Modern concepts in angiogenesis /:
This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed a...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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London : Hackensack, NJ :
Imperial College Press ; Distributed by World Scientific Pub.,
©2007.
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| Online-Zugang: | Volltext |
| Zusammenfassung: | This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts. The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF HIF and NOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors, endostatin and NO). These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis. |
| Beschreibung: | 1 online resource (xxi, 430 pages) : illustrations (some color) |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9781860949456 1860949452 1281867543 9781281867544 9786611867546 6611867546 |
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| 260 | |a London : |b Imperial College Press ; |a Hackensack, NJ : |b Distributed by World Scientific Pub., |c ©2007. | ||
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| 520 | |a This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts. The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF HIF and NOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors, endostatin and NO). These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis. | ||
| 505 | 0 | |a CONTENTS -- Contributors -- Preface -- I Components of Angiogenic Cascades -- Chapter 1. Semaphorins, Plexins and Neuropilins and Their Role in Vasculogenesis and Angiogenesis Gera Neufeld, Niva Shraga-Heled, Tali Lange and Ofra Kessler -- 1. Introduction and Historical Perspective -- 2. The Semaphorins -- 3. The Plexin Receptor Family -- 4. The Neuropilins -- 5. Vascular Endothelial Growth Factors and Their Receptors -- 6. Signal Transduction by Neuropilins -- 7. The Role of the Neuropilins in the Regulation of Vasculogenesis and Angiogenesis | |
| 505 | 8 | |a 8. Modulation of Angiogenesis by Semaphorins that Bind Directly to PlexinsAcknowledgments -- References -- Chapter 2. EPH Receptors and Ephrins Elena B. Pasquale -- 1. Introduction -- 1.1. Eph receptor domain structure -- 1.2. The ephrin domain structure -- 1.3. Eph-Ephrin bidirectional signaling at sites of cell-to-cell contact -- 2. Effects on Vascular Cell Behavior and Signaling Pathways -- 2.1. Ephrin-A1 and EphA2 -- 2.2. Ephrin-A1 and EphA4 -- 2.3. Ephrin-B and EphB -- 2.3.1. EphB forward signaling -- 2.3.2. Ephrin-B reverse signaling | |
| 505 | 8 | |a 2.4. Crosstalk with other angiogenic pathways3. Endothelial Cell Fate -- 4. Angiogenic Remodeling of Embryonic Blood Vessels -- 4.1. Ephrin-A1 and EphA receptors -- 4.2. EphB4 and Ephrin-B2 -- 4.3. Other EphB receptors and Ephrin-Bs -- 5. Lymphatic Vessels -- 6. Adult Vasculature -- 6.1. Quiescent vasculature -- 6.2. Physiological angiogenesis -- 6.3. Inflammation and wound healing -- 6.4. Tumor angiogenesis -- 6.4.1. Ephrin-A1 and EphA2 -- 6.4.2. Ephrin-B2 and EphB4 -- 7. Targeting Eph Receptor-Ephrin Interactions to Modulate Angiogenesis | |
| 505 | 8 | |a 8. PerspectivesAcknowledgments -- References -- Chapter 3. The FGF Family of Angiogenic Growth Factors Patrick Auguste and Andreas Bikfalvi -- 1. Introduction -- 2. Molecular Mechanisms -- 3. Role in Vascular Development -- 4. FGFs in Tumor Angiogenesis -- 5. Role of FGFs in Developmental and Tumor Lymphangiogenesis -- 6. Role in Repair-Associated Angiogenesis and Ischemia Revascularization -- 7. Conclusion -- Acknowledgments -- References -- Chapter 4. Neuropeptide Y: Neurogenic Mediator of Angiogenesis and Arteriogenesis Joanna B. Kitlinska and Zofia Zukowska | |
| 505 | 8 | |a 1. The NPY System2. NPY as a Growth Factor for Vascular Cells -- 3. DPPIV: A Molecular Switch of the NPY Angiogenic System -- 4. Downstream Mediators of NPY Actions -- 5. NPY in Revascularization of Ischemic Tissues -- 6. NPY in Wound Healing -- 7. NPY in Adipose Tissue Growth and Obesity -- 8. NPY in Retinopathy -- 9. NPY-Induced Angiogenesis in Angioplasty-Induced Neointima and Atherogenesis -- 10. NPY in Tumor Angiogenesis -- 11. NPY-Mediated Angiogenesis and Neurogenesis -- References | |
| 546 | |a English. | ||
| 650 | 0 | |a Neovascularization. |0 http://id.loc.gov/authorities/subjects/sh87002299 | |
| 650 | 0 | |a Vascular endothelial growth factors. |0 http://id.loc.gov/authorities/subjects/sh2004000517 | |
| 650 | 0 | |a Vascular endothelial growth factors |x Therapeutic use. | |
| 650 | 0 | |a Neovascularization inhibitors. |0 http://id.loc.gov/authorities/subjects/sh93004625 | |
| 650 | 2 | |a Neovascularization, Physiologic | |
| 650 | 2 | |a Neovascularization, Pathologic |0 https://id.nlm.nih.gov/mesh/D009389 | |
| 650 | 2 | |a Angiogenesis Inhibitors |0 https://id.nlm.nih.gov/mesh/D020533 | |
| 650 | 6 | |a Néovascularisation. | |
| 650 | 6 | |a Néovascularisation |x Inhibiteurs. | |
| 650 | 7 | |a MEDICAL |x Physiology. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Human Anatomy & Physiology. |2 bisacsh | |
| 650 | 7 | |a Neovascularization |2 fast | |
| 650 | 7 | |a Neovascularization inhibitors |2 fast | |
| 650 | 7 | |a Vascular endothelial growth factors |2 fast | |
| 700 | 1 | |a Simons, Michael. | |
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| contents | CONTENTS -- Contributors -- Preface -- I Components of Angiogenic Cascades -- Chapter 1. Semaphorins, Plexins and Neuropilins and Their Role in Vasculogenesis and Angiogenesis Gera Neufeld, Niva Shraga-Heled, Tali Lange and Ofra Kessler -- 1. Introduction and Historical Perspective -- 2. The Semaphorins -- 3. The Plexin Receptor Family -- 4. The Neuropilins -- 5. Vascular Endothelial Growth Factors and Their Receptors -- 6. Signal Transduction by Neuropilins -- 7. The Role of the Neuropilins in the Regulation of Vasculogenesis and Angiogenesis 8. Modulation of Angiogenesis by Semaphorins that Bind Directly to PlexinsAcknowledgments -- References -- Chapter 2. EPH Receptors and Ephrins Elena B. Pasquale -- 1. Introduction -- 1.1. Eph receptor domain structure -- 1.2. The ephrin domain structure -- 1.3. Eph-Ephrin bidirectional signaling at sites of cell-to-cell contact -- 2. Effects on Vascular Cell Behavior and Signaling Pathways -- 2.1. Ephrin-A1 and EphA2 -- 2.2. Ephrin-A1 and EphA4 -- 2.3. Ephrin-B and EphB -- 2.3.1. EphB forward signaling -- 2.3.2. Ephrin-B reverse signaling 2.4. Crosstalk with other angiogenic pathways3. Endothelial Cell Fate -- 4. Angiogenic Remodeling of Embryonic Blood Vessels -- 4.1. Ephrin-A1 and EphA receptors -- 4.2. EphB4 and Ephrin-B2 -- 4.3. Other EphB receptors and Ephrin-Bs -- 5. Lymphatic Vessels -- 6. Adult Vasculature -- 6.1. Quiescent vasculature -- 6.2. Physiological angiogenesis -- 6.3. Inflammation and wound healing -- 6.4. Tumor angiogenesis -- 6.4.1. Ephrin-A1 and EphA2 -- 6.4.2. Ephrin-B2 and EphB4 -- 7. Targeting Eph Receptor-Ephrin Interactions to Modulate Angiogenesis 8. PerspectivesAcknowledgments -- References -- Chapter 3. The FGF Family of Angiogenic Growth Factors Patrick Auguste and Andreas Bikfalvi -- 1. Introduction -- 2. Molecular Mechanisms -- 3. Role in Vascular Development -- 4. FGFs in Tumor Angiogenesis -- 5. Role of FGFs in Developmental and Tumor Lymphangiogenesis -- 6. Role in Repair-Associated Angiogenesis and Ischemia Revascularization -- 7. Conclusion -- Acknowledgments -- References -- Chapter 4. Neuropeptide Y: Neurogenic Mediator of Angiogenesis and Arteriogenesis Joanna B. Kitlinska and Zofia Zukowska 1. The NPY System2. NPY as a Growth Factor for Vascular Cells -- 3. DPPIV: A Molecular Switch of the NPY Angiogenic System -- 4. Downstream Mediators of NPY Actions -- 5. NPY in Revascularization of Ischemic Tissues -- 6. NPY in Wound Healing -- 7. NPY in Adipose Tissue Growth and Obesity -- 8. NPY in Retinopathy -- 9. NPY-Induced Angiogenesis in Angioplasty-Induced Neointima and Atherogenesis -- 10. NPY in Tumor Angiogenesis -- 11. NPY-Mediated Angiogenesis and Neurogenesis -- References |
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| id | ZDB-4-EBA-ocn827947340 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:25:11Z |
| institution | BVB |
| isbn | 9781860949456 1860949452 1281867543 9781281867544 9786611867546 6611867546 |
| language | English |
| oclc_num | 827947340 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (xxi, 430 pages) : illustrations (some color) |
| psigel | ZDB-4-EBA |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Imperial College Press ; Distributed by World Scientific Pub., |
| record_format | marc |
| spelling | Modern concepts in angiogenesis / edited by Michael Simons, Gabor M. Rubanyi. London : Imperial College Press ; Hackensack, NJ : Distributed by World Scientific Pub., ©2007. 1 online resource (xxi, 430 pages) : illustrations (some color) text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Print version record. This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts. The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF HIF and NOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors, endostatin and NO). These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis. CONTENTS -- Contributors -- Preface -- I Components of Angiogenic Cascades -- Chapter 1. Semaphorins, Plexins and Neuropilins and Their Role in Vasculogenesis and Angiogenesis Gera Neufeld, Niva Shraga-Heled, Tali Lange and Ofra Kessler -- 1. Introduction and Historical Perspective -- 2. The Semaphorins -- 3. The Plexin Receptor Family -- 4. The Neuropilins -- 5. Vascular Endothelial Growth Factors and Their Receptors -- 6. Signal Transduction by Neuropilins -- 7. The Role of the Neuropilins in the Regulation of Vasculogenesis and Angiogenesis 8. Modulation of Angiogenesis by Semaphorins that Bind Directly to PlexinsAcknowledgments -- References -- Chapter 2. EPH Receptors and Ephrins Elena B. Pasquale -- 1. Introduction -- 1.1. Eph receptor domain structure -- 1.2. The ephrin domain structure -- 1.3. Eph-Ephrin bidirectional signaling at sites of cell-to-cell contact -- 2. Effects on Vascular Cell Behavior and Signaling Pathways -- 2.1. Ephrin-A1 and EphA2 -- 2.2. Ephrin-A1 and EphA4 -- 2.3. Ephrin-B and EphB -- 2.3.1. EphB forward signaling -- 2.3.2. Ephrin-B reverse signaling 2.4. Crosstalk with other angiogenic pathways3. Endothelial Cell Fate -- 4. Angiogenic Remodeling of Embryonic Blood Vessels -- 4.1. Ephrin-A1 and EphA receptors -- 4.2. EphB4 and Ephrin-B2 -- 4.3. Other EphB receptors and Ephrin-Bs -- 5. Lymphatic Vessels -- 6. Adult Vasculature -- 6.1. Quiescent vasculature -- 6.2. Physiological angiogenesis -- 6.3. Inflammation and wound healing -- 6.4. Tumor angiogenesis -- 6.4.1. Ephrin-A1 and EphA2 -- 6.4.2. Ephrin-B2 and EphB4 -- 7. Targeting Eph Receptor-Ephrin Interactions to Modulate Angiogenesis 8. PerspectivesAcknowledgments -- References -- Chapter 3. The FGF Family of Angiogenic Growth Factors Patrick Auguste and Andreas Bikfalvi -- 1. Introduction -- 2. Molecular Mechanisms -- 3. Role in Vascular Development -- 4. FGFs in Tumor Angiogenesis -- 5. Role of FGFs in Developmental and Tumor Lymphangiogenesis -- 6. Role in Repair-Associated Angiogenesis and Ischemia Revascularization -- 7. Conclusion -- Acknowledgments -- References -- Chapter 4. Neuropeptide Y: Neurogenic Mediator of Angiogenesis and Arteriogenesis Joanna B. Kitlinska and Zofia Zukowska 1. The NPY System2. NPY as a Growth Factor for Vascular Cells -- 3. DPPIV: A Molecular Switch of the NPY Angiogenic System -- 4. Downstream Mediators of NPY Actions -- 5. NPY in Revascularization of Ischemic Tissues -- 6. NPY in Wound Healing -- 7. NPY in Adipose Tissue Growth and Obesity -- 8. NPY in Retinopathy -- 9. NPY-Induced Angiogenesis in Angioplasty-Induced Neointima and Atherogenesis -- 10. NPY in Tumor Angiogenesis -- 11. NPY-Mediated Angiogenesis and Neurogenesis -- References English. Neovascularization. http://id.loc.gov/authorities/subjects/sh87002299 Vascular endothelial growth factors. http://id.loc.gov/authorities/subjects/sh2004000517 Vascular endothelial growth factors Therapeutic use. Neovascularization inhibitors. http://id.loc.gov/authorities/subjects/sh93004625 Neovascularization, Physiologic Neovascularization, Pathologic https://id.nlm.nih.gov/mesh/D009389 Angiogenesis Inhibitors https://id.nlm.nih.gov/mesh/D020533 Néovascularisation. Néovascularisation Inhibiteurs. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Neovascularization fast Neovascularization inhibitors fast Vascular endothelial growth factors fast Simons, Michael. Rubanyi, Gabor M., 1947- https://id.oclc.org/worldcat/entity/E39PCjrfdWq38jWcYKY7phkrHK http://id.loc.gov/authorities/names/n88095954 has work: Modern concepts in angiogenesis (Text) https://id.oclc.org/worldcat/entity/E39PCFG3dYRPrFH9tQ4gTxTwkC https://id.oclc.org/worldcat/ontology/hasWork Print version: Modern concepts in angiogenesis. London : Imperial College Press ; Hackensack, NJ : Distributed by World Scientific Pub., ©2007 9781860947636 (DLC) 2008353385 (OCoLC)144224886 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=516738 Volltext |
| spellingShingle | Modern concepts in angiogenesis / CONTENTS -- Contributors -- Preface -- I Components of Angiogenic Cascades -- Chapter 1. Semaphorins, Plexins and Neuropilins and Their Role in Vasculogenesis and Angiogenesis Gera Neufeld, Niva Shraga-Heled, Tali Lange and Ofra Kessler -- 1. Introduction and Historical Perspective -- 2. The Semaphorins -- 3. The Plexin Receptor Family -- 4. The Neuropilins -- 5. Vascular Endothelial Growth Factors and Their Receptors -- 6. Signal Transduction by Neuropilins -- 7. The Role of the Neuropilins in the Regulation of Vasculogenesis and Angiogenesis 8. Modulation of Angiogenesis by Semaphorins that Bind Directly to PlexinsAcknowledgments -- References -- Chapter 2. EPH Receptors and Ephrins Elena B. Pasquale -- 1. Introduction -- 1.1. Eph receptor domain structure -- 1.2. The ephrin domain structure -- 1.3. Eph-Ephrin bidirectional signaling at sites of cell-to-cell contact -- 2. Effects on Vascular Cell Behavior and Signaling Pathways -- 2.1. Ephrin-A1 and EphA2 -- 2.2. Ephrin-A1 and EphA4 -- 2.3. Ephrin-B and EphB -- 2.3.1. EphB forward signaling -- 2.3.2. Ephrin-B reverse signaling 2.4. Crosstalk with other angiogenic pathways3. Endothelial Cell Fate -- 4. Angiogenic Remodeling of Embryonic Blood Vessels -- 4.1. Ephrin-A1 and EphA receptors -- 4.2. EphB4 and Ephrin-B2 -- 4.3. Other EphB receptors and Ephrin-Bs -- 5. Lymphatic Vessels -- 6. Adult Vasculature -- 6.1. Quiescent vasculature -- 6.2. Physiological angiogenesis -- 6.3. Inflammation and wound healing -- 6.4. Tumor angiogenesis -- 6.4.1. Ephrin-A1 and EphA2 -- 6.4.2. Ephrin-B2 and EphB4 -- 7. Targeting Eph Receptor-Ephrin Interactions to Modulate Angiogenesis 8. PerspectivesAcknowledgments -- References -- Chapter 3. The FGF Family of Angiogenic Growth Factors Patrick Auguste and Andreas Bikfalvi -- 1. Introduction -- 2. Molecular Mechanisms -- 3. Role in Vascular Development -- 4. FGFs in Tumor Angiogenesis -- 5. Role of FGFs in Developmental and Tumor Lymphangiogenesis -- 6. Role in Repair-Associated Angiogenesis and Ischemia Revascularization -- 7. Conclusion -- Acknowledgments -- References -- Chapter 4. Neuropeptide Y: Neurogenic Mediator of Angiogenesis and Arteriogenesis Joanna B. Kitlinska and Zofia Zukowska 1. The NPY System2. NPY as a Growth Factor for Vascular Cells -- 3. DPPIV: A Molecular Switch of the NPY Angiogenic System -- 4. Downstream Mediators of NPY Actions -- 5. NPY in Revascularization of Ischemic Tissues -- 6. NPY in Wound Healing -- 7. NPY in Adipose Tissue Growth and Obesity -- 8. NPY in Retinopathy -- 9. NPY-Induced Angiogenesis in Angioplasty-Induced Neointima and Atherogenesis -- 10. NPY in Tumor Angiogenesis -- 11. NPY-Mediated Angiogenesis and Neurogenesis -- References Neovascularization. http://id.loc.gov/authorities/subjects/sh87002299 Vascular endothelial growth factors. http://id.loc.gov/authorities/subjects/sh2004000517 Vascular endothelial growth factors Therapeutic use. Neovascularization inhibitors. http://id.loc.gov/authorities/subjects/sh93004625 Neovascularization, Physiologic Neovascularization, Pathologic https://id.nlm.nih.gov/mesh/D009389 Angiogenesis Inhibitors https://id.nlm.nih.gov/mesh/D020533 Néovascularisation. Néovascularisation Inhibiteurs. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Neovascularization fast Neovascularization inhibitors fast Vascular endothelial growth factors fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh87002299 http://id.loc.gov/authorities/subjects/sh2004000517 http://id.loc.gov/authorities/subjects/sh93004625 https://id.nlm.nih.gov/mesh/D009389 https://id.nlm.nih.gov/mesh/D020533 |
| title | Modern concepts in angiogenesis / |
| title_auth | Modern concepts in angiogenesis / |
| title_exact_search | Modern concepts in angiogenesis / |
| title_full | Modern concepts in angiogenesis / edited by Michael Simons, Gabor M. Rubanyi. |
| title_fullStr | Modern concepts in angiogenesis / edited by Michael Simons, Gabor M. Rubanyi. |
| title_full_unstemmed | Modern concepts in angiogenesis / edited by Michael Simons, Gabor M. Rubanyi. |
| title_short | Modern concepts in angiogenesis / |
| title_sort | modern concepts in angiogenesis |
| topic | Neovascularization. http://id.loc.gov/authorities/subjects/sh87002299 Vascular endothelial growth factors. http://id.loc.gov/authorities/subjects/sh2004000517 Vascular endothelial growth factors Therapeutic use. Neovascularization inhibitors. http://id.loc.gov/authorities/subjects/sh93004625 Neovascularization, Physiologic Neovascularization, Pathologic https://id.nlm.nih.gov/mesh/D009389 Angiogenesis Inhibitors https://id.nlm.nih.gov/mesh/D020533 Néovascularisation. Néovascularisation Inhibiteurs. MEDICAL Physiology. bisacsh SCIENCE Life Sciences Human Anatomy & Physiology. bisacsh Neovascularization fast Neovascularization inhibitors fast Vascular endothelial growth factors fast |
| topic_facet | Neovascularization. Vascular endothelial growth factors. Vascular endothelial growth factors Therapeutic use. Neovascularization inhibitors. Neovascularization, Physiologic Neovascularization, Pathologic Angiogenesis Inhibitors Néovascularisation. Néovascularisation Inhibiteurs. MEDICAL Physiology. SCIENCE Life Sciences Human Anatomy & Physiology. Neovascularization Neovascularization inhibitors Vascular endothelial growth factors |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=516738 |
| work_keys_str_mv | AT simonsmichael modernconceptsinangiogenesis AT rubanyigaborm modernconceptsinangiogenesis |