Dynamics of cancer :: mathematical foundations of oncology /
The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evoluti...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
[Hackensack] New Jersey :
World Scientific,
2014.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells. |
| Beschreibung: | 1 online resource |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9789814566377 9814566373 |
Internformat
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| 100 | 1 | |a Wodarz, Dominik, |e author. |0 http://id.loc.gov/authorities/names/n2004009574 | |
| 245 | 1 | 0 | |a Dynamics of cancer : |b mathematical foundations of oncology / |c by Dominik Wodarz (University of California, Irvine, USA) & Natalia L. Komarova (University of California, Irvine, USA). |
| 264 | 1 | |a [Hackensack] New Jersey : |b World Scientific, |c 2014. | |
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| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a 1. Teaching guide -- 2. Cancer and somatic evolution -- 3. Mathematical modeling of tumorigenesis -- 4. Single species growth -- 5. Two-species competition dynamics -- 6. Competition between genetically stable and unstable cells -- 7. Chromosomal instability and tumor growth -- 8. Angiogenesis, inhibitors, promoters, and spatial growth -- 9. Evolutionary dynamics of tumor initiation through oncogenes: the gain-of-function model -- 10. Evolutionary dynamics of tumor initiation through tumor-suppressor genes: the loss-of-function model and stochastic tunneling -- 11. Microsatellite and chromosomal instability in sporadic and familial colorectal cancers -- 12. Evolutionary dynamics in hierarchical populations -- 13. Spatial evolutionary dynamics of tumor initiation -- 14. Complex tumor dynamics in space -- 15. Stochastic modeling of cancer growth, treatment, and resistance generation -- 16. Evolutionary dynamics of drug resistance in chronic myeloid leukemia -- 17. Evolutionary dynamics of stem-cell driven tumor growth -- 18. Tumor growth kinetics and disease progression -- 19. Epigenetic changes and the rate of DNA methylation -- 20. Telomeres and cancer protection -- 21. Gene therapy and oncolytic virus therapy -- 22. Immune responses, tumor growth, and therapy -- 23. Towards higher complexities: social interactions. | |
| 520 | |a The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells. | ||
| 650 | 0 | |a Oncology |x Mathematics. | |
| 650 | 0 | |a Cancer |x Treatment |x Data processing. | |
| 650 | 0 | |a Computational biology. |0 http://id.loc.gov/authorities/subjects/sh2003008355 | |
| 650 | 2 | |a Neoplasms | |
| 650 | 2 | |a Computational Biology |0 https://id.nlm.nih.gov/mesh/D019295 | |
| 650 | 6 | |a Cancérologie |x Mathématiques. | |
| 650 | 6 | |a Cancer |x Traitement |x Informatique. | |
| 650 | 6 | |a Bio-informatique. | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
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| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Cancer |x Treatment |x Data processing |2 fast | |
| 650 | 7 | |a Computational biology |2 fast | |
| 700 | 1 | |a Komarova, Natalia L., |e author. | |
| 758 | |i has work: |a Dynamics of cancer (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGkHGQCR6yTKRbf3bCmQYP |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
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Datensatz im Suchindex
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| _version_ | 1816882275015458816 |
| adam_text | |
| any_adam_object | |
| author | Wodarz, Dominik Komarova, Natalia L. |
| author_GND | http://id.loc.gov/authorities/names/n2004009574 |
| author_facet | Wodarz, Dominik Komarova, Natalia L. |
| author_role | aut aut |
| author_sort | Wodarz, Dominik |
| author_variant | d w dw n l k nl nlk |
| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | R - Medicine |
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| callnumber-raw | RC254 .W66 2014eb |
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| callnumber-subject | RC - Internal Medicine |
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| contents | 1. Teaching guide -- 2. Cancer and somatic evolution -- 3. Mathematical modeling of tumorigenesis -- 4. Single species growth -- 5. Two-species competition dynamics -- 6. Competition between genetically stable and unstable cells -- 7. Chromosomal instability and tumor growth -- 8. Angiogenesis, inhibitors, promoters, and spatial growth -- 9. Evolutionary dynamics of tumor initiation through oncogenes: the gain-of-function model -- 10. Evolutionary dynamics of tumor initiation through tumor-suppressor genes: the loss-of-function model and stochastic tunneling -- 11. Microsatellite and chromosomal instability in sporadic and familial colorectal cancers -- 12. Evolutionary dynamics in hierarchical populations -- 13. Spatial evolutionary dynamics of tumor initiation -- 14. Complex tumor dynamics in space -- 15. Stochastic modeling of cancer growth, treatment, and resistance generation -- 16. Evolutionary dynamics of drug resistance in chronic myeloid leukemia -- 17. Evolutionary dynamics of stem-cell driven tumor growth -- 18. Tumor growth kinetics and disease progression -- 19. Epigenetic changes and the rate of DNA methylation -- 20. Telomeres and cancer protection -- 21. Gene therapy and oncolytic virus therapy -- 22. Immune responses, tumor growth, and therapy -- 23. Towards higher complexities: social interactions. |
| ctrlnum | (OCoLC)881183816 |
| dewey-full | 616.99/400285 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/400285 |
| dewey-search | 616.99/400285 |
| dewey-sort | 3616.99 6400285 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| indexdate | 2024-11-27T13:26:01Z |
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| language | English |
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| spelling | Wodarz, Dominik, author. http://id.loc.gov/authorities/names/n2004009574 Dynamics of cancer : mathematical foundations of oncology / by Dominik Wodarz (University of California, Irvine, USA) & Natalia L. Komarova (University of California, Irvine, USA). [Hackensack] New Jersey : World Scientific, 2014. 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Print version record. 1. Teaching guide -- 2. Cancer and somatic evolution -- 3. Mathematical modeling of tumorigenesis -- 4. Single species growth -- 5. Two-species competition dynamics -- 6. Competition between genetically stable and unstable cells -- 7. Chromosomal instability and tumor growth -- 8. Angiogenesis, inhibitors, promoters, and spatial growth -- 9. Evolutionary dynamics of tumor initiation through oncogenes: the gain-of-function model -- 10. Evolutionary dynamics of tumor initiation through tumor-suppressor genes: the loss-of-function model and stochastic tunneling -- 11. Microsatellite and chromosomal instability in sporadic and familial colorectal cancers -- 12. Evolutionary dynamics in hierarchical populations -- 13. Spatial evolutionary dynamics of tumor initiation -- 14. Complex tumor dynamics in space -- 15. Stochastic modeling of cancer growth, treatment, and resistance generation -- 16. Evolutionary dynamics of drug resistance in chronic myeloid leukemia -- 17. Evolutionary dynamics of stem-cell driven tumor growth -- 18. Tumor growth kinetics and disease progression -- 19. Epigenetic changes and the rate of DNA methylation -- 20. Telomeres and cancer protection -- 21. Gene therapy and oncolytic virus therapy -- 22. Immune responses, tumor growth, and therapy -- 23. Towards higher complexities: social interactions. The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells. Oncology Mathematics. Cancer Treatment Data processing. Computational biology. http://id.loc.gov/authorities/subjects/sh2003008355 Neoplasms Computational Biology https://id.nlm.nih.gov/mesh/D019295 Cancérologie Mathématiques. Cancer Traitement Informatique. Bio-informatique. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Cancer Treatment Data processing fast Computational biology fast Komarova, Natalia L., author. has work: Dynamics of cancer (Text) https://id.oclc.org/worldcat/entity/E39PCGkHGQCR6yTKRbf3bCmQYP https://id.oclc.org/worldcat/ontology/hasWork Print version: Wodarz, Dominik. Dynamics of cancer 9789814566360 (DLC) 2013033157 (OCoLC)858778219 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=787883 Volltext |
| spellingShingle | Wodarz, Dominik Komarova, Natalia L. Dynamics of cancer : mathematical foundations of oncology / 1. Teaching guide -- 2. Cancer and somatic evolution -- 3. Mathematical modeling of tumorigenesis -- 4. Single species growth -- 5. Two-species competition dynamics -- 6. Competition between genetically stable and unstable cells -- 7. Chromosomal instability and tumor growth -- 8. Angiogenesis, inhibitors, promoters, and spatial growth -- 9. Evolutionary dynamics of tumor initiation through oncogenes: the gain-of-function model -- 10. Evolutionary dynamics of tumor initiation through tumor-suppressor genes: the loss-of-function model and stochastic tunneling -- 11. Microsatellite and chromosomal instability in sporadic and familial colorectal cancers -- 12. Evolutionary dynamics in hierarchical populations -- 13. Spatial evolutionary dynamics of tumor initiation -- 14. Complex tumor dynamics in space -- 15. Stochastic modeling of cancer growth, treatment, and resistance generation -- 16. Evolutionary dynamics of drug resistance in chronic myeloid leukemia -- 17. Evolutionary dynamics of stem-cell driven tumor growth -- 18. Tumor growth kinetics and disease progression -- 19. Epigenetic changes and the rate of DNA methylation -- 20. Telomeres and cancer protection -- 21. Gene therapy and oncolytic virus therapy -- 22. Immune responses, tumor growth, and therapy -- 23. Towards higher complexities: social interactions. Oncology Mathematics. Cancer Treatment Data processing. Computational biology. http://id.loc.gov/authorities/subjects/sh2003008355 Neoplasms Computational Biology https://id.nlm.nih.gov/mesh/D019295 Cancérologie Mathématiques. Cancer Traitement Informatique. Bio-informatique. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Cancer Treatment Data processing fast Computational biology fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh2003008355 https://id.nlm.nih.gov/mesh/D019295 |
| title | Dynamics of cancer : mathematical foundations of oncology / |
| title_auth | Dynamics of cancer : mathematical foundations of oncology / |
| title_exact_search | Dynamics of cancer : mathematical foundations of oncology / |
| title_full | Dynamics of cancer : mathematical foundations of oncology / by Dominik Wodarz (University of California, Irvine, USA) & Natalia L. Komarova (University of California, Irvine, USA). |
| title_fullStr | Dynamics of cancer : mathematical foundations of oncology / by Dominik Wodarz (University of California, Irvine, USA) & Natalia L. Komarova (University of California, Irvine, USA). |
| title_full_unstemmed | Dynamics of cancer : mathematical foundations of oncology / by Dominik Wodarz (University of California, Irvine, USA) & Natalia L. Komarova (University of California, Irvine, USA). |
| title_short | Dynamics of cancer : |
| title_sort | dynamics of cancer mathematical foundations of oncology |
| title_sub | mathematical foundations of oncology / |
| topic | Oncology Mathematics. Cancer Treatment Data processing. Computational biology. http://id.loc.gov/authorities/subjects/sh2003008355 Neoplasms Computational Biology https://id.nlm.nih.gov/mesh/D019295 Cancérologie Mathématiques. Cancer Traitement Informatique. Bio-informatique. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Cancer Treatment Data processing fast Computational biology fast |
| topic_facet | Oncology Mathematics. Cancer Treatment Data processing. Computational biology. Neoplasms Computational Biology Cancérologie Mathématiques. Cancer Traitement Informatique. Bio-informatique. HEALTH & FITNESS Diseases General. MEDICAL Clinical Medicine. MEDICAL Diseases. MEDICAL Evidence-Based Medicine. MEDICAL Internal Medicine. Cancer Treatment Data processing Computational biology |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=787883 |
| work_keys_str_mv | AT wodarzdominik dynamicsofcancermathematicalfoundationsofoncology AT komarovanatalial dynamicsofcancermathematicalfoundationsofoncology |