The role of clinical studies for pets with naturally occurring tumors in translational cancer research :: workshop summary /
Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models....
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| Körperschaft: | |
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| Format: | Elektronisch Tagungsbericht E-Book |
| Sprache: | English |
| Veröffentlicht: |
Washington, DC :
The National Academies Press,
[2015]
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| Schriftenreihe: | Online access: NCBI NCBI Bookshelf.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop. |
| Beschreibung: | "The National Academies of Sciences, Engineering, Medicine." |
| Beschreibung: | 1 online resource (1 PDF file (xx, 62 pages)) : illustrations |
| Bibliographie: | Includes bibliographical references. |
| ISBN: | 9780309379915 0309379911 |
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| 245 | 1 | 4 | |a The role of clinical studies for pets with naturally occurring tumors in translational cancer research : |b workshop summary / |c Sharyl J. Nass and Heather Gorby, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine. |
| 246 | 3 | |a Translational cancer research | |
| 264 | 1 | |a Washington, DC : |b The National Academies Press, |c [2015] | |
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| 520 | 3 | |a Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop. | |
| 536 | |a This project was supported by the Animal Cancer Foundation; the College of Veterinary Medicine at North Carolina State University; the Cornell University School of Veterinary Medicine; Flint Animal Cancer Center, Colorado State University; the Morris Animal Foundation; the Ohio State University School of Veterinary Medicine; Purdue University College of Veterinary Medicine and the Center for Cancer Research; the Skippy Frank Translational Medicine and Life Sciences Fund; the University of California, Davis, School of Veterinary Medicine; the University of Colorado Cancer Center; the University of Florida College of Veterinary Medicine; the University of Georgia College of Veterinary Medicine; the University of Illinois College of Veterinary Medicine; the University of Minnesota College of Veterinary Medicine; the University of Missouri College of Veterinary Medicine and the Ellis Fischel Cancer Center; the University of Pennsylvania; the University of Wisconsin-Madison Carbone Cancer Center, Institute for Clinical and Translational Research, and the School of Veterinary Medicine; and the Washington State University College of Veterinary Medicine. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. | ||
| 588 | 0 | |a Online resource; title from PDF title page (viewed February 16, 2016). | |
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| 650 | 2 | 2 | |a Translational Research, Biomedical. |
| 650 | 6 | |a Cancer chez les animaux |v Congrès. | |
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| 711 | 2 | |a Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research (Workshop) |d (2015 : |c Washington, D.C.) |0 http://id.loc.gov/authorities/names/no2015171507 | |
| 776 | 0 | 8 | |i Print version: |a Nass, Sharyl J. |t Role of clinical studies for pets with naturally occurring tumors in translational cancer research. |d Washington, DC : The National Academies Press, [2015] |w (DLC) 2016427424 |
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| genre | Congress proceedings (reports) aat Conference papers and proceedings fast Conference papers and proceedings. lcgft http://id.loc.gov/authorities/genreForms/gf2014026068 Actes de congrès. rvmgf |
| genre_facet | Congress proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. |
| id | ZDB-4-EBA-ocn932037667 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:26:56Z |
| institution | BVB |
| institution_GND | http://id.loc.gov/authorities/names/n2006183479 http://id.loc.gov/authorities/names/no2015135192 http://id.loc.gov/authorities/names/no2015171507 |
| isbn | 9780309379915 0309379911 |
| language | English |
| oclc_num | 932037667 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (1 PDF file (xx, 62 pages)) : illustrations |
| psigel | ZDB-4-EBA |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | The National Academies Press, |
| record_format | marc |
| series | Online access: NCBI NCBI Bookshelf. |
| spelling | Nass, Sharyl J., rapporteur. http://id.loc.gov/authorities/names/n2001127655 The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / Sharyl J. Nass and Heather Gorby, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine. Translational cancer research Washington, DC : The National Academies Press, [2015] 1 online resource (1 PDF file (xx, 62 pages)) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier "The National Academies of Sciences, Engineering, Medicine." Includes bibliographical references. Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop. This project was supported by the Animal Cancer Foundation; the College of Veterinary Medicine at North Carolina State University; the Cornell University School of Veterinary Medicine; Flint Animal Cancer Center, Colorado State University; the Morris Animal Foundation; the Ohio State University School of Veterinary Medicine; Purdue University College of Veterinary Medicine and the Center for Cancer Research; the Skippy Frank Translational Medicine and Life Sciences Fund; the University of California, Davis, School of Veterinary Medicine; the University of Colorado Cancer Center; the University of Florida College of Veterinary Medicine; the University of Georgia College of Veterinary Medicine; the University of Illinois College of Veterinary Medicine; the University of Minnesota College of Veterinary Medicine; the University of Missouri College of Veterinary Medicine and the Ellis Fischel Cancer Center; the University of Pennsylvania; the University of Wisconsin-Madison Carbone Cancer Center, Institute for Clinical and Translational Research, and the School of Veterinary Medicine; and the Washington State University College of Veterinary Medicine. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. Online resource; title from PDF title page (viewed February 16, 2016). Cancer in animals Congresses. Veterinary oncology Congresses. Medicine Research Congresses. Diseases Animal models. http://id.loc.gov/authorities/subjects/sh85038412 Neoplasms veterinary Antineoplastic Agents therapeutic use Clinical Trials as Topic Disease Models, Animal Neoplasms etiology Neoplasms pathology Translational Research, Biomedical. Cancer chez les animaux Congrès. Cancérologie vétérinaire Congrès. Médecine Recherche Congrès. Maladies Modèles animaux. TECHNOLOGY & ENGINEERING Agriculture Animal Husbandry. bisacsh Diseases Animal models fast Cancer in animals fast Medicine Research fast Veterinary oncology fast Congress proceedings (reports) aat Conference papers and proceedings fast Conference papers and proceedings. lcgft http://id.loc.gov/authorities/genreForms/gf2014026068 Actes de congrès. rvmgf Gorby, Heather, rapporteur. http://id.loc.gov/authorities/names/no2015171477 National Cancer Policy Forum (U.S.), issuing body. http://id.loc.gov/authorities/names/n2006183479 National Academies of Sciences, Engineering, and Medicine (U.S.), issuing body. http://id.loc.gov/authorities/names/no2015135192 Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research (Workshop) (2015 : Washington, D.C.) http://id.loc.gov/authorities/names/no2015171507 Print version: Nass, Sharyl J. Role of clinical studies for pets with naturally occurring tumors in translational cancer research. Washington, DC : The National Academies Press, [2015] (DLC) 2016427424 Online access: NCBI NCBI Bookshelf. FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1099362 Volltext |
| spellingShingle | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / Online access: NCBI NCBI Bookshelf. Cancer in animals Congresses. Veterinary oncology Congresses. Medicine Research Congresses. Diseases Animal models. http://id.loc.gov/authorities/subjects/sh85038412 Neoplasms veterinary Antineoplastic Agents therapeutic use Clinical Trials as Topic Disease Models, Animal Neoplasms etiology Neoplasms pathology Translational Research, Biomedical. Cancer chez les animaux Congrès. Cancérologie vétérinaire Congrès. Médecine Recherche Congrès. Maladies Modèles animaux. TECHNOLOGY & ENGINEERING Agriculture Animal Husbandry. bisacsh Diseases Animal models fast Cancer in animals fast Medicine Research fast Veterinary oncology fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85038412 http://id.loc.gov/authorities/genreForms/gf2014026068 |
| title | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / |
| title_alt | Translational cancer research |
| title_auth | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / |
| title_exact_search | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / |
| title_full | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / Sharyl J. Nass and Heather Gorby, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine. |
| title_fullStr | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / Sharyl J. Nass and Heather Gorby, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine. |
| title_full_unstemmed | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : workshop summary / Sharyl J. Nass and Heather Gorby, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine. |
| title_short | The role of clinical studies for pets with naturally occurring tumors in translational cancer research : |
| title_sort | role of clinical studies for pets with naturally occurring tumors in translational cancer research workshop summary |
| title_sub | workshop summary / |
| topic | Cancer in animals Congresses. Veterinary oncology Congresses. Medicine Research Congresses. Diseases Animal models. http://id.loc.gov/authorities/subjects/sh85038412 Neoplasms veterinary Antineoplastic Agents therapeutic use Clinical Trials as Topic Disease Models, Animal Neoplasms etiology Neoplasms pathology Translational Research, Biomedical. Cancer chez les animaux Congrès. Cancérologie vétérinaire Congrès. Médecine Recherche Congrès. Maladies Modèles animaux. TECHNOLOGY & ENGINEERING Agriculture Animal Husbandry. bisacsh Diseases Animal models fast Cancer in animals fast Medicine Research fast Veterinary oncology fast |
| topic_facet | Cancer in animals Congresses. Veterinary oncology Congresses. Medicine Research Congresses. Diseases Animal models. Neoplasms veterinary Antineoplastic Agents therapeutic use Clinical Trials as Topic Disease Models, Animal Neoplasms etiology Neoplasms pathology Translational Research, Biomedical. Cancer chez les animaux Congrès. Cancérologie vétérinaire Congrès. Médecine Recherche Congrès. Maladies Modèles animaux. TECHNOLOGY & ENGINEERING Agriculture Animal Husbandry. Diseases Animal models Cancer in animals Medicine Research Veterinary oncology Congress proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1099362 |
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