><subfield code="c">©2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (xxxvii, pages) :</subfield><subfield code="b">illustrations (chiefly color), color portraits</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Revised edition of: Vitamin D / editor-in-chief, David Feldman; associate editors, J. Wesley Pike, John S. Adams. 3rd ed. 2011.</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="6">880-01</subfield><subfield code="a">Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d -- Evolutionary biology: mysteries of vitamin D in fish -- Evolution of human skin color and vitamin D -- Photobiology of vitamin D -- The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases) -- CYP24A1: structure, function, and physiological role -- The vitamin D binding protein DBP -- Regulation of renal and extra-renal 1[alpha]-hydroxylase -- Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells -- Diverse mechanisms of transcriptional regulation by the vitamin D receptor -- Structural basis for ligand activity in VDR -- Ligand independent actions of vitamin D receptor -- Vitamin D and chromatin -- Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR -- Vitamin D and microRNAs -- Vitamin D sterol/VDR conformational dynamics and nongenomic actions -- Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function -- Osteoclastogenesis and vitamin D -- Vitamin D activities in osteocytes -- Regulation of intestinal calcium and phosphate absorption -- Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6 -- Calcium homeostasis and eggshell biomineralization in female chicken -- Mineralization in mammals -- Cartilage -- Vitamin D and bone: an integrated approach -- Section IV. Extra-skeletal targets. Vitamin D and the kidney -- Vitamin D and the parathyroids -- The calcium-sensing receptor and vitamin d -- Vitamin D in dentoalveolar and oral health -- The role of vitamin D and its receptor in hair follicle biology -- Vitamin D, calcium and the epidermis -- Vitamin D and the cardiovascular system -- Vitamin D brain development and function -- Vitamin D, VDR and adipose tissue: focus on cellular mechanisms -- Vitamin D and skeletal muscle -- Understanding vitamin D from mouse knockout models -- Section V. Human physiology. Pharmacology and pharmacokinetics -- Vitamin D role in the calcium and phosphorus economies -- Fetus, neonate and infant -- Consequences of perinatal vitamin D deficiency on later bone health -- Adolescence and acquisition of peak bone mass -- Pregnancy, lactation, and post-weaning recovery -- Role in reproductive biology and reproductive dysfunction in women -- Vitamin d, reproductive biology, and dysfunction in men -- Vitamin D and the renin-angiotensin system -- Parathyroid hormone, parathyroid hormone-related protein, and calcitonin -- FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity -- Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease -- Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology -- Mass spectrometry assays of vitamin D metabolites -- Free vitamin d: concepts, assays, outcomes and prospects -- 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation -- Bone histomorphometry -- Radiology of rickets and osteomalcia -- High-resolution imaging techniques for bone quality assessment -- The role of vitamin D in orthopedic surgery -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">"Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description</subfield></datafield><datafield tag="588" ind1="0" ind2=" "><subfield code="a">Online resource; title from electronic title page (ClinicalKey, viewed December 14, 2017).</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Vitamin D.</subfield><subfield code="0">http://id.loc.gov/authorities/subjects/sh85143982</subfield></datafield><datafield tag="650" ind1="1" ind2="2"><subfield code="a">Vitamin D</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Vitamin D.</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Vitamine D.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL</subfield><subfield code="x">Physiology.</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">SCIENCE</subfield><subfield code="x">Life Sciences</subfield><subfield code="x">Human Anatomy & Physiology.</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Vitamin D</subfield><subfield code="2">fast</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Feldman, David,</subfield><subfield code="d">1939-</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pike, J. Wesley,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bouillon, R.,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="730" ind1="0" ind2=" "><subfield code="i">Companion to:</subfield><subfield code="a">Vitamin D.</subfield><subfield code="n">Volume 2,</subfield><subfield code="p">Health, disease and therapeutics.</subfield></datafield><datafield tag="730" ind1="0" ind2=" "><subfield code="i">Preceded by:</subfield><subfield code="a">Vitamin D.</subfield><subfield code="s">3rd ed.</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Print version:</subfield><subfield code="t">Vitamin D.</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="l">FWS01</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FWS_PDA_EBA</subfield><subfield code="u">https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1483177</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="l">FWS01</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FWS_PDA_EBA</subfield><subfield code="u">https://www.sciencedirect.com/science/book/9780128099650</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="880" ind1="0" ind2="0"><subfield code="6">505-00/(S</subfield><subfield code="t">Van Der Eerden --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Properties of Mature Osteoblasts and Osteocytes --</subfield><subfield code="t">Major Regulatory Functions of Osteoblasts and Osteocytes and Control by the Vitamin D Endocrine System --</subfield><subfield code="t">Effects of 1,25(OH)2D3 on Osteoblast Differentiation --</subfield><subfield code="t">Regulation of Intracellular Signaling Pathways by 1,25(OH)2D3 --</subfield><subfield code="t">Summary and Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">18.</subfield><subfield code="t">Osteoclastogenesis and Vitamin D /</subfield><subfield code="r">Tatsuo Suda --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Regulation of Mineral Metabolism by Vitamin D, Parathyroid Hormone, and Fibroblast Growth Factor 23 --</subfield><subfield code="t">Phenotypes of Vitamin D Receptor Knockout Mice --</subfield><subfield code="t">Regulation of Osteoclastogenesis by the Receptor Activator of Nuclear Factor-κ B Ligand/Receptor Activator of Nuclear Factor-κ B/Osteoprotegerin System --</subfield><subfield code="t">In Vitro Regulation of Osteoclastogenesis by Vitamin D --</subfield><subfield code="t">In Vivo Regulation of Osteoclastogenesis by Vitamin D Compounds --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">References --</subfield><subfield code="g">19.</subfield><subfield code="t">Vitamin D Activities in Osteocytes /</subfield><subfield code="r">David M. Findlay --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Cell Biology of Osteocytes --</subfield><subfield code="t">Direct Actions of 1,25-Dihydroxyvitamin D on Osteocyte Maturation and Activities --</subfield><subfield code="t">Receptor Activator of Nuclear Factor κ B Ligand --</subfield><subfield code="t">Vitamin D Metabolism Within Osteocytes --</subfield><subfield code="t">Role of Osteocytes and Vitamin D in Bone Turnover --</subfield><subfield code="t">Role of Vitamin D and Osteocytes in Endocrine Feedback --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">20.</subfield><subfield code="t">Regulation of Intestinal Calcium and Phosphate Absorption /</subfield><subfield code="r">James C. Fleet --</subfield><subfield code="t">Overview of Intestinal Calcium Absorption --</subfield><subfield code="t">Overview of Intestinal Phosphate Absorption --</subfield><subfield code="t">References --</subfield><subfield code="g">21.</subfield><subfield code="t">Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 /</subfield><subfield code="r">Puneet Dhawan --</subfield><subfield code="t">Introduction and General Considerations, the Calbindins --</subfield><subfield code="t">Localization and Proposed Functional Significance of the Calbindins --</subfield><subfield code="t">Regulation of Calbindin Gene Expression --</subfield><subfield code="t">Epithelial Calcium Channels --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">References --</subfield><subfield code="g">22.</subfield><subfield code="t">Calcium Homeostasis and Eggshell Biomineralization in Female Chicken /</subfield><subfield code="r">Nathalie Le Roy --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Mineralization Associated With Laying Hen Reproduction --</subfield><subfield code="t">Transepithelial Transfer of Calcium --</subfield><subfield code="t">Regulation of Calcium Metabolism in Hens --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References.</subfield></datafield><datafield tag="880" ind1="0" ind2="0"><subfield code="6">505-00/(S</subfield><subfield code="g">Contents note continued:</subfield><subfield code="g">23.</subfield><subfield code="t">Mineralization in Mammals /</subfield><subfield code="r">Adele L. Boskey --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Direct and Indirect Effects of Vitamin D and Vitamin D Metabolites on Mineralization --</subfield><subfield code="t">Methods for Quantifying Tissue Mineralization --</subfield><subfield code="t">Mechanism of Effects of Vitamin D on Mineralization --</subfield><subfield code="t">Mineralization and Mineral Properties in Systems With Vitamin D Alterations --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="t">Further Reading --</subfield><subfield code="g">24.</subfield><subfield code="t">Cartilage /</subfield><subfield code="r">Zvi Schwartz --</subfield><subfield code="t">Properties of Cartilage Tissues --</subfield><subfield code="t">Regulation by Vitamin D --</subfield><subfield code="t">Rapid Actions of Vitamin D and Nongenomic Mechanisms --</subfield><subfield code="t">Summary --</subfield><subfield code="t">References --</subfield><subfield code="g">25.</subfield><subfield code="t">Vitamin D and Bone: An Integrated Approach /</subfield><subfield code="r">Geert Carmeliet --</subfield><subfield code="t">Link Between Bone Metabolism, Calcium Homeostasis, and 1,25(OH)2D3 Activity --</subfield><subfield code="t">1,25(OH)2D3 and Bone Metabolism During a Positive Calcium Balance --</subfield><subfield code="t">Negative Calcium Balance Resulting From Insufficient Vitamin D Action --</subfield><subfield code="t">Negative Calcium Balance With Sufficient Vitamin D --</subfield><subfield code="t">Vitamin D and Fibroblast Growth Factor 23 --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">References --</subfield><subfield code="g">IV.</subfield><subfield code="t">EXTRA-SKELETAL TARGETS --</subfield><subfield code="g">26.</subfield><subfield code="t">Vitamin D and the Kidney /</subfield><subfield code="r">Rajiv Kumar --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Role of the Kidney in the Metabolism of 25-Hydroxyvitamin D --</subfield><subfield code="t">Effects of Vitamin D, 25(OH)D3 and 1α, 25(OH)2D3 on the Renal Handling of Calcium and Phosphorus --</subfield><subfield code="t">Distribution and Regulation of Vitamin D-Dependent Proteins in the Kidney --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">References --</subfield><subfield code="g">27.</subfield><subfield code="t">Vitamin D and the Parathyroids /</subfield><subfield code="r">Tally Naveh-Many --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Parathyroid Hormone Biosynthesis --</subfield><subfield code="t">Parathyroid Hormone Gene --</subfield><subfield code="t">Development of the Parathyroid and Tissue-Specific Expression of the Parathyroid Hormone Gene --</subfield><subfield code="t">Regulation of Parathyroid Hormone Gene Expression --</subfield><subfield code="t">Summary --</subfield><subfield code="t">References --</subfield><subfield code="g">28.</subfield><subfield code="t">Calcium-Sensing Receptor and Vitamin D /</subfield><subfield code="r">Geoffrey N. Hendy --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Calcium-Sensing Receptor --</subfield><subfield code="t">Overview of Extracellular Ca2+ Homeostasis: Roles of Calcium-Sensing Receptor and Vitamin D Receptor --</subfield><subfield code="t">Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Involved in Ca2+ Homeostasis --</subfield><subfield code="t">Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Uninvolved in Extracellular Ca2+ Homeostasis --</subfield><subfield code="t">Mouse Models of Calcium-Sensing Receptor Deletion Relative to Presentation in Humans --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">29.</subfield><subfield code="t">Vitamin D in Dentoalveolar and Oral Health /</subfield><subfield code="r">Philippe P. Hujoel --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Brief Primer on Dentoalveolar Cells and Tissues --</subfield><subfield code="t">Vitamin D Metabolism and Mechanisms of Action on Dental Cells --</subfield><subfield code="t">Vitamin D, Rickets, and the Oral Tissues --</subfield><subfield code="t">Hereditary Vitamin D-Related Diseases and Dentoalveolar Tissues --</subfield><subfield code="t">Vitamin D and Oral Health --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">30.</subfield><subfield code="t">Role of Vitamin D and Its Receptor in Hair Follicle Biology /</subfield><subfield code="r">Marie B. Demay --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Hair Cycle --</subfield><subfield code="t">Keratinocyte Stem Cells --</subfield><subfield code="t">Pathways Important for Keratinocyte Stem Cell Function --</subfield><subfield code="t">Vitamin D Receptor Suppresses PPARγ Signaling in Keratinocyte Stem Cells --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">31.</subfield><subfield code="t">Vitamin D, Calcium, and the Epidermis /</subfield><subfield code="r">Daniel D. Bikle --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Cutaneous Production of Vitamin D and Its Biologically Active Metabolites --</subfield><subfield code="t">Regulation of Keratinocyte Differentiation --</subfield><subfield code="t">Role of Vitamin D Signaling in Skin Cancer --</subfield><subfield code="t">Role of Vitamin D Signaling in Epidermal Wound Repair --</subfield><subfield code="t">References --</subfield><subfield code="g">32.</subfield><subfield code="t">Vitamin D and the Cardiovascular System /</subfield><subfield code="r">Carlos Bernal-Mizrachi --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Vascular Physiology --</subfield><subfield code="t">Identification of the Vitamin D Receptor in the Vascular System --</subfield><subfield code="t">Vascular Relaxation --</subfield><subfield code="t">Structural Vascular Changes --</subfield><subfield code="t">Vascular Inflammation --</subfield><subfield code="t">Angiogenesis --</subfield><subfield code="t">Blood Coagulation and Fibrinolysis --</subfield><subfield code="t">Animal Models --</subfield><subfield code="t">Clinical Studies in Cardiovascular Disease --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">33.</subfield><subfield code="t">Vitamin D Brain Development and Function /</subfield><subfield code="r">John J. Mcgrath --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Vitamin D Signaling in the Brain --</subfield><subfield code="t">Dietary Vitamin D Deficiency, Effect on Brain Development and Function --</subfield><subfield code="t">Effects of Excess Vitamin D on Brain Development and Function --</subfield><subfield code="t">Vitamin D Regulates Essential Processes in Normal Brain Development --</subfield><subfield code="t">Possible Neuroprotective Mechanisms of Vitamin D in the Developing Brain --</subfield><subfield code="t">Developmental Vitamin D Deficiency and Neuropsychiatric Disorders --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">34.</subfield><subfield code="t">Vitamin D, Vitamin D Receptor, and Adipose Tissue: Focus on Cellular Mechanisms /</subfield><subfield code="r">Joellen Welsh --</subfield><subfield code="t">Adipose Tissue: Storage Depot and Target for Vitamin D --</subfield><subfield code="t">Effect of Vitamin D on Adipogenesis at the Cellular Level --</subfield><subfield code="t">Impact of Vitamin D Signaling on Adiposity in Mouse Models --</subfield><subfield code="t">Translational Considerations --</subfield><subfield code="t">Conclusions and Future Directions --</subfield><subfield code="t">References --</subfield><subfield code="g">35.</subfield><subfield code="t">Vitamin D and Skeletal Muscle /</subfield><subfield code="r">Christian M. Girgis --</subfield><subfield code="t">Skeletal Muscle Physiology --</subfield><subfield code="t">Vitamin D Receptor in Muscle --</subfield><subfield code="t">Vitamin D and Calcium Signaling in Muscle --</subfield><subfield code="t">Vitamin D and Phosphate Signaling in Muscle --</subfield><subfield code="t">Vitamin D and Insulin Signaling in Muscle --</subfield><subfield code="t">Vitamin D, Muscle Contraction, and Strength --</subfield><subfield code="t">Vitamin D, Muscle Development, and Mass --</subfield><subfield code="t">Vitamin D, Muscle Injury, and Repair --</subfield><subfield code="t">Vitamin D and Age-Related Changes in Muscle --</subfield><subfield code="t">Vitamin D and Bone Muscle Cross-Talk --</subfield><subfield code="t">Conclusions and Future Directions --</subfield><subfield code="t">References --</subfield><subfield code="g">36.</subfield><subfield code="t">Understanding Vitamin D From Mouse Knockout Models /</subfield><subfield code="r">Denshun Miao --</subfield><subfield code="t">Vitamin D Metabolism --</subfield><subfield code="t">1,25 Dihydroxyvitamin D/Vitamin D Receptor System and Mineral and Skeletal Homeostasis --</subfield><subfield code="t">Extraskeletal Actions of 1,25 dihydroxyvitamin D --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">References --</subfield><subfield code="t">Further Reading --</subfield><subfield code="g">V.</subfield><subfield code="t">HUMAN PHYSIOLOGY --</subfield><subfield code="g">37.</subfield><subfield code="t">Pharmacology and Pharmacokinetics /</subfield><subfield code="r">Kerry S. Jones --</subfield><subfield code="t">Overview --</subfield><subfield code="t">Vitamin D Absorption --</subfield><subfield code="t">Kinetics of Cutaneous Synthesis --</subfield><subfield code="t">Tissue Distribution --</subfield><subfield code="t">Metabolism and Determinants of Metabolic Fate of Vitamin D --</subfield><subfield code="t">Half-Lives of Vitamin D Metabolites --</subfield><subfield code="t">Factors Influencing Vitamin D Half-Life --</subfield><subfield code="t">Pharmacokinetics of Bound and Free Vitamin D Metabolites --</subfield><subfield code="t">Influence of Vitamin D-Binding Protein Genotype and Concentration on Vitamin D Metabolism and 25(OH)D Half-Life --</subfield><subfield code="t">Dose-Response to Vitamin D Supplementation --</subfield><subfield code="t">3-Epimer of 25(OH)D and 1,25(OH)2D --</subfield><subfield code="t">Catabolism and Excretion --</subfield><subfield code="t">Vitamin D Toxicity --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">38.</subfield><subfield code="t">Vitamin D Role in the Calcium and Phosphorus Economies /</subfield><subfield code="r">Laura A. Graeff-Armas --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Overview of the Calcium Economy --</subfield><subfield code="t">Overview of the Phosphorus Economy --</subfield><subfield code="t">Calcium and Phosphorus Absorptive Inputs --</subfield><subfield code="t">Physiological Sources of Vitamin D Activity --</subfield><subfield code="t">Optimal Vitamin D Status --</subfield><subfield code="t">Summary and Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">39.</subfield><subfield code="t">Fetus, Neonate, and Infant /</subfield><subfield code="r">Christopher S. Kovacs --</subfield><subfield code="t">Overview of Calcium Metabolism in the Fetus --</subfield><subfield code="t">Animal Data Relevant to Vitamin D and the Fetus --</subfield><subfield code="t">Human Data Relevant to Vitamin D and the Fetus --</subfield><subfield code="t">Overview of Calcium Metabolism in the Neonate and Infant --</subfield><subfield code="t">Animal Data Relevant to Vitamin D and the Neonate and Infant --</subfield><subfield code="t">Human Data Relevant to Vitamin D and the Neonate and Infant --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">40.</subfield><subfield code="t">Consequences of Perinatal Vitamin D Deficiency on Later Bone Health /</subfield><subfield code="r">Nicholas C. Harvey --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Vitamin D Physiology and Epidemiology in Pregnancy --</subfield><subfield code="t">Lifecourse Determinants of Osteoporosis --</subfield><subfield code="t">Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health --</subfield><subfield code="t">Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health: The MAVIDOS Trial --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">Acknowledgment --</subfield><subfield code="t">References --</subfield><subfield code="g">41.</subfield><subfield code="t">Adolescence and Acquisition of Peak Bone Mass /</subfield><subfield code="r">Connie Weaver --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Pubertal Bone Acquisition --</subfield><subfield code="t">Sex and Race Differences --</subfield><subfield code="t">Serum 25(OH)D in Children and Adolescents --</subfield><subfield code="t">Vitamin D and Intermediate Endpoints of Vitamin D and Bone Metabolism --</subfield><subfield code="t">Vitamin D and Other Predictors of Calcium Retention --</subfield><subfield code="t">Vitamin D and Bone --</subfield><subfield code="t">Vitamin D and Muscle --</subfield><subfield code="t">Vitamin D Requirements in Children and Adolescents --</subfield><subfield code="t">Summary and Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">42.</subfield><subfield code="t">Pregnancy, Lactation, and Postweaning Recovery /</subfield><subfield code="r">Christopher S.</subfield></datafield><datafield tag="880" ind1="0" ind2="0"><subfield code="6">505-00/(S</subfield><subfield code="g">Machine generated contents note:</subfield><subfield code="t">VOLUME I --</subfield><subfield code="g">I.</subfield><subfield code="t">HISTORY, CHEMISTRY METABOLISM, CIRCULATION & REGULATION --</subfield><subfield code="g">1.</subfield><subfield code="t">Historical Overview of Vitamin D /</subfield><subfield code="r">Hector F. Deluca --</subfield><subfield code="t">Discovery of the Vitamins --</subfield><subfield code="t">Discovery of the Physiological Functions of Vitamin D --</subfield><subfield code="t">Discovery of the Hormonal Form of Vitamin D --</subfield><subfield code="t">Acknowledgment --</subfield><subfield code="t">References --</subfield><subfield code="g">2.</subfield><subfield code="t">Evolutionary Biology: Mysteries of Vitamin D in Fish /</subfield><subfield code="r">David R. Fraser --</subfield><subfield code="t">Biological Distribution of Vitamin D --</subfield><subfield code="t">Evolutionary Origins of Vitamin D --</subfield><subfield code="t">Evolution of Vitamin D Function --</subfield><subfield code="t">Origin of Vitamin D in Fish --</subfield><subfield code="t">Functional Metabolism of Vitamin D in Fish --</subfield><subfield code="t">Possible Role for Sunlight in the Origin of Vitamin D in Fish --</subfield><subfield code="t">Vitamin D Function in Fish --</subfield><subfield code="t">Transport of Vitamin D and Its Metabolites --</subfield><subfield code="t">Vitamin D Toxicity From Oral Ingestion --</subfield><subfield code="t">References --</subfield><subfield code="g">3.</subfield><subfield code="t">Evolution of Human Skin Color and Vitamin D /</subfield><subfield code="r">Nina G. Jablonski --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Solar Context of Human Skin Color Evolution --</subfield><subfield code="t">Nature of the Selective Factors Leading to the Evolution of Skin Pigmentation in Early Homo --</subfield><subfield code="t">Folate Conservation and the Evolution of Permanent Protective Pigmentation --</subfield><subfield code="t">Early Hominin Dispersal Out of the Tropics and Vitamin D Production --</subfield><subfield code="t">Evolution of Skin Pigmentation in Homo sapiens --</subfield><subfield code="t">Effects of Cultural Buffering, Rapid Migrations, and Modern Lifestyles on Skin Color and Vitamin D --</subfield><subfield code="t">References --</subfield><subfield code="t">Further Reading --</subfield><subfield code="g">4.</subfield><subfield code="t">Photobiology of Vitamin D /</subfield><subfield code="r">Michael F. Holick --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Historical Perspective --</subfield><subfield code="t">Photobiology of Vitamin D --</subfield><subfield code="t">Role of Sunlight and Dietary Vitamin D in Bone Health, Overall Health, and Well-being --</subfield><subfield code="t">Sunlight, Vitamin D, and Skin Cancer --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="t">Further Reading --</subfield><subfield code="g">5.</subfield><subfield code="t">Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases) /</subfield><subfield code="r">Martin Kaufmann --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">General Information Regarding Vitamin D Hydroxylases --</subfield><subfield code="t">Vitamin D3-25-Hydroxylases --</subfield><subfield code="t">25-Hydroxyvitamin D-1α-hydroxylase --</subfield><subfield code="t">Additional Topics --</subfield><subfield code="t">References --</subfield><subfield code="g">6.</subfield><subfield code="t">CYP24A1: Structure, Function, and Physiological Role /</subfield><subfield code="r">Glenville Jones --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">CYP24A1-Catalyzed Pathways --</subfield><subfield code="t">C24-Oxidation Pathway --</subfield><subfield code="t">C23-Hydroxylation Pathway --</subfield><subfield code="t">CYP24A1, a Multifunctional Enzyme --</subfield><subfield code="t">Biological Relevance of the C24-Oxidation Pathway --</subfield><subfield code="t">Structure-Function Relationships --</subfield><subfield code="t">Mutations of CYP24A1 and Idiopathic Infantile Hypercalcemia --</subfield><subfield code="t">Preclinical Models of Idiopathic Infantile Hypercalcemia --</subfield><subfield code="t">Putative CYP24A1 Involvement in Other Systems --</subfield><subfield code="t">CYP24A1 in Chronic Kidney Disease --</subfield><subfield code="t">Role of 24,25(OH)2D in Chondrocyte Maturation --</subfield><subfield code="t">24,25(OH)2D and Fracture Repair --</subfield><subfield code="t">Perspectives --</subfield><subfield code="t">References --</subfield><subfield code="g">7.</subfield><subfield code="t">Vitamin D-Binding Protein /</subfield><subfield code="r">Steven Pauwels --</subfield><subfield code="t">Summary --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Vitamin D-Binding Protein: Gene and Protein Structure --</subfield><subfield code="t">Functions of Vitamin D-Binding Protein --</subfield><subfield code="t">Vitamin D-Binding Protein-Actin Complex --</subfield><subfield code="t">Conclusions and Perspectives --</subfield><subfield code="t">References --</subfield><subfield code="g">8.</subfield><subfield code="t">Regulation of Renal and Extrarenal 1α-Hydroxylase /</subfield><subfield code="r">Martin Hewison --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Renal la-Hydroxylase --</subfield><subfield code="t">Extrarenal Expression of 1α-Hydroxylase --</subfield><subfield code="t">Conclusions and Future Prospects --</subfield><subfield code="t">References --</subfield><subfield code="g">II.</subfield><subfield code="t">MECHANISM OF ACTION --</subfield><subfield code="g">9.</subfield><subfield code="t">Genome-Wide Perspectives on Vitamin D Receptor--Mediated Control of Gene Expression in Target Cells /</subfield><subfield code="r">Nancy A. Benkusky --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Biology of Vitamin D --</subfield><subfield code="t">Metabolic Activation of Vitamin D --</subfield><subfield code="t">Overview of the Vitamin D Receptor: The Protein, Its Structure, and Function --</subfield><subfield code="t">Recent Advances in the Mechanisms of Action of Vitamin D --</subfield><subfield code="t">Advances in Understanding the Regulation of the Vitamin D Receptor Gene --</subfield><subfield code="t">Exploiting Humanized VDR Transgenic Mice to Understand Expression, Regulation, and VDR Protein Function In Vivo --</subfield><subfield code="t">Establishing a Humanized Mouse Model for the Study of Human Disease --</subfield><subfield code="t">Summary and Conclusions --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">10.</subfield><subfield code="t">Diverse Mechanisms of Transcriptional Regulation by the Vitamin D Receptor /</subfield><subfield code="r">Manuella Bouttier --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Interplay Between Transforming Growth Factor β and Vitamin D Receptor Signaling --</subfield><subfield code="t">Vitamin D Receptor and Transcription Factor Activator Protein-1 --</subfield><subfield code="t">Interplay Between VDR and JAK/STAT Signaling in Immunity --</subfield><subfield code="t">Regulation of Wnt Signaling by the Vitamin D Receptor: A Molecular Basis for Cancer Prevention --</subfield><subfield code="t">Control of FoxO Protein Function by the Vitamin D Receptor --</subfield><subfield code="t">Regulation of the c-MYC/MXD1 Network by the Hormone-Bound Vitamin D Receptor --</subfield><subfield code="t">Multiple Mechanisms of Regulation of NF-κ B Signaling by the Hormone-Bound Vitamin D Receptor --</subfield><subfield code="t">Insights Into Transcriptional Regulation by the Vitamin D Receptor from Genomics Studies --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">11.</subfield><subfield code="t">Structural Basis for Ligand Activity in Vitamin D Receptor /</subfield><subfield code="r">Natacha Rochel --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">1α, 25-Dihydroxyvitamin D3 Recognition by Vitamin D Receptor --</subfield><subfield code="t">Natural Metabolites --</subfield><subfield code="t">Other Vitamin D Receptor Natural Ligands --</subfield><subfield code="t">Secosteroidal Analogs of 1α, 25-Dihydroxyvitamin D3 --</subfield><subfield code="t">Structures of Vitamin D Receptor With Analogs That Induce Structural Rearrangements --</subfield><subfield code="t">Synthetic Mimics of 1α,25-Dihydroxyvitamin D3 --</subfield><subfield code="t">Conclusions and Perspectives --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">12.</subfield><subfield code="t">Ligand-Independent Actions of Vitamin D Receptor /</subfield><subfield code="r">Daniel Metzger --</subfield><subfield code="t">Vitamin D Receptor --</subfield><subfield code="t">Skeletal Defects Induced by Impaired Vitamin D Receptor Signaling --</subfield><subfield code="t">Ligand-Independent Role of Vitamin D Receptor in Hair Cycle --</subfield><subfield code="t">Unliganded Vitamin D Receptor Repressive Activities Induce Severe Skeletal Defects --</subfield><subfield code="t">Toward Improved Diagnosis and Treatments of Hereditary Vitamin D Resistant Rickets Patients --</subfield><subfield code="t">Conclusion and Perspectives --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">13.</subfield><subfield code="t">Vitamin D and Chromatin /</subfield><subfield code="r">Carsten Carlberg --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Nuclear Receptor Superfamily Member Vitamin D Receptor --</subfield><subfield code="t">Genome-Wide Location of Vitamin D Receptor-Binding Sites --</subfield><subfield code="t">CTCF as Organizer of Vitamin D-Dependent Chromatin Domains --</subfield><subfield code="t">Impact of Epigenomics --</subfield><subfield code="t">Vitamin D-Triggered Epigenome Changes --</subfield><subfield code="t">Chromatin Model of Vitamin D Signaling Emerges --</subfield><subfield code="t">Vitamin D Signaling In Vivo --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">14.</subfield><subfield code="t">Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions With VDR /</subfield><subfield code="r">J. Wesley Pike --</subfield><subfield code="t">Genetic Control of Mesenchymal Lineage Cells --</subfield><subfield code="t">Epigenetic Fate Determination --</subfield><subfield code="t">Osteoblast Enhancer Complex: Consolidated and Dispersed --</subfield><subfield code="t">Dynamics of Transdifferentiation --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">Conflict of Interest --</subfield><subfield code="t">References --</subfield><subfield code="g">15.</subfield><subfield code="t">Vitamin D and MicroRNAs /</subfield><subfield code="r">Thomas S. Lisse --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">MicroRNAs: The Posttranscriptional Age --</subfield><subfield code="t">Complexity of MicroRNA Regulation, Biogenesis, and Posttranscriptional Regulatory Actions --</subfield><subfield code="t">Nuclear Receptors and MicroRNAs --</subfield><subfield code="t">Duality Among MicroRNAs and the Vitamin D Synthesis, Metabolism, and Signaling Systems --</subfield><subfield code="t">Interplay Between Vitamin D and MicroRNAs in Biological Systems --</subfield><subfield code="t">Strategies for MicroRNA and Target Identification for Vitamin D Research --</subfield><subfield code="t">Concluding Remarks --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">16.</subfield><subfield code="t">Vitamin D Sterol/Vitamin D Receptor Conformational Dynamics and Nongenomic Actions /</subfield><subfield code="r">Anthony W. Norman --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">1α, 25(OH)2 Vitamin D3 Regulation of Genomic Versus Nongenomic Signaling --</subfield><subfield code="t">Vitamin D3 Sterol Chemistry --</subfield><subfield code="t">1,25(OH)2D3-Mediated Rapid, Nongenomic Responses --</subfield><subfield code="t">Plasma Membrane Vitamin D Receptor --</subfield><subfield code="t">Vitamin D Receptor Conformational Ensemble Model --</subfield><subfield code="t">Vitamin D Receptor Ligand Specificity: Does an Unliganded Vitamin D Receptor Ever Exist In Vivo--</subfield><subfield code="t">References --</subfield><subfield code="g">III.</subfield><subfield code="t">MINERAL AND BONE HOMEOSTASIS --</subfield><subfield code="g">17.</subfield><subfield code="t">Vitamin D Regulation of Osteoblast Function /</subfield><subfield code="r">Bram C.J.</subfield></datafield><datafield tag="880" ind1="0" ind2="0"><subfield code="6">505-01/(S</subfield><subfield code="g">Contents note continued:</subfield><subfield code="t">Renin-Angiotensin System --</subfield><subfield code="t">Vitamin D Regulation of the Renin-Angiotensin System --</subfield><subfield code="t">Vitamin D and the Renin-Angiotensin System in Disease --</subfield><subfield code="t">Conclusion --</subfield><subfield code="t">References --</subfield><subfield code="g">46.</subfield><subfield code="t">Parathyroid Hormone, Parathyroid Hormone--Related Protein, and Calcitonin /</subfield><subfield code="r">John J. Wysolmerski --</subfield><subfield code="t">Parathyroid Hormone --</subfield><subfield code="t">Parathyroid Hormone--Related Protein --</subfield><subfield code="t">Calcitonin --</subfield><subfield code="t">References --</subfield><subfield code="g">47.</subfield><subfield code="t">FGF23 Counter-Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity /</subfield><subfield code="r">L. Darryl Quarles --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Parathyroid Hormone--Vitamin D Axis: Key Regulator of Calcium Homeostasis --</subfield><subfield code="t">Fibroblast Growth Factor-23/α-Klotho --</subfield><subfield code="t">Fibroblast Growth Factor-23 Endocrine Networks --</subfield><subfield code="t">Noncanonical α-Klotho and Fibroblast Growth Factor-23 Signaling --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">VI.</subfield><subfield code="t">DIAGNOSIS AND MANAGEMENT --</subfield><subfield code="g">48.</subfield><subfield code="t">Approach to the Patient With Metabolic Bone Disease /</subfield><subfield code="r">Michael P. Whyte --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Diagnostic Evaluation --</subfield><subfield code="t">Biochemical Investigation --</subfield><subfield code="t">Histopathological Assessment --</subfield><subfield code="t">Treatment --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">Acknowledgments --</subfield><subfield code="t">References --</subfield><subfield code="g">49.</subfield><subfield code="t">Detection of 1,25-Dihydroxyvitamin D in Human Serum Using Receptor Assisted Chemiluminescent Hormone Assay Technology /</subfield><subfield code="r">Bruce W. Hollis --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Methodology --</subfield><subfield code="t">Identification of the DNA Consensus Sequence of the Immunoglobulin G VH and VL Gene, Expressed by Hybridoma Clone 11B4 --</subfield><subfield code="t">Preparation of the Assay Reagents --</subfield><subfield code="t">Assay Format and Performance --</subfield><subfield code="t">Discussion --</subfield><subfield code="t">References --</subfield><subfield code="g">50.</subfield><subfield code="t">Mass Spectrometry Assays of Vitamin D Metabolites /</subfield><subfield code="r">Ravinder J. Singh --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Approaches and Utility of Vitamin D Metabolite Measurements in the Clinical Laboratory Setting --</subfield><subfield code="t">Overview of Methodology for Analysis of Circulating Vitamin D Metabolites by LC-MS/MS --</subfield><subfield code="t">Application of LC-MS/MS to the Study of Vitamin D Metabolism in Animal Models --</subfield><subfield code="t">Future Directions --</subfield><subfield code="t">References --</subfield><subfield code="g">51.</subfield><subfield code="t">Free Vitamin D: Concepts, Assays, Outcomes, and Prospects /</subfield><subfield code="r">Carrie M. Nielson --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Metabolism --</subfield><subfield code="t">Transportation and Internalization: Free Hormone Hypothesis and Bioavailable Ligand --</subfield><subfield code="t">Vitamin D-Binding Protein Genotype --</subfield><subfield code="t">Free Vitamin D: Mathematical Estimation --</subfield><subfield code="t">Free Vitamin D: Direct Physical Measurement --</subfield><subfield code="t">Potential Utility of Free 25(OH)D for Clinical- and Population-Based Detection of Vitamin D Deficiency --</subfield><subfield code="t">Conclusions and Knowledge Gaps --</subfield><subfield code="t">References --</subfield><subfield code="g">52.</subfield><subfield code="t">25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems, and Interpretation /</subfield><subfield code="r">Neil C. Binkley --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Vitamin D Standardization Program Objectives --</subfield><subfield code="t">Standardization and Traceability --</subfield><subfield code="t">Vitamin D Standardization Program Standardization Protocols --</subfield><subfield code="t">Performance Testing/Quality Assessment of Assays for Vitamin D Metabolites --</subfield><subfield code="t">Vitamin D Standardization Program Efforts Going Into the Future --</subfield><subfield code="t">Summary and Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">53.</subfield><subfield code="t">Bone Histomorphometry /</subfield><subfield code="r">David W. Dempster --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Bone Biopsy --</subfield><subfield code="t">Histomorphometry --</subfield><subfield code="t">Assessment of Mineralization --</subfield><subfield code="t">Histological Diagnosis of Osteomalacia --</subfield><subfield code="t">Assessment of Bone Turnover --</subfield><subfield code="t">Assessment of Remodeling Balance --</subfield><subfield code="t">Assessment of Bone Structure --</subfield><subfield code="t">Influence of Vitamin D Status on Bone Histomorphometry --</subfield><subfield code="t">Future Developments --</subfield><subfield code="t">References --</subfield><subfield code="g">54.</subfield><subfield code="t">Radiology of Rickets and Osteomalacia /</subfield><subfield code="r">Judith E. Adams --</subfield><subfield code="t">Introduction and Historical Aspects --</subfield><subfield code="t">Vitamin D Deficiency --</subfield><subfield code="t">Renal Osteodystrophy --</subfield><subfield code="t">Renal Tubular Defects and Hypophosphatemia --</subfield><subfield code="t">Differential Diagnoses --</subfield><subfield code="t">Vitamin D Intoxication --</subfield><subfield code="t">Conclusions --</subfield><subfield code="t">References --</subfield><subfield code="g">55.</subfield><subfield code="t">High-Resolution Imaging Techniques for Bone Quality Assessment /</subfield><subfield code="r">Sharmila Majumdar --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">X-ray Computed Tomography --</subfield><subfield code="t">Magnetic Resonance Imaging --</subfield><subfield code="t">References --</subfield><subfield code="g">56.</subfield><subfield code="t">Role of Vitamin D in Orthopedic Surgery /</subfield><subfield code="r">Joseph M. Lane --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Impact on Orthopedic Trauma --</subfield><subfield code="t">Impact on Pediatric Orthopedics --</subfield><subfield code="t">Impact on Total Joint Arthroplasty --</subfield><subfield code="t">References --</subfield><subfield code="t">Introduction to Chapters 57A and 57B References --</subfield><subfield code="g">57A.</subfield><subfield code="t">IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position /</subfield><subfield code="r">Cliff Rosen --</subfield><subfield code="t">Introduction --</subfield><subfield code="t">Vitamin D Status and Bone Health in Adults and the Elderly --</subfield><subfield code="t">Vitamin D and Extraskeletal Health --</subfield><subfield code="t">Lessons From Recently Updated Guidelines on Vitamin D Supplementation --</subfield><subfield code="t">Vitamin D and Human Health: What is the Optimal Vitamin D Status --</subfield><subfield code="t">Summary of Recommendations --</subfield><subfield code="t">Highlights --</subfield><subfield code="t">References --</subfield><subfield code="g">57B.</subfield><subfield code="t">IOM---Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position /</subfield><subfield code="r">Michael F. Holick --</subfield><subfield code="g">Section I</subfield><subfield code="t">Defining the Disagreement Between IOM and Endocrine Society --</subfield><subfield code="g">Section II</subfield><subfield code="t">Scientific Basis for Why IOM Versus Endocrine Society Values Differ in Terms of Bone Health --</subfield><subfield code="g">Section III</subfield><subfield code="t">Toxicity and Perceptions of Risk of Higher Vitamin D Intakes: Higher-Dose Clinical Trials and Epidemiology U-Shaped Risk Findings --</subfield><subfield code="g">Section IV</subfield><subfield code="t">Extraskeletal Effects of Vitamin D --</subfield><subfield code="g">Section V</subfield><subfield code="t">Extraskeletal Effects: Cross-Sectional Observations Versus the Findings of Double-Blind, Randomized Clinical Trials --</subfield><subfield code="g">Section VI</subfield><subfield code="t">Emerging Benefits of Higher Vitamin D: Life Expectancy --</subfield><subfield code="g">Section VII</subfield><subfield code="t">New Evidence That Vitamin D Lowers Risk of Preterm Birth --</subfield><subfield code="g">Section VIII</subfield><subfield code="t">Conclusion.</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">YBP Library Services</subfield><subfield code="b">YANK</subfield><subfield code="n">15012197</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">ProQuest MyiLibrary Digital eBook Collection</subfield><subfield code="b">IDEB</subfield><subfield code="n">cis39532288</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">EBSCOhost</subfield><subfield code="b">EBSC</subfield><subfield code="n">1483177</subfield></datafield><datafield tag="994" ind1=" " ind2=" "><subfield code="a">92</subfield><subfield code="b">GEBAY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-4-EBA</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-863</subfield></datafield></record></collection> |
| id | ZDB-4-EBA-on1013541228 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:28:07Z |
| institution | BVB |
| isbn | 9780128099667 0128099666 |
| language | English |
| oclc_num | 1013541228 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (xxxvii, pages) : illustrations (chiefly color), color portraits |
| psigel | ZDB-4-EBA |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Academic Press is an imprint of Elsevier, |
| record_format | marc |
| spelling | Vitamin D. Volume 1, Biochemistry, physiology and diagnostics / editor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon [and 3 others]. Biochemistry, physiology and diagnostics Fourth edition. London ; San Diego, CA : Academic Press is an imprint of Elsevier, [2018] ©2018 1 online resource (xxxvii, pages) : illustrations (chiefly color), color portraits text txt rdacontent computer c rdamedia online resource cr rdacarrier Revised edition of: Vitamin D / editor-in-chief, David Feldman; associate editors, J. Wesley Pike, John S. Adams. 3rd ed. 2011. Includes bibliographical references. 880-01 Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d -- Evolutionary biology: mysteries of vitamin D in fish -- Evolution of human skin color and vitamin D -- Photobiology of vitamin D -- The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases) -- CYP24A1: structure, function, and physiological role -- The vitamin D binding protein DBP -- Regulation of renal and extra-renal 1[alpha]-hydroxylase -- Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells -- Diverse mechanisms of transcriptional regulation by the vitamin D receptor -- Structural basis for ligand activity in VDR -- Ligand independent actions of vitamin D receptor -- Vitamin D and chromatin -- Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR -- Vitamin D and microRNAs -- Vitamin D sterol/VDR conformational dynamics and nongenomic actions -- Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function -- Osteoclastogenesis and vitamin D -- Vitamin D activities in osteocytes -- Regulation of intestinal calcium and phosphate absorption -- Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6 -- Calcium homeostasis and eggshell biomineralization in female chicken -- Mineralization in mammals -- Cartilage -- Vitamin D and bone: an integrated approach -- Section IV. Extra-skeletal targets. Vitamin D and the kidney -- Vitamin D and the parathyroids -- The calcium-sensing receptor and vitamin d -- Vitamin D in dentoalveolar and oral health -- The role of vitamin D and its receptor in hair follicle biology -- Vitamin D, calcium and the epidermis -- Vitamin D and the cardiovascular system -- Vitamin D brain development and function -- Vitamin D, VDR and adipose tissue: focus on cellular mechanisms -- Vitamin D and skeletal muscle -- Understanding vitamin D from mouse knockout models -- Section V. Human physiology. Pharmacology and pharmacokinetics -- Vitamin D role in the calcium and phosphorus economies -- Fetus, neonate and infant -- Consequences of perinatal vitamin D deficiency on later bone health -- Adolescence and acquisition of peak bone mass -- Pregnancy, lactation, and post-weaning recovery -- Role in reproductive biology and reproductive dysfunction in women -- Vitamin d, reproductive biology, and dysfunction in men -- Vitamin D and the renin-angiotensin system -- Parathyroid hormone, parathyroid hormone-related protein, and calcitonin -- FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity -- Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease -- Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology -- Mass spectrometry assays of vitamin D metabolites -- Free vitamin d: concepts, assays, outcomes and prospects -- 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation -- Bone histomorphometry -- Radiology of rickets and osteomalcia -- High-resolution imaging techniques for bone quality assessment -- The role of vitamin D in orthopedic surgery -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position. "Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description Online resource; title from electronic title page (ClinicalKey, viewed December 14, 2017). Vitamin D. http://id.loc.gov/authorities/subjects/sh85143982 Vitamin D Vitamin D. Vitamine D. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Vitamin D fast Feldman, David, 1939- editor. Pike, J. Wesley, editor. Bouillon, R., editor. Companion to: Vitamin D. Volume 2, Health, disease and therapeutics. Preceded by: Vitamin D. 3rd ed. Print version: Vitamin D. FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1483177 Volltext FWS01 ZDB-4-EBA FWS_PDA_EBA https://www.sciencedirect.com/science/book/9780128099650 Volltext 505-00/(S Van Der Eerden -- Introduction -- Properties of Mature Osteoblasts and Osteocytes -- Major Regulatory Functions of Osteoblasts and Osteocytes and Control by the Vitamin D Endocrine System -- Effects of 1,25(OH)2D3 on Osteoblast Differentiation -- Regulation of Intracellular Signaling Pathways by 1,25(OH)2D3 -- Summary and Conclusions -- References -- 18. Osteoclastogenesis and Vitamin D / Tatsuo Suda -- Introduction -- Regulation of Mineral Metabolism by Vitamin D, Parathyroid Hormone, and Fibroblast Growth Factor 23 -- Phenotypes of Vitamin D Receptor Knockout Mice -- Regulation of Osteoclastogenesis by the Receptor Activator of Nuclear Factor-κ B Ligand/Receptor Activator of Nuclear Factor-κ B/Osteoprotegerin System -- In Vitro Regulation of Osteoclastogenesis by Vitamin D -- In Vivo Regulation of Osteoclastogenesis by Vitamin D Compounds -- Conclusion -- References -- 19. Vitamin D Activities in Osteocytes / David M. Findlay -- Introduction -- Cell Biology of Osteocytes -- Direct Actions of 1,25-Dihydroxyvitamin D on Osteocyte Maturation and Activities -- Receptor Activator of Nuclear Factor κ B Ligand -- Vitamin D Metabolism Within Osteocytes -- Role of Osteocytes and Vitamin D in Bone Turnover -- Role of Vitamin D and Osteocytes in Endocrine Feedback -- Conclusions -- References -- 20. Regulation of Intestinal Calcium and Phosphate Absorption / James C. Fleet -- Overview of Intestinal Calcium Absorption -- Overview of Intestinal Phosphate Absorption -- References -- 21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 / Puneet Dhawan -- Introduction and General Considerations, the Calbindins -- Localization and Proposed Functional Significance of the Calbindins -- Regulation of Calbindin Gene Expression -- Epithelial Calcium Channels -- Conclusion -- References -- 22. Calcium Homeostasis and Eggshell Biomineralization in Female Chicken / Nathalie Le Roy -- Introduction -- Mineralization Associated With Laying Hen Reproduction -- Transepithelial Transfer of Calcium -- Regulation of Calcium Metabolism in Hens -- Acknowledgments -- References. 505-00/(S Contents note continued: 23. Mineralization in Mammals / Adele L. Boskey -- Introduction -- Direct and Indirect Effects of Vitamin D and Vitamin D Metabolites on Mineralization -- Methods for Quantifying Tissue Mineralization -- Mechanism of Effects of Vitamin D on Mineralization -- Mineralization and Mineral Properties in Systems With Vitamin D Alterations -- Conclusions -- Acknowledgments -- References -- Further Reading -- 24. Cartilage / Zvi Schwartz -- Properties of Cartilage Tissues -- Regulation by Vitamin D -- Rapid Actions of Vitamin D and Nongenomic Mechanisms -- Summary -- References -- 25. Vitamin D and Bone: An Integrated Approach / Geert Carmeliet -- Link Between Bone Metabolism, Calcium Homeostasis, and 1,25(OH)2D3 Activity -- 1,25(OH)2D3 and Bone Metabolism During a Positive Calcium Balance -- Negative Calcium Balance Resulting From Insufficient Vitamin D Action -- Negative Calcium Balance With Sufficient Vitamin D -- Vitamin D and Fibroblast Growth Factor 23 -- Conclusion -- References -- IV. EXTRA-SKELETAL TARGETS -- 26. Vitamin D and the Kidney / Rajiv Kumar -- Introduction -- Role of the Kidney in the Metabolism of 25-Hydroxyvitamin D -- Effects of Vitamin D, 25(OH)D3 and 1α, 25(OH)2D3 on the Renal Handling of Calcium and Phosphorus -- Distribution and Regulation of Vitamin D-Dependent Proteins in the Kidney -- Conclusion -- References -- 27. Vitamin D and the Parathyroids / Tally Naveh-Many -- Introduction -- Parathyroid Hormone Biosynthesis -- Parathyroid Hormone Gene -- Development of the Parathyroid and Tissue-Specific Expression of the Parathyroid Hormone Gene -- Regulation of Parathyroid Hormone Gene Expression -- Summary -- References -- 28. Calcium-Sensing Receptor and Vitamin D / Geoffrey N. Hendy -- Introduction -- Calcium-Sensing Receptor -- Overview of Extracellular Ca2+ Homeostasis: Roles of Calcium-Sensing Receptor and Vitamin D Receptor -- Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Involved in Ca2+ Homeostasis -- Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Uninvolved in Extracellular Ca2+ Homeostasis -- Mouse Models of Calcium-Sensing Receptor Deletion Relative to Presentation in Humans -- Conclusions -- References -- 29. Vitamin D in Dentoalveolar and Oral Health / Philippe P. Hujoel -- Introduction -- Brief Primer on Dentoalveolar Cells and Tissues -- Vitamin D Metabolism and Mechanisms of Action on Dental Cells -- Vitamin D, Rickets, and the Oral Tissues -- Hereditary Vitamin D-Related Diseases and Dentoalveolar Tissues -- Vitamin D and Oral Health -- Conclusions -- Acknowledgments -- References -- 30. Role of Vitamin D and Its Receptor in Hair Follicle Biology / Marie B. Demay -- Introduction -- Hair Cycle -- Keratinocyte Stem Cells -- Pathways Important for Keratinocyte Stem Cell Function -- Vitamin D Receptor Suppresses PPARγ Signaling in Keratinocyte Stem Cells -- Conclusions -- References -- 31. Vitamin D, Calcium, and the Epidermis / Daniel D. Bikle -- Introduction -- Cutaneous Production of Vitamin D and Its Biologically Active Metabolites -- Regulation of Keratinocyte Differentiation -- Role of Vitamin D Signaling in Skin Cancer -- Role of Vitamin D Signaling in Epidermal Wound Repair -- References -- 32. Vitamin D and the Cardiovascular System / Carlos Bernal-Mizrachi -- Introduction -- Vascular Physiology -- Identification of the Vitamin D Receptor in the Vascular System -- Vascular Relaxation -- Structural Vascular Changes -- Vascular Inflammation -- Angiogenesis -- Blood Coagulation and Fibrinolysis -- Animal Models -- Clinical Studies in Cardiovascular Disease -- Conclusion -- Acknowledgments -- References -- 33. Vitamin D Brain Development and Function / John J. Mcgrath -- Introduction -- Vitamin D Signaling in the Brain -- Dietary Vitamin D Deficiency, Effect on Brain Development and Function -- Effects of Excess Vitamin D on Brain Development and Function -- Vitamin D Regulates Essential Processes in Normal Brain Development -- Possible Neuroprotective Mechanisms of Vitamin D in the Developing Brain -- Developmental Vitamin D Deficiency and Neuropsychiatric Disorders -- Conclusions -- References -- 34. Vitamin D, Vitamin D Receptor, and Adipose Tissue: Focus on Cellular Mechanisms / Joellen Welsh -- Adipose Tissue: Storage Depot and Target for Vitamin D -- Effect of Vitamin D on Adipogenesis at the Cellular Level -- Impact of Vitamin D Signaling on Adiposity in Mouse Models -- Translational Considerations -- Conclusions and Future Directions -- References -- 35. Vitamin D and Skeletal Muscle / Christian M. Girgis -- Skeletal Muscle Physiology -- Vitamin D Receptor in Muscle -- Vitamin D and Calcium Signaling in Muscle -- Vitamin D and Phosphate Signaling in Muscle -- Vitamin D and Insulin Signaling in Muscle -- Vitamin D, Muscle Contraction, and Strength -- Vitamin D, Muscle Development, and Mass -- Vitamin D, Muscle Injury, and Repair -- Vitamin D and Age-Related Changes in Muscle -- Vitamin D and Bone Muscle Cross-Talk -- Conclusions and Future Directions -- References -- 36. Understanding Vitamin D From Mouse Knockout Models / Denshun Miao -- Vitamin D Metabolism -- 1,25 Dihydroxyvitamin D/Vitamin D Receptor System and Mineral and Skeletal Homeostasis -- Extraskeletal Actions of 1,25 dihydroxyvitamin D -- Conclusion -- References -- Further Reading -- V. HUMAN PHYSIOLOGY -- 37. Pharmacology and Pharmacokinetics / Kerry S. Jones -- Overview -- Vitamin D Absorption -- Kinetics of Cutaneous Synthesis -- Tissue Distribution -- Metabolism and Determinants of Metabolic Fate of Vitamin D -- Half-Lives of Vitamin D Metabolites -- Factors Influencing Vitamin D Half-Life -- Pharmacokinetics of Bound and Free Vitamin D Metabolites -- Influence of Vitamin D-Binding Protein Genotype and Concentration on Vitamin D Metabolism and 25(OH)D Half-Life -- Dose-Response to Vitamin D Supplementation -- 3-Epimer of 25(OH)D and 1,25(OH)2D -- Catabolism and Excretion -- Vitamin D Toxicity -- Acknowledgments -- References -- 38. Vitamin D Role in the Calcium and Phosphorus Economies / Laura A. Graeff-Armas -- Introduction -- Overview of the Calcium Economy -- Overview of the Phosphorus Economy -- Calcium and Phosphorus Absorptive Inputs -- Physiological Sources of Vitamin D Activity -- Optimal Vitamin D Status -- Summary and Conclusions -- References -- 39. Fetus, Neonate, and Infant / Christopher S. Kovacs -- Overview of Calcium Metabolism in the Fetus -- Animal Data Relevant to Vitamin D and the Fetus -- Human Data Relevant to Vitamin D and the Fetus -- Overview of Calcium Metabolism in the Neonate and Infant -- Animal Data Relevant to Vitamin D and the Neonate and Infant -- Human Data Relevant to Vitamin D and the Neonate and Infant -- Conclusions -- References -- 40. Consequences of Perinatal Vitamin D Deficiency on Later Bone Health / Nicholas C. Harvey -- Introduction -- Vitamin D Physiology and Epidemiology in Pregnancy -- Lifecourse Determinants of Osteoporosis -- Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health -- Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health: The MAVIDOS Trial -- Conclusion -- Acknowledgment -- References -- 41. Adolescence and Acquisition of Peak Bone Mass / Connie Weaver -- Introduction -- Pubertal Bone Acquisition -- Sex and Race Differences -- Serum 25(OH)D in Children and Adolescents -- Vitamin D and Intermediate Endpoints of Vitamin D and Bone Metabolism -- Vitamin D and Other Predictors of Calcium Retention -- Vitamin D and Bone -- Vitamin D and Muscle -- Vitamin D Requirements in Children and Adolescents -- Summary and Conclusions -- References -- 42. Pregnancy, Lactation, and Postweaning Recovery / Christopher S. 505-00/(S Machine generated contents note: VOLUME I -- I. HISTORY, CHEMISTRY METABOLISM, CIRCULATION & REGULATION -- 1. Historical Overview of Vitamin D / Hector F. Deluca -- Discovery of the Vitamins -- Discovery of the Physiological Functions of Vitamin D -- Discovery of the Hormonal Form of Vitamin D -- Acknowledgment -- References -- 2. Evolutionary Biology: Mysteries of Vitamin D in Fish / David R. Fraser -- Biological Distribution of Vitamin D -- Evolutionary Origins of Vitamin D -- Evolution of Vitamin D Function -- Origin of Vitamin D in Fish -- Functional Metabolism of Vitamin D in Fish -- Possible Role for Sunlight in the Origin of Vitamin D in Fish -- Vitamin D Function in Fish -- Transport of Vitamin D and Its Metabolites -- Vitamin D Toxicity From Oral Ingestion -- References -- 3. Evolution of Human Skin Color and Vitamin D / Nina G. Jablonski -- Introduction -- Solar Context of Human Skin Color Evolution -- Nature of the Selective Factors Leading to the Evolution of Skin Pigmentation in Early Homo -- Folate Conservation and the Evolution of Permanent Protective Pigmentation -- Early Hominin Dispersal Out of the Tropics and Vitamin D Production -- Evolution of Skin Pigmentation in Homo sapiens -- Effects of Cultural Buffering, Rapid Migrations, and Modern Lifestyles on Skin Color and Vitamin D -- References -- Further Reading -- 4. Photobiology of Vitamin D / Michael F. Holick -- Introduction -- Historical Perspective -- Photobiology of Vitamin D -- Role of Sunlight and Dietary Vitamin D in Bone Health, Overall Health, and Well-being -- Sunlight, Vitamin D, and Skin Cancer -- Conclusions -- References -- Further Reading -- 5. Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases) / Martin Kaufmann -- Introduction -- General Information Regarding Vitamin D Hydroxylases -- Vitamin D3-25-Hydroxylases -- 25-Hydroxyvitamin D-1α-hydroxylase -- Additional Topics -- References -- 6. CYP24A1: Structure, Function, and Physiological Role / Glenville Jones -- Introduction -- CYP24A1-Catalyzed Pathways -- C24-Oxidation Pathway -- C23-Hydroxylation Pathway -- CYP24A1, a Multifunctional Enzyme -- Biological Relevance of the C24-Oxidation Pathway -- Structure-Function Relationships -- Mutations of CYP24A1 and Idiopathic Infantile Hypercalcemia -- Preclinical Models of Idiopathic Infantile Hypercalcemia -- Putative CYP24A1 Involvement in Other Systems -- CYP24A1 in Chronic Kidney Disease -- Role of 24,25(OH)2D in Chondrocyte Maturation -- 24,25(OH)2D and Fracture Repair -- Perspectives -- References -- 7. Vitamin D-Binding Protein / Steven Pauwels -- Summary -- Introduction -- Vitamin D-Binding Protein: Gene and Protein Structure -- Functions of Vitamin D-Binding Protein -- Vitamin D-Binding Protein-Actin Complex -- Conclusions and Perspectives -- References -- 8. Regulation of Renal and Extrarenal 1α-Hydroxylase / Martin Hewison -- Introduction -- Renal la-Hydroxylase -- Extrarenal Expression of 1α-Hydroxylase -- Conclusions and Future Prospects -- References -- II. MECHANISM OF ACTION -- 9. Genome-Wide Perspectives on Vitamin D Receptor--Mediated Control of Gene Expression in Target Cells / Nancy A. Benkusky -- Introduction -- Biology of Vitamin D -- Metabolic Activation of Vitamin D -- Overview of the Vitamin D Receptor: The Protein, Its Structure, and Function -- Recent Advances in the Mechanisms of Action of Vitamin D -- Advances in Understanding the Regulation of the Vitamin D Receptor Gene -- Exploiting Humanized VDR Transgenic Mice to Understand Expression, Regulation, and VDR Protein Function In Vivo -- Establishing a Humanized Mouse Model for the Study of Human Disease -- Summary and Conclusions -- Acknowledgments -- References -- 10. Diverse Mechanisms of Transcriptional Regulation by the Vitamin D Receptor / Manuella Bouttier -- Introduction -- Interplay Between Transforming Growth Factor β and Vitamin D Receptor Signaling -- Vitamin D Receptor and Transcription Factor Activator Protein-1 -- Interplay Between VDR and JAK/STAT Signaling in Immunity -- Regulation of Wnt Signaling by the Vitamin D Receptor: A Molecular Basis for Cancer Prevention -- Control of FoxO Protein Function by the Vitamin D Receptor -- Regulation of the c-MYC/MXD1 Network by the Hormone-Bound Vitamin D Receptor -- Multiple Mechanisms of Regulation of NF-κ B Signaling by the Hormone-Bound Vitamin D Receptor -- Insights Into Transcriptional Regulation by the Vitamin D Receptor from Genomics Studies -- Conclusions -- References -- 11. Structural Basis for Ligand Activity in Vitamin D Receptor / Natacha Rochel -- Introduction -- 1α, 25-Dihydroxyvitamin D3 Recognition by Vitamin D Receptor -- Natural Metabolites -- Other Vitamin D Receptor Natural Ligands -- Secosteroidal Analogs of 1α, 25-Dihydroxyvitamin D3 -- Structures of Vitamin D Receptor With Analogs That Induce Structural Rearrangements -- Synthetic Mimics of 1α,25-Dihydroxyvitamin D3 -- Conclusions and Perspectives -- Acknowledgments -- References -- 12. Ligand-Independent Actions of Vitamin D Receptor / Daniel Metzger -- Vitamin D Receptor -- Skeletal Defects Induced by Impaired Vitamin D Receptor Signaling -- Ligand-Independent Role of Vitamin D Receptor in Hair Cycle -- Unliganded Vitamin D Receptor Repressive Activities Induce Severe Skeletal Defects -- Toward Improved Diagnosis and Treatments of Hereditary Vitamin D Resistant Rickets Patients -- Conclusion and Perspectives -- Acknowledgments -- References -- 13. Vitamin D and Chromatin / Carsten Carlberg -- Introduction -- Nuclear Receptor Superfamily Member Vitamin D Receptor -- Genome-Wide Location of Vitamin D Receptor-Binding Sites -- CTCF as Organizer of Vitamin D-Dependent Chromatin Domains -- Impact of Epigenomics -- Vitamin D-Triggered Epigenome Changes -- Chromatin Model of Vitamin D Signaling Emerges -- Vitamin D Signaling In Vivo -- Conclusion -- Acknowledgments -- References -- 14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions With VDR / J. Wesley Pike -- Genetic Control of Mesenchymal Lineage Cells -- Epigenetic Fate Determination -- Osteoblast Enhancer Complex: Consolidated and Dispersed -- Dynamics of Transdifferentiation -- Conclusions -- Conflict of Interest -- References -- 15. Vitamin D and MicroRNAs / Thomas S. Lisse -- Introduction -- MicroRNAs: The Posttranscriptional Age -- Complexity of MicroRNA Regulation, Biogenesis, and Posttranscriptional Regulatory Actions -- Nuclear Receptors and MicroRNAs -- Duality Among MicroRNAs and the Vitamin D Synthesis, Metabolism, and Signaling Systems -- Interplay Between Vitamin D and MicroRNAs in Biological Systems -- Strategies for MicroRNA and Target Identification for Vitamin D Research -- Concluding Remarks -- Acknowledgments -- References -- 16. Vitamin D Sterol/Vitamin D Receptor Conformational Dynamics and Nongenomic Actions / Anthony W. Norman -- Introduction -- 1α, 25(OH)2 Vitamin D3 Regulation of Genomic Versus Nongenomic Signaling -- Vitamin D3 Sterol Chemistry -- 1,25(OH)2D3-Mediated Rapid, Nongenomic Responses -- Plasma Membrane Vitamin D Receptor -- Vitamin D Receptor Conformational Ensemble Model -- Vitamin D Receptor Ligand Specificity: Does an Unliganded Vitamin D Receptor Ever Exist In Vivo-- References -- III. MINERAL AND BONE HOMEOSTASIS -- 17. Vitamin D Regulation of Osteoblast Function / Bram C.J. 505-01/(S Contents note continued: Renin-Angiotensin System -- Vitamin D Regulation of the Renin-Angiotensin System -- Vitamin D and the Renin-Angiotensin System in Disease -- Conclusion -- References -- 46. Parathyroid Hormone, Parathyroid Hormone--Related Protein, and Calcitonin / John J. Wysolmerski -- Parathyroid Hormone -- Parathyroid Hormone--Related Protein -- Calcitonin -- References -- 47. FGF23 Counter-Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity / L. Darryl Quarles -- Introduction -- Parathyroid Hormone--Vitamin D Axis: Key Regulator of Calcium Homeostasis -- Fibroblast Growth Factor-23/α-Klotho -- Fibroblast Growth Factor-23 Endocrine Networks -- Noncanonical α-Klotho and Fibroblast Growth Factor-23 Signaling -- Conclusions -- References -- VI. DIAGNOSIS AND MANAGEMENT -- 48. Approach to the Patient With Metabolic Bone Disease / Michael P. Whyte -- Introduction -- Diagnostic Evaluation -- Biochemical Investigation -- Histopathological Assessment -- Treatment -- Conclusions -- Acknowledgments -- References -- 49. Detection of 1,25-Dihydroxyvitamin D in Human Serum Using Receptor Assisted Chemiluminescent Hormone Assay Technology / Bruce W. Hollis -- Introduction -- Methodology -- Identification of the DNA Consensus Sequence of the Immunoglobulin G VH and VL Gene, Expressed by Hybridoma Clone 11B4 -- Preparation of the Assay Reagents -- Assay Format and Performance -- Discussion -- References -- 50. Mass Spectrometry Assays of Vitamin D Metabolites / Ravinder J. Singh -- Introduction -- Approaches and Utility of Vitamin D Metabolite Measurements in the Clinical Laboratory Setting -- Overview of Methodology for Analysis of Circulating Vitamin D Metabolites by LC-MS/MS -- Application of LC-MS/MS to the Study of Vitamin D Metabolism in Animal Models -- Future Directions -- References -- 51. Free Vitamin D: Concepts, Assays, Outcomes, and Prospects / Carrie M. Nielson -- Introduction -- Metabolism -- Transportation and Internalization: Free Hormone Hypothesis and Bioavailable Ligand -- Vitamin D-Binding Protein Genotype -- Free Vitamin D: Mathematical Estimation -- Free Vitamin D: Direct Physical Measurement -- Potential Utility of Free 25(OH)D for Clinical- and Population-Based Detection of Vitamin D Deficiency -- Conclusions and Knowledge Gaps -- References -- 52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems, and Interpretation / Neil C. Binkley -- Introduction -- Vitamin D Standardization Program Objectives -- Standardization and Traceability -- Vitamin D Standardization Program Standardization Protocols -- Performance Testing/Quality Assessment of Assays for Vitamin D Metabolites -- Vitamin D Standardization Program Efforts Going Into the Future -- Summary and Conclusions -- References -- 53. Bone Histomorphometry / David W. Dempster -- Introduction -- Bone Biopsy -- Histomorphometry -- Assessment of Mineralization -- Histological Diagnosis of Osteomalacia -- Assessment of Bone Turnover -- Assessment of Remodeling Balance -- Assessment of Bone Structure -- Influence of Vitamin D Status on Bone Histomorphometry -- Future Developments -- References -- 54. Radiology of Rickets and Osteomalacia / Judith E. Adams -- Introduction and Historical Aspects -- Vitamin D Deficiency -- Renal Osteodystrophy -- Renal Tubular Defects and Hypophosphatemia -- Differential Diagnoses -- Vitamin D Intoxication -- Conclusions -- References -- 55. High-Resolution Imaging Techniques for Bone Quality Assessment / Sharmila Majumdar -- Introduction -- X-ray Computed Tomography -- Magnetic Resonance Imaging -- References -- 56. Role of Vitamin D in Orthopedic Surgery / Joseph M. Lane -- Introduction -- Impact on Orthopedic Trauma -- Impact on Pediatric Orthopedics -- Impact on Total Joint Arthroplasty -- References -- Introduction to Chapters 57A and 57B References -- 57A. IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position / Cliff Rosen -- Introduction -- Vitamin D Status and Bone Health in Adults and the Elderly -- Vitamin D and Extraskeletal Health -- Lessons From Recently Updated Guidelines on Vitamin D Supplementation -- Vitamin D and Human Health: What is the Optimal Vitamin D Status -- Summary of Recommendations -- Highlights -- References -- 57B. IOM---Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position / Michael F. Holick -- Section I Defining the Disagreement Between IOM and Endocrine Society -- Section II Scientific Basis for Why IOM Versus Endocrine Society Values Differ in Terms of Bone Health -- Section III Toxicity and Perceptions of Risk of Higher Vitamin D Intakes: Higher-Dose Clinical Trials and Epidemiology U-Shaped Risk Findings -- Section IV Extraskeletal Effects of Vitamin D -- Section V Extraskeletal Effects: Cross-Sectional Observations Versus the Findings of Double-Blind, Randomized Clinical Trials -- Section VI Emerging Benefits of Higher Vitamin D: Life Expectancy -- Section VII New Evidence That Vitamin D Lowers Risk of Preterm Birth -- Section VIII Conclusion. |
| spellingShingle | Vitamin D. Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d -- Evolutionary biology: mysteries of vitamin D in fish -- Evolution of human skin color and vitamin D -- Photobiology of vitamin D -- The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases) -- CYP24A1: structure, function, and physiological role -- The vitamin D binding protein DBP -- Regulation of renal and extra-renal 1[alpha]-hydroxylase -- Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells -- Diverse mechanisms of transcriptional regulation by the vitamin D receptor -- Structural basis for ligand activity in VDR -- Ligand independent actions of vitamin D receptor -- Vitamin D and chromatin -- Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR -- Vitamin D and microRNAs -- Vitamin D sterol/VDR conformational dynamics and nongenomic actions -- Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function -- Osteoclastogenesis and vitamin D -- Vitamin D activities in osteocytes -- Regulation of intestinal calcium and phosphate absorption -- Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6 -- Calcium homeostasis and eggshell biomineralization in female chicken -- Mineralization in mammals -- Cartilage -- Vitamin D and bone: an integrated approach -- Section IV. Extra-skeletal targets. Vitamin D and the kidney -- Vitamin D and the parathyroids -- The calcium-sensing receptor and vitamin d -- Vitamin D in dentoalveolar and oral health -- The role of vitamin D and its receptor in hair follicle biology -- Vitamin D, calcium and the epidermis -- Vitamin D and the cardiovascular system -- Vitamin D brain development and function -- Vitamin D, VDR and adipose tissue: focus on cellular mechanisms -- Vitamin D and skeletal muscle -- Understanding vitamin D from mouse knockout models -- Section V. Human physiology. Pharmacology and pharmacokinetics -- Vitamin D role in the calcium and phosphorus economies -- Fetus, neonate and infant -- Consequences of perinatal vitamin D deficiency on later bone health -- Adolescence and acquisition of peak bone mass -- Pregnancy, lactation, and post-weaning recovery -- Role in reproductive biology and reproductive dysfunction in women -- Vitamin d, reproductive biology, and dysfunction in men -- Vitamin D and the renin-angiotensin system -- Parathyroid hormone, parathyroid hormone-related protein, and calcitonin -- FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity -- Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease -- Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology -- Mass spectrometry assays of vitamin D metabolites -- Free vitamin d: concepts, assays, outcomes and prospects -- 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation -- Bone histomorphometry -- Radiology of rickets and osteomalcia -- High-resolution imaging techniques for bone quality assessment -- The role of vitamin D in orthopedic surgery -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position. Vitamin D. http://id.loc.gov/authorities/subjects/sh85143982 Vitamin D Vitamin D. Vitamine D. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Vitamin D fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85143982 |
| title | Vitamin D. |
| title_alt | Biochemistry, physiology and diagnostics Vitamin D. Volume 2, Health, disease and therapeutics. Vitamin D. 3rd ed. |
| title_auth | Vitamin D. |
| title_exact_search | Vitamin D. |
| title_full | Vitamin D. Volume 1, Biochemistry, physiology and diagnostics / editor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon [and 3 others]. |
| title_fullStr | Vitamin D. Volume 1, Biochemistry, physiology and diagnostics / editor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon [and 3 others]. |
| title_full_unstemmed | Vitamin D. Volume 1, Biochemistry, physiology and diagnostics / editor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon [and 3 others]. |
| title_short | Vitamin D. |
| title_sort | vitamin d biochemistry physiology and diagnostics |
| topic | Vitamin D. http://id.loc.gov/authorities/subjects/sh85143982 Vitamin D Vitamin D. Vitamine D. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Vitamin D fast |
| topic_facet | Vitamin D. Vitamin D Vitamine D. MEDICAL Physiology. SCIENCE Life Sciences Human Anatomy & Physiology. |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1483177 https://www.sciencedirect.com/science/book/9780128099650 |
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