Biosimulation :: simulation of living systems /
A hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences.
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge ; New York :
Cambridge University Press,
2012.
|
| Schriftenreihe: | Cambridge texts in biomedical engineering.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | A hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences. |
| Beschreibung: | 1 online resource |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9781139379489 1139379488 9781139375191 1139375199 9781139045582 113904558X |
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| 100 | 1 | |a Beard, Daniel A., |d 1971- |e author. |1 https://id.oclc.org/worldcat/entity/E39PCjxMDYWGqXVBbVhVVMrYmq |0 http://id.loc.gov/authorities/names/no98065538 | |
| 245 | 1 | 0 | |a Biosimulation : |b simulation of living systems / |c Daniel A. Beard. |
| 264 | 1 | |a Cambridge ; |a New York : |b Cambridge University Press, |c 2012. | |
| 264 | 4 | |c ©2012 | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 490 | 1 | |a Cambridge texts in biomedical engineering | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Cover; Biosimulation; Series; Title; Copyright; Contents; Preface; Extracts; 1: Introduction to simulation of biological systems; Overview; 1.1 Modeling approaches; 1.2 An introductory example: biochemistry of a home aquarium; 1.2.1 First model: a nonmechanistic analysis; 1.2.2 Nonmechanistic analysis with noise; 1.2.3 Mechanistic modeling; 1.3 Recapitulation and lessons learned; Problems; 2: Transport and reaction of solutes in biological systems; Overview; 2.1 Well-mixed systems: compartmental modeling; 2.2 Passive flow of water, solutes, and electrical current across membranes. | |
| 505 | 8 | |a 2.2.1 Basic equations2.2.2 Example: volume changes in isolated glomeruli; 2.3 Simulating chemical reactions; 2.3.1 Example: synthesis of ethanol from xylose; 2.4 Distributed transport modeling; 2.4.1 Flowing systems: the advection equation; 2.4.2 Reaction-diffusion systems; 2.4.3 Advection-reaction-diffusion systems; 2.5 Recapitulation and lessons learned; Problems; 3: Physiologically based pharmacokinetic modeling; Overview; 3.1 Introduction to lumped compartmental PBPK modeling; 3.1.1 Basic equations; 3.1.2 Comparison of distributed and lumped transport models. | |
| 505 | 8 | |a 3.1.3 Quasi-steady model reduction3.1.4 Lumped versus distributed transport modeling: a final word; 3.2 Overview of the mammalian circulatory system; 3.3 Whole-body PBPK simulation; 3.4 Example: uptake and delivery of matrine in rat; 3.4.1 A PBPK model for rat; 3.4.2 Model parameters; 3.4.3 Flow-limited transport; 3.4.4 Model validation and discrimination; 3.5 Recapitulation and lessons learned; Problems; 4: Cardiovascular systems simulation; Overview; 4.1 The Frank-Starling mechanism of heart; 4.2 An analysis of the physiological factors that control cardiac output. | |
| 505 | 8 | |a 4.2.1 Guyton's model of the systemic circulation4.2.2 What the model tells us about the relationship between flow and right atrial pressure; 4.2.3 How the simple Guyton model is commonly misinterpreted; 4.3 Pulsatile mechanics of the circulatory system; 4.3.1 Time-varying elastance models of the heart; 4.3.2 Simulation of the aortic pressure waveform; 4.4 Dynamic changes in blood pressures and flows; 4.4.1 Baroreceptor control of systemic pressure; 4.5 Mechanisms of hypertension; 4.6 Recapitulation and lessons learned; Problems. | |
| 505 | 8 | |a 5: Chemical reaction systems: thermodynamics and chemical equilibriumOverview; 5.1 Temperature, pressure, and entropy; 5.1.1 Microstates and macrostates; 5.1.2 Example: a simple two-state system; 5.1.3 Relationship between temperature and entropy; 5.1.4 Relationship between pressure and entropy; 5.2 Free energy under constant-temperature and constant-volume conditions; 5.3 Free energy under constant-temperature and constant-pressure conditions; 5.4 Thermodynamic ensembles, partition functions, and driving forces; 5.5 Chemical reactions, stoichiometry, and equilibrium constants; 5.6 Acids, bases, and buffers. | |
| 520 | |a A hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Biophysics |x Computer simulation. | |
| 650 | 0 | |a Biophysics |x Simulation methods. | |
| 650 | 0 | |a Biomedical engineering |x Computer simulation. | |
| 650 | 0 | |a Medical sciences |v Case studies. | |
| 650 | 0 | |a Biomedical engineering. |0 http://id.loc.gov/authorities/subjects/sh85014237 | |
| 650 | 0 | |a Computer simulation. |0 http://id.loc.gov/authorities/subjects/sh85029533 | |
| 650 | 0 | |a Digital computer simulation. |0 http://id.loc.gov/authorities/subjects/sh85037973 | |
| 650 | 1 | 2 | |a Biophysical Phenomena |
| 650 | 2 | 2 | |a Biomedical Engineering |
| 650 | 2 | 2 | |a Computer Simulation |
| 650 | 2 | |a Biomedical Technology |0 https://id.nlm.nih.gov/mesh/D020811 | |
| 650 | 6 | |a Biophysique |x Simulation par ordinateur. | |
| 650 | 6 | |a Biophysique |x Méthodes de simulation. | |
| 650 | 6 | |a Génie biomédical |x Simulation par ordinateur. | |
| 650 | 6 | |a Sciences de la santé |v Études de cas. | |
| 650 | 6 | |a Phénomènes biophysiques. | |
| 650 | 6 | |a Génie biomédical. | |
| 650 | 6 | |a Simulation par ordinateur. | |
| 650 | 7 | |a biomedical engineering. |2 aat | |
| 650 | 7 | |a simulation. |2 aat | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biophysics. |2 bisacsh | |
| 650 | 7 | |a Digital computer simulation |2 fast | |
| 650 | 7 | |a Computer simulation |2 fast | |
| 650 | 7 | |a Biomedical engineering |2 fast | |
| 650 | 7 | |a Biomedical engineering |x Computer simulation |2 fast | |
| 650 | 7 | |a Medical sciences |2 fast | |
| 655 | 2 | |a Case Reports |0 https://id.nlm.nih.gov/mesh/D002363 | |
| 655 | 7 | |a Case studies |2 fast | |
| 655 | 7 | |a Case studies. |2 lcgft |0 http://id.loc.gov/authorities/genreForms/gf2017026140 | |
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Datensatz im Suchindex
| DE-BY-FWS_katkey | ZDB-4-EBA-ocn794327677 |
|---|---|
| _version_ | 1816881795517382656 |
| adam_text | |
| any_adam_object | |
| author | Beard, Daniel A., 1971- |
| author_GND | http://id.loc.gov/authorities/names/no98065538 |
| author_facet | Beard, Daniel A., 1971- |
| author_role | aut |
| author_sort | Beard, Daniel A., 1971- |
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| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | Q - Science |
| callnumber-label | QH505 |
| callnumber-raw | QH505 .B43 2012 |
| callnumber-search | QH505 .B43 2012 |
| callnumber-sort | QH 3505 B43 42012 |
| callnumber-subject | QH - Natural History and Biology |
| collection | ZDB-4-EBA |
| contents | Cover; Biosimulation; Series; Title; Copyright; Contents; Preface; Extracts; 1: Introduction to simulation of biological systems; Overview; 1.1 Modeling approaches; 1.2 An introductory example: biochemistry of a home aquarium; 1.2.1 First model: a nonmechanistic analysis; 1.2.2 Nonmechanistic analysis with noise; 1.2.3 Mechanistic modeling; 1.3 Recapitulation and lessons learned; Problems; 2: Transport and reaction of solutes in biological systems; Overview; 2.1 Well-mixed systems: compartmental modeling; 2.2 Passive flow of water, solutes, and electrical current across membranes. 2.2.1 Basic equations2.2.2 Example: volume changes in isolated glomeruli; 2.3 Simulating chemical reactions; 2.3.1 Example: synthesis of ethanol from xylose; 2.4 Distributed transport modeling; 2.4.1 Flowing systems: the advection equation; 2.4.2 Reaction-diffusion systems; 2.4.3 Advection-reaction-diffusion systems; 2.5 Recapitulation and lessons learned; Problems; 3: Physiologically based pharmacokinetic modeling; Overview; 3.1 Introduction to lumped compartmental PBPK modeling; 3.1.1 Basic equations; 3.1.2 Comparison of distributed and lumped transport models. 3.1.3 Quasi-steady model reduction3.1.4 Lumped versus distributed transport modeling: a final word; 3.2 Overview of the mammalian circulatory system; 3.3 Whole-body PBPK simulation; 3.4 Example: uptake and delivery of matrine in rat; 3.4.1 A PBPK model for rat; 3.4.2 Model parameters; 3.4.3 Flow-limited transport; 3.4.4 Model validation and discrimination; 3.5 Recapitulation and lessons learned; Problems; 4: Cardiovascular systems simulation; Overview; 4.1 The Frank-Starling mechanism of heart; 4.2 An analysis of the physiological factors that control cardiac output. 4.2.1 Guyton's model of the systemic circulation4.2.2 What the model tells us about the relationship between flow and right atrial pressure; 4.2.3 How the simple Guyton model is commonly misinterpreted; 4.3 Pulsatile mechanics of the circulatory system; 4.3.1 Time-varying elastance models of the heart; 4.3.2 Simulation of the aortic pressure waveform; 4.4 Dynamic changes in blood pressures and flows; 4.4.1 Baroreceptor control of systemic pressure; 4.5 Mechanisms of hypertension; 4.6 Recapitulation and lessons learned; Problems. 5: Chemical reaction systems: thermodynamics and chemical equilibriumOverview; 5.1 Temperature, pressure, and entropy; 5.1.1 Microstates and macrostates; 5.1.2 Example: a simple two-state system; 5.1.3 Relationship between temperature and entropy; 5.1.4 Relationship between pressure and entropy; 5.2 Free energy under constant-temperature and constant-volume conditions; 5.3 Free energy under constant-temperature and constant-pressure conditions; 5.4 Thermodynamic ensembles, partition functions, and driving forces; 5.5 Chemical reactions, stoichiometry, and equilibrium constants; 5.6 Acids, bases, and buffers. |
| ctrlnum | (OCoLC)794327677 |
| dewey-full | 571.401/13 571.40113 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.401/13 571.40113 |
| dewey-search | 571.401/13 571.40113 |
| dewey-sort | 3571.401 213 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Electronic eBook |
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| genre_facet | Case Reports Case studies Case studies. Études de cas. |
| id | ZDB-4-EBA-ocn794327677 |
| illustrated | Not Illustrated |
| indexdate | 2024-11-27T13:18:24Z |
| institution | BVB |
| isbn | 9781139379489 1139379488 9781139375191 1139375199 9781139045582 113904558X |
| language | English |
| oclc_num | 794327677 |
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| owner_facet | MAIN DE-863 DE-BY-FWS |
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| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Cambridge University Press, |
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| series | Cambridge texts in biomedical engineering. |
| series2 | Cambridge texts in biomedical engineering |
| spelling | Beard, Daniel A., 1971- author. https://id.oclc.org/worldcat/entity/E39PCjxMDYWGqXVBbVhVVMrYmq http://id.loc.gov/authorities/names/no98065538 Biosimulation : simulation of living systems / Daniel A. Beard. Cambridge ; New York : Cambridge University Press, 2012. ©2012 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Cambridge texts in biomedical engineering Includes bibliographical references and index. Cover; Biosimulation; Series; Title; Copyright; Contents; Preface; Extracts; 1: Introduction to simulation of biological systems; Overview; 1.1 Modeling approaches; 1.2 An introductory example: biochemistry of a home aquarium; 1.2.1 First model: a nonmechanistic analysis; 1.2.2 Nonmechanistic analysis with noise; 1.2.3 Mechanistic modeling; 1.3 Recapitulation and lessons learned; Problems; 2: Transport and reaction of solutes in biological systems; Overview; 2.1 Well-mixed systems: compartmental modeling; 2.2 Passive flow of water, solutes, and electrical current across membranes. 2.2.1 Basic equations2.2.2 Example: volume changes in isolated glomeruli; 2.3 Simulating chemical reactions; 2.3.1 Example: synthesis of ethanol from xylose; 2.4 Distributed transport modeling; 2.4.1 Flowing systems: the advection equation; 2.4.2 Reaction-diffusion systems; 2.4.3 Advection-reaction-diffusion systems; 2.5 Recapitulation and lessons learned; Problems; 3: Physiologically based pharmacokinetic modeling; Overview; 3.1 Introduction to lumped compartmental PBPK modeling; 3.1.1 Basic equations; 3.1.2 Comparison of distributed and lumped transport models. 3.1.3 Quasi-steady model reduction3.1.4 Lumped versus distributed transport modeling: a final word; 3.2 Overview of the mammalian circulatory system; 3.3 Whole-body PBPK simulation; 3.4 Example: uptake and delivery of matrine in rat; 3.4.1 A PBPK model for rat; 3.4.2 Model parameters; 3.4.3 Flow-limited transport; 3.4.4 Model validation and discrimination; 3.5 Recapitulation and lessons learned; Problems; 4: Cardiovascular systems simulation; Overview; 4.1 The Frank-Starling mechanism of heart; 4.2 An analysis of the physiological factors that control cardiac output. 4.2.1 Guyton's model of the systemic circulation4.2.2 What the model tells us about the relationship between flow and right atrial pressure; 4.2.3 How the simple Guyton model is commonly misinterpreted; 4.3 Pulsatile mechanics of the circulatory system; 4.3.1 Time-varying elastance models of the heart; 4.3.2 Simulation of the aortic pressure waveform; 4.4 Dynamic changes in blood pressures and flows; 4.4.1 Baroreceptor control of systemic pressure; 4.5 Mechanisms of hypertension; 4.6 Recapitulation and lessons learned; Problems. 5: Chemical reaction systems: thermodynamics and chemical equilibriumOverview; 5.1 Temperature, pressure, and entropy; 5.1.1 Microstates and macrostates; 5.1.2 Example: a simple two-state system; 5.1.3 Relationship between temperature and entropy; 5.1.4 Relationship between pressure and entropy; 5.2 Free energy under constant-temperature and constant-volume conditions; 5.3 Free energy under constant-temperature and constant-pressure conditions; 5.4 Thermodynamic ensembles, partition functions, and driving forces; 5.5 Chemical reactions, stoichiometry, and equilibrium constants; 5.6 Acids, bases, and buffers. A hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences. Print version record. Biophysics Computer simulation. Biophysics Simulation methods. Biomedical engineering Computer simulation. Medical sciences Case studies. Biomedical engineering. http://id.loc.gov/authorities/subjects/sh85014237 Computer simulation. http://id.loc.gov/authorities/subjects/sh85029533 Digital computer simulation. http://id.loc.gov/authorities/subjects/sh85037973 Biophysical Phenomena Biomedical Engineering Computer Simulation Biomedical Technology https://id.nlm.nih.gov/mesh/D020811 Biophysique Simulation par ordinateur. Biophysique Méthodes de simulation. Génie biomédical Simulation par ordinateur. Sciences de la santé Études de cas. Phénomènes biophysiques. Génie biomédical. Simulation par ordinateur. biomedical engineering. aat simulation. aat SCIENCE Life Sciences Biophysics. bisacsh Digital computer simulation fast Computer simulation fast Biomedical engineering fast Biomedical engineering Computer simulation fast Medical sciences fast Case Reports https://id.nlm.nih.gov/mesh/D002363 Case studies fast Case studies. lcgft http://id.loc.gov/authorities/genreForms/gf2017026140 Études de cas. rvmgf has work: Biosimulation (Text) https://id.oclc.org/worldcat/entity/E39PCFTGmYyx6Gqp7pVKhbyy3P https://id.oclc.org/worldcat/ontology/hasWork Print version: Beard, Daniel A., 1971- Biosimulation. Cambridge ; New York : Cambridge University Press, 2012 9780521768238 (DLC) 2011046839 (OCoLC)761858511 Cambridge texts in biomedical engineering. http://id.loc.gov/authorities/names/no2007047067 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=443737 Volltext |
| spellingShingle | Beard, Daniel A., 1971- Biosimulation : simulation of living systems / Cambridge texts in biomedical engineering. Cover; Biosimulation; Series; Title; Copyright; Contents; Preface; Extracts; 1: Introduction to simulation of biological systems; Overview; 1.1 Modeling approaches; 1.2 An introductory example: biochemistry of a home aquarium; 1.2.1 First model: a nonmechanistic analysis; 1.2.2 Nonmechanistic analysis with noise; 1.2.3 Mechanistic modeling; 1.3 Recapitulation and lessons learned; Problems; 2: Transport and reaction of solutes in biological systems; Overview; 2.1 Well-mixed systems: compartmental modeling; 2.2 Passive flow of water, solutes, and electrical current across membranes. 2.2.1 Basic equations2.2.2 Example: volume changes in isolated glomeruli; 2.3 Simulating chemical reactions; 2.3.1 Example: synthesis of ethanol from xylose; 2.4 Distributed transport modeling; 2.4.1 Flowing systems: the advection equation; 2.4.2 Reaction-diffusion systems; 2.4.3 Advection-reaction-diffusion systems; 2.5 Recapitulation and lessons learned; Problems; 3: Physiologically based pharmacokinetic modeling; Overview; 3.1 Introduction to lumped compartmental PBPK modeling; 3.1.1 Basic equations; 3.1.2 Comparison of distributed and lumped transport models. 3.1.3 Quasi-steady model reduction3.1.4 Lumped versus distributed transport modeling: a final word; 3.2 Overview of the mammalian circulatory system; 3.3 Whole-body PBPK simulation; 3.4 Example: uptake and delivery of matrine in rat; 3.4.1 A PBPK model for rat; 3.4.2 Model parameters; 3.4.3 Flow-limited transport; 3.4.4 Model validation and discrimination; 3.5 Recapitulation and lessons learned; Problems; 4: Cardiovascular systems simulation; Overview; 4.1 The Frank-Starling mechanism of heart; 4.2 An analysis of the physiological factors that control cardiac output. 4.2.1 Guyton's model of the systemic circulation4.2.2 What the model tells us about the relationship between flow and right atrial pressure; 4.2.3 How the simple Guyton model is commonly misinterpreted; 4.3 Pulsatile mechanics of the circulatory system; 4.3.1 Time-varying elastance models of the heart; 4.3.2 Simulation of the aortic pressure waveform; 4.4 Dynamic changes in blood pressures and flows; 4.4.1 Baroreceptor control of systemic pressure; 4.5 Mechanisms of hypertension; 4.6 Recapitulation and lessons learned; Problems. 5: Chemical reaction systems: thermodynamics and chemical equilibriumOverview; 5.1 Temperature, pressure, and entropy; 5.1.1 Microstates and macrostates; 5.1.2 Example: a simple two-state system; 5.1.3 Relationship between temperature and entropy; 5.1.4 Relationship between pressure and entropy; 5.2 Free energy under constant-temperature and constant-volume conditions; 5.3 Free energy under constant-temperature and constant-pressure conditions; 5.4 Thermodynamic ensembles, partition functions, and driving forces; 5.5 Chemical reactions, stoichiometry, and equilibrium constants; 5.6 Acids, bases, and buffers. Biophysics Computer simulation. Biophysics Simulation methods. Biomedical engineering Computer simulation. Medical sciences Case studies. Biomedical engineering. http://id.loc.gov/authorities/subjects/sh85014237 Computer simulation. http://id.loc.gov/authorities/subjects/sh85029533 Digital computer simulation. http://id.loc.gov/authorities/subjects/sh85037973 Biophysical Phenomena Biomedical Engineering Computer Simulation Biomedical Technology https://id.nlm.nih.gov/mesh/D020811 Biophysique Simulation par ordinateur. Biophysique Méthodes de simulation. Génie biomédical Simulation par ordinateur. Sciences de la santé Études de cas. Phénomènes biophysiques. Génie biomédical. Simulation par ordinateur. biomedical engineering. aat simulation. aat SCIENCE Life Sciences Biophysics. bisacsh Digital computer simulation fast Computer simulation fast Biomedical engineering fast Biomedical engineering Computer simulation fast Medical sciences fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85014237 http://id.loc.gov/authorities/subjects/sh85029533 http://id.loc.gov/authorities/subjects/sh85037973 https://id.nlm.nih.gov/mesh/D020811 https://id.nlm.nih.gov/mesh/D002363 http://id.loc.gov/authorities/genreForms/gf2017026140 |
| title | Biosimulation : simulation of living systems / |
| title_auth | Biosimulation : simulation of living systems / |
| title_exact_search | Biosimulation : simulation of living systems / |
| title_full | Biosimulation : simulation of living systems / Daniel A. Beard. |
| title_fullStr | Biosimulation : simulation of living systems / Daniel A. Beard. |
| title_full_unstemmed | Biosimulation : simulation of living systems / Daniel A. Beard. |
| title_short | Biosimulation : |
| title_sort | biosimulation simulation of living systems |
| title_sub | simulation of living systems / |
| topic | Biophysics Computer simulation. Biophysics Simulation methods. Biomedical engineering Computer simulation. Medical sciences Case studies. Biomedical engineering. http://id.loc.gov/authorities/subjects/sh85014237 Computer simulation. http://id.loc.gov/authorities/subjects/sh85029533 Digital computer simulation. http://id.loc.gov/authorities/subjects/sh85037973 Biophysical Phenomena Biomedical Engineering Computer Simulation Biomedical Technology https://id.nlm.nih.gov/mesh/D020811 Biophysique Simulation par ordinateur. Biophysique Méthodes de simulation. Génie biomédical Simulation par ordinateur. Sciences de la santé Études de cas. Phénomènes biophysiques. Génie biomédical. Simulation par ordinateur. biomedical engineering. aat simulation. aat SCIENCE Life Sciences Biophysics. bisacsh Digital computer simulation fast Computer simulation fast Biomedical engineering fast Biomedical engineering Computer simulation fast Medical sciences fast |
| topic_facet | Biophysics Computer simulation. Biophysics Simulation methods. Biomedical engineering Computer simulation. Medical sciences Case studies. Biomedical engineering. Computer simulation. Digital computer simulation. Biophysical Phenomena Biomedical Engineering Computer Simulation Biomedical Technology Biophysique Simulation par ordinateur. Biophysique Méthodes de simulation. Génie biomédical Simulation par ordinateur. Sciences de la santé Études de cas. Phénomènes biophysiques. Génie biomédical. Simulation par ordinateur. biomedical engineering. simulation. SCIENCE Life Sciences Biophysics. Digital computer simulation Computer simulation Biomedical engineering Biomedical engineering Computer simulation Medical sciences Case Reports Case studies Case studies. Études de cas. |
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| work_keys_str_mv | AT bearddaniela biosimulationsimulationoflivingsystems |