A means to an end :: the biological basis of aging and death /
Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York ; Oxford :
Oxford University Press,
2002.
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century. |
| Beschreibung: | Originally published: 1999. |
| Beschreibung: | 1 online resource (xv, 234 pages) : illustrations |
| Bibliographie: | Includes bibliographical references and index. |
| ISBN: | 9780198029113 019802911X 0195303369 9780195303360 9780195125931 0195125932 9780195153750 0195153758 1280502045 9781280502040 1602567751 9781602567757 |
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| 100 | 1 | |a Clark, William R., |d 1938- |1 https://id.oclc.org/worldcat/entity/E39PCjtBmDJGftjmkThhMD8xKq |0 http://id.loc.gov/authorities/names/n80031981 | |
| 245 | 1 | 2 | |a A means to an end : |b the biological basis of aging and death / |c William R. Clark. |
| 260 | |a New York ; |a Oxford : |b Oxford University Press, |c 2002. | ||
| 300 | |a 1 online resource (xv, 234 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 500 | |a Originally published: 1999. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century. | ||
| 505 | 0 | |a Acknowledgments; Introduction; 1. Aging, Senescence, and Lifespan; 2. The Nature of Cellular Senescence and Death; 3. The Evolution of Senescence and Death; 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan; 5. Human Genetic Diseases That Mimic the Aging Process; 6. Cycling to Senescence; 7. Replicative Immortality: Cancer and Aging; 8. Caloric Restriction and Maximum Lifespan; 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence; 10. The Aging Brain; 11. A Conditional Benefit; Bibliography; Index. | |
| 650 | 0 | |a Apoptosis. |0 http://id.loc.gov/authorities/subjects/sh91000743 | |
| 650 | 0 | |a Aging |x Molecular aspects. |0 http://id.loc.gov/authorities/subjects/sh89007028 | |
| 650 | 0 | |a Cells |x Aging. |0 http://id.loc.gov/authorities/subjects/sh85021680 | |
| 650 | 6 | |a Apoptose. | |
| 650 | 6 | |a Vieillissement |x Aspect moléculaire. | |
| 650 | 6 | |a Cellules |x Vieillissement. | |
| 650 | 7 | |a MEDICAL |x Nursing |x Gerontology. |2 bisacsh | |
| 650 | 7 | |a FAMILY & RELATIONSHIPS |x Aging. |2 bisacsh | |
| 650 | 7 | |a Aging |x Molecular aspects |2 fast | |
| 650 | 7 | |a Apoptosis |2 fast | |
| 650 | 7 | |a Cells |x Aging |2 fast | |
| 655 | 4 | |a Electronic book. | |
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| 776 | 0 | 8 | |i Print version: |a Clark, William R., 1938- |t Means to an end. |d New York ; Oxford : Oxford University Press, 2002 |z 0195125932 |z 0195153758 |w (OCoLC)48784366 |
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| _version_ | 1816881628846227456 |
| adam_text | |
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| author | Clark, William R., 1938- |
| author_GND | http://id.loc.gov/authorities/names/n80031981 |
| author_facet | Clark, William R., 1938- |
| author_role | |
| author_sort | Clark, William R., 1938- |
| author_variant | w r c wr wrc |
| building | Verbundindex |
| bvnumber | localFWS |
| callnumber-first | Q - Science |
| callnumber-label | QH608 |
| callnumber-raw | QH608 .C53 2002eb |
| callnumber-search | QH608 .C53 2002eb |
| callnumber-sort | QH 3608 C53 42002EB |
| callnumber-subject | QH - Natural History and Biology |
| collection | ZDB-4-EBA |
| contents | Acknowledgments; Introduction; 1. Aging, Senescence, and Lifespan; 2. The Nature of Cellular Senescence and Death; 3. The Evolution of Senescence and Death; 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan; 5. Human Genetic Diseases That Mimic the Aging Process; 6. Cycling to Senescence; 7. Replicative Immortality: Cancer and Aging; 8. Caloric Restriction and Maximum Lifespan; 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence; 10. The Aging Brain; 11. A Conditional Benefit; Bibliography; Index. |
| ctrlnum | (OCoLC)60932736 |
| dewey-full | 612.6/7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.6/7 |
| dewey-search | 612.6/7 |
| dewey-sort | 3612.6 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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Clark.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="a">New York ;</subfield><subfield code="a">Oxford :</subfield><subfield code="b">Oxford University Press,</subfield><subfield code="c">2002.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (xv, 234 pages) :</subfield><subfield code="b">illustrations</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">data file</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Originally published: 1999.</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index.</subfield></datafield><datafield tag="588" ind1="0" ind2=" "><subfield code="a">Print version record.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.</subfield></datafield><datafield tag="505" ind1="0" ind2=" "><subfield code="a">Acknowledgments; Introduction; 1. Aging, Senescence, and Lifespan; 2. The Nature of Cellular Senescence and Death; 3. The Evolution of Senescence and Death; 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan; 5. Human Genetic Diseases That Mimic the Aging Process; 6. Cycling to Senescence; 7. Replicative Immortality: Cancer and Aging; 8. Caloric Restriction and Maximum Lifespan; 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence; 10. The Aging Brain; 11. 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| genre | Electronic book. |
| genre_facet | Electronic book. |
| id | ZDB-4-EBA-ocm60932736 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:15:45Z |
| institution | BVB |
| isbn | 9780198029113 019802911X 0195303369 9780195303360 9780195125931 0195125932 9780195153750 0195153758 1280502045 9781280502040 1602567751 9781602567757 |
| language | English |
| oclc_num | 60932736 |
| open_access_boolean | |
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| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (xv, 234 pages) : illustrations |
| psigel | ZDB-4-EBA |
| publishDate | 2002 |
| publishDateSearch | 2002 |
| publishDateSort | 2002 |
| publisher | Oxford University Press, |
| record_format | marc |
| spelling | Clark, William R., 1938- https://id.oclc.org/worldcat/entity/E39PCjtBmDJGftjmkThhMD8xKq http://id.loc.gov/authorities/names/n80031981 A means to an end : the biological basis of aging and death / William R. Clark. New York ; Oxford : Oxford University Press, 2002. 1 online resource (xv, 234 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier data file Originally published: 1999. Includes bibliographical references and index. Print version record. Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century. Acknowledgments; Introduction; 1. Aging, Senescence, and Lifespan; 2. The Nature of Cellular Senescence and Death; 3. The Evolution of Senescence and Death; 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan; 5. Human Genetic Diseases That Mimic the Aging Process; 6. Cycling to Senescence; 7. Replicative Immortality: Cancer and Aging; 8. Caloric Restriction and Maximum Lifespan; 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence; 10. The Aging Brain; 11. A Conditional Benefit; Bibliography; Index. Apoptosis. http://id.loc.gov/authorities/subjects/sh91000743 Aging Molecular aspects. http://id.loc.gov/authorities/subjects/sh89007028 Cells Aging. http://id.loc.gov/authorities/subjects/sh85021680 Apoptose. Vieillissement Aspect moléculaire. Cellules Vieillissement. MEDICAL Nursing Gerontology. bisacsh FAMILY & RELATIONSHIPS Aging. bisacsh Aging Molecular aspects fast Apoptosis fast Cells Aging fast Electronic book. has work: A means to an end (Text) https://id.oclc.org/worldcat/entity/E39PCFwFVvDfy46hHwDCjCpRXd https://id.oclc.org/worldcat/ontology/hasWork Print version: Clark, William R., 1938- Means to an end. New York ; Oxford : Oxford University Press, 2002 0195125932 0195153758 (OCoLC)48784366 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=121455 Volltext |
| spellingShingle | Clark, William R., 1938- A means to an end : the biological basis of aging and death / Acknowledgments; Introduction; 1. Aging, Senescence, and Lifespan; 2. The Nature of Cellular Senescence and Death; 3. The Evolution of Senescence and Death; 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan; 5. Human Genetic Diseases That Mimic the Aging Process; 6. Cycling to Senescence; 7. Replicative Immortality: Cancer and Aging; 8. Caloric Restriction and Maximum Lifespan; 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence; 10. The Aging Brain; 11. A Conditional Benefit; Bibliography; Index. Apoptosis. http://id.loc.gov/authorities/subjects/sh91000743 Aging Molecular aspects. http://id.loc.gov/authorities/subjects/sh89007028 Cells Aging. http://id.loc.gov/authorities/subjects/sh85021680 Apoptose. Vieillissement Aspect moléculaire. Cellules Vieillissement. MEDICAL Nursing Gerontology. bisacsh FAMILY & RELATIONSHIPS Aging. bisacsh Aging Molecular aspects fast Apoptosis fast Cells Aging fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh91000743 http://id.loc.gov/authorities/subjects/sh89007028 http://id.loc.gov/authorities/subjects/sh85021680 |
| title | A means to an end : the biological basis of aging and death / |
| title_auth | A means to an end : the biological basis of aging and death / |
| title_exact_search | A means to an end : the biological basis of aging and death / |
| title_full | A means to an end : the biological basis of aging and death / William R. Clark. |
| title_fullStr | A means to an end : the biological basis of aging and death / William R. Clark. |
| title_full_unstemmed | A means to an end : the biological basis of aging and death / William R. Clark. |
| title_short | A means to an end : |
| title_sort | means to an end the biological basis of aging and death |
| title_sub | the biological basis of aging and death / |
| topic | Apoptosis. http://id.loc.gov/authorities/subjects/sh91000743 Aging Molecular aspects. http://id.loc.gov/authorities/subjects/sh89007028 Cells Aging. http://id.loc.gov/authorities/subjects/sh85021680 Apoptose. Vieillissement Aspect moléculaire. Cellules Vieillissement. MEDICAL Nursing Gerontology. bisacsh FAMILY & RELATIONSHIPS Aging. bisacsh Aging Molecular aspects fast Apoptosis fast Cells Aging fast |
| topic_facet | Apoptosis. Aging Molecular aspects. Cells Aging. Apoptose. Vieillissement Aspect moléculaire. Cellules Vieillissement. MEDICAL Nursing Gerontology. FAMILY & RELATIONSHIPS Aging. Aging Molecular aspects Apoptosis Cells Aging Electronic book. |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=121455 |
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