Experimental Models in Serotonin Transporter Research.:
The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top expert...
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| Weitere Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge University Press
2010.
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| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research. |
| Beschreibung: | 1 online resource (300) |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9780511729935 0511729936 9780521514873 0521514878 1107190320 9781107190320 0511846894 9780511846892 9786612619731 6612619732 0511728980 9780511728983 0511728034 9780511728037 0511724276 9780511724275 0511727089 9780511727085 |
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| 505 | 0 | |a Cover13; -- Contents13; -- List of contributors -- Preface: Focus on the serotonin transporter -- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake -- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages -- 3 Developmental roles for the serotonin transporter -- 4 SERT models of emotional dysregulation -- 5 The serotonin transporter and animal models of depression -- 6 The serotonin transporter knock-out rat: a review -- 7 WistarZagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter -- 8 The role of the serotonin transporter in reward mechanisms -- 9 Modeling SERT X BDNF interactions in brain disorders: 13;single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice -- 10 Primate models in serotonin transporter research -- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain -- Index. | |
| 520 | |a The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research. | ||
| 504 | |a Includes bibliographical references and index. | ||
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| 650 | 0 | |a Diseases |x Animal models. |0 http://id.loc.gov/authorities/subjects/sh85038412 | |
| 650 | 1 | 2 | |a Serotonin |x metabolism |0 https://id.nlm.nih.gov/mesh/D012701Q000378 |
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| 650 | 2 | 2 | |a Selective Serotonin Reuptake Inhibitors |x pharmacology |
| 650 | 2 | |a Serotonin |0 https://id.nlm.nih.gov/mesh/D012701 | |
| 650 | 2 | |a Carrier Proteins |0 https://id.nlm.nih.gov/mesh/D002352 | |
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| contents | Cover13; -- Contents13; -- List of contributors -- Preface: Focus on the serotonin transporter -- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake -- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages -- 3 Developmental roles for the serotonin transporter -- 4 SERT models of emotional dysregulation -- 5 The serotonin transporter and animal models of depression -- 6 The serotonin transporter knock-out rat: a review -- 7 WistarZagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter -- 8 The role of the serotonin transporter in reward mechanisms -- 9 Modeling SERT X BDNF interactions in brain disorders: 13;single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice -- 10 Primate models in serotonin transporter research -- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain -- Index. |
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| genre | Electronic resource. |
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| illustrated | Not Illustrated |
| indexdate | 2024-11-27T13:17:54Z |
| institution | BVB |
| isbn | 9780511729935 0511729936 9780521514873 0521514878 1107190320 9781107190320 0511846894 9780511846892 9786612619731 6612619732 0511728980 9780511728983 0511728034 9780511728037 0511724276 9780511724275 0511727089 9780511727085 |
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| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Cambridge University Press |
| record_format | marc |
| spelling | Experimental Models in Serotonin Transporter Research. Cambridge University Press 2010. 1 online resource (300) text txt rdacontent computer c rdamedia online resource cr rdacarrier Cover13; -- Contents13; -- List of contributors -- Preface: Focus on the serotonin transporter -- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake -- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages -- 3 Developmental roles for the serotonin transporter -- 4 SERT models of emotional dysregulation -- 5 The serotonin transporter and animal models of depression -- 6 The serotonin transporter knock-out rat: a review -- 7 WistarZagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter -- 8 The role of the serotonin transporter in reward mechanisms -- 9 Modeling SERT X BDNF interactions in brain disorders: 13;single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice -- 10 Primate models in serotonin transporter research -- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain -- Index. The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research. Includes bibliographical references and index. English. Serotonin. http://id.loc.gov/authorities/subjects/sh85120301 Carrier proteins. http://id.loc.gov/authorities/subjects/sh85020470 Serotoninergic mechanisms. http://id.loc.gov/authorities/subjects/sh89006313 Serotonin Metabolism. Serotonin Plasma Membrane Transport Proteins metabolism. Diseases Animal models. http://id.loc.gov/authorities/subjects/sh85038412 Serotonin metabolism https://id.nlm.nih.gov/mesh/D012701Q000378 Serotonin Plasma Membrane Transport Proteins metabolism Disease Models, Animal Mental Disorders drug therapy Models, Psychological Selective Serotonin Reuptake Inhibitors pharmacology Serotonin https://id.nlm.nih.gov/mesh/D012701 Carrier Proteins https://id.nlm.nih.gov/mesh/D002352 Sérotonine. Protéines de liaison. Systèmes sérotoninergiques. Sérotonine Métabolisme. Maladies Modèles animaux. Psychologie Méthodes de simulation. Diseases Animal models fast Carrier proteins fast Serotonin fast Serotonin Metabolism fast Serotoninergic mechanisms fast Electronic resource. Kalueff, Allan V., LaPorte, Justin L. edt has work: Experimental models in serotonin transporter research (Text) https://id.oclc.org/worldcat/entity/E39PCH7Bmcc97wkYmPjhhMwxj3 https://id.oclc.org/worldcat/ontology/hasWork 0-521-51487-8 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=320360 Volltext |
| spellingShingle | Experimental Models in Serotonin Transporter Research. Cover13; -- Contents13; -- List of contributors -- Preface: Focus on the serotonin transporter -- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake -- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages -- 3 Developmental roles for the serotonin transporter -- 4 SERT models of emotional dysregulation -- 5 The serotonin transporter and animal models of depression -- 6 The serotonin transporter knock-out rat: a review -- 7 WistarZagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter -- 8 The role of the serotonin transporter in reward mechanisms -- 9 Modeling SERT X BDNF interactions in brain disorders: 13;single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice -- 10 Primate models in serotonin transporter research -- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain -- Index. Serotonin. http://id.loc.gov/authorities/subjects/sh85120301 Carrier proteins. http://id.loc.gov/authorities/subjects/sh85020470 Serotoninergic mechanisms. http://id.loc.gov/authorities/subjects/sh89006313 Serotonin Metabolism. Serotonin Plasma Membrane Transport Proteins metabolism. Diseases Animal models. http://id.loc.gov/authorities/subjects/sh85038412 Serotonin metabolism https://id.nlm.nih.gov/mesh/D012701Q000378 Serotonin Plasma Membrane Transport Proteins metabolism Disease Models, Animal Mental Disorders drug therapy Models, Psychological Selective Serotonin Reuptake Inhibitors pharmacology Serotonin https://id.nlm.nih.gov/mesh/D012701 Carrier Proteins https://id.nlm.nih.gov/mesh/D002352 Sérotonine. Protéines de liaison. Systèmes sérotoninergiques. Sérotonine Métabolisme. Maladies Modèles animaux. Psychologie Méthodes de simulation. Diseases Animal models fast Carrier proteins fast Serotonin fast Serotonin Metabolism fast Serotoninergic mechanisms fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh85120301 http://id.loc.gov/authorities/subjects/sh85020470 http://id.loc.gov/authorities/subjects/sh89006313 http://id.loc.gov/authorities/subjects/sh85038412 https://id.nlm.nih.gov/mesh/D012701Q000378 https://id.nlm.nih.gov/mesh/D012701 https://id.nlm.nih.gov/mesh/D002352 |
| title | Experimental Models in Serotonin Transporter Research. |
| title_auth | Experimental Models in Serotonin Transporter Research. |
| title_exact_search | Experimental Models in Serotonin Transporter Research. |
| title_full | Experimental Models in Serotonin Transporter Research. |
| title_fullStr | Experimental Models in Serotonin Transporter Research. |
| title_full_unstemmed | Experimental Models in Serotonin Transporter Research. |
| title_short | Experimental Models in Serotonin Transporter Research. |
| title_sort | experimental models in serotonin transporter research |
| topic | Serotonin. http://id.loc.gov/authorities/subjects/sh85120301 Carrier proteins. http://id.loc.gov/authorities/subjects/sh85020470 Serotoninergic mechanisms. http://id.loc.gov/authorities/subjects/sh89006313 Serotonin Metabolism. Serotonin Plasma Membrane Transport Proteins metabolism. Diseases Animal models. http://id.loc.gov/authorities/subjects/sh85038412 Serotonin metabolism https://id.nlm.nih.gov/mesh/D012701Q000378 Serotonin Plasma Membrane Transport Proteins metabolism Disease Models, Animal Mental Disorders drug therapy Models, Psychological Selective Serotonin Reuptake Inhibitors pharmacology Serotonin https://id.nlm.nih.gov/mesh/D012701 Carrier Proteins https://id.nlm.nih.gov/mesh/D002352 Sérotonine. Protéines de liaison. Systèmes sérotoninergiques. Sérotonine Métabolisme. Maladies Modèles animaux. Psychologie Méthodes de simulation. Diseases Animal models fast Carrier proteins fast Serotonin fast Serotonin Metabolism fast Serotoninergic mechanisms fast |
| topic_facet | Serotonin. Carrier proteins. Serotoninergic mechanisms. Serotonin Metabolism. Serotonin Plasma Membrane Transport Proteins metabolism. Diseases Animal models. Serotonin metabolism Serotonin Plasma Membrane Transport Proteins metabolism Disease Models, Animal Mental Disorders drug therapy Models, Psychological Selective Serotonin Reuptake Inhibitors pharmacology Serotonin Carrier Proteins Sérotonine. Protéines de liaison. Systèmes sérotoninergiques. Sérotonine Métabolisme. Maladies Modèles animaux. Psychologie Méthodes de simulation. Diseases Animal models Carrier proteins Serotonin Metabolism Serotoninergic mechanisms Electronic resource. |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=320360 |
| work_keys_str_mv | AT kalueffallanvlaportejustinl experimentalmodelsinserotonintransporterresearch |