Recent advances in psoriasis :: the role of the immune system /
This book presents the evidence for the belief that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. The latest approaches to investigating the immunopathogenesis of this disease, and a review of previous findings, are presented to give an overall picture of the curr...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
London : River Edge, N.J. :
Imperial College Press ; Distributed by World Scientific Pub. Co.,
©2000.
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| Zusammenfassung: | This book presents the evidence for the belief that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. The latest approaches to investigating the immunopathogenesis of this disease, and a review of previous findings, are presented to give an overall picture of the current knowledge in this field. Each topic is discussed in detail, clearly illustrated and well referenced. The book should prove invaluable to clinical dermatologists, and researchers in the fields of immunology and dermatology who have an interest in skin diseases. |
| Beschreibung: | 1 online resource (xii, 172 pages) : illustrations (some color) |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9781848160637 1848160631 |
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| 505 | 0 | |a Ch. 1. Aetiology, clinical and histological features of psoriasis. 1.1. Clinical features -- 1.2. Genetics -- 1.3. Environmental factors -- 1.4. Histological features -- ch. 2. Skin immune system in psoriasis. 2.1. Skin immune system (SIS) -- 2.2. T cell subpopulations: normal skin -- 2.3. T cell subpopulations: psoriatic skin -- 2.4. Antigen-presenting cells: normal skin -- 2.5. Antigen-presenting cells: psoriatic skin -- 2.6. Endothelial cells -- 2.7. Neutrophils -- 2.8. Mast cells -- 2.9. Keratinocytes -- ch. 3. Immune cell function in psoriasis. 3.1. T lymphocytes: peripheral blood -- 3.2. T lymphocytes: skin -- 3.3. Antigen-presenting cells -- ch. 4. Psoriasis is a T cell-mediated disease. 4.1. Anti-psoriatic treatments -- 4.2. Anti-CD4 monoclonal antibodies -- 4.3. Lymphocyte-selective toxin (DAB[symbol]IL-2) -- 4.4. SCID mouse models -- 4.5. Bone-marrow transplantation -- 4.6. T cell supernatants promote keratinocyte proliferation -- 4.7. Low CD4[symbol]/HIV infection -- ch. 5. ß haemolytic streptococci and psoriasis. 5.1. Group A streptococci as a trigger for guttate psoriasis -- 5.2. Group A streptococci and CP psoriasis -- 5.3. Induction of psoriatic lesions by streptococci -- 5.4. Streptococcal antigens -- 5.5. Immune response to extracellular streptococcal proteins and superantigens -- 5.6. Immune response to streptococcal cellular proteins -- ch. 6. Immune function of psoriatic keratinocytes. 6.1. Cytokine production -- 6.2. Response to cytokines -- 6.3. Antigen/superantigen presentation -- 6.4. Integrins -- 6.5. Apoptosis -- ch. 7. Current and future immunological approaches to treatment of psoriasis. 7.1. Current treatments -- 7.2. Future treatments -- ch. 8. Model for the immunopathogenesis of psoriasis. 8.1. Outline of proposed model -- 8.2. Antigen trigger: group A streptococci (GAS) -- 8.3. CD4[symbol] T lymphocyte/KC interaction -- 8.4. Role of CD8[symbol] T lymphocytes -- 8.5. Site of altered gene expression -- 8.6. Other antigenic triggers. | |
| 520 | |a This book presents the evidence for the belief that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. The latest approaches to investigating the immunopathogenesis of this disease, and a review of previous findings, are presented to give an overall picture of the current knowledge in this field. Each topic is discussed in detail, clearly illustrated and well referenced. The book should prove invaluable to clinical dermatologists, and researchers in the fields of immunology and dermatology who have an interest in skin diseases. | ||
| 650 | 0 | |a Psoriasis. |0 http://id.loc.gov/authorities/subjects/sh85108334 | |
| 650 | 0 | |a Immune system. |0 http://id.loc.gov/authorities/subjects/sh86006453 | |
| 650 | 2 | |a Psoriasis |0 https://id.nlm.nih.gov/mesh/D011565 | |
| 650 | 2 | |a Immune System |0 https://id.nlm.nih.gov/mesh/D007107 | |
| 650 | 2 | |a Immune System Phenomena |0 https://id.nlm.nih.gov/mesh/D055633 | |
| 650 | 6 | |a Psoriasis. | |
| 650 | 6 | |a Système immunitaire. | |
| 650 | 7 | |a MEDICAL |x Dermatology. |2 bisacsh | |
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| 650 | 7 | |a Psoriasis |2 fast | |
| 650 | 7 | |a Autoimmunität |2 gnd |0 http://d-nb.info/gnd/4319435-7 | |
| 650 | 7 | |a Schuppenflechte |2 gnd |0 http://d-nb.info/gnd/4077221-4 | |
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| author | Baker, Barbara S. |
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| contents | Ch. 1. Aetiology, clinical and histological features of psoriasis. 1.1. Clinical features -- 1.2. Genetics -- 1.3. Environmental factors -- 1.4. Histological features -- ch. 2. Skin immune system in psoriasis. 2.1. Skin immune system (SIS) -- 2.2. T cell subpopulations: normal skin -- 2.3. T cell subpopulations: psoriatic skin -- 2.4. Antigen-presenting cells: normal skin -- 2.5. Antigen-presenting cells: psoriatic skin -- 2.6. Endothelial cells -- 2.7. Neutrophils -- 2.8. Mast cells -- 2.9. Keratinocytes -- ch. 3. Immune cell function in psoriasis. 3.1. T lymphocytes: peripheral blood -- 3.2. T lymphocytes: skin -- 3.3. Antigen-presenting cells -- ch. 4. Psoriasis is a T cell-mediated disease. 4.1. Anti-psoriatic treatments -- 4.2. Anti-CD4 monoclonal antibodies -- 4.3. Lymphocyte-selective toxin (DAB[symbol]IL-2) -- 4.4. SCID mouse models -- 4.5. Bone-marrow transplantation -- 4.6. T cell supernatants promote keratinocyte proliferation -- 4.7. Low CD4[symbol]/HIV infection -- ch. 5. ß haemolytic streptococci and psoriasis. 5.1. Group A streptococci as a trigger for guttate psoriasis -- 5.2. Group A streptococci and CP psoriasis -- 5.3. Induction of psoriatic lesions by streptococci -- 5.4. Streptococcal antigens -- 5.5. Immune response to extracellular streptococcal proteins and superantigens -- 5.6. Immune response to streptococcal cellular proteins -- ch. 6. Immune function of psoriatic keratinocytes. 6.1. Cytokine production -- 6.2. Response to cytokines -- 6.3. Antigen/superantigen presentation -- 6.4. Integrins -- 6.5. Apoptosis -- ch. 7. Current and future immunological approaches to treatment of psoriasis. 7.1. Current treatments -- 7.2. Future treatments -- ch. 8. Model for the immunopathogenesis of psoriasis. 8.1. Outline of proposed model -- 8.2. Antigen trigger: group A streptococci (GAS) -- 8.3. CD4[symbol] T lymphocyte/KC interaction -- 8.4. Role of CD8[symbol] T lymphocytes -- 8.5. Site of altered gene expression -- 8.6. Other antigenic triggers. |
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| id | ZDB-4-EBA-ocn825768767 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:25:09Z |
| institution | BVB |
| isbn | 9781848160637 1848160631 |
| language | English |
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| publisher | Imperial College Press ; Distributed by World Scientific Pub. Co., |
| record_format | marc |
| spelling | Baker, Barbara S. Recent advances in psoriasis : the role of the immune system / Barbara S. Baker. London : Imperial College Press ; River Edge, N.J. : Distributed by World Scientific Pub. Co., ©2000. 1 online resource (xii, 172 pages) : illustrations (some color) text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Print version record. Ch. 1. Aetiology, clinical and histological features of psoriasis. 1.1. Clinical features -- 1.2. Genetics -- 1.3. Environmental factors -- 1.4. Histological features -- ch. 2. Skin immune system in psoriasis. 2.1. Skin immune system (SIS) -- 2.2. T cell subpopulations: normal skin -- 2.3. T cell subpopulations: psoriatic skin -- 2.4. Antigen-presenting cells: normal skin -- 2.5. Antigen-presenting cells: psoriatic skin -- 2.6. Endothelial cells -- 2.7. Neutrophils -- 2.8. Mast cells -- 2.9. Keratinocytes -- ch. 3. Immune cell function in psoriasis. 3.1. T lymphocytes: peripheral blood -- 3.2. T lymphocytes: skin -- 3.3. Antigen-presenting cells -- ch. 4. Psoriasis is a T cell-mediated disease. 4.1. Anti-psoriatic treatments -- 4.2. Anti-CD4 monoclonal antibodies -- 4.3. Lymphocyte-selective toxin (DAB[symbol]IL-2) -- 4.4. SCID mouse models -- 4.5. Bone-marrow transplantation -- 4.6. T cell supernatants promote keratinocyte proliferation -- 4.7. Low CD4[symbol]/HIV infection -- ch. 5. ß haemolytic streptococci and psoriasis. 5.1. Group A streptococci as a trigger for guttate psoriasis -- 5.2. Group A streptococci and CP psoriasis -- 5.3. Induction of psoriatic lesions by streptococci -- 5.4. Streptococcal antigens -- 5.5. Immune response to extracellular streptococcal proteins and superantigens -- 5.6. Immune response to streptococcal cellular proteins -- ch. 6. Immune function of psoriatic keratinocytes. 6.1. Cytokine production -- 6.2. Response to cytokines -- 6.3. Antigen/superantigen presentation -- 6.4. Integrins -- 6.5. Apoptosis -- ch. 7. Current and future immunological approaches to treatment of psoriasis. 7.1. Current treatments -- 7.2. Future treatments -- ch. 8. Model for the immunopathogenesis of psoriasis. 8.1. Outline of proposed model -- 8.2. Antigen trigger: group A streptococci (GAS) -- 8.3. CD4[symbol] T lymphocyte/KC interaction -- 8.4. Role of CD8[symbol] T lymphocytes -- 8.5. Site of altered gene expression -- 8.6. Other antigenic triggers. This book presents the evidence for the belief that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. The latest approaches to investigating the immunopathogenesis of this disease, and a review of previous findings, are presented to give an overall picture of the current knowledge in this field. Each topic is discussed in detail, clearly illustrated and well referenced. The book should prove invaluable to clinical dermatologists, and researchers in the fields of immunology and dermatology who have an interest in skin diseases. Psoriasis. http://id.loc.gov/authorities/subjects/sh85108334 Immune system. http://id.loc.gov/authorities/subjects/sh86006453 Psoriasis https://id.nlm.nih.gov/mesh/D011565 Immune System https://id.nlm.nih.gov/mesh/D007107 Immune System Phenomena https://id.nlm.nih.gov/mesh/D055633 Psoriasis. Système immunitaire. MEDICAL Dermatology. bisacsh Immune system fast Psoriasis fast Autoimmunität gnd http://d-nb.info/gnd/4319435-7 Schuppenflechte gnd http://d-nb.info/gnd/4077221-4 Print version: Baker, Barbara S. Recent advances in psoriasis. London : Imperial College Press ; River Edge, N.J. : Distributed by World Scientific Pub. Co., ©2000 1860941206 (OCoLC)44438511 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=521286 Volltext |
| spellingShingle | Baker, Barbara S. Recent advances in psoriasis : the role of the immune system / Ch. 1. Aetiology, clinical and histological features of psoriasis. 1.1. Clinical features -- 1.2. Genetics -- 1.3. Environmental factors -- 1.4. Histological features -- ch. 2. Skin immune system in psoriasis. 2.1. Skin immune system (SIS) -- 2.2. T cell subpopulations: normal skin -- 2.3. T cell subpopulations: psoriatic skin -- 2.4. Antigen-presenting cells: normal skin -- 2.5. Antigen-presenting cells: psoriatic skin -- 2.6. Endothelial cells -- 2.7. Neutrophils -- 2.8. Mast cells -- 2.9. Keratinocytes -- ch. 3. Immune cell function in psoriasis. 3.1. T lymphocytes: peripheral blood -- 3.2. T lymphocytes: skin -- 3.3. Antigen-presenting cells -- ch. 4. Psoriasis is a T cell-mediated disease. 4.1. Anti-psoriatic treatments -- 4.2. Anti-CD4 monoclonal antibodies -- 4.3. Lymphocyte-selective toxin (DAB[symbol]IL-2) -- 4.4. SCID mouse models -- 4.5. Bone-marrow transplantation -- 4.6. T cell supernatants promote keratinocyte proliferation -- 4.7. Low CD4[symbol]/HIV infection -- ch. 5. ß haemolytic streptococci and psoriasis. 5.1. Group A streptococci as a trigger for guttate psoriasis -- 5.2. Group A streptococci and CP psoriasis -- 5.3. Induction of psoriatic lesions by streptococci -- 5.4. Streptococcal antigens -- 5.5. Immune response to extracellular streptococcal proteins and superantigens -- 5.6. Immune response to streptococcal cellular proteins -- ch. 6. Immune function of psoriatic keratinocytes. 6.1. Cytokine production -- 6.2. Response to cytokines -- 6.3. Antigen/superantigen presentation -- 6.4. Integrins -- 6.5. Apoptosis -- ch. 7. Current and future immunological approaches to treatment of psoriasis. 7.1. Current treatments -- 7.2. Future treatments -- ch. 8. Model for the immunopathogenesis of psoriasis. 8.1. Outline of proposed model -- 8.2. Antigen trigger: group A streptococci (GAS) -- 8.3. CD4[symbol] T lymphocyte/KC interaction -- 8.4. Role of CD8[symbol] T lymphocytes -- 8.5. Site of altered gene expression -- 8.6. Other antigenic triggers. Psoriasis. http://id.loc.gov/authorities/subjects/sh85108334 Immune system. http://id.loc.gov/authorities/subjects/sh86006453 Psoriasis https://id.nlm.nih.gov/mesh/D011565 Immune System https://id.nlm.nih.gov/mesh/D007107 Immune System Phenomena https://id.nlm.nih.gov/mesh/D055633 Psoriasis. Système immunitaire. MEDICAL Dermatology. bisacsh Immune system fast Psoriasis fast Autoimmunität gnd http://d-nb.info/gnd/4319435-7 Schuppenflechte gnd http://d-nb.info/gnd/4077221-4 |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85108334 http://id.loc.gov/authorities/subjects/sh86006453 https://id.nlm.nih.gov/mesh/D011565 https://id.nlm.nih.gov/mesh/D007107 https://id.nlm.nih.gov/mesh/D055633 http://d-nb.info/gnd/4319435-7 http://d-nb.info/gnd/4077221-4 |
| title | Recent advances in psoriasis : the role of the immune system / |
| title_auth | Recent advances in psoriasis : the role of the immune system / |
| title_exact_search | Recent advances in psoriasis : the role of the immune system / |
| title_full | Recent advances in psoriasis : the role of the immune system / Barbara S. Baker. |
| title_fullStr | Recent advances in psoriasis : the role of the immune system / Barbara S. Baker. |
| title_full_unstemmed | Recent advances in psoriasis : the role of the immune system / Barbara S. Baker. |
| title_short | Recent advances in psoriasis : |
| title_sort | recent advances in psoriasis the role of the immune system |
| title_sub | the role of the immune system / |
| topic | Psoriasis. http://id.loc.gov/authorities/subjects/sh85108334 Immune system. http://id.loc.gov/authorities/subjects/sh86006453 Psoriasis https://id.nlm.nih.gov/mesh/D011565 Immune System https://id.nlm.nih.gov/mesh/D007107 Immune System Phenomena https://id.nlm.nih.gov/mesh/D055633 Psoriasis. Système immunitaire. MEDICAL Dermatology. bisacsh Immune system fast Psoriasis fast Autoimmunität gnd http://d-nb.info/gnd/4319435-7 Schuppenflechte gnd http://d-nb.info/gnd/4077221-4 |
| topic_facet | Psoriasis. Immune system. Psoriasis Immune System Immune System Phenomena Système immunitaire. MEDICAL Dermatology. Immune system Autoimmunität Schuppenflechte |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=521286 |
| work_keys_str_mv | AT bakerbarbaras recentadvancesinpsoriasistheroleoftheimmunesystem |