Translational neuroscience :: toward new therapies /
Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA :
The MIT Press,
[2015]
|
| Schriftenreihe: | Strüngmann Forum reports.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. |
| Beschreibung: | 1 online resource : illustrations |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9780262329859 0262329859 0262029863 9780262029865 9780262329866 0262329867 |
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| 520 | 8 | |a Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. | |
| 505 | 0 | |a Intro; Contents; The Ernst Strüngmann Forum; List of Contributors; 1 -- Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2 -- What Do We Know about Early Onset Neurodevelopmental Disorders?; 3 -- Psychotic Disorders and the Neurodevelopmental Continuum; 4 -- Neurodevelopmental Disorders; 5 -- Neurodegenerative Diseases; 6 -- Preclinical and Clinical Understanding; 7 -- Neurodegenerative Diseases. | |
| 505 | 8 | |a 8 -- How Might We Get from Genes to Circuits to Disease?9 -- How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10 -- Pathophysiological Toolkit; 11 -- Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12 -- From Rodent Behavioral Models to Human Disorders; 13 -- Bridging the Gap between Patients and Models; 14 -- The Revolution Has Begun. | |
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| contents | Intro; Contents; The Ernst Strüngmann Forum; List of Contributors; 1 -- Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2 -- What Do We Know about Early Onset Neurodevelopmental Disorders?; 3 -- Psychotic Disorders and the Neurodevelopmental Continuum; 4 -- Neurodevelopmental Disorders; 5 -- Neurodegenerative Diseases; 6 -- Preclinical and Clinical Understanding; 7 -- Neurodegenerative Diseases. 8 -- How Might We Get from Genes to Circuits to Disease?9 -- How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10 -- Pathophysiological Toolkit; 11 -- Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12 -- From Rodent Behavioral Models to Human Disorders; 13 -- Bridging the Gap between Patients and Models; 14 -- The Revolution Has Begun. |
| ctrlnum | (OCoLC)919201534 |
| dewey-full | 616.80072 |
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| dewey-raw | 616.80072 |
| dewey-search | 616.80072 |
| dewey-sort | 3616.80072 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| genre | Congress proceedings (reports) aat Conference papers and proceedings fast Conference papers and proceedings. lcgft http://id.loc.gov/authorities/genreForms/gf2014026068 Actes de congrès. rvmgf |
| genre_facet | Congress proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. |
| id | ZDB-4-EBA-ocn919201534 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:26:46Z |
| institution | BVB |
| isbn | 9780262329859 0262329859 0262029863 9780262029865 9780262329866 0262329867 |
| language | English |
| oclc_num | 919201534 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource : illustrations |
| psigel | ZDB-4-EBA |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | The MIT Press, |
| record_format | marc |
| series | Strüngmann Forum reports. |
| series2 | Strungmann forum reports |
| spelling | Translational neuroscience : toward new therapies / edited by Karoly Nikolich and Steven E. Hyman ; Program Advisory Committee, Steven E. Hyman, Julia Lupp, Robert C. Malenka, Karoly Nikolich, Menelas N. Pangalos, and Bernd Sommer. Cambridge, MA : The MIT Press, [2015] 1 online resource : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier data file Strungmann forum reports Includes bibliographical references and index. Print version record. Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. Intro; Contents; The Ernst Strüngmann Forum; List of Contributors; 1 -- Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2 -- What Do We Know about Early Onset Neurodevelopmental Disorders?; 3 -- Psychotic Disorders and the Neurodevelopmental Continuum; 4 -- Neurodevelopmental Disorders; 5 -- Neurodegenerative Diseases; 6 -- Preclinical and Clinical Understanding; 7 -- Neurodegenerative Diseases. 8 -- How Might We Get from Genes to Circuits to Disease?9 -- How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10 -- Pathophysiological Toolkit; 11 -- Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12 -- From Rodent Behavioral Models to Human Disorders; 13 -- Bridging the Gap between Patients and Models; 14 -- The Revolution Has Begun. English. Neurosciences Research. Nervous system Diseases. Drug development. http://id.loc.gov/authorities/subjects/sh97007921 Nervous System Diseases therapy Translational Research, Biomedical. Models, Animal Nervous System Diseases https://id.nlm.nih.gov/mesh/D009422 Neurosciences Recherche. Système nerveux Maladies. Médicaments Développement. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Drug development fast Nervous system Diseases fast Neurosciences Research fast NEUROSCIENCE/General BIOMEDICAL SCIENCES/General Congress proceedings (reports) aat Conference papers and proceedings fast Conference papers and proceedings. lcgft http://id.loc.gov/authorities/genreForms/gf2014026068 Actes de congrès. rvmgf Nikolich, Karoly. Hyman, Steven E. Print version: Translational neuroscience 9780262029865 (DLC) 2015012872 (OCoLC)907512577 Strüngmann Forum reports. http://id.loc.gov/authorities/names/n2008180042 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1056174 Volltext |
| spellingShingle | Translational neuroscience : toward new therapies / Strüngmann Forum reports. Intro; Contents; The Ernst Strüngmann Forum; List of Contributors; 1 -- Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2 -- What Do We Know about Early Onset Neurodevelopmental Disorders?; 3 -- Psychotic Disorders and the Neurodevelopmental Continuum; 4 -- Neurodevelopmental Disorders; 5 -- Neurodegenerative Diseases; 6 -- Preclinical and Clinical Understanding; 7 -- Neurodegenerative Diseases. 8 -- How Might We Get from Genes to Circuits to Disease?9 -- How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10 -- Pathophysiological Toolkit; 11 -- Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12 -- From Rodent Behavioral Models to Human Disorders; 13 -- Bridging the Gap between Patients and Models; 14 -- The Revolution Has Begun. Neurosciences Research. Nervous system Diseases. Drug development. http://id.loc.gov/authorities/subjects/sh97007921 Nervous System Diseases therapy Translational Research, Biomedical. Models, Animal Nervous System Diseases https://id.nlm.nih.gov/mesh/D009422 Neurosciences Recherche. Système nerveux Maladies. Médicaments Développement. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Drug development fast Nervous system Diseases fast Neurosciences Research fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh97007921 https://id.nlm.nih.gov/mesh/D009422 http://id.loc.gov/authorities/genreForms/gf2014026068 |
| title | Translational neuroscience : toward new therapies / |
| title_auth | Translational neuroscience : toward new therapies / |
| title_exact_search | Translational neuroscience : toward new therapies / |
| title_full | Translational neuroscience : toward new therapies / edited by Karoly Nikolich and Steven E. Hyman ; Program Advisory Committee, Steven E. Hyman, Julia Lupp, Robert C. Malenka, Karoly Nikolich, Menelas N. Pangalos, and Bernd Sommer. |
| title_fullStr | Translational neuroscience : toward new therapies / edited by Karoly Nikolich and Steven E. Hyman ; Program Advisory Committee, Steven E. Hyman, Julia Lupp, Robert C. Malenka, Karoly Nikolich, Menelas N. Pangalos, and Bernd Sommer. |
| title_full_unstemmed | Translational neuroscience : toward new therapies / edited by Karoly Nikolich and Steven E. Hyman ; Program Advisory Committee, Steven E. Hyman, Julia Lupp, Robert C. Malenka, Karoly Nikolich, Menelas N. Pangalos, and Bernd Sommer. |
| title_short | Translational neuroscience : |
| title_sort | translational neuroscience toward new therapies |
| title_sub | toward new therapies / |
| topic | Neurosciences Research. Nervous system Diseases. Drug development. http://id.loc.gov/authorities/subjects/sh97007921 Nervous System Diseases therapy Translational Research, Biomedical. Models, Animal Nervous System Diseases https://id.nlm.nih.gov/mesh/D009422 Neurosciences Recherche. Système nerveux Maladies. Médicaments Développement. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Drug development fast Nervous system Diseases fast Neurosciences Research fast |
| topic_facet | Neurosciences Research. Nervous system Diseases. Drug development. Nervous System Diseases therapy Translational Research, Biomedical. Models, Animal Nervous System Diseases Neurosciences Recherche. Système nerveux Maladies. Médicaments Développement. HEALTH & FITNESS Diseases General. MEDICAL Clinical Medicine. MEDICAL Diseases. MEDICAL Evidence-Based Medicine. MEDICAL Internal Medicine. Drug development Nervous system Diseases Neurosciences Research Congress proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1056174 |
| work_keys_str_mv | AT nikolichkaroly translationalneurosciencetowardnewtherapies AT hymanstevene translationalneurosciencetowardnewtherapies |