Robustness and evolvability in living systems /:
All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Princeton, N.J. ; Woodstock :
Princeton University Press,
2007.
|
| Schriftenreihe: | Princeton studies in complexity.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations. |
| Beschreibung: | Originally published: 2005. |
| Beschreibung: | 1 online resource |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9781400849383 1400849381 |
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| 245 | 1 | 0 | |a Robustness and evolvability in living systems / |c Andreas Wagner. |
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| 505 | 0 | 0 | |t Frontmatter -- |t Contents -- |t Figures -- |t Acknowledgments -- |t 1. Introduction -- |t 2. The Genetic Alphabet -- |t 3. The Genetic Code -- |t 4. RNA Structure -- |t 5. Proteins and Point Mutations -- |t 6. Proteins and Recombination -- |t 7. Regulatory DNA Regions and Their Reorganization in Evolution -- |t 8. Metabolic Pathways -- |t 9. Metabolic Networks -- |t 10. Drosophila Segmentation and Other Gene Regulatory Networks -- |t 11. Phenotypic Traits, Cryptic Variation, and Human Diseases -- |t 12. The Many Ways of Building the Same Body -- |t 13. Neutral Spaces -- |t 14. Evolvability and Neutral Mutations -- |t 15. Redundancy of Parts or Distributed Robustness? -- |t 16. Robustness as an Evolved Adaptation to Mutations -- |t 17. Robustness as an Evolved Adaptation to Environmental Change and Noise -- |t 18. Robustness and Fragility: Advantages to Variation and Trade-offs -- |t 19. Robustness in Natural Systems and Self-Organization -- |t 20. Robustness in Man-made Systems -- |t Epilogue: Seven Open Questions for Systems Biology -- |t Bibliography -- |t Index. |
| 520 | |a All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations. | ||
| 546 | |a In English. | ||
| 650 | 0 | |a Molecular evolution. |0 http://id.loc.gov/authorities/subjects/sh85022912 | |
| 650 | 0 | |a Mutation (Biology) |0 http://id.loc.gov/authorities/subjects/sh85089128 | |
| 650 | 0 | |a Robust control. |0 http://id.loc.gov/authorities/subjects/sh99013330 | |
| 650 | 2 | |a Evolution, Molecular |0 https://id.nlm.nih.gov/mesh/D019143 | |
| 650 | 2 | |a Mutation |0 https://id.nlm.nih.gov/mesh/D009154 | |
| 650 | 6 | |a Évolution moléculaire. | |
| 650 | 6 | |a Mutation (Biologie) | |
| 650 | 6 | |a Commande robuste. | |
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| 650 | 7 | |a Molecular evolution |2 fast | |
| 650 | 7 | |a Mutation (Biology) |2 fast | |
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| 650 | 7 | |a Stabilität |2 gnd |0 http://d-nb.info/gnd/4056693-6 | |
| 776 | 0 | 8 | |i Print version: |a Wagner, Andreas, 1967 January 26- |t Robustness and evolvability in living systems |z 9780691134048 |w (OCoLC)132299281 |
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| contents | Frontmatter -- Contents -- Figures -- Acknowledgments -- 1. Introduction -- 2. The Genetic Alphabet -- 3. The Genetic Code -- 4. RNA Structure -- 5. Proteins and Point Mutations -- 6. Proteins and Recombination -- 7. Regulatory DNA Regions and Their Reorganization in Evolution -- 8. Metabolic Pathways -- 9. Metabolic Networks -- 10. Drosophila Segmentation and Other Gene Regulatory Networks -- 11. Phenotypic Traits, Cryptic Variation, and Human Diseases -- 12. The Many Ways of Building the Same Body -- 13. Neutral Spaces -- 14. Evolvability and Neutral Mutations -- 15. Redundancy of Parts or Distributed Robustness? -- 16. Robustness as an Evolved Adaptation to Mutations -- 17. Robustness as an Evolved Adaptation to Environmental Change and Noise -- 18. Robustness and Fragility: Advantages to Variation and Trade-offs -- 19. Robustness in Natural Systems and Self-Organization -- 20. Robustness in Man-made Systems -- Epilogue: Seven Open Questions for Systems Biology -- Bibliography -- Index. |
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| id | ZDB-4-EBA-ocn861199758 |
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| indexdate | 2024-11-27T13:25:35Z |
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| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource |
| psigel | ZDB-4-EBA |
| publishDate | 2007 |
| publishDateSearch | 2005 2007 |
| publishDateSort | 2007 |
| publisher | Princeton University Press, |
| record_format | marc |
| series | Princeton studies in complexity. |
| series2 | Princeton studies in complexity |
| spelling | Wagner, Andreas, 1967 January 26- https://id.oclc.org/worldcat/entity/E39PBJbCRrWTbvyfT4K8kXymVC http://id.loc.gov/authorities/names/n2003017138 Robustness and evolvability in living systems / Andreas Wagner. Princeton, N.J. ; Woodstock : Princeton University Press, 2007. 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier text file Princeton studies in complexity Originally published: 2005. Includes bibliographical references and index. Print version record. Frontmatter -- Contents -- Figures -- Acknowledgments -- 1. Introduction -- 2. The Genetic Alphabet -- 3. The Genetic Code -- 4. RNA Structure -- 5. Proteins and Point Mutations -- 6. Proteins and Recombination -- 7. Regulatory DNA Regions and Their Reorganization in Evolution -- 8. Metabolic Pathways -- 9. Metabolic Networks -- 10. Drosophila Segmentation and Other Gene Regulatory Networks -- 11. Phenotypic Traits, Cryptic Variation, and Human Diseases -- 12. The Many Ways of Building the Same Body -- 13. Neutral Spaces -- 14. Evolvability and Neutral Mutations -- 15. Redundancy of Parts or Distributed Robustness? -- 16. Robustness as an Evolved Adaptation to Mutations -- 17. Robustness as an Evolved Adaptation to Environmental Change and Noise -- 18. Robustness and Fragility: Advantages to Variation and Trade-offs -- 19. Robustness in Natural Systems and Self-Organization -- 20. Robustness in Man-made Systems -- Epilogue: Seven Open Questions for Systems Biology -- Bibliography -- Index. All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations. In English. Molecular evolution. http://id.loc.gov/authorities/subjects/sh85022912 Mutation (Biology) http://id.loc.gov/authorities/subjects/sh85089128 Robust control. http://id.loc.gov/authorities/subjects/sh99013330 Evolution, Molecular https://id.nlm.nih.gov/mesh/D019143 Mutation https://id.nlm.nih.gov/mesh/D009154 Évolution moléculaire. Mutation (Biologie) Commande robuste. SCIENCE Life Sciences Biochemistry. bisacsh SCIENCE Life Sciences Developmental Biology. bisacsh Molecular evolution fast Mutation (Biology) fast Robust control fast Biologisches System gnd http://d-nb.info/gnd/4122930-7 Evolution gnd http://d-nb.info/gnd/4071050-6 Molekulare Evolution gnd http://d-nb.info/gnd/4812902-1 Stabilität gnd http://d-nb.info/gnd/4056693-6 Print version: Wagner, Andreas, 1967 January 26- Robustness and evolvability in living systems 9780691134048 (OCoLC)132299281 Princeton studies in complexity. http://id.loc.gov/authorities/names/n96109405 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=644650 Volltext |
| spellingShingle | Wagner, Andreas, 1967 January 26- Robustness and evolvability in living systems / Princeton studies in complexity. Frontmatter -- Contents -- Figures -- Acknowledgments -- 1. Introduction -- 2. The Genetic Alphabet -- 3. The Genetic Code -- 4. RNA Structure -- 5. Proteins and Point Mutations -- 6. Proteins and Recombination -- 7. Regulatory DNA Regions and Their Reorganization in Evolution -- 8. Metabolic Pathways -- 9. Metabolic Networks -- 10. Drosophila Segmentation and Other Gene Regulatory Networks -- 11. Phenotypic Traits, Cryptic Variation, and Human Diseases -- 12. The Many Ways of Building the Same Body -- 13. Neutral Spaces -- 14. Evolvability and Neutral Mutations -- 15. Redundancy of Parts or Distributed Robustness? -- 16. Robustness as an Evolved Adaptation to Mutations -- 17. Robustness as an Evolved Adaptation to Environmental Change and Noise -- 18. Robustness and Fragility: Advantages to Variation and Trade-offs -- 19. Robustness in Natural Systems and Self-Organization -- 20. Robustness in Man-made Systems -- Epilogue: Seven Open Questions for Systems Biology -- Bibliography -- Index. Molecular evolution. http://id.loc.gov/authorities/subjects/sh85022912 Mutation (Biology) http://id.loc.gov/authorities/subjects/sh85089128 Robust control. http://id.loc.gov/authorities/subjects/sh99013330 Evolution, Molecular https://id.nlm.nih.gov/mesh/D019143 Mutation https://id.nlm.nih.gov/mesh/D009154 Évolution moléculaire. Mutation (Biologie) Commande robuste. SCIENCE Life Sciences Biochemistry. bisacsh SCIENCE Life Sciences Developmental Biology. bisacsh Molecular evolution fast Mutation (Biology) fast Robust control fast Biologisches System gnd http://d-nb.info/gnd/4122930-7 Evolution gnd http://d-nb.info/gnd/4071050-6 Molekulare Evolution gnd http://d-nb.info/gnd/4812902-1 Stabilität gnd http://d-nb.info/gnd/4056693-6 |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85022912 http://id.loc.gov/authorities/subjects/sh85089128 http://id.loc.gov/authorities/subjects/sh99013330 https://id.nlm.nih.gov/mesh/D019143 https://id.nlm.nih.gov/mesh/D009154 http://d-nb.info/gnd/4122930-7 http://d-nb.info/gnd/4071050-6 http://d-nb.info/gnd/4812902-1 http://d-nb.info/gnd/4056693-6 |
| title | Robustness and evolvability in living systems / |
| title_alt | Frontmatter -- Contents -- Figures -- Acknowledgments -- 1. Introduction -- 2. The Genetic Alphabet -- 3. The Genetic Code -- 4. RNA Structure -- 5. Proteins and Point Mutations -- 6. Proteins and Recombination -- 7. Regulatory DNA Regions and Their Reorganization in Evolution -- 8. Metabolic Pathways -- 9. Metabolic Networks -- 10. Drosophila Segmentation and Other Gene Regulatory Networks -- 11. Phenotypic Traits, Cryptic Variation, and Human Diseases -- 12. The Many Ways of Building the Same Body -- 13. Neutral Spaces -- 14. Evolvability and Neutral Mutations -- 15. Redundancy of Parts or Distributed Robustness? -- 16. Robustness as an Evolved Adaptation to Mutations -- 17. Robustness as an Evolved Adaptation to Environmental Change and Noise -- 18. Robustness and Fragility: Advantages to Variation and Trade-offs -- 19. Robustness in Natural Systems and Self-Organization -- 20. Robustness in Man-made Systems -- Epilogue: Seven Open Questions for Systems Biology -- Bibliography -- Index. |
| title_auth | Robustness and evolvability in living systems / |
| title_exact_search | Robustness and evolvability in living systems / |
| title_full | Robustness and evolvability in living systems / Andreas Wagner. |
| title_fullStr | Robustness and evolvability in living systems / Andreas Wagner. |
| title_full_unstemmed | Robustness and evolvability in living systems / Andreas Wagner. |
| title_short | Robustness and evolvability in living systems / |
| title_sort | robustness and evolvability in living systems |
| topic | Molecular evolution. http://id.loc.gov/authorities/subjects/sh85022912 Mutation (Biology) http://id.loc.gov/authorities/subjects/sh85089128 Robust control. http://id.loc.gov/authorities/subjects/sh99013330 Evolution, Molecular https://id.nlm.nih.gov/mesh/D019143 Mutation https://id.nlm.nih.gov/mesh/D009154 Évolution moléculaire. Mutation (Biologie) Commande robuste. SCIENCE Life Sciences Biochemistry. bisacsh SCIENCE Life Sciences Developmental Biology. bisacsh Molecular evolution fast Mutation (Biology) fast Robust control fast Biologisches System gnd http://d-nb.info/gnd/4122930-7 Evolution gnd http://d-nb.info/gnd/4071050-6 Molekulare Evolution gnd http://d-nb.info/gnd/4812902-1 Stabilität gnd http://d-nb.info/gnd/4056693-6 |
| topic_facet | Molecular evolution. Mutation (Biology) Robust control. Evolution, Molecular Mutation Évolution moléculaire. Mutation (Biologie) Commande robuste. SCIENCE Life Sciences Biochemistry. SCIENCE Life Sciences Developmental Biology. Molecular evolution Robust control Biologisches System Evolution Molekulare Evolution Stabilität |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=644650 |
| work_keys_str_mv | AT wagnerandreas robustnessandevolvabilityinlivingsystems |