Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression :: workshop summary /
Major depressive disorder (MDD) is recognized worldwide as a major cause of disability, morbidity, and mortality. According to the World Health Organization, unipolar depressive disorders affect more than 150 million people around the world and represent the leading cause of years lost due to disabi...
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| Format: | Elektronisch Tagungsbericht E-Book |
| Sprache: | English |
| Veröffentlicht: |
Washington, DC :
National Academies Press,
[2015]
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| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Major depressive disorder (MDD) is recognized worldwide as a major cause of disability, morbidity, and mortality. According to the World Health Organization, unipolar depressive disorders affect more than 150 million people around the world and represent the leading cause of years lost due to disability among both men and women. In the United States alone, nearly 8 percent of persons over the age of 12 report current depression. MDD has long been defined primarily as a mood disorder. However, more recently people have begun to recognize effects on cognition as a major contributor to the disablement that accompanies depression and to consider this an underrecognized treatment target for depression. To explore how best to enable the discovery, development, and translation of treatments for cognitive dysfunction in depression, including a focus on the regulatory path forward, the Institute of Medicine's Forum on Neuroscience and Nervous Disorders convened key stakeholders at a workshop in February 2015. This report summarizes the presentations from expert speakers and discussions among workshop participants. |
| Beschreibung: | Title from PDF title page. |
| Beschreibung: | 1 online resource (1 PDF file (xii, 77 pages)) : illustrations |
| Bibliographie: | Includes bibliographical references. |
| ISBN: | 9780309373944 0309373948 |
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| 245 | 1 | 0 | |a Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : |b workshop summary / |c Lisa Bain and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine, the National Academies of Sciences, Engineering, and Medicine. |
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| 520 | 3 | |a Major depressive disorder (MDD) is recognized worldwide as a major cause of disability, morbidity, and mortality. According to the World Health Organization, unipolar depressive disorders affect more than 150 million people around the world and represent the leading cause of years lost due to disability among both men and women. In the United States alone, nearly 8 percent of persons over the age of 12 report current depression. MDD has long been defined primarily as a mood disorder. However, more recently people have begun to recognize effects on cognition as a major contributor to the disablement that accompanies depression and to consider this an underrecognized treatment target for depression. To explore how best to enable the discovery, development, and translation of treatments for cognitive dysfunction in depression, including a focus on the regulatory path forward, the Institute of Medicine's Forum on Neuroscience and Nervous Disorders convened key stakeholders at a workshop in February 2015. This report summarizes the presentations from expert speakers and discussions among workshop participants. | |
| 536 | |a This activity was supported by contracts between the National Academy of Sciences and the Alzheimer's Association; Brain Canada Foundation; the Department of Health and Human Services' Food and Drug Administration and National Institutes of Health (NIH, Contract No. HHSN26300026 [Under Master Base #DHHS-10001292]) through the National Center for Complementary and Integrative Health, National Eye Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and NIH Blueprint for Neuroscience Research; the Department of Veterans Affairs (VA240-14-C-0057); Eli Lilly and Company; Foundation for the National Institutes of Health; the Gatsby Charitable Foundation; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson's Research; the National Multiple Sclerosis Society; the National Science Foundation (BCS-1064270); One Mind for Research; Orion Bionetworks; Pfizer Inc.; Pharmaceutical Product Development, LLC; Sanofi; the Society for Neuroscience; Takeda Pharmaceutical Company Limited; and Wellcome Trust. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. | ||
| 588 | 0 | |a Version viewed December 21, 2015. | |
| 505 | 0 | |a Introduction and overview -- The burden of cognitive dysfunction in depression -- State of the science: treatment development -- Challenges and potential solutions to enable development of successful treatments -- Regulatory issues -- Lessons learned from the schizophrenia field. | |
| 650 | 0 | |a Cognition disorders |z United States |x Etiology |v Congresses. | |
| 650 | 0 | |a Cognition disorders |x Treatment |z United States |v Congresses. | |
| 650 | 0 | |a Depression, Mental |x Treatment |z United States |v Congresses. | |
| 650 | 0 | |a Drug development |x Law and legislation |z United States |v Congresses. | |
| 650 | 1 | 2 | |a Depressive Disorder, Major |x complications |0 https://id.nlm.nih.gov/mesh/D003865Q000150 |
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| 650 | 6 | |a Troubles de la cognition |x Traitement |z États-Unis |v Congrès. | |
| 650 | 6 | |a Dépression |x Traitement |z États-Unis |v Congrès. | |
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| 700 | 1 | |a Bain, Lisa J., |e author. | |
| 700 | 1 | |a Stroud, Clare, |e author. | |
| 710 | 2 | |a Institute of Medicine (U.S.). |b Forum on Neuroscience and Nervous System Disorders, |e sponsoring body. |0 http://id.loc.gov/authorities/names/no2008032406 | |
| 710 | 2 | |a Institute of Medicine (U.S.). |b Forum on Drug Discovery, Development, and Translation, |e sponsoring body. |0 http://id.loc.gov/authorities/names/no2007051854 | |
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| 776 | 0 | 8 | |i Print version: |a Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression (Workshop) (2015 : Washington, D.C.). |t Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression. |d Washington, D.C. : National Academies Press, [2015] |z 9780309373937 |w (OCoLC)921241697 |
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| author | Bain, Lisa J. Stroud, Clare |
| author_corporate | Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression (Workshop) Washington, D.C.) |
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| author_facet | Bain, Lisa J. Stroud, Clare Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression (Workshop) Washington, D.C.) |
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| contents | Introduction and overview -- The burden of cognitive dysfunction in depression -- State of the science: treatment development -- Challenges and potential solutions to enable development of successful treatments -- Regulatory issues -- Lessons learned from the schizophrenia field. |
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| spelling | Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression (Workshop) (2015 : Washington, D.C.), author. http://id.loc.gov/authorities/names/no2015151506 Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / Lisa Bain and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine, the National Academies of Sciences, Engineering, and Medicine. Washington, DC : National Academies Press, [2015] 1 online resource (1 PDF file (xii, 77 pages)) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Title from PDF title page. Includes bibliographical references. Major depressive disorder (MDD) is recognized worldwide as a major cause of disability, morbidity, and mortality. According to the World Health Organization, unipolar depressive disorders affect more than 150 million people around the world and represent the leading cause of years lost due to disability among both men and women. In the United States alone, nearly 8 percent of persons over the age of 12 report current depression. MDD has long been defined primarily as a mood disorder. However, more recently people have begun to recognize effects on cognition as a major contributor to the disablement that accompanies depression and to consider this an underrecognized treatment target for depression. To explore how best to enable the discovery, development, and translation of treatments for cognitive dysfunction in depression, including a focus on the regulatory path forward, the Institute of Medicine's Forum on Neuroscience and Nervous Disorders convened key stakeholders at a workshop in February 2015. This report summarizes the presentations from expert speakers and discussions among workshop participants. This activity was supported by contracts between the National Academy of Sciences and the Alzheimer's Association; Brain Canada Foundation; the Department of Health and Human Services' Food and Drug Administration and National Institutes of Health (NIH, Contract No. HHSN26300026 [Under Master Base #DHHS-10001292]) through the National Center for Complementary and Integrative Health, National Eye Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and NIH Blueprint for Neuroscience Research; the Department of Veterans Affairs (VA240-14-C-0057); Eli Lilly and Company; Foundation for the National Institutes of Health; the Gatsby Charitable Foundation; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson's Research; the National Multiple Sclerosis Society; the National Science Foundation (BCS-1064270); One Mind for Research; Orion Bionetworks; Pfizer Inc.; Pharmaceutical Product Development, LLC; Sanofi; the Society for Neuroscience; Takeda Pharmaceutical Company Limited; and Wellcome Trust. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. Version viewed December 21, 2015. Introduction and overview -- The burden of cognitive dysfunction in depression -- State of the science: treatment development -- Challenges and potential solutions to enable development of successful treatments -- Regulatory issues -- Lessons learned from the schizophrenia field. Cognition disorders United States Etiology Congresses. Cognition disorders Treatment United States Congresses. Depression, Mental Treatment United States Congresses. Drug development Law and legislation United States Congresses. Depressive Disorder, Major complications https://id.nlm.nih.gov/mesh/D003865Q000150 Cognition Disorders complications Cognition Disorders therapy Depressive Disorder, Major therapy https://id.nlm.nih.gov/mesh/D003865Q000628 Troubles de la cognition États-Unis Étiologie Congrès. Troubles de la cognition Traitement États-Unis Congrès. Dépression Traitement États-Unis Congrès. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Cognition disorders Etiology fast Cognition disorders Treatment fast Depression, Mental Treatment fast United States fast https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq Congress https://id.nlm.nih.gov/mesh/D016423 proceedings (reports) aat Conference papers and proceedings fast Conference papers and proceedings. lcgft http://id.loc.gov/authorities/genreForms/gf2014026068 Actes de congrès. rvmgf Bain, Lisa J., author. Stroud, Clare, author. Institute of Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders, sponsoring body. http://id.loc.gov/authorities/names/no2008032406 Institute of Medicine (U.S.). Forum on Drug Discovery, Development, and Translation, sponsoring body. http://id.loc.gov/authorities/names/no2007051854 has work: Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression (Text) https://id.oclc.org/worldcat/entity/E39PD3twVPMGj7RkDqWqg3RxjC https://id.oclc.org/worldcat/ontology/hasWork Print version: Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression (Workshop) (2015 : Washington, D.C.). Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression. Washington, D.C. : National Academies Press, [2015] 9780309373937 (OCoLC)921241697 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1029481 Volltext |
| spellingShingle | Bain, Lisa J. Stroud, Clare Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / Introduction and overview -- The burden of cognitive dysfunction in depression -- State of the science: treatment development -- Challenges and potential solutions to enable development of successful treatments -- Regulatory issues -- Lessons learned from the schizophrenia field. Cognition disorders United States Etiology Congresses. Cognition disorders Treatment United States Congresses. Depression, Mental Treatment United States Congresses. Drug development Law and legislation United States Congresses. Depressive Disorder, Major complications https://id.nlm.nih.gov/mesh/D003865Q000150 Cognition Disorders complications Cognition Disorders therapy Depressive Disorder, Major therapy https://id.nlm.nih.gov/mesh/D003865Q000628 Troubles de la cognition États-Unis Étiologie Congrès. Troubles de la cognition Traitement États-Unis Congrès. Dépression Traitement États-Unis Congrès. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Cognition disorders Etiology fast Cognition disorders Treatment fast Depression, Mental Treatment fast |
| subject_GND | https://id.nlm.nih.gov/mesh/D003865Q000150 https://id.nlm.nih.gov/mesh/D003865Q000628 https://id.nlm.nih.gov/mesh/D016423 http://id.loc.gov/authorities/genreForms/gf2014026068 |
| title | Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / |
| title_auth | Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / |
| title_exact_search | Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / |
| title_full | Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / Lisa Bain and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine, the National Academies of Sciences, Engineering, and Medicine. |
| title_fullStr | Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / Lisa Bain and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine, the National Academies of Sciences, Engineering, and Medicine. |
| title_full_unstemmed | Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : workshop summary / Lisa Bain and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine, the National Academies of Sciences, Engineering, and Medicine. |
| title_short | Enabling discovery, development, and translation of treatments for cognitive dysfunction in depression : |
| title_sort | enabling discovery development and translation of treatments for cognitive dysfunction in depression workshop summary |
| title_sub | workshop summary / |
| topic | Cognition disorders United States Etiology Congresses. Cognition disorders Treatment United States Congresses. Depression, Mental Treatment United States Congresses. Drug development Law and legislation United States Congresses. Depressive Disorder, Major complications https://id.nlm.nih.gov/mesh/D003865Q000150 Cognition Disorders complications Cognition Disorders therapy Depressive Disorder, Major therapy https://id.nlm.nih.gov/mesh/D003865Q000628 Troubles de la cognition États-Unis Étiologie Congrès. Troubles de la cognition Traitement États-Unis Congrès. Dépression Traitement États-Unis Congrès. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Cognition disorders Etiology fast Cognition disorders Treatment fast Depression, Mental Treatment fast |
| topic_facet | Cognition disorders United States Etiology Congresses. Cognition disorders Treatment United States Congresses. Depression, Mental Treatment United States Congresses. Drug development Law and legislation United States Congresses. Depressive Disorder, Major complications Cognition Disorders complications Cognition Disorders therapy Depressive Disorder, Major therapy Troubles de la cognition États-Unis Étiologie Congrès. Troubles de la cognition Traitement États-Unis Congrès. Dépression Traitement États-Unis Congrès. HEALTH & FITNESS Diseases General. MEDICAL Clinical Medicine. MEDICAL Diseases. MEDICAL Evidence-Based Medicine. MEDICAL Internal Medicine. Cognition disorders Etiology Cognition disorders Treatment Depression, Mental Treatment United States Congress proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. |
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