Handbook for clinical research :: design, statistics, and implementation /
With over 80 information-packed chapters, Handbook for Clinical Research delivers the practical insights and expert tips necessary for successful research design, analysis, and implementation. Using clear language and accessible bullet point format, the authors present the knowledge and expertise de...
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| Weitere Verfasser: | , , , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY :
Demos Medical Publishing, LLC,
[2015]
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| Online-Zugang: | Volltext |
| Zusammenfassung: | With over 80 information-packed chapters, Handbook for Clinical Research delivers the practical insights and expert tips necessary for successful research design, analysis, and implementation. Using clear language and accessible bullet point format, the authors present the knowledge and expertise developed over time and traditionally shared from mentor to mentee and colleague to colleague. Organized for quick access to key topics and replete with practical examples, the book describes a variety of research designs and statistical methods and explains how to choose the best design for a particular project. Research implementation, including regulatory issues and grant writing is also covered. The book opens with a section on the basics of research design, discussing the many ways in which studies can be organized, executed, and evaluated. The second section is devoted to statistics; it explains how to choose the correct statistical approach and reviews the varieties of data types, descriptive and inferential statistics, methods for demonstrating associations, hypothesis testing and prediction, specialized methods, and considerations in epidemiological studies and measure construction. The third section covers implementation, including how to develop a grant application step by step, the project budget, and the nuts and bolts of the timely and successful completion of a research project and documentation of findings; procedural manuals and case report forms; collecting, managing, and securing data; operational structure and ongoing monitoring and evaluation; and ethical and regulatory concerns in research with human subjects. With a concise presentation of the essentials for successful research, the Handbook for Clinical Research is a valuable addition to the library of any student, researcher, professional, or clinician interested in expanding the knowledge base of his or her field. |
| Beschreibung: | 1 online resource (xiv, 332 pages .) |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 1617050997 9781617050992 |
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| 245 | 0 | 0 | |a Handbook for clinical research : |b design, statistics, and implementation / |c editors, Flora M. Hammond, James F. Malec, Todd G. Nick, Ralph M. Buschbacher. |
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| 520 | |a With over 80 information-packed chapters, Handbook for Clinical Research delivers the practical insights and expert tips necessary for successful research design, analysis, and implementation. Using clear language and accessible bullet point format, the authors present the knowledge and expertise developed over time and traditionally shared from mentor to mentee and colleague to colleague. Organized for quick access to key topics and replete with practical examples, the book describes a variety of research designs and statistical methods and explains how to choose the best design for a particular project. Research implementation, including regulatory issues and grant writing is also covered. The book opens with a section on the basics of research design, discussing the many ways in which studies can be organized, executed, and evaluated. The second section is devoted to statistics; it explains how to choose the correct statistical approach and reviews the varieties of data types, descriptive and inferential statistics, methods for demonstrating associations, hypothesis testing and prediction, specialized methods, and considerations in epidemiological studies and measure construction. The third section covers implementation, including how to develop a grant application step by step, the project budget, and the nuts and bolts of the timely and successful completion of a research project and documentation of findings; procedural manuals and case report forms; collecting, managing, and securing data; operational structure and ongoing monitoring and evaluation; and ethical and regulatory concerns in research with human subjects. With a concise presentation of the essentials for successful research, the Handbook for Clinical Research is a valuable addition to the library of any student, researcher, professional, or clinician interested in expanding the knowledge base of his or her field. | ||
| 505 | 0 | |a Machine generated contents note: pt. I DESIGN -- 1. Development and Testing of Treatments / John Whyte -- 2. Qualitative Research / Elena Gillespie -- 3. Single-Case Experimental Designs / Michael Perdices -- 4. Studies of Associations / Michael Schonberger -- 5. Observational Studies: Retrospective Versus Prospective / Katherine W. Stenson -- 6. Historical Controls / Katherine W. Stenson -- 7. Subject as Own Control / Lisa A. Lombard -- 8. Longitudinal Cohort Versus Cross-Sectional Cohort Studies / Katherine W. Stenson -- 9. Survey Research / Amanda Leigh Harrington -- 10. Choice of Control Groups in Treatment Studies / Sureyya S. Dikmen -- 11. Randomization / Emilia Bagiella -- 12. Special Issues in Randomized Controlled Trials / Michael L. Boninger -- 13. Secondary Data Analysis / Amol Karmarkar -- 14. Scoping Study / Xinsheng Cai -- 15. Systematic Reviews / Xinsheng Cai -- 16. Meta-Analysis / Xinsheng Cai -- 17. Recommendations for Reporting Research Studies / Ronald T. Seel | |
| 505 | 0 | |a Note continued: 18. Developing and Evaluating Systematic Reviews and Practice Guidelines / Ronald T. Seel -- pt. II STATISTICS -- 19. Introduction / Christopher J. Swearingen -- 20. Types of Data / Marcus Wellen -- 21. Descriptive Statistics / Todd G. Nick -- 22. Data Distributions / Marcus Wellen -- 23. Samples and Populations / Marcus Wellen -- 24. Visual Display of Data / Marcus Wellen -- 25. Data Cleaning / Jingyun Li -- 26. Missing Data and Imputation / Christopher J. Swearingen -- 27. Estimation / Mallikarjuna Rettiganti -- 28. Hypothesis Testing / Mallikarjuna Rettiganti -- 29. Sample Size and Power / Mallikarjuna Rettiganti -- 30.Comparing Matched Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 31.Comparing Independent Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 32.Comparing Independent Samples for Continuous-Type Outcomes: Three Groups or More / Ming Li -- 33. Correlation / Christopher J. Swearingen | |
| 505 | 0 | |a Note continued: 34. Simple Linear Regression / Christopher J. Swearingen -- 35. Multiple Linear Regression / Christopher J. Swearingen -- 36. Longitudinal and Clustered Data / Mallikarjuna Rettiganti -- 37. Significance Tests: Categorical Data / Xinyu Tang -- 38. Measures of Effect Sizes for Categorical Outcomes / Todd G. Nick -- 39. Logistic Regression / Chunqiao Luo -- 40. Kaplan-Meier Estimator / Xinyu Tang -- 41. Log-Rank Test / Xinyu Tang -- 42. Proportional Hazards Model / Xinyu Tang -- 43. Sources of Error: Selection Bias, Information Bias, and Confounding / Laura Smith -- 44. Mediation Analyses / Todd G. Nick -- 45. Epidemiology Study: Incidence and Prevalence / Laura Smith -- 46. Validity and Performance of Screening: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value / Laura Smith -- 47. Statistical Tools for Agreement and Reliability Studies / Shasha Bai -- 48. Classical Test Theory / Jamie Reilly -- 49. Item Response Theory / Jamie Reilly | |
| 505 | 0 | |a Note continued: pt. III IMPLEMENTATION -- Grant Proposals -- 50. Successful Grant Applications / Flora M. Hammond -- 51. Sources of Research Funding / James F. Malec -- 52. Planning Grants / Eric Lenze -- 53. Developing the Idea With Stakeholder Input / John D. Corrigan -- 54. Research Questions, Hypotheses, Aims, and Abstract / Flora M. Hammond -- 55. Reviewing the Literature / Edward Garay -- 56. Background and Significance / Flora M. Hammond -- 57. Preliminary Studies and Experience / Flora M. Hammond -- 58. Methods and Design / Kathleen R. Bell -- 59. Types of Measures / James F. Malec -- 60. Letters of Support / James F. Malec -- 61. Budget and Budget Justification / Rob Dimmitt -- 62. Preaward Management / Rob Dimmitt -- Conducting the Research -- 63. Post-Award Management / LaMoria Patterson -- 64. Good Clinical Practices / John R. Baumann -- 65. Research Misconduct / Rebecca Hopson -- 66. Study Protocol / Flora M. Hammond -- 67. Manual of Procedures / Flora M. Hammond | |
| 505 | 0 | |a Note continued: 68. Treatment Manuals / Kathleen R. Bell -- 69. Participant Recruitment and Enrollment / Flora M. Hammond -- 70. Participant Retention / Flora M. Hammond -- 71. Data Collection / Flora M. Hammond -- 72. Case Report Forms / Flora M. Hammond -- 73. Database Development / Emilia Bagiella -- 74. Data Dictionary / Emilia Bagiella -- 75. Data Management / Emilia Bagiella -- 76. Plan of Operation / Angelle M. Sander -- 77. Evaluation / Angelle M. Sander -- 78. Regulatory Binder and Essentia Documents / Flora M. Hammond -- 79. Adverse Events / Flora M. Hammond -- 80. Protocol Deviations and Violations / Flora M. Hammond -- 81. Data and Safety Monitoring / Emilia Bagiella -- 82. Multicenter Trials / Flora M. Hammond -- 83. Site Monitoring and Oversight / Flora M. Hammond. | |
| 650 | 0 | |a Clinical trials. |0 http://id.loc.gov/authorities/subjects/sh85027069 | |
| 650 | 0 | |a Statistics. |0 http://id.loc.gov/authorities/subjects/sh85127580 | |
| 650 | 1 | 2 | |a Biomedical Research |
| 650 | 2 | 2 | |a Clinical Trials as Topic |
| 650 | 2 | 2 | |a Epidemiologic Research Design |0 https://id.nlm.nih.gov/mesh/D015340 |
| 650 | 2 | 2 | |a Statistics as Topic |
| 650 | 6 | |a Études cliniques. | |
| 650 | 6 | |a Statistiques. | |
| 650 | 6 | |a Statistique. | |
| 650 | 7 | |a statistics. |2 aat | |
| 650 | 7 | |a HEALTH & FITNESS |x Holism. |2 bisacsh | |
| 650 | 7 | |a HEALTH & FITNESS |x Reference. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Alternative Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Atlases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Essays. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Family & General Practice. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Holistic Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Osteopathy. |2 bisacsh | |
| 650 | 7 | |a Statistics |2 fast | |
| 650 | 7 | |a Clinical trials |2 fast | |
| 700 | 1 | |a Hammond, Flora, |e editor. |0 http://id.loc.gov/authorities/names/n2008053933 | |
| 700 | 1 | |a Malec, James F., |e editor. |0 http://id.loc.gov/authorities/names/n2014183847 | |
| 700 | 1 | |a Nick, Todd, |e editor. |0 http://id.loc.gov/authorities/names/n2014183848 | |
| 700 | 1 | |a Buschbacher, Ralph M., |e editor. |0 http://id.loc.gov/authorities/names/n93804083 | |
| 758 | |i has work: |a Handbook for clinical research (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGy8ypJy4fWffgrqppWkpd |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
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| contents | Machine generated contents note: pt. I DESIGN -- 1. Development and Testing of Treatments / John Whyte -- 2. Qualitative Research / Elena Gillespie -- 3. Single-Case Experimental Designs / Michael Perdices -- 4. Studies of Associations / Michael Schonberger -- 5. Observational Studies: Retrospective Versus Prospective / Katherine W. Stenson -- 6. Historical Controls / Katherine W. Stenson -- 7. Subject as Own Control / Lisa A. Lombard -- 8. Longitudinal Cohort Versus Cross-Sectional Cohort Studies / Katherine W. Stenson -- 9. Survey Research / Amanda Leigh Harrington -- 10. Choice of Control Groups in Treatment Studies / Sureyya S. Dikmen -- 11. Randomization / Emilia Bagiella -- 12. Special Issues in Randomized Controlled Trials / Michael L. Boninger -- 13. Secondary Data Analysis / Amol Karmarkar -- 14. Scoping Study / Xinsheng Cai -- 15. Systematic Reviews / Xinsheng Cai -- 16. Meta-Analysis / Xinsheng Cai -- 17. Recommendations for Reporting Research Studies / Ronald T. Seel Note continued: 18. Developing and Evaluating Systematic Reviews and Practice Guidelines / Ronald T. Seel -- pt. II STATISTICS -- 19. Introduction / Christopher J. Swearingen -- 20. Types of Data / Marcus Wellen -- 21. Descriptive Statistics / Todd G. Nick -- 22. Data Distributions / Marcus Wellen -- 23. Samples and Populations / Marcus Wellen -- 24. Visual Display of Data / Marcus Wellen -- 25. Data Cleaning / Jingyun Li -- 26. Missing Data and Imputation / Christopher J. Swearingen -- 27. Estimation / Mallikarjuna Rettiganti -- 28. Hypothesis Testing / Mallikarjuna Rettiganti -- 29. Sample Size and Power / Mallikarjuna Rettiganti -- 30.Comparing Matched Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 31.Comparing Independent Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 32.Comparing Independent Samples for Continuous-Type Outcomes: Three Groups or More / Ming Li -- 33. Correlation / Christopher J. Swearingen Note continued: 34. Simple Linear Regression / Christopher J. Swearingen -- 35. Multiple Linear Regression / Christopher J. Swearingen -- 36. Longitudinal and Clustered Data / Mallikarjuna Rettiganti -- 37. Significance Tests: Categorical Data / Xinyu Tang -- 38. Measures of Effect Sizes for Categorical Outcomes / Todd G. Nick -- 39. Logistic Regression / Chunqiao Luo -- 40. Kaplan-Meier Estimator / Xinyu Tang -- 41. Log-Rank Test / Xinyu Tang -- 42. Proportional Hazards Model / Xinyu Tang -- 43. Sources of Error: Selection Bias, Information Bias, and Confounding / Laura Smith -- 44. Mediation Analyses / Todd G. Nick -- 45. Epidemiology Study: Incidence and Prevalence / Laura Smith -- 46. Validity and Performance of Screening: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value / Laura Smith -- 47. Statistical Tools for Agreement and Reliability Studies / Shasha Bai -- 48. Classical Test Theory / Jamie Reilly -- 49. Item Response Theory / Jamie Reilly Note continued: pt. III IMPLEMENTATION -- Grant Proposals -- 50. Successful Grant Applications / Flora M. Hammond -- 51. Sources of Research Funding / James F. Malec -- 52. Planning Grants / Eric Lenze -- 53. Developing the Idea With Stakeholder Input / John D. Corrigan -- 54. Research Questions, Hypotheses, Aims, and Abstract / Flora M. Hammond -- 55. Reviewing the Literature / Edward Garay -- 56. Background and Significance / Flora M. Hammond -- 57. Preliminary Studies and Experience / Flora M. Hammond -- 58. Methods and Design / Kathleen R. Bell -- 59. Types of Measures / James F. Malec -- 60. Letters of Support / James F. Malec -- 61. Budget and Budget Justification / Rob Dimmitt -- 62. Preaward Management / Rob Dimmitt -- Conducting the Research -- 63. Post-Award Management / LaMoria Patterson -- 64. Good Clinical Practices / John R. Baumann -- 65. Research Misconduct / Rebecca Hopson -- 66. Study Protocol / Flora M. Hammond -- 67. Manual of Procedures / Flora M. Hammond Note continued: 68. Treatment Manuals / Kathleen R. Bell -- 69. Participant Recruitment and Enrollment / Flora M. Hammond -- 70. Participant Retention / Flora M. Hammond -- 71. Data Collection / Flora M. Hammond -- 72. Case Report Forms / Flora M. Hammond -- 73. Database Development / Emilia Bagiella -- 74. Data Dictionary / Emilia Bagiella -- 75. Data Management / Emilia Bagiella -- 76. Plan of Operation / Angelle M. Sander -- 77. Evaluation / Angelle M. Sander -- 78. Regulatory Binder and Essentia Documents / Flora M. Hammond -- 79. Adverse Events / Flora M. Hammond -- 80. Protocol Deviations and Violations / Flora M. Hammond -- 81. Data and Safety Monitoring / Emilia Bagiella -- 82. Multicenter Trials / Flora M. Hammond -- 83. Site Monitoring and Oversight / Flora M. Hammond. |
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Buschbacher.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York, NY :</subfield><subfield code="b">Demos Medical Publishing, LLC,</subfield><subfield code="c">[2015]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (xiv, 332 pages .)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">data file</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index.</subfield></datafield><datafield tag="588" ind1="0" ind2=" "><subfield code="a">Print version record.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">With over 80 information-packed chapters, Handbook for Clinical Research delivers the practical insights and expert tips necessary for successful research design, analysis, and implementation. Using clear language and accessible bullet point format, the authors present the knowledge and expertise developed over time and traditionally shared from mentor to mentee and colleague to colleague. Organized for quick access to key topics and replete with practical examples, the book describes a variety of research designs and statistical methods and explains how to choose the best design for a particular project. Research implementation, including regulatory issues and grant writing is also covered. The book opens with a section on the basics of research design, discussing the many ways in which studies can be organized, executed, and evaluated. The second section is devoted to statistics; it explains how to choose the correct statistical approach and reviews the varieties of data types, descriptive and inferential statistics, methods for demonstrating associations, hypothesis testing and prediction, specialized methods, and considerations in epidemiological studies and measure construction. The third section covers implementation, including how to develop a grant application step by step, the project budget, and the nuts and bolts of the timely and successful completion of a research project and documentation of findings; procedural manuals and case report forms; collecting, managing, and securing data; operational structure and ongoing monitoring and evaluation; and ethical and regulatory concerns in research with human subjects. With a concise presentation of the essentials for successful research, the Handbook for Clinical Research is a valuable addition to the library of any student, researcher, professional, or clinician interested in expanding the knowledge base of his or her field.</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">Machine generated contents note: pt. I DESIGN -- 1. Development and Testing of Treatments / John Whyte -- 2. Qualitative Research / Elena Gillespie -- 3. Single-Case Experimental Designs / Michael Perdices -- 4. Studies of Associations / Michael Schonberger -- 5. Observational Studies: Retrospective Versus Prospective / Katherine W. Stenson -- 6. Historical Controls / Katherine W. Stenson -- 7. Subject as Own Control / Lisa A. Lombard -- 8. Longitudinal Cohort Versus Cross-Sectional Cohort Studies / Katherine W. Stenson -- 9. Survey Research / Amanda Leigh Harrington -- 10. Choice of Control Groups in Treatment Studies / Sureyya S. Dikmen -- 11. Randomization / Emilia Bagiella -- 12. Special Issues in Randomized Controlled Trials / Michael L. Boninger -- 13. Secondary Data Analysis / Amol Karmarkar -- 14. Scoping Study / Xinsheng Cai -- 15. Systematic Reviews / Xinsheng Cai -- 16. Meta-Analysis / Xinsheng Cai -- 17. Recommendations for Reporting Research Studies / Ronald T. Seel</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">Note continued: 18. Developing and Evaluating Systematic Reviews and Practice Guidelines / Ronald T. Seel -- pt. II STATISTICS -- 19. Introduction / Christopher J. Swearingen -- 20. Types of Data / Marcus Wellen -- 21. Descriptive Statistics / Todd G. Nick -- 22. Data Distributions / Marcus Wellen -- 23. Samples and Populations / Marcus Wellen -- 24. Visual Display of Data / Marcus Wellen -- 25. Data Cleaning / Jingyun Li -- 26. Missing Data and Imputation / Christopher J. Swearingen -- 27. Estimation / Mallikarjuna Rettiganti -- 28. Hypothesis Testing / Mallikarjuna Rettiganti -- 29. Sample Size and Power / Mallikarjuna Rettiganti -- 30.Comparing Matched Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 31.Comparing Independent Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 32.Comparing Independent Samples for Continuous-Type Outcomes: Three Groups or More / Ming Li -- 33. Correlation / Christopher J. Swearingen</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">Note continued: 34. Simple Linear Regression / Christopher J. Swearingen -- 35. Multiple Linear Regression / Christopher J. Swearingen -- 36. Longitudinal and Clustered Data / Mallikarjuna Rettiganti -- 37. Significance Tests: Categorical Data / Xinyu Tang -- 38. Measures of Effect Sizes for Categorical Outcomes / Todd G. Nick -- 39. Logistic Regression / Chunqiao Luo -- 40. Kaplan-Meier Estimator / Xinyu Tang -- 41. Log-Rank Test / Xinyu Tang -- 42. Proportional Hazards Model / Xinyu Tang -- 43. Sources of Error: Selection Bias, Information Bias, and Confounding / Laura Smith -- 44. Mediation Analyses / Todd G. Nick -- 45. Epidemiology Study: Incidence and Prevalence / Laura Smith -- 46. Validity and Performance of Screening: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value / Laura Smith -- 47. Statistical Tools for Agreement and Reliability Studies / Shasha Bai -- 48. Classical Test Theory / Jamie Reilly -- 49. Item Response Theory / Jamie Reilly</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">Note continued: pt. III IMPLEMENTATION -- Grant Proposals -- 50. Successful Grant Applications / Flora M. Hammond -- 51. Sources of Research Funding / James F. Malec -- 52. Planning Grants / Eric Lenze -- 53. Developing the Idea With Stakeholder Input / John D. Corrigan -- 54. Research Questions, Hypotheses, Aims, and Abstract / Flora M. Hammond -- 55. Reviewing the Literature / Edward Garay -- 56. Background and Significance / Flora M. Hammond -- 57. Preliminary Studies and Experience / Flora M. Hammond -- 58. Methods and Design / Kathleen R. Bell -- 59. Types of Measures / James F. Malec -- 60. Letters of Support / James F. Malec -- 61. Budget and Budget Justification / Rob Dimmitt -- 62. Preaward Management / Rob Dimmitt -- Conducting the Research -- 63. Post-Award Management / LaMoria Patterson -- 64. Good Clinical Practices / John R. Baumann -- 65. Research Misconduct / Rebecca Hopson -- 66. Study Protocol / Flora M. Hammond -- 67. Manual of Procedures / Flora M. Hammond</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">Note continued: 68. Treatment Manuals / Kathleen R. Bell -- 69. Participant Recruitment and Enrollment / Flora M. Hammond -- 70. Participant Retention / Flora M. Hammond -- 71. Data Collection / Flora M. Hammond -- 72. Case Report Forms / Flora M. Hammond -- 73. Database Development / Emilia Bagiella -- 74. Data Dictionary / Emilia Bagiella -- 75. Data Management / Emilia Bagiella -- 76. Plan of Operation / Angelle M. Sander -- 77. Evaluation / Angelle M. Sander -- 78. Regulatory Binder and Essentia Documents / Flora M. Hammond -- 79. Adverse Events / Flora M. Hammond -- 80. Protocol Deviations and Violations / Flora M. Hammond -- 81. Data and Safety Monitoring / Emilia Bagiella -- 82. Multicenter Trials / Flora M. Hammond -- 83. Site Monitoring and Oversight / Flora M. 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| id | ZDB-4-EBA-ocn891676467 |
| illustrated | Not Illustrated |
| indexdate | 2024-11-27T13:26:14Z |
| institution | BVB |
| isbn | 1617050997 9781617050992 |
| language | English |
| oclc_num | 891676467 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (xiv, 332 pages .) |
| psigel | ZDB-4-EBA |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Demos Medical Publishing, LLC, |
| record_format | marc |
| spelling | Handbook for clinical research : design, statistics, and implementation / editors, Flora M. Hammond, James F. Malec, Todd G. Nick, Ralph M. Buschbacher. New York, NY : Demos Medical Publishing, LLC, [2015] 1 online resource (xiv, 332 pages .) text txt rdacontent computer c rdamedia online resource cr rdacarrier data file Includes bibliographical references and index. Print version record. With over 80 information-packed chapters, Handbook for Clinical Research delivers the practical insights and expert tips necessary for successful research design, analysis, and implementation. Using clear language and accessible bullet point format, the authors present the knowledge and expertise developed over time and traditionally shared from mentor to mentee and colleague to colleague. Organized for quick access to key topics and replete with practical examples, the book describes a variety of research designs and statistical methods and explains how to choose the best design for a particular project. Research implementation, including regulatory issues and grant writing is also covered. The book opens with a section on the basics of research design, discussing the many ways in which studies can be organized, executed, and evaluated. The second section is devoted to statistics; it explains how to choose the correct statistical approach and reviews the varieties of data types, descriptive and inferential statistics, methods for demonstrating associations, hypothesis testing and prediction, specialized methods, and considerations in epidemiological studies and measure construction. The third section covers implementation, including how to develop a grant application step by step, the project budget, and the nuts and bolts of the timely and successful completion of a research project and documentation of findings; procedural manuals and case report forms; collecting, managing, and securing data; operational structure and ongoing monitoring and evaluation; and ethical and regulatory concerns in research with human subjects. With a concise presentation of the essentials for successful research, the Handbook for Clinical Research is a valuable addition to the library of any student, researcher, professional, or clinician interested in expanding the knowledge base of his or her field. Machine generated contents note: pt. I DESIGN -- 1. Development and Testing of Treatments / John Whyte -- 2. Qualitative Research / Elena Gillespie -- 3. Single-Case Experimental Designs / Michael Perdices -- 4. Studies of Associations / Michael Schonberger -- 5. Observational Studies: Retrospective Versus Prospective / Katherine W. Stenson -- 6. Historical Controls / Katherine W. Stenson -- 7. Subject as Own Control / Lisa A. Lombard -- 8. Longitudinal Cohort Versus Cross-Sectional Cohort Studies / Katherine W. Stenson -- 9. Survey Research / Amanda Leigh Harrington -- 10. Choice of Control Groups in Treatment Studies / Sureyya S. Dikmen -- 11. Randomization / Emilia Bagiella -- 12. Special Issues in Randomized Controlled Trials / Michael L. Boninger -- 13. Secondary Data Analysis / Amol Karmarkar -- 14. Scoping Study / Xinsheng Cai -- 15. Systematic Reviews / Xinsheng Cai -- 16. Meta-Analysis / Xinsheng Cai -- 17. Recommendations for Reporting Research Studies / Ronald T. Seel Note continued: 18. Developing and Evaluating Systematic Reviews and Practice Guidelines / Ronald T. Seel -- pt. II STATISTICS -- 19. Introduction / Christopher J. Swearingen -- 20. Types of Data / Marcus Wellen -- 21. Descriptive Statistics / Todd G. Nick -- 22. Data Distributions / Marcus Wellen -- 23. Samples and Populations / Marcus Wellen -- 24. Visual Display of Data / Marcus Wellen -- 25. Data Cleaning / Jingyun Li -- 26. Missing Data and Imputation / Christopher J. Swearingen -- 27. Estimation / Mallikarjuna Rettiganti -- 28. Hypothesis Testing / Mallikarjuna Rettiganti -- 29. Sample Size and Power / Mallikarjuna Rettiganti -- 30.Comparing Matched Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 31.Comparing Independent Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 32.Comparing Independent Samples for Continuous-Type Outcomes: Three Groups or More / Ming Li -- 33. Correlation / Christopher J. Swearingen Note continued: 34. Simple Linear Regression / Christopher J. Swearingen -- 35. Multiple Linear Regression / Christopher J. Swearingen -- 36. Longitudinal and Clustered Data / Mallikarjuna Rettiganti -- 37. Significance Tests: Categorical Data / Xinyu Tang -- 38. Measures of Effect Sizes for Categorical Outcomes / Todd G. Nick -- 39. Logistic Regression / Chunqiao Luo -- 40. Kaplan-Meier Estimator / Xinyu Tang -- 41. Log-Rank Test / Xinyu Tang -- 42. Proportional Hazards Model / Xinyu Tang -- 43. Sources of Error: Selection Bias, Information Bias, and Confounding / Laura Smith -- 44. Mediation Analyses / Todd G. Nick -- 45. Epidemiology Study: Incidence and Prevalence / Laura Smith -- 46. Validity and Performance of Screening: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value / Laura Smith -- 47. Statistical Tools for Agreement and Reliability Studies / Shasha Bai -- 48. Classical Test Theory / Jamie Reilly -- 49. Item Response Theory / Jamie Reilly Note continued: pt. III IMPLEMENTATION -- Grant Proposals -- 50. Successful Grant Applications / Flora M. Hammond -- 51. Sources of Research Funding / James F. Malec -- 52. Planning Grants / Eric Lenze -- 53. Developing the Idea With Stakeholder Input / John D. Corrigan -- 54. Research Questions, Hypotheses, Aims, and Abstract / Flora M. Hammond -- 55. Reviewing the Literature / Edward Garay -- 56. Background and Significance / Flora M. Hammond -- 57. Preliminary Studies and Experience / Flora M. Hammond -- 58. Methods and Design / Kathleen R. Bell -- 59. Types of Measures / James F. Malec -- 60. Letters of Support / James F. Malec -- 61. Budget and Budget Justification / Rob Dimmitt -- 62. Preaward Management / Rob Dimmitt -- Conducting the Research -- 63. Post-Award Management / LaMoria Patterson -- 64. Good Clinical Practices / John R. Baumann -- 65. Research Misconduct / Rebecca Hopson -- 66. Study Protocol / Flora M. Hammond -- 67. Manual of Procedures / Flora M. Hammond Note continued: 68. Treatment Manuals / Kathleen R. Bell -- 69. Participant Recruitment and Enrollment / Flora M. Hammond -- 70. Participant Retention / Flora M. Hammond -- 71. Data Collection / Flora M. Hammond -- 72. Case Report Forms / Flora M. Hammond -- 73. Database Development / Emilia Bagiella -- 74. Data Dictionary / Emilia Bagiella -- 75. Data Management / Emilia Bagiella -- 76. Plan of Operation / Angelle M. Sander -- 77. Evaluation / Angelle M. Sander -- 78. Regulatory Binder and Essentia Documents / Flora M. Hammond -- 79. Adverse Events / Flora M. Hammond -- 80. Protocol Deviations and Violations / Flora M. Hammond -- 81. Data and Safety Monitoring / Emilia Bagiella -- 82. Multicenter Trials / Flora M. Hammond -- 83. Site Monitoring and Oversight / Flora M. Hammond. Clinical trials. http://id.loc.gov/authorities/subjects/sh85027069 Statistics. http://id.loc.gov/authorities/subjects/sh85127580 Biomedical Research Clinical Trials as Topic Epidemiologic Research Design https://id.nlm.nih.gov/mesh/D015340 Statistics as Topic Études cliniques. Statistiques. Statistique. statistics. aat HEALTH & FITNESS Holism. bisacsh HEALTH & FITNESS Reference. bisacsh MEDICAL Alternative Medicine. bisacsh MEDICAL Atlases. bisacsh MEDICAL Essays. bisacsh MEDICAL Family & General Practice. bisacsh MEDICAL Holistic Medicine. bisacsh MEDICAL Osteopathy. bisacsh Statistics fast Clinical trials fast Hammond, Flora, editor. http://id.loc.gov/authorities/names/n2008053933 Malec, James F., editor. http://id.loc.gov/authorities/names/n2014183847 Nick, Todd, editor. http://id.loc.gov/authorities/names/n2014183848 Buschbacher, Ralph M., editor. http://id.loc.gov/authorities/names/n93804083 has work: Handbook for clinical research (Text) https://id.oclc.org/worldcat/entity/E39PCGy8ypJy4fWffgrqppWkpd https://id.oclc.org/worldcat/ontology/hasWork Print version: 9781936287543 1936287544 (DLC) 2014015700 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=844462 Volltext |
| spellingShingle | Handbook for clinical research : design, statistics, and implementation / Machine generated contents note: pt. I DESIGN -- 1. Development and Testing of Treatments / John Whyte -- 2. Qualitative Research / Elena Gillespie -- 3. Single-Case Experimental Designs / Michael Perdices -- 4. Studies of Associations / Michael Schonberger -- 5. Observational Studies: Retrospective Versus Prospective / Katherine W. Stenson -- 6. Historical Controls / Katherine W. Stenson -- 7. Subject as Own Control / Lisa A. Lombard -- 8. Longitudinal Cohort Versus Cross-Sectional Cohort Studies / Katherine W. Stenson -- 9. Survey Research / Amanda Leigh Harrington -- 10. Choice of Control Groups in Treatment Studies / Sureyya S. Dikmen -- 11. Randomization / Emilia Bagiella -- 12. Special Issues in Randomized Controlled Trials / Michael L. Boninger -- 13. Secondary Data Analysis / Amol Karmarkar -- 14. Scoping Study / Xinsheng Cai -- 15. Systematic Reviews / Xinsheng Cai -- 16. Meta-Analysis / Xinsheng Cai -- 17. Recommendations for Reporting Research Studies / Ronald T. Seel Note continued: 18. Developing and Evaluating Systematic Reviews and Practice Guidelines / Ronald T. Seel -- pt. II STATISTICS -- 19. Introduction / Christopher J. Swearingen -- 20. Types of Data / Marcus Wellen -- 21. Descriptive Statistics / Todd G. Nick -- 22. Data Distributions / Marcus Wellen -- 23. Samples and Populations / Marcus Wellen -- 24. Visual Display of Data / Marcus Wellen -- 25. Data Cleaning / Jingyun Li -- 26. Missing Data and Imputation / Christopher J. Swearingen -- 27. Estimation / Mallikarjuna Rettiganti -- 28. Hypothesis Testing / Mallikarjuna Rettiganti -- 29. Sample Size and Power / Mallikarjuna Rettiganti -- 30.Comparing Matched Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 31.Comparing Independent Samples With Continuous-Type Outcomes: Two Groups / Ming Li -- 32.Comparing Independent Samples for Continuous-Type Outcomes: Three Groups or More / Ming Li -- 33. Correlation / Christopher J. Swearingen Note continued: 34. Simple Linear Regression / Christopher J. Swearingen -- 35. Multiple Linear Regression / Christopher J. Swearingen -- 36. Longitudinal and Clustered Data / Mallikarjuna Rettiganti -- 37. Significance Tests: Categorical Data / Xinyu Tang -- 38. Measures of Effect Sizes for Categorical Outcomes / Todd G. Nick -- 39. Logistic Regression / Chunqiao Luo -- 40. Kaplan-Meier Estimator / Xinyu Tang -- 41. Log-Rank Test / Xinyu Tang -- 42. Proportional Hazards Model / Xinyu Tang -- 43. Sources of Error: Selection Bias, Information Bias, and Confounding / Laura Smith -- 44. Mediation Analyses / Todd G. Nick -- 45. Epidemiology Study: Incidence and Prevalence / Laura Smith -- 46. Validity and Performance of Screening: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value / Laura Smith -- 47. Statistical Tools for Agreement and Reliability Studies / Shasha Bai -- 48. Classical Test Theory / Jamie Reilly -- 49. Item Response Theory / Jamie Reilly Note continued: pt. III IMPLEMENTATION -- Grant Proposals -- 50. Successful Grant Applications / Flora M. Hammond -- 51. Sources of Research Funding / James F. Malec -- 52. Planning Grants / Eric Lenze -- 53. Developing the Idea With Stakeholder Input / John D. Corrigan -- 54. Research Questions, Hypotheses, Aims, and Abstract / Flora M. Hammond -- 55. Reviewing the Literature / Edward Garay -- 56. Background and Significance / Flora M. Hammond -- 57. Preliminary Studies and Experience / Flora M. Hammond -- 58. Methods and Design / Kathleen R. Bell -- 59. Types of Measures / James F. Malec -- 60. Letters of Support / James F. Malec -- 61. Budget and Budget Justification / Rob Dimmitt -- 62. Preaward Management / Rob Dimmitt -- Conducting the Research -- 63. Post-Award Management / LaMoria Patterson -- 64. Good Clinical Practices / John R. Baumann -- 65. Research Misconduct / Rebecca Hopson -- 66. Study Protocol / Flora M. Hammond -- 67. Manual of Procedures / Flora M. Hammond Note continued: 68. Treatment Manuals / Kathleen R. Bell -- 69. Participant Recruitment and Enrollment / Flora M. Hammond -- 70. Participant Retention / Flora M. Hammond -- 71. Data Collection / Flora M. Hammond -- 72. Case Report Forms / Flora M. Hammond -- 73. Database Development / Emilia Bagiella -- 74. Data Dictionary / Emilia Bagiella -- 75. Data Management / Emilia Bagiella -- 76. Plan of Operation / Angelle M. Sander -- 77. Evaluation / Angelle M. Sander -- 78. Regulatory Binder and Essentia Documents / Flora M. Hammond -- 79. Adverse Events / Flora M. Hammond -- 80. Protocol Deviations and Violations / Flora M. Hammond -- 81. Data and Safety Monitoring / Emilia Bagiella -- 82. Multicenter Trials / Flora M. Hammond -- 83. Site Monitoring and Oversight / Flora M. Hammond. Clinical trials. http://id.loc.gov/authorities/subjects/sh85027069 Statistics. http://id.loc.gov/authorities/subjects/sh85127580 Biomedical Research Clinical Trials as Topic Epidemiologic Research Design https://id.nlm.nih.gov/mesh/D015340 Statistics as Topic Études cliniques. Statistiques. Statistique. statistics. aat HEALTH & FITNESS Holism. bisacsh HEALTH & FITNESS Reference. bisacsh MEDICAL Alternative Medicine. bisacsh MEDICAL Atlases. bisacsh MEDICAL Essays. bisacsh MEDICAL Family & General Practice. bisacsh MEDICAL Holistic Medicine. bisacsh MEDICAL Osteopathy. bisacsh Statistics fast Clinical trials fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85027069 http://id.loc.gov/authorities/subjects/sh85127580 https://id.nlm.nih.gov/mesh/D015340 |
| title | Handbook for clinical research : design, statistics, and implementation / |
| title_auth | Handbook for clinical research : design, statistics, and implementation / |
| title_exact_search | Handbook for clinical research : design, statistics, and implementation / |
| title_full | Handbook for clinical research : design, statistics, and implementation / editors, Flora M. Hammond, James F. Malec, Todd G. Nick, Ralph M. Buschbacher. |
| title_fullStr | Handbook for clinical research : design, statistics, and implementation / editors, Flora M. Hammond, James F. Malec, Todd G. Nick, Ralph M. Buschbacher. |
| title_full_unstemmed | Handbook for clinical research : design, statistics, and implementation / editors, Flora M. Hammond, James F. Malec, Todd G. Nick, Ralph M. Buschbacher. |
| title_short | Handbook for clinical research : |
| title_sort | handbook for clinical research design statistics and implementation |
| title_sub | design, statistics, and implementation / |
| topic | Clinical trials. http://id.loc.gov/authorities/subjects/sh85027069 Statistics. http://id.loc.gov/authorities/subjects/sh85127580 Biomedical Research Clinical Trials as Topic Epidemiologic Research Design https://id.nlm.nih.gov/mesh/D015340 Statistics as Topic Études cliniques. Statistiques. Statistique. statistics. aat HEALTH & FITNESS Holism. bisacsh HEALTH & FITNESS Reference. bisacsh MEDICAL Alternative Medicine. bisacsh MEDICAL Atlases. bisacsh MEDICAL Essays. bisacsh MEDICAL Family & General Practice. bisacsh MEDICAL Holistic Medicine. bisacsh MEDICAL Osteopathy. bisacsh Statistics fast Clinical trials fast |
| topic_facet | Clinical trials. Statistics. Biomedical Research Clinical Trials as Topic Epidemiologic Research Design Statistics as Topic Études cliniques. Statistiques. Statistique. statistics. HEALTH & FITNESS Holism. HEALTH & FITNESS Reference. MEDICAL Alternative Medicine. MEDICAL Atlases. MEDICAL Essays. MEDICAL Family & General Practice. MEDICAL Holistic Medicine. MEDICAL Osteopathy. Statistics Clinical trials |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=844462 |
| work_keys_str_mv | AT hammondflora handbookforclinicalresearchdesignstatisticsandimplementation AT malecjamesf handbookforclinicalresearchdesignstatisticsandimplementation AT nicktodd handbookforclinicalresearchdesignstatisticsandimplementation AT buschbacherralphm handbookforclinicalresearchdesignstatisticsandimplementation |