The clinibook :: clinical gene transfer : state of the art /
This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory is...
Gespeichert in:
| Weitere Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris :
EDP Sciences,
2012.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. |
| Beschreibung: | 1 online resource (xxxviii, 545 pages) : illustrations |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9782842542375 2842542371 2842541715 9782842541712 1299276822 9781299276826 |
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| 520 | |a This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. | ||
| 650 | 0 | |a Genetic transformation. |0 http://id.loc.gov/authorities/subjects/sh85053873 | |
| 650 | 0 | |a Genetic vectors. |0 http://id.loc.gov/authorities/subjects/sh85053875 | |
| 650 | 1 | 2 | |a Gene Transfer Techniques |
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| 650 | 2 | 2 | |a Genetic Therapy |x ethics |
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| 650 | 2 | 2 | |a Clinical Trials as Topic |
| 650 | 6 | |a Vecteurs de clonage. | |
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| spelling | The clinibook : clinical gene transfer : state of the art / edited by Odile Cohen-Haguenauer. Paris : EDP Sciences, 2012. 1 online resource (xxxviii, 545 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier data file rda Includes bibliographical references and index. pt. 1. Technologies and pre-clinical studies -- pt. 2. Clinical trials and regulatory issues. English. This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. Genetic transformation. http://id.loc.gov/authorities/subjects/sh85053873 Genetic vectors. http://id.loc.gov/authorities/subjects/sh85053875 Gene Transfer Techniques Genetic Therapy methods Genetic Therapy ethics Genetic Vectors Clinical Trials as Topic Vecteurs de clonage. SCIENCE Life Sciences Anatomy & Physiology. bisacsh Genetic vectors fast Genetic transformation fast Cohen-Haguenauer, Odile. http://id.loc.gov/authorities/names/n92037240 has work: The clinibook (Text) https://id.oclc.org/worldcat/entity/E39PCFM7drmTGMtY4F83QVm7d3 https://id.oclc.org/worldcat/ontology/hasWork Print version: Cohen-Haguenauer, Odile. Clinibook : Clinical gene transfer state of the art. Les Ulis : EDP Sciences, ©2011 9782842541712 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=555317 Volltext |
| spellingShingle | The clinibook : clinical gene transfer : state of the art / pt. 1. Technologies and pre-clinical studies -- pt. 2. Clinical trials and regulatory issues. Genetic transformation. http://id.loc.gov/authorities/subjects/sh85053873 Genetic vectors. http://id.loc.gov/authorities/subjects/sh85053875 Gene Transfer Techniques Genetic Therapy methods Genetic Therapy ethics Genetic Vectors Clinical Trials as Topic Vecteurs de clonage. SCIENCE Life Sciences Anatomy & Physiology. bisacsh Genetic vectors fast Genetic transformation fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85053873 http://id.loc.gov/authorities/subjects/sh85053875 |
| title | The clinibook : clinical gene transfer : state of the art / |
| title_auth | The clinibook : clinical gene transfer : state of the art / |
| title_exact_search | The clinibook : clinical gene transfer : state of the art / |
| title_full | The clinibook : clinical gene transfer : state of the art / edited by Odile Cohen-Haguenauer. |
| title_fullStr | The clinibook : clinical gene transfer : state of the art / edited by Odile Cohen-Haguenauer. |
| title_full_unstemmed | The clinibook : clinical gene transfer : state of the art / edited by Odile Cohen-Haguenauer. |
| title_short | The clinibook : |
| title_sort | clinibook clinical gene transfer state of the art |
| title_sub | clinical gene transfer : state of the art / |
| topic | Genetic transformation. http://id.loc.gov/authorities/subjects/sh85053873 Genetic vectors. http://id.loc.gov/authorities/subjects/sh85053875 Gene Transfer Techniques Genetic Therapy methods Genetic Therapy ethics Genetic Vectors Clinical Trials as Topic Vecteurs de clonage. SCIENCE Life Sciences Anatomy & Physiology. bisacsh Genetic vectors fast Genetic transformation fast |
| topic_facet | Genetic transformation. Genetic vectors. Gene Transfer Techniques Genetic Therapy methods Genetic Therapy ethics Genetic Vectors Clinical Trials as Topic Vecteurs de clonage. SCIENCE Life Sciences Anatomy & Physiology. Genetic vectors Genetic transformation |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=555317 |
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