Veterans and Agent Orange :: update 2012 /
From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mix...
Gespeichert in:
| Körperschaften: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Washington (DC) :
National Academies Press (US),
2014.
|
| Schlagworte: | |
| Online-Zugang: | DE-862 DE-863 |
| Zusammenfassung: | From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences (NAS) was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations are conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 2012 reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010--September 2012 and integrates this information with the previously established evidence database. This report considers whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiological methods used to detect the association; the increased risk of disease among those exposed to herbicides during service in the Republic of Vietnam during the Vietnam era; and whether there exists a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease. |
| Beschreibung: | Title from PDF title page. |
| Beschreibung: | 1 online resource (1 PDF file (xix, 986 pages)) |
| Bibliographie: | Includes bibliographical references. |
| ISBN: | 9780309288866 030928886X 9780309288873 0309288878 |
Internformat
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | ZDB-4-EBA-ocn881019388 | ||
| 003 | OCoLC | ||
| 005 | 20250103110447.0 | ||
| 006 | m o d | ||
| 007 | cr bn||||||||| | ||
| 008 | 140416s2014 dcu obt 000 0 eng | ||
| 040 | |a NLM |b eng |e rda |e pn |c NLM |d YDXCP |d OCLCO |d COO |d COP |d MMU |d E7B |d N$T |d OCLCO |d EBLCP |d OCLCQ |d OCLCO |d OCLCQ |d OCLCO |d OCLCQ |d OCLCO |d OCLCA |d VT2 |d AGLDB |d ZCU |d MERUC |d U3W |d STF |d OCLCQ |d VTS |d EZ9 |d ICG |d AU@ |d REC |d OCLCO |d OCLCQ |d OCLCO |d WYU |d OCLCA |d LVT |d TKN |d DKC |d OCLCQ |d SFB |d OCLCQ |d UKAHL |d OCL |d AJS |d OCL |d OCLCO |d OCLCQ |d OCLCO |d OCLCL |d UEJ |d OCLCO |d OCLCQ | ||
| 016 | 7 | |a 101631408 |2 DNLM | |
| 019 | |a 872152405 |a 877447375 |a 880451287 |a 961580171 |a 1055319227 |a 1066002014 |a 1081281526 |a 1156361794 |a 1228542426 |a 1249215970 | ||
| 020 | |a 9780309288866 | ||
| 020 | |a 030928886X | ||
| 020 | |a 9780309288873 | ||
| 020 | |a 0309288878 | ||
| 035 | |a (OCoLC)881019388 |z (OCoLC)872152405 |z (OCoLC)877447375 |z (OCoLC)880451287 |z (OCoLC)961580171 |z (OCoLC)1055319227 |z (OCoLC)1066002014 |z (OCoLC)1081281526 |z (OCoLC)1156361794 |z (OCoLC)1228542426 |z (OCoLC)1249215970 | ||
| 042 | |a pcc | ||
| 043 | |a n-us--- |a a-vt--- | ||
| 050 | 4 | |a RA1270.T44 |b I57 2014 | |
| 060 | 4 | |a WA 240 | |
| 072 | 7 | |a HIS |x 048000 |2 bisacsh | |
| 082 | 7 | |a 615.9/5137 |2 22 | |
| 049 | |a MAIN | ||
| 110 | 2 | |a Institute of Medicine (U.S.). |b Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, |e author, |e issuing body. |0 http://id.loc.gov/authorities/names/n93803281 | |
| 245 | 1 | 0 | |a Veterans and Agent Orange : |b update 2012 / |c Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update), Board on the Health of Select Populations, Institute of Medicine. |
| 264 | 1 | |a Washington (DC) : |b National Academies Press (US), |c 2014. | |
| 300 | |a 1 online resource (1 PDF file (xix, 986 pages)) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Title from PDF title page. | ||
| 504 | |a Includes bibliographical references. | ||
| 520 | 3 | |a From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences (NAS) was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations are conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 2012 reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010--September 2012 and integrates this information with the previously established evidence database. This report considers whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiological methods used to detect the association; the increased risk of disease among those exposed to herbicides during service in the Republic of Vietnam during the Vietnam era; and whether there exists a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease. | |
| 536 | |a This study was supported by Contract/Grant No. VA241-P-2024 between the National Academy of Sciences and the US Department of Veterans Affairs. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project. | ||
| 588 | 0 | |a Version viewed June 2, 2014. | |
| 505 | 0 | |a Summary -- 1. Introduction -- 2. Evaluating the evidence -- 3. Exposure to the herbicides used in Vietnam -- 4. Information related to biologic plausibility -- 5. Epidemiologic studies: compendium of new publications -- 6. Epidemiologic studies: background on multiply referenced populations -- 7. Immune-system disorders -- 8. Cancer -- 9. Fertility and gestational outcomes -- 10. Effects on future generations -- 11. Neurologic disorders -- 12. Cardiovascular and metabolic outcomes -- 13. Other chronic health outcomes -- 14. Conclusions and recommendations -- Appendix A: Issues raised by the public and agendas of public meetings held by the Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and other written submissions to the Committee -- Appendix B: Short-term adverse health responses -- Appendix C: Clarification of cancer groupings used in reporting results, with correspondence to National Institute for Occupational Safety and Health and health cause-of-death codes and international classification of diseases codes for cancers -- Appendix D: Biographies of Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and staff. | |
| 650 | 0 | |a Agent Orange |x Toxicology. | |
| 650 | 0 | |a Vietnam War, 1961-1975 |x Veterans |x Health aspects. | |
| 650 | 0 | |a Vietnam War, 1961-1975 |x Veterans |x Diseases. | |
| 650 | 0 | |a Herbicides |x Toxicology. |0 http://id.loc.gov/authorities/subjects/sh85060345 | |
| 650 | 0 | |a Epidemiology. |0 http://id.loc.gov/authorities/subjects/sh85044373 | |
| 650 | 1 | 2 | |a Polychlorinated Dibenzodioxins |x adverse effects |
| 650 | 2 | |a Epidemiology |0 https://id.nlm.nih.gov/mesh/D004813 | |
| 650 | 2 | 2 | |a Defoliants, Chemical |x adverse effects |
| 650 | 2 | 2 | |a Occupational Exposure |
| 650 | 2 | 2 | |a Veterans Health |
| 650 | 2 | 2 | |a Vietnam Conflict |
| 651 | 2 | |a United States | |
| 650 | 6 | |a Agent Orange |x Toxicologie. | |
| 650 | 6 | |a Guerre du Viêt-nam, 1961-1975 |x Anciens combattants |x Maladies. | |
| 650 | 6 | |a Herbicides |x Toxicologie. | |
| 650 | 6 | |a Épidémiologie. | |
| 650 | 7 | |a MEDICAL |x Toxicology. |2 bisacsh | |
| 650 | 7 | |a Veterans |2 fast | |
| 650 | 7 | |a Herbicides |x Toxicology |2 fast | |
| 650 | 7 | |a Epidemiology |2 fast | |
| 650 | 7 | |a Diseases |2 fast | |
| 650 | 7 | |a Agent Orange |x Health aspects |2 fast | |
| 650 | 7 | |a Agent Orange |x Toxicology |2 fast | |
| 650 | 7 | |a Veterans |x Health risk assessment |2 fast | |
| 651 | 7 | |a United States |2 fast |1 https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq | |
| 647 | 7 | |a Vietnam War |d (1961-1975) |2 fast |1 https://id.oclc.org/worldcat/entity/E39Qhp4vB9HVwcPb3whDTtrg7b | |
| 648 | 7 | |a 1961-1975 |2 fast | |
| 710 | 2 | |a Institute of Medicine (U.S.). |b Board on the Health of Select Populations. |0 http://id.loc.gov/authorities/names/no2010177267 | |
| 776 | 0 | 8 | |i Print version: |a Institute of Medicine (U.S.) Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides. |t Veterans and agent orange. |d Washington, D.C. : National Academies Press, [2014] |z 030928886X |w (OCoLC)866096687 |
| 966 | 4 | 0 | |l DE-862 |p ZDB-4-EBA |q FWS_PDA_EBA |u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=867988 |3 Volltext |
| 966 | 4 | 0 | |l DE-863 |p ZDB-4-EBA |q FWS_PDA_EBA |u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=867988 |3 Volltext |
| 938 | |a Askews and Holts Library Services |b ASKH |n AH36561434 | ||
| 938 | |a Askews and Holts Library Services |b ASKH |n AH36617790 | ||
| 938 | |a EBL - Ebook Library |b EBLB |n EBL3564288 | ||
| 938 | |a ebrary |b EBRY |n ebr10863759 | ||
| 938 | |a EBSCOhost |b EBSC |n 867988 | ||
| 938 | |a YBP Library Services |b YANK |n 11864864 | ||
| 994 | |a 92 |b GEBAY | ||
| 912 | |a ZDB-4-EBA | ||
| 049 | |a DE-862 | ||
| 049 | |a DE-863 | ||
Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-ocn881019388 |
|---|---|
| _version_ | 1829094998457450496 |
| adam_text | |
| any_adam_object | |
| author_corporate | Institute of Medicine (U.S.). Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides Institute of Medicine (U.S.). Board on the Health of Select Populations |
| author_corporate_role | aut |
| author_facet | Institute of Medicine (U.S.). Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides Institute of Medicine (U.S.). Board on the Health of Select Populations |
| author_sort | Institute of Medicine (U.S.). Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides |
| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | R - Medicine |
| callnumber-label | RA1270 |
| callnumber-raw | RA1270.T44 I57 2014 |
| callnumber-search | RA1270.T44 I57 2014 |
| callnumber-sort | RA 41270 T44 I57 42014 |
| callnumber-subject | RA - Public Medicine |
| collection | ZDB-4-EBA |
| contents | Summary -- 1. Introduction -- 2. Evaluating the evidence -- 3. Exposure to the herbicides used in Vietnam -- 4. Information related to biologic plausibility -- 5. Epidemiologic studies: compendium of new publications -- 6. Epidemiologic studies: background on multiply referenced populations -- 7. Immune-system disorders -- 8. Cancer -- 9. Fertility and gestational outcomes -- 10. Effects on future generations -- 11. Neurologic disorders -- 12. Cardiovascular and metabolic outcomes -- 13. Other chronic health outcomes -- 14. Conclusions and recommendations -- Appendix A: Issues raised by the public and agendas of public meetings held by the Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and other written submissions to the Committee -- Appendix B: Short-term adverse health responses -- Appendix C: Clarification of cancer groupings used in reporting results, with correspondence to National Institute for Occupational Safety and Health and health cause-of-death codes and international classification of diseases codes for cancers -- Appendix D: Biographies of Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and staff. |
| ctrlnum | (OCoLC)881019388 |
| dewey-full | 615.9/5137 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.9/5137 |
| dewey-search | 615.9/5137 |
| dewey-sort | 3615.9 45137 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| era | 1961-1975 fast |
| era_facet | 1961-1975 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>08344cam a2200877 i 4500</leader><controlfield tag="001">ZDB-4-EBA-ocn881019388</controlfield><controlfield tag="003">OCoLC</controlfield><controlfield tag="005">20250103110447.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr bn|||||||||</controlfield><controlfield tag="008">140416s2014 dcu obt 000 0 eng </controlfield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">NLM</subfield><subfield code="b">eng</subfield><subfield code="e">rda</subfield><subfield code="e">pn</subfield><subfield code="c">NLM</subfield><subfield code="d">YDXCP</subfield><subfield code="d">OCLCO</subfield><subfield code="d">COO</subfield><subfield code="d">COP</subfield><subfield code="d">MMU</subfield><subfield code="d">E7B</subfield><subfield code="d">N$T</subfield><subfield code="d">OCLCO</subfield><subfield code="d">EBLCP</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCA</subfield><subfield code="d">VT2</subfield><subfield code="d">AGLDB</subfield><subfield code="d">ZCU</subfield><subfield code="d">MERUC</subfield><subfield code="d">U3W</subfield><subfield code="d">STF</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">VTS</subfield><subfield code="d">EZ9</subfield><subfield code="d">ICG</subfield><subfield code="d">AU@</subfield><subfield code="d">REC</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">WYU</subfield><subfield code="d">OCLCA</subfield><subfield code="d">LVT</subfield><subfield code="d">TKN</subfield><subfield code="d">DKC</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">SFB</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">UKAHL</subfield><subfield code="d">OCL</subfield><subfield code="d">AJS</subfield><subfield code="d">OCL</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCL</subfield><subfield code="d">UEJ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCQ</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">101631408</subfield><subfield code="2">DNLM</subfield></datafield><datafield tag="019" ind1=" " ind2=" "><subfield code="a">872152405</subfield><subfield code="a">877447375</subfield><subfield code="a">880451287</subfield><subfield code="a">961580171</subfield><subfield code="a">1055319227</subfield><subfield code="a">1066002014</subfield><subfield code="a">1081281526</subfield><subfield code="a">1156361794</subfield><subfield code="a">1228542426</subfield><subfield code="a">1249215970</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780309288866</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">030928886X</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780309288873</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0309288878</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)881019388</subfield><subfield code="z">(OCoLC)872152405</subfield><subfield code="z">(OCoLC)877447375</subfield><subfield code="z">(OCoLC)880451287</subfield><subfield code="z">(OCoLC)961580171</subfield><subfield code="z">(OCoLC)1055319227</subfield><subfield code="z">(OCoLC)1066002014</subfield><subfield code="z">(OCoLC)1081281526</subfield><subfield code="z">(OCoLC)1156361794</subfield><subfield code="z">(OCoLC)1228542426</subfield><subfield code="z">(OCoLC)1249215970</subfield></datafield><datafield tag="042" ind1=" " ind2=" "><subfield code="a">pcc</subfield></datafield><datafield tag="043" ind1=" " ind2=" "><subfield code="a">n-us---</subfield><subfield code="a">a-vt---</subfield></datafield><datafield tag="050" ind1=" " ind2="4"><subfield code="a">RA1270.T44</subfield><subfield code="b">I57 2014</subfield></datafield><datafield tag="060" ind1=" " ind2="4"><subfield code="a">WA 240</subfield></datafield><datafield tag="072" ind1=" " ind2="7"><subfield code="a">HIS</subfield><subfield code="x">048000</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="082" ind1="7" ind2=" "><subfield code="a">615.9/5137</subfield><subfield code="2">22</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">MAIN</subfield></datafield><datafield tag="110" ind1="2" ind2=" "><subfield code="a">Institute of Medicine (U.S.).</subfield><subfield code="b">Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides,</subfield><subfield code="e">author,</subfield><subfield code="e">issuing body.</subfield><subfield code="0">http://id.loc.gov/authorities/names/n93803281</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Veterans and Agent Orange :</subfield><subfield code="b">update 2012 /</subfield><subfield code="c">Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update), Board on the Health of Select Populations, Institute of Medicine.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Washington (DC) :</subfield><subfield code="b">National Academies Press (US),</subfield><subfield code="c">2014.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (1 PDF file (xix, 986 pages))</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Title from PDF title page.</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences (NAS) was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations are conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 2012 reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010--September 2012 and integrates this information with the previously established evidence database. This report considers whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiological methods used to detect the association; the increased risk of disease among those exposed to herbicides during service in the Republic of Vietnam during the Vietnam era; and whether there exists a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease.</subfield></datafield><datafield tag="536" ind1=" " ind2=" "><subfield code="a">This study was supported by Contract/Grant No. VA241-P-2024 between the National Academy of Sciences and the US Department of Veterans Affairs. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project.</subfield></datafield><datafield tag="588" ind1="0" ind2=" "><subfield code="a">Version viewed June 2, 2014.</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">Summary -- 1. Introduction -- 2. Evaluating the evidence -- 3. Exposure to the herbicides used in Vietnam -- 4. Information related to biologic plausibility -- 5. Epidemiologic studies: compendium of new publications -- 6. Epidemiologic studies: background on multiply referenced populations -- 7. Immune-system disorders -- 8. Cancer -- 9. Fertility and gestational outcomes -- 10. Effects on future generations -- 11. Neurologic disorders -- 12. Cardiovascular and metabolic outcomes -- 13. Other chronic health outcomes -- 14. Conclusions and recommendations -- Appendix A: Issues raised by the public and agendas of public meetings held by the Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and other written submissions to the Committee -- Appendix B: Short-term adverse health responses -- Appendix C: Clarification of cancer groupings used in reporting results, with correspondence to National Institute for Occupational Safety and Health and health cause-of-death codes and international classification of diseases codes for cancers -- Appendix D: Biographies of Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and staff.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Agent Orange</subfield><subfield code="x">Toxicology.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Vietnam War, 1961-1975</subfield><subfield code="x">Veterans</subfield><subfield code="x">Health aspects.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Vietnam War, 1961-1975</subfield><subfield code="x">Veterans</subfield><subfield code="x">Diseases.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Herbicides</subfield><subfield code="x">Toxicology.</subfield><subfield code="0">http://id.loc.gov/authorities/subjects/sh85060345</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Epidemiology.</subfield><subfield code="0">http://id.loc.gov/authorities/subjects/sh85044373</subfield></datafield><datafield tag="650" ind1="1" ind2="2"><subfield code="a">Polychlorinated Dibenzodioxins</subfield><subfield code="x">adverse effects</subfield></datafield><datafield tag="650" ind1=" " ind2="2"><subfield code="a">Epidemiology</subfield><subfield code="0">https://id.nlm.nih.gov/mesh/D004813</subfield></datafield><datafield tag="650" ind1="2" ind2="2"><subfield code="a">Defoliants, Chemical</subfield><subfield code="x">adverse effects</subfield></datafield><datafield tag="650" ind1="2" ind2="2"><subfield code="a">Occupational Exposure</subfield></datafield><datafield tag="650" ind1="2" ind2="2"><subfield code="a">Veterans Health</subfield></datafield><datafield tag="650" ind1="2" ind2="2"><subfield code="a">Vietnam Conflict</subfield></datafield><datafield tag="651" ind1=" " ind2="2"><subfield code="a">United States</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Agent Orange</subfield><subfield code="x">Toxicologie.</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Guerre du Viêt-nam, 1961-1975</subfield><subfield code="x">Anciens combattants</subfield><subfield code="x">Maladies.</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Herbicides</subfield><subfield code="x">Toxicologie.</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Épidémiologie.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL</subfield><subfield code="x">Toxicology.</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Veterans</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Herbicides</subfield><subfield code="x">Toxicology</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Epidemiology</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Diseases</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Agent Orange</subfield><subfield code="x">Health aspects</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Agent Orange</subfield><subfield code="x">Toxicology</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Veterans</subfield><subfield code="x">Health risk assessment</subfield><subfield code="2">fast</subfield></datafield><datafield tag="651" ind1=" " ind2="7"><subfield code="a">United States</subfield><subfield code="2">fast</subfield><subfield code="1">https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq</subfield></datafield><datafield tag="647" ind1=" " ind2="7"><subfield code="a">Vietnam War</subfield><subfield code="d">(1961-1975)</subfield><subfield code="2">fast</subfield><subfield code="1">https://id.oclc.org/worldcat/entity/E39Qhp4vB9HVwcPb3whDTtrg7b</subfield></datafield><datafield tag="648" ind1=" " ind2="7"><subfield code="a">1961-1975</subfield><subfield code="2">fast</subfield></datafield><datafield tag="710" ind1="2" ind2=" "><subfield code="a">Institute of Medicine (U.S.).</subfield><subfield code="b">Board on the Health of Select Populations.</subfield><subfield code="0">http://id.loc.gov/authorities/names/no2010177267</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Print version:</subfield><subfield code="a">Institute of Medicine (U.S.) Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides.</subfield><subfield code="t">Veterans and agent orange.</subfield><subfield code="d">Washington, D.C. : National Academies Press, [2014]</subfield><subfield code="z">030928886X</subfield><subfield code="w">(OCoLC)866096687</subfield></datafield><datafield tag="966" ind1="4" ind2="0"><subfield code="l">DE-862</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FWS_PDA_EBA</subfield><subfield code="u">https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=867988</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="4" ind2="0"><subfield code="l">DE-863</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FWS_PDA_EBA</subfield><subfield code="u">https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=867988</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">Askews and Holts Library Services</subfield><subfield code="b">ASKH</subfield><subfield code="n">AH36561434</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">Askews and Holts Library Services</subfield><subfield code="b">ASKH</subfield><subfield code="n">AH36617790</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">EBL - Ebook Library</subfield><subfield code="b">EBLB</subfield><subfield code="n">EBL3564288</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">ebrary</subfield><subfield code="b">EBRY</subfield><subfield code="n">ebr10863759</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">EBSCOhost</subfield><subfield code="b">EBSC</subfield><subfield code="n">867988</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">YBP Library Services</subfield><subfield code="b">YANK</subfield><subfield code="n">11864864</subfield></datafield><datafield tag="994" ind1=" " ind2=" "><subfield code="a">92</subfield><subfield code="b">GEBAY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-4-EBA</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-862</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-863</subfield></datafield></record></collection> |
| geographic | United States United States fast https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq |
| geographic_facet | United States |
| id | ZDB-4-EBA-ocn881019388 |
| illustrated | Not Illustrated |
| indexdate | 2025-04-11T08:42:02Z |
| institution | BVB |
| institution_GND | http://id.loc.gov/authorities/names/n93803281 http://id.loc.gov/authorities/names/no2010177267 |
| isbn | 9780309288866 030928886X 9780309288873 0309288878 |
| language | English |
| oclc_num | 881019388 |
| open_access_boolean | |
| owner | MAIN DE-862 DE-BY-FWS DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-862 DE-BY-FWS DE-863 DE-BY-FWS |
| physical | 1 online resource (1 PDF file (xix, 986 pages)) |
| psigel | ZDB-4-EBA FWS_PDA_EBA ZDB-4-EBA |
| publishDate | 2014 |
| publishDateSearch | 2014 |
| publishDateSort | 2014 |
| publisher | National Academies Press (US), |
| record_format | marc |
| spelling | Institute of Medicine (U.S.). Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, author, issuing body. http://id.loc.gov/authorities/names/n93803281 Veterans and Agent Orange : update 2012 / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update), Board on the Health of Select Populations, Institute of Medicine. Washington (DC) : National Academies Press (US), 2014. 1 online resource (1 PDF file (xix, 986 pages)) text txt rdacontent computer c rdamedia online resource cr rdacarrier Title from PDF title page. Includes bibliographical references. From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences (NAS) was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations are conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 2012 reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010--September 2012 and integrates this information with the previously established evidence database. This report considers whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiological methods used to detect the association; the increased risk of disease among those exposed to herbicides during service in the Republic of Vietnam during the Vietnam era; and whether there exists a plausible biological mechanism or other evidence of a causal relationship between herbicide exposure and the disease. This study was supported by Contract/Grant No. VA241-P-2024 between the National Academy of Sciences and the US Department of Veterans Affairs. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project. Version viewed June 2, 2014. Summary -- 1. Introduction -- 2. Evaluating the evidence -- 3. Exposure to the herbicides used in Vietnam -- 4. Information related to biologic plausibility -- 5. Epidemiologic studies: compendium of new publications -- 6. Epidemiologic studies: background on multiply referenced populations -- 7. Immune-system disorders -- 8. Cancer -- 9. Fertility and gestational outcomes -- 10. Effects on future generations -- 11. Neurologic disorders -- 12. Cardiovascular and metabolic outcomes -- 13. Other chronic health outcomes -- 14. Conclusions and recommendations -- Appendix A: Issues raised by the public and agendas of public meetings held by the Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and other written submissions to the Committee -- Appendix B: Short-term adverse health responses -- Appendix C: Clarification of cancer groupings used in reporting results, with correspondence to National Institute for Occupational Safety and Health and health cause-of-death codes and international classification of diseases codes for cancers -- Appendix D: Biographies of Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and staff. Agent Orange Toxicology. Vietnam War, 1961-1975 Veterans Health aspects. Vietnam War, 1961-1975 Veterans Diseases. Herbicides Toxicology. http://id.loc.gov/authorities/subjects/sh85060345 Epidemiology. http://id.loc.gov/authorities/subjects/sh85044373 Polychlorinated Dibenzodioxins adverse effects Epidemiology https://id.nlm.nih.gov/mesh/D004813 Defoliants, Chemical adverse effects Occupational Exposure Veterans Health Vietnam Conflict United States Agent Orange Toxicologie. Guerre du Viêt-nam, 1961-1975 Anciens combattants Maladies. Herbicides Toxicologie. Épidémiologie. MEDICAL Toxicology. bisacsh Veterans fast Herbicides Toxicology fast Epidemiology fast Diseases fast Agent Orange Health aspects fast Agent Orange Toxicology fast Veterans Health risk assessment fast United States fast https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq Vietnam War (1961-1975) fast https://id.oclc.org/worldcat/entity/E39Qhp4vB9HVwcPb3whDTtrg7b 1961-1975 fast Institute of Medicine (U.S.). Board on the Health of Select Populations. http://id.loc.gov/authorities/names/no2010177267 Print version: Institute of Medicine (U.S.) Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides. Veterans and agent orange. Washington, D.C. : National Academies Press, [2014] 030928886X (OCoLC)866096687 |
| spellingShingle | Veterans and Agent Orange : update 2012 / Summary -- 1. Introduction -- 2. Evaluating the evidence -- 3. Exposure to the herbicides used in Vietnam -- 4. Information related to biologic plausibility -- 5. Epidemiologic studies: compendium of new publications -- 6. Epidemiologic studies: background on multiply referenced populations -- 7. Immune-system disorders -- 8. Cancer -- 9. Fertility and gestational outcomes -- 10. Effects on future generations -- 11. Neurologic disorders -- 12. Cardiovascular and metabolic outcomes -- 13. Other chronic health outcomes -- 14. Conclusions and recommendations -- Appendix A: Issues raised by the public and agendas of public meetings held by the Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and other written submissions to the Committee -- Appendix B: Short-term adverse health responses -- Appendix C: Clarification of cancer groupings used in reporting results, with correspondence to National Institute for Occupational Safety and Health and health cause-of-death codes and international classification of diseases codes for cancers -- Appendix D: Biographies of Commitee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update) and staff. Agent Orange Toxicology. Vietnam War, 1961-1975 Veterans Health aspects. Vietnam War, 1961-1975 Veterans Diseases. Herbicides Toxicology. http://id.loc.gov/authorities/subjects/sh85060345 Epidemiology. http://id.loc.gov/authorities/subjects/sh85044373 Polychlorinated Dibenzodioxins adverse effects Epidemiology https://id.nlm.nih.gov/mesh/D004813 Defoliants, Chemical adverse effects Occupational Exposure Veterans Health Vietnam Conflict Agent Orange Toxicologie. Guerre du Viêt-nam, 1961-1975 Anciens combattants Maladies. Herbicides Toxicologie. Épidémiologie. MEDICAL Toxicology. bisacsh Veterans fast Herbicides Toxicology fast Epidemiology fast Diseases fast Agent Orange Health aspects fast Agent Orange Toxicology fast Veterans Health risk assessment fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85060345 http://id.loc.gov/authorities/subjects/sh85044373 https://id.nlm.nih.gov/mesh/D004813 |
| title | Veterans and Agent Orange : update 2012 / |
| title_auth | Veterans and Agent Orange : update 2012 / |
| title_exact_search | Veterans and Agent Orange : update 2012 / |
| title_full | Veterans and Agent Orange : update 2012 / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update), Board on the Health of Select Populations, Institute of Medicine. |
| title_fullStr | Veterans and Agent Orange : update 2012 / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update), Board on the Health of Select Populations, Institute of Medicine. |
| title_full_unstemmed | Veterans and Agent Orange : update 2012 / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update), Board on the Health of Select Populations, Institute of Medicine. |
| title_short | Veterans and Agent Orange : |
| title_sort | veterans and agent orange update 2012 |
| title_sub | update 2012 / |
| topic | Agent Orange Toxicology. Vietnam War, 1961-1975 Veterans Health aspects. Vietnam War, 1961-1975 Veterans Diseases. Herbicides Toxicology. http://id.loc.gov/authorities/subjects/sh85060345 Epidemiology. http://id.loc.gov/authorities/subjects/sh85044373 Polychlorinated Dibenzodioxins adverse effects Epidemiology https://id.nlm.nih.gov/mesh/D004813 Defoliants, Chemical adverse effects Occupational Exposure Veterans Health Vietnam Conflict Agent Orange Toxicologie. Guerre du Viêt-nam, 1961-1975 Anciens combattants Maladies. Herbicides Toxicologie. Épidémiologie. MEDICAL Toxicology. bisacsh Veterans fast Herbicides Toxicology fast Epidemiology fast Diseases fast Agent Orange Health aspects fast Agent Orange Toxicology fast Veterans Health risk assessment fast |
| topic_facet | Agent Orange Toxicology. Vietnam War, 1961-1975 Veterans Health aspects. Vietnam War, 1961-1975 Veterans Diseases. Herbicides Toxicology. Epidemiology. Polychlorinated Dibenzodioxins adverse effects Epidemiology Defoliants, Chemical adverse effects Occupational Exposure Veterans Health Vietnam Conflict United States Agent Orange Toxicologie. Guerre du Viêt-nam, 1961-1975 Anciens combattants Maladies. Herbicides Toxicologie. Épidémiologie. MEDICAL Toxicology. Veterans Herbicides Toxicology Diseases Agent Orange Health aspects Agent Orange Toxicology Veterans Health risk assessment |
| work_keys_str_mv | AT instituteofmedicineuscommitteetoreviewthehealtheffectsinvietnamveteransofexposuretoherbicides veteransandagentorangeupdate2012 AT instituteofmedicineusboardonthehealthofselectpopulations veteransandagentorangeupdate2012 |