Verfügbarkeit: Target validation in drug discovery /

Target validation in drug discovery /:

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug develo...

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Weitere Verfasser:	Metcalf, Brian W., Dillon, Susan, 1952-
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Amsterdam ; Boston : Academic Press, ©2007.
Schlagworte:	Drug development. Drugs > Testing. High throughput screening (Drug development) Drugs > Design. Pharmaceutical technology. Drug Design Drug Delivery Systems Technology, Pharmaceutical Médicaments > Développement. Médicaments > Essais cliniques. Criblage à haut débit (Développement des médicaments) Médicaments > Conception. Techniques pharmaceutiques. MEDICAL > Drug Guides. MEDICAL > Pharmacology. MEDICAL > Pharmacy. MEDICAL > Nursing > Pharmacology. Pharmaceutical technology Drugs > Design Drug development Drugs > Testing Médicaments > Mise au point. Criblage pharmacologique.
Online-Zugang:	Volltext Volltext
Zusammenfassung:	This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book
Beschreibung:	1 online resource (xii, 279 pages) : illustrations
Bibliographie:	Includes bibliographical references and index.
ISBN:	9780123693938 0123693934 9780080465975 0080465978

Internformat

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publisher	Academic Press,
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spelling	Target validation in drug discovery / editors, Brian W. Metcalf and Susan Dillon. Amsterdam ; Boston : Academic Press, ©2007. 1 online resource (xii, 279 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier data file This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches. Includes bibliographical references and index. Print version record. Drug development. http://id.loc.gov/authorities/subjects/sh97007921 Drugs Testing. http://id.loc.gov/authorities/subjects/sh85039755 High throughput screening (Drug development) http://id.loc.gov/authorities/subjects/sh2001002949 Drugs Design. http://id.loc.gov/authorities/subjects/sh88001157 Pharmaceutical technology. http://id.loc.gov/authorities/subjects/sh85100590 Drug Design Drug Delivery Systems Technology, Pharmaceutical Médicaments Développement. Médicaments Essais cliniques. Criblage à haut débit (Développement des médicaments) Médicaments Conception. Techniques pharmaceutiques. MEDICAL Drug Guides. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh MEDICAL Nursing Pharmacology. bisacsh Pharmaceutical technology fast Drugs Design fast Drug development fast Drugs Testing fast High throughput screening (Drug development) fast Médicaments Mise au point. ram Médicaments Essais cliniques. ram Criblage pharmacologique. ram Metcalf, Brian W. Dillon, Susan, 1952- https://id.oclc.org/worldcat/entity/E39PCjxTjPrxWGjxkv6FwXy4xC http://id.loc.gov/authorities/names/n2006058857 has work: Target validation in drug discovery (Text) https://id.oclc.org/worldcat/entity/E39PCFTfy3xVTXvYc4XdQVBmJP https://id.oclc.org/worldcat/ontology/hasWork Print version: Target validation in drug discovery. Amsterdam ; Boston : Academic Press, ©2007 0123693934 9780123693938 (DLC) 2006049868 (OCoLC)70823305 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=182182 Volltext FWS01 ZDB-4-EBA FWS_PDA_EBA https://www.sciencedirect.com/science/book/9780123693938 Volltext
spellingShingle	Target validation in drug discovery / Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches. Drug development. http://id.loc.gov/authorities/subjects/sh97007921 Drugs Testing. http://id.loc.gov/authorities/subjects/sh85039755 High throughput screening (Drug development) http://id.loc.gov/authorities/subjects/sh2001002949 Drugs Design. http://id.loc.gov/authorities/subjects/sh88001157 Pharmaceutical technology. http://id.loc.gov/authorities/subjects/sh85100590 Drug Design Drug Delivery Systems Technology, Pharmaceutical Médicaments Développement. Médicaments Essais cliniques. Criblage à haut débit (Développement des médicaments) Médicaments Conception. Techniques pharmaceutiques. MEDICAL Drug Guides. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh MEDICAL Nursing Pharmacology. bisacsh Pharmaceutical technology fast Drugs Design fast Drug development fast Drugs Testing fast High throughput screening (Drug development) fast Médicaments Mise au point. ram Médicaments Essais cliniques. ram Criblage pharmacologique. ram
subject_GND	http://id.loc.gov/authorities/subjects/sh97007921 http://id.loc.gov/authorities/subjects/sh85039755 http://id.loc.gov/authorities/subjects/sh2001002949 http://id.loc.gov/authorities/subjects/sh88001157 http://id.loc.gov/authorities/subjects/sh85100590
title	Target validation in drug discovery /
title_auth	Target validation in drug discovery /
title_exact_search	Target validation in drug discovery /
title_full	Target validation in drug discovery / editors, Brian W. Metcalf and Susan Dillon.
title_fullStr	Target validation in drug discovery / editors, Brian W. Metcalf and Susan Dillon.
title_full_unstemmed	Target validation in drug discovery / editors, Brian W. Metcalf and Susan Dillon.
title_short	Target validation in drug discovery /
title_sort	target validation in drug discovery
topic	Drug development. http://id.loc.gov/authorities/subjects/sh97007921 Drugs Testing. http://id.loc.gov/authorities/subjects/sh85039755 High throughput screening (Drug development) http://id.loc.gov/authorities/subjects/sh2001002949 Drugs Design. http://id.loc.gov/authorities/subjects/sh88001157 Pharmaceutical technology. http://id.loc.gov/authorities/subjects/sh85100590 Drug Design Drug Delivery Systems Technology, Pharmaceutical Médicaments Développement. Médicaments Essais cliniques. Criblage à haut débit (Développement des médicaments) Médicaments Conception. Techniques pharmaceutiques. MEDICAL Drug Guides. bisacsh MEDICAL Pharmacology. bisacsh MEDICAL Pharmacy. bisacsh MEDICAL Nursing Pharmacology. bisacsh Pharmaceutical technology fast Drugs Design fast Drug development fast Drugs Testing fast High throughput screening (Drug development) fast Médicaments Mise au point. ram Médicaments Essais cliniques. ram Criblage pharmacologique. ram
topic_facet	Drug development. Drugs Testing. High throughput screening (Drug development) Drugs Design. Pharmaceutical technology. Drug Design Drug Delivery Systems Technology, Pharmaceutical Médicaments Développement. Médicaments Essais cliniques. Criblage à haut débit (Développement des médicaments) Médicaments Conception. Techniques pharmaceutiques. MEDICAL Drug Guides. MEDICAL Pharmacology. MEDICAL Pharmacy. MEDICAL Nursing Pharmacology. Pharmaceutical technology Drugs Design Drug development Drugs Testing Médicaments Mise au point. Criblage pharmacologique.
url	https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=182182 https://www.sciencedirect.com/science/book/9780123693938
work_keys_str_mv	AT metcalfbrianw targetvalidationindrugdiscovery AT dillonsusan targetvalidationindrugdiscovery

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