Cancer stem cells :: philosophy and therapies /
"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and ph...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, Massachusetts :
Harvard University Press,
2016.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | "An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher |
| Beschreibung: | 1 online resource (x, 252 pages) : illustrations |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9780674969582 0674969588 |
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| 100 | 1 | |a Laplane, Lucie, |d 1984- |e author. |1 https://id.oclc.org/worldcat/entity/E39PBJgt6WYJRfKGXHhDqJtkDq |0 http://id.loc.gov/authorities/names/no2015147270 | |
| 245 | 1 | 0 | |a Cancer stem cells : |b philosophy and therapies / |c Lucie Laplane. |
| 264 | 1 | |a Cambridge, Massachusetts : |b Harvard University Press, |c 2016. | |
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| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? | |
| 520 | |a "An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Cancer cells. |0 http://id.loc.gov/authorities/subjects/sh85019549 | |
| 650 | 0 | |a Stem cells. |0 http://id.loc.gov/authorities/subjects/sh85127923 | |
| 650 | 0 | |a Cancer |x Treatment |x Philosophy. | |
| 650 | 0 | |a Oncology. |0 http://id.loc.gov/authorities/subjects/sh85094724 | |
| 650 | 1 | 2 | |a Neoplastic Stem Cells |
| 650 | 2 | 2 | |a Stem Cells |
| 650 | 2 | 2 | |a Neoplasms |x therapy |
| 650 | 2 | |a Medical Oncology |0 https://id.nlm.nih.gov/mesh/D008495 | |
| 650 | 6 | |a Cellules cancéreuses. | |
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| 758 | |i has work: |a Cancer stem cells (Text) |1 https://id.oclc.org/worldcat/entity/E39PCFHrVHGwy69HBBx9WRM8fq |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
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Datensatz im Suchindex
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| author | Laplane, Lucie, 1984- |
| author_GND | http://id.loc.gov/authorities/names/no2015147270 |
| author_facet | Laplane, Lucie, 1984- |
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| contents | Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? |
| ctrlnum | (OCoLC)953735250 |
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| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/407 |
| dewey-search | 616.99/407 |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| indexdate | 2024-11-27T13:27:17Z |
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| publisher | Harvard University Press, |
| record_format | marc |
| spelling | Laplane, Lucie, 1984- author. https://id.oclc.org/worldcat/entity/E39PBJgt6WYJRfKGXHhDqJtkDq http://id.loc.gov/authorities/names/no2015147270 Cancer stem cells : philosophy and therapies / Lucie Laplane. Cambridge, Massachusetts : Harvard University Press, 2016. 1 online resource (x, 252 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? "An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher Print version record. Cancer cells. http://id.loc.gov/authorities/subjects/sh85019549 Stem cells. http://id.loc.gov/authorities/subjects/sh85127923 Cancer Treatment Philosophy. Oncology. http://id.loc.gov/authorities/subjects/sh85094724 Neoplastic Stem Cells Stem Cells Neoplasms therapy Medical Oncology https://id.nlm.nih.gov/mesh/D008495 Cellules cancéreuses. Cellules souches. Cancer Traitement Philosophie. Cancérologie. Cellules souches tumorales. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh SCIENCE Life Sciences Cell Biology. bisacsh Cancer cells fast Cancer Treatment Philosophy fast Oncology fast Stem cells fast has work: Cancer stem cells (Text) https://id.oclc.org/worldcat/entity/E39PCFHrVHGwy69HBBx9WRM8fq https://id.oclc.org/worldcat/ontology/hasWork Print version: Laplane, Lucie, 1984- Cancer stem cells. Cambridge, Massachusetts : Harvard University Press, 2016 9780674088740 (DLC) 2015042054 (OCoLC)926061404 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1287333 Volltext |
| spellingShingle | Laplane, Lucie, 1984- Cancer stem cells : philosophy and therapies / Part I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer? Cancer cells. http://id.loc.gov/authorities/subjects/sh85019549 Stem cells. http://id.loc.gov/authorities/subjects/sh85127923 Cancer Treatment Philosophy. Oncology. http://id.loc.gov/authorities/subjects/sh85094724 Neoplastic Stem Cells Stem Cells Neoplasms therapy Medical Oncology https://id.nlm.nih.gov/mesh/D008495 Cellules cancéreuses. Cellules souches. Cancer Traitement Philosophie. Cancérologie. Cellules souches tumorales. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh SCIENCE Life Sciences Cell Biology. bisacsh Cancer cells fast Cancer Treatment Philosophy fast Oncology fast Stem cells fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85019549 http://id.loc.gov/authorities/subjects/sh85127923 http://id.loc.gov/authorities/subjects/sh85094724 https://id.nlm.nih.gov/mesh/D008495 |
| title | Cancer stem cells : philosophy and therapies / |
| title_auth | Cancer stem cells : philosophy and therapies / |
| title_exact_search | Cancer stem cells : philosophy and therapies / |
| title_full | Cancer stem cells : philosophy and therapies / Lucie Laplane. |
| title_fullStr | Cancer stem cells : philosophy and therapies / Lucie Laplane. |
| title_full_unstemmed | Cancer stem cells : philosophy and therapies / Lucie Laplane. |
| title_short | Cancer stem cells : |
| title_sort | cancer stem cells philosophy and therapies |
| title_sub | philosophy and therapies / |
| topic | Cancer cells. http://id.loc.gov/authorities/subjects/sh85019549 Stem cells. http://id.loc.gov/authorities/subjects/sh85127923 Cancer Treatment Philosophy. Oncology. http://id.loc.gov/authorities/subjects/sh85094724 Neoplastic Stem Cells Stem Cells Neoplasms therapy Medical Oncology https://id.nlm.nih.gov/mesh/D008495 Cellules cancéreuses. Cellules souches. Cancer Traitement Philosophie. Cancérologie. Cellules souches tumorales. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh SCIENCE Life Sciences Cell Biology. bisacsh Cancer cells fast Cancer Treatment Philosophy fast Oncology fast Stem cells fast |
| topic_facet | Cancer cells. Stem cells. Cancer Treatment Philosophy. Oncology. Neoplastic Stem Cells Stem Cells Neoplasms therapy Medical Oncology Cellules cancéreuses. Cellules souches. Cancer Traitement Philosophie. Cancérologie. Cellules souches tumorales. HEALTH & FITNESS Diseases General. MEDICAL Clinical Medicine. MEDICAL Diseases. MEDICAL Evidence-Based Medicine. MEDICAL Internal Medicine. SCIENCE Life Sciences Cell Biology. Cancer cells Cancer Treatment Philosophy Oncology Stem cells |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1287333 |
| work_keys_str_mv | AT laplanelucie cancerstemcellsphilosophyandtherapies |