A Mathematical Approach to Multilevel, Multiscale Health Interventions :: Pharmaceutical Industry Decline and Policy Response.
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States -...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Weitere Verfasser: | |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Singapore :
World Scientific Publishing Company,
2013.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing. The book adapts formalism across a number of disciplines to the strategy for design of mu. |
| Beschreibung: | 1 online resource (238 pages) |
| Bibliographie: | Includes bibliographical references (pages 207-222) and index. |
| ISBN: | 9781848169975 1848169973 |
Internformat
MARC
| LEADER | 00000cam a2200000Mi 4500 | ||
|---|---|---|---|
| 001 | ZDB-4-EBA-ocn841913830 | ||
| 003 | OCoLC | ||
| 005 | 20241004212047.0 | ||
| 006 | m o d | ||
| 007 | cr |n|---||||| | ||
| 008 | 130418s2013 si ob 001 0 eng d | ||
| 040 | |a MHW |b eng |e pn |c MHW |d CDX |d YDXCP |d N$T |d IDEBK |d STF |d E7B |d OCLCF |d GGVRL |d OCLCQ |d OCLCO |d NKT |d OCLCQ |d ICA |d AGLDB |d ZCU |d MERUC |d OCLCQ |d VTS |d OCLCA |d ICG |d OCLCQ |d DKC |d AU@ |d OCLCQ |d UKAHL |d OCLCQ |d AJS |d OCLCO |d OCLCQ |d OCLCO |d OCLCL | ||
| 019 | |a 838790821 |a 840466710 | ||
| 020 | |a 9781848169975 | ||
| 020 | |a 1848169973 | ||
| 020 | |z 1848169965 | ||
| 020 | |z 9781848169968 | ||
| 020 | |z 9781299462168 | ||
| 020 | |z 1299462162 | ||
| 035 | |a (OCoLC)841913830 |z (OCoLC)838790821 |z (OCoLC)840466710 | ||
| 037 | |a 477466 |b MIL | ||
| 043 | |a n-us--- | ||
| 050 | 4 | |a RM301.25 .W35 2013 | |
| 072 | 7 | |a BUS |x 070130 |2 bisacsh | |
| 082 | 7 | |a 362.1015118 |a 615.5/80151 |a 615.580151 | |
| 049 | |a MAIN | ||
| 100 | 1 | |a Wallace, Rodrick. | |
| 245 | 1 | 2 | |a A Mathematical Approach to Multilevel, Multiscale Health Interventions : |b Pharmaceutical Industry Decline and Policy Response. |
| 260 | |a Singapore : |b World Scientific Publishing Company, |c 2013. | ||
| 300 | |a 1 online resource (238 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing. The book adapts formalism across a number of disciplines to the strategy for design of mu. | ||
| 504 | |a Includes bibliographical references (pages 207-222) and index. | ||
| 505 | 0 | |a 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations. | |
| 650 | 0 | |a Pharmaceutical industry |z United States. | |
| 650 | 0 | |a Pharmaceutical industry |x Economic aspects |z United States. | |
| 650 | 0 | |a Pharmaceutical industry |x Government policy |z United States. | |
| 650 | 6 | |a Industrie pharmaceutique |z États-Unis. | |
| 650 | 6 | |a Industrie pharmaceutique |x Aspect économique |z États-Unis. | |
| 650 | 6 | |a Industrie pharmaceutique |x Politique gouvernementale |z États-Unis. | |
| 650 | 7 | |a BUSINESS & ECONOMICS |x Industries |x Pharmaceutical & Biotechnology. |2 bisacsh | |
| 650 | 7 | |a Pharmaceutical industry |2 fast | |
| 650 | 7 | |a Pharmaceutical industry |x Economic aspects |2 fast | |
| 650 | 7 | |a Pharmaceutical industry |x Government policy |2 fast | |
| 651 | 7 | |a United States |2 fast |1 https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq | |
| 700 | 1 | |a Wallace, Deborah. | |
| 758 | |i has work: |a Mathematical Approach to Multilevel, Multiscale Health Interventions (Text) |1 https://id.oclc.org/worldcat/entity/E39PCXD3M6PrMdFp6PMB8rFqHy |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |z 9781848169968 |
| 856 | 4 | 0 | |l FWS01 |p ZDB-4-EBA |q FWS_PDA_EBA |u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=564487 |3 Volltext |
| 938 | |a Askews and Holts Library Services |b ASKH |n AH25070710 | ||
| 938 | |a Coutts Information Services |b COUT |n 25251127 | ||
| 938 | |a ebrary |b EBRY |n ebr10699110 | ||
| 938 | |a EBSCOhost |b EBSC |n 564487 | ||
| 938 | |a Cengage Learning |b GVRL |n GVRL8RIR | ||
| 938 | |a ProQuest MyiLibrary Digital eBook Collection |b IDEB |n cis25251127 | ||
| 938 | |a YBP Library Services |b YANK |n 10411678 | ||
| 994 | |a 92 |b GEBAY | ||
| 912 | |a ZDB-4-EBA | ||
| 049 | |a DE-863 | ||
Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-ocn841913830 |
|---|---|
| _version_ | 1816882231744921601 |
| adam_text | |
| any_adam_object | |
| author | Wallace, Rodrick |
| author2 | Wallace, Deborah |
| author2_role | |
| author2_variant | d w dw |
| author_facet | Wallace, Rodrick Wallace, Deborah |
| author_role | |
| author_sort | Wallace, Rodrick |
| author_variant | r w rw |
| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | R - Medicine |
| callnumber-label | RM301 |
| callnumber-raw | RM301.25 .W35 2013 |
| callnumber-search | RM301.25 .W35 2013 |
| callnumber-sort | RM 3301.25 W35 42013 |
| callnumber-subject | RM - Therapeutics and Pharmacology |
| collection | ZDB-4-EBA |
| contents | 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations. |
| ctrlnum | (OCoLC)841913830 |
| dewey-full | 362.1015118 615.5/80151 615.580151 |
| dewey-hundreds | 300 - Social sciences 600 - Technology (Applied sciences) |
| dewey-ones | 362 - Social problems and services to groups 615 - Pharmacology and therapeutics |
| dewey-raw | 362.1015118 615.5/80151 615.580151 |
| dewey-search | 362.1015118 615.5/80151 615.580151 |
| dewey-sort | 3362.1015118 |
| dewey-tens | 360 - Social problems and services; associations 610 - Medicine and health |
| discipline | Soziologie |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>05898cam a2200685Mi 4500</leader><controlfield tag="001">ZDB-4-EBA-ocn841913830</controlfield><controlfield tag="003">OCoLC</controlfield><controlfield tag="005">20241004212047.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr |n|---|||||</controlfield><controlfield tag="008">130418s2013 si ob 001 0 eng d</controlfield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">MHW</subfield><subfield code="b">eng</subfield><subfield code="e">pn</subfield><subfield code="c">MHW</subfield><subfield code="d">CDX</subfield><subfield code="d">YDXCP</subfield><subfield code="d">N$T</subfield><subfield code="d">IDEBK</subfield><subfield code="d">STF</subfield><subfield code="d">E7B</subfield><subfield code="d">OCLCF</subfield><subfield code="d">GGVRL</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">NKT</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">ICA</subfield><subfield code="d">AGLDB</subfield><subfield code="d">ZCU</subfield><subfield code="d">MERUC</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">VTS</subfield><subfield code="d">OCLCA</subfield><subfield code="d">ICG</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">DKC</subfield><subfield code="d">AU@</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">UKAHL</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">AJS</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCQ</subfield><subfield code="d">OCLCO</subfield><subfield code="d">OCLCL</subfield></datafield><datafield tag="019" ind1=" " ind2=" "><subfield code="a">838790821</subfield><subfield code="a">840466710</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781848169975</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1848169973</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="z">1848169965</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="z">9781848169968</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="z">9781299462168</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="z">1299462162</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)841913830</subfield><subfield code="z">(OCoLC)838790821</subfield><subfield code="z">(OCoLC)840466710</subfield></datafield><datafield tag="037" ind1=" " ind2=" "><subfield code="a">477466</subfield><subfield code="b">MIL</subfield></datafield><datafield tag="043" ind1=" " ind2=" "><subfield code="a">n-us---</subfield></datafield><datafield tag="050" ind1=" " ind2="4"><subfield code="a">RM301.25 .W35 2013</subfield></datafield><datafield tag="072" ind1=" " ind2="7"><subfield code="a">BUS</subfield><subfield code="x">070130</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="082" ind1="7" ind2=" "><subfield code="a">362.1015118</subfield><subfield code="a">615.5/80151</subfield><subfield code="a">615.580151</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">MAIN</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wallace, Rodrick.</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A Mathematical Approach to Multilevel, Multiscale Health Interventions :</subfield><subfield code="b">Pharmaceutical Industry Decline and Policy Response.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="a">Singapore :</subfield><subfield code="b">World Scientific Publishing Company,</subfield><subfield code="c">2013.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (238 pages)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="588" ind1="0" ind2=" "><subfield code="a">Print version record.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing. The book adapts formalism across a number of disciplines to the strategy for design of mu.</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references (pages 207-222) and index.</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Pharmaceutical industry</subfield><subfield code="z">United States.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Pharmaceutical industry</subfield><subfield code="x">Economic aspects</subfield><subfield code="z">United States.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Pharmaceutical industry</subfield><subfield code="x">Government policy</subfield><subfield code="z">United States.</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Industrie pharmaceutique</subfield><subfield code="z">États-Unis.</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Industrie pharmaceutique</subfield><subfield code="x">Aspect économique</subfield><subfield code="z">États-Unis.</subfield></datafield><datafield tag="650" ind1=" " ind2="6"><subfield code="a">Industrie pharmaceutique</subfield><subfield code="x">Politique gouvernementale</subfield><subfield code="z">États-Unis.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">BUSINESS & ECONOMICS</subfield><subfield code="x">Industries</subfield><subfield code="x">Pharmaceutical & Biotechnology.</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmaceutical industry</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmaceutical industry</subfield><subfield code="x">Economic aspects</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmaceutical industry</subfield><subfield code="x">Government policy</subfield><subfield code="2">fast</subfield></datafield><datafield tag="651" ind1=" " ind2="7"><subfield code="a">United States</subfield><subfield code="2">fast</subfield><subfield code="1">https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wallace, Deborah.</subfield></datafield><datafield tag="758" ind1=" " ind2=" "><subfield code="i">has work:</subfield><subfield code="a">Mathematical Approach to Multilevel, Multiscale Health Interventions (Text)</subfield><subfield code="1">https://id.oclc.org/worldcat/entity/E39PCXD3M6PrMdFp6PMB8rFqHy</subfield><subfield code="4">https://id.oclc.org/worldcat/ontology/hasWork</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Print version:</subfield><subfield code="z">9781848169968</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="l">FWS01</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FWS_PDA_EBA</subfield><subfield code="u">https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=564487</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">Askews and Holts Library Services</subfield><subfield code="b">ASKH</subfield><subfield code="n">AH25070710</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">Coutts Information Services</subfield><subfield code="b">COUT</subfield><subfield code="n">25251127</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">ebrary</subfield><subfield code="b">EBRY</subfield><subfield code="n">ebr10699110</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">EBSCOhost</subfield><subfield code="b">EBSC</subfield><subfield code="n">564487</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">Cengage Learning</subfield><subfield code="b">GVRL</subfield><subfield code="n">GVRL8RIR</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">ProQuest MyiLibrary Digital eBook Collection</subfield><subfield code="b">IDEB</subfield><subfield code="n">cis25251127</subfield></datafield><datafield tag="938" ind1=" " ind2=" "><subfield code="a">YBP Library Services</subfield><subfield code="b">YANK</subfield><subfield code="n">10411678</subfield></datafield><datafield tag="994" ind1=" " ind2=" "><subfield code="a">92</subfield><subfield code="b">GEBAY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-4-EBA</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-863</subfield></datafield></record></collection> |
| geographic | United States fast https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq |
| geographic_facet | United States |
| id | ZDB-4-EBA-ocn841913830 |
| illustrated | Not Illustrated |
| indexdate | 2024-11-27T13:25:19Z |
| institution | BVB |
| isbn | 9781848169975 1848169973 |
| language | English |
| oclc_num | 841913830 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (238 pages) |
| psigel | ZDB-4-EBA |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | World Scientific Publishing Company, |
| record_format | marc |
| spelling | Wallace, Rodrick. A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. Singapore : World Scientific Publishing Company, 2013. 1 online resource (238 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Print version record. This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from 200 million in 1950 to 1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing. The book adapts formalism across a number of disciplines to the strategy for design of mu. Includes bibliographical references (pages 207-222) and index. 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations. Pharmaceutical industry United States. Pharmaceutical industry Economic aspects United States. Pharmaceutical industry Government policy United States. Industrie pharmaceutique États-Unis. Industrie pharmaceutique Aspect économique États-Unis. Industrie pharmaceutique Politique gouvernementale États-Unis. BUSINESS & ECONOMICS Industries Pharmaceutical & Biotechnology. bisacsh Pharmaceutical industry fast Pharmaceutical industry Economic aspects fast Pharmaceutical industry Government policy fast United States fast https://id.oclc.org/worldcat/entity/E39PBJtxgQXMWqmjMjjwXRHgrq Wallace, Deborah. has work: Mathematical Approach to Multilevel, Multiscale Health Interventions (Text) https://id.oclc.org/worldcat/entity/E39PCXD3M6PrMdFp6PMB8rFqHy https://id.oclc.org/worldcat/ontology/hasWork Print version: 9781848169968 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=564487 Volltext |
| spellingShingle | Wallace, Rodrick A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. 1. Beyond magic bullets. 1.1. The pharmaceutical catastrophe. 1.2. A new perspective. 1.3. Cognition as 'language'. 1.4. The human cognome -- 2. Expanding the theory. 2.1. No free lunch. 2.2. Multiple broadcasts, punctuated detection. 2.3. Metabolic constraints. 2.4. Environmental signals -- 3. Dynamic 'regression' models. 3.1. The simplest approach. 3.2. A rate distortion reformulation. 3.3. Multiple time scales. 3.4. Incoming information. 3.5. Pathologies. 3.6. Refining the model -- 4. An evolutionary excursion. 4.1. Introduction. 4.2. Ecosystems as information sources. 4.3. Genetic heritage. 4.4. Gene expression. 4.5. Interacting information sources. 4.6. Conclusions -- 5. Example: mental disorders. 5.1. Introduction. 5.2. Two classes. 5.3. Global broadcast models. 5.4. Gene expression. 5.5. Summary -- 6. Example: protein folding. 6.1. Introduction. 6.2. Spontaneous symmetry breaking. 6.3. A formal approach. 6.4. The energy picture. 6.5. The developmental picture. 6.6. A comprehensive treatment. 6.7. Aging and protein folding. 6.8. Summary -- 7. Example: glycome determinants. 7.1. Introduction. 7.2. Stochastic topology. 7.3. The glycomic conundrum. 7.4. Another cognitive paradigm. 7.5. Regulating glycan determinants. 7.6. Glycan spectra. 7.7. Summary -- 8. Example: glycan/lectin logic gates. 8.1. Introduction. 8.2. The critical exponent. 8.3. Two examples. 8.4. Information catalysis. 8.5. A tiling symmetry model. 8.6. Summary -- 9. Example: IDP logic gates. 9.1. Introduction. 9.2. Symbolic dynamics of molecular switching. 9.3. Another dual information source. 9.4. Information catalysis. 9.5. Summary -- 10. Treatment. 10.1. The generalized retina. 10.2. Therapeutic efficacy. 10.3. Psychosocial stress. 10.4. Flight, fight, and helplessness. 10.5. Institutions as niche construction. 10.6. The hall of mirrors. 10.7. Side effects reconsidered -- 11. History and health. 11.1. Malaria and the Fulani. 11.2. The American catastrophe -- 12. Beyond Glasperlenspiel -- 13. Mathematical appendix. 13.1. The tuning theorem. 13.2. The rate distortion theorem. 13.3. Stochastic differential equations. 13.4. Morse theory. 13.5. Groupoids. 13.6. 'Biological' renormalization. 13.7. Large deviations. Pharmaceutical industry United States. Pharmaceutical industry Economic aspects United States. Pharmaceutical industry Government policy United States. Industrie pharmaceutique États-Unis. Industrie pharmaceutique Aspect économique États-Unis. Industrie pharmaceutique Politique gouvernementale États-Unis. BUSINESS & ECONOMICS Industries Pharmaceutical & Biotechnology. bisacsh Pharmaceutical industry fast Pharmaceutical industry Economic aspects fast Pharmaceutical industry Government policy fast |
| title | A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. |
| title_auth | A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. |
| title_exact_search | A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. |
| title_full | A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. |
| title_fullStr | A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. |
| title_full_unstemmed | A Mathematical Approach to Multilevel, Multiscale Health Interventions : Pharmaceutical Industry Decline and Policy Response. |
| title_short | A Mathematical Approach to Multilevel, Multiscale Health Interventions : |
| title_sort | mathematical approach to multilevel multiscale health interventions pharmaceutical industry decline and policy response |
| title_sub | Pharmaceutical Industry Decline and Policy Response. |
| topic | Pharmaceutical industry United States. Pharmaceutical industry Economic aspects United States. Pharmaceutical industry Government policy United States. Industrie pharmaceutique États-Unis. Industrie pharmaceutique Aspect économique États-Unis. Industrie pharmaceutique Politique gouvernementale États-Unis. BUSINESS & ECONOMICS Industries Pharmaceutical & Biotechnology. bisacsh Pharmaceutical industry fast Pharmaceutical industry Economic aspects fast Pharmaceutical industry Government policy fast |
| topic_facet | Pharmaceutical industry United States. Pharmaceutical industry Economic aspects United States. Pharmaceutical industry Government policy United States. Industrie pharmaceutique États-Unis. Industrie pharmaceutique Aspect économique États-Unis. Industrie pharmaceutique Politique gouvernementale États-Unis. BUSINESS & ECONOMICS Industries Pharmaceutical & Biotechnology. Pharmaceutical industry Pharmaceutical industry Economic aspects Pharmaceutical industry Government policy United States |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=564487 |
| work_keys_str_mv | AT wallacerodrick amathematicalapproachtomultilevelmultiscalehealthinterventionspharmaceuticalindustrydeclineandpolicyresponse AT wallacedeborah amathematicalapproachtomultilevelmultiscalehealthinterventionspharmaceuticalindustrydeclineandpolicyresponse AT wallacerodrick mathematicalapproachtomultilevelmultiscalehealthinterventionspharmaceuticalindustrydeclineandpolicyresponse AT wallacedeborah mathematicalapproachtomultilevelmultiscalehealthinterventionspharmaceuticalindustrydeclineandpolicyresponse |