Pyridostigmine bromide :: executive summary /
The United States and its allies in the Persian Gulf War (PGW) knew that Iraq had used nerve agents and chemical weapons in its previous conflicts and so took steps to protect their troops. Pyridostigmine bromide (PB) was distributed as a pretreatment that would enhance the effectiveness of postexpo...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Körperschaft: | |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Santa Monica, Calif. :
National Defense Research Institute, RAND,
1999.
|
| Schriftenreihe: | Review of the scientific literature as it pertains to Gulf War illnesses ;
v. 2. Gulf War illnesses series. |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The United States and its allies in the Persian Gulf War (PGW) knew that Iraq had used nerve agents and chemical weapons in its previous conflicts and so took steps to protect their troops. Pyridostigmine bromide (PB) was distributed as a pretreatment that would enhance the effectiveness of postexposure treatments in the event that the nerve agent soman was used. This report examines the role that PB played in the ongoing chronic health problems documented in PGW veterans. After careful examination of the known effects of PB on the central and peripheral nervous systems, the author finds the evidence consistent with a possible role for PB as a contributor to the health complaints of some PGW veterans and calls for immediate attention in the form of additional investigation to clarify the role of PB. -- Provided by publisher. |
| Beschreibung: | "Prepared for the Office of the Secretary of Defense." "This executive summary reproduces the preface and summary from Pyridostigmine bromide by Beatrice Alexandra Golomb, MR-1018/2-OSD"--Title page verso "MR-1018/2/1-OSD"--Page 4 of cover |
| Beschreibung: | 1 online resource (xxi (21) pages) : illustrations |
| Bibliographie: | Includes bibliographical references. |
| ISBN: | 9780833055514 0833055518 0585308896 9780585308890 |
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| 100 | 1 | |a Golomb, Beatrice Alexandra. | |
| 245 | 1 | 0 | |a Pyridostigmine bromide : |b executive summary / |c Beatrice Alexandra Golomb. |
| 260 | |a Santa Monica, Calif. : |b National Defense Research Institute, RAND, |c 1999. | ||
| 300 | |a 1 online resource (xxi (21) pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a A review of the scientific literature as it pertains to Gulf War illnesses ; |v v. 2 | |
| 490 | 1 | |a Gulf War illnesses series | |
| 500 | |a "Prepared for the Office of the Secretary of Defense." | ||
| 500 | |a "This executive summary reproduces the preface and summary from Pyridostigmine bromide by Beatrice Alexandra Golomb, MR-1018/2-OSD"--Title page verso | ||
| 500 | |a "MR-1018/2/1-OSD"--Page 4 of cover | ||
| 504 | |a Includes bibliographical references. | ||
| 505 | 0 | |a Ch. 1. Introduction -- Ch. 2. Fact Sheet: PB Pretreatment for Soman Exposure -- Ch. 3. Characteristics of PB -- Ch. 4. PB Use in the Persian Gulf War -- Ch. 5. Health Problems in PGW Veterans -- Ch. 6. Theories Linking PB to Illness in PGW Veterans -- Ch. 7. Blood-Brain Barrier Passage -- Ch. 8. Individual Differences in Reactions to PB -- Ch. 9. Interactions between PB and other Exposures -- Ch. 10. Bromism -- Ch. 11. Multiple Chemical Sensitivity -- Ch. 12. Neuromuscular Junction Effects -- Ch. 13. Neurotransmitter Dysregulation -- Ch. 14. Chronic Effects -- Ch. 15. Other Considerations -- Ch. 16. Conclusions -- Addendum: Evidence for Neurotransmitter Dysregulation Identified or Published Since the Review Process -- App. A. Pyridostigmine Pharmacokinetic Data -- App. B. Effects of PB in Humans -- App. C. Further Discussion of the Acetylcholine-Serotonin Relationship. | |
| 520 | |a The United States and its allies in the Persian Gulf War (PGW) knew that Iraq had used nerve agents and chemical weapons in its previous conflicts and so took steps to protect their troops. Pyridostigmine bromide (PB) was distributed as a pretreatment that would enhance the effectiveness of postexposure treatments in the event that the nerve agent soman was used. This report examines the role that PB played in the ongoing chronic health problems documented in PGW veterans. After careful examination of the known effects of PB on the central and peripheral nervous systems, the author finds the evidence consistent with a possible role for PB as a contributor to the health complaints of some PGW veterans and calls for immediate attention in the form of additional investigation to clarify the role of PB. -- Provided by publisher. | ||
| 588 | 0 | |a Print version record. | |
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| 650 | 0 | |a Chemical warfare. |0 http://id.loc.gov/authorities/subjects/sh85022958 | |
| 650 | 2 | |a Perisan Gulf Syndrome | |
| 650 | 2 | |a Chemical Warfare | |
| 650 | 2 | |a Persian Gulf Syndrome |0 https://id.nlm.nih.gov/mesh/D018923 | |
| 650 | 2 | |a Chemical Warfare Agents |0 https://id.nlm.nih.gov/mesh/D002619 | |
| 650 | 6 | |a Syndrome de la guerre du Golfe. | |
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| 650 | 6 | |a Guerre chimique. | |
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Datensatz im Suchindex
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| _version_ | 1816881591370121216 |
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| author | Golomb, Beatrice Alexandra |
| author_corporate | National Defense Research Institute (U.S.) |
| author_corporate_role | |
| author_facet | Golomb, Beatrice Alexandra National Defense Research Institute (U.S.) |
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| contents | Ch. 1. Introduction -- Ch. 2. Fact Sheet: PB Pretreatment for Soman Exposure -- Ch. 3. Characteristics of PB -- Ch. 4. PB Use in the Persian Gulf War -- Ch. 5. Health Problems in PGW Veterans -- Ch. 6. Theories Linking PB to Illness in PGW Veterans -- Ch. 7. Blood-Brain Barrier Passage -- Ch. 8. Individual Differences in Reactions to PB -- Ch. 9. Interactions between PB and other Exposures -- Ch. 10. Bromism -- Ch. 11. Multiple Chemical Sensitivity -- Ch. 12. Neuromuscular Junction Effects -- Ch. 13. Neurotransmitter Dysregulation -- Ch. 14. Chronic Effects -- Ch. 15. Other Considerations -- Ch. 16. Conclusions -- Addendum: Evidence for Neurotransmitter Dysregulation Identified or Published Since the Review Process -- App. A. Pyridostigmine Pharmacokinetic Data -- App. B. Effects of PB in Humans -- App. C. Further Discussion of the Acetylcholine-Serotonin Relationship. |
| ctrlnum | (OCoLC)45730880 |
| dewey-full | 616.9/8023 |
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| dewey-raw | 616.9/8023 |
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| discipline | Medizin |
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| id | ZDB-4-EBA-ocm45730880 |
| illustrated | Illustrated |
| indexdate | 2024-11-27T13:15:09Z |
| institution | BVB |
| institution_GND | http://id.loc.gov/authorities/names/n91060525 |
| isbn | 9780833055514 0833055518 0585308896 9780585308890 |
| language | English |
| oclc_num | 45730880 |
| open_access_boolean | |
| owner | MAIN DE-863 DE-BY-FWS |
| owner_facet | MAIN DE-863 DE-BY-FWS |
| physical | 1 online resource (xxi (21) pages) : illustrations |
| psigel | ZDB-4-EBA |
| publishDate | 1999 |
| publishDateSearch | 1999 |
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| publisher | National Defense Research Institute, RAND, |
| record_format | marc |
| series | Review of the scientific literature as it pertains to Gulf War illnesses ; Gulf War illnesses series. |
| series2 | A review of the scientific literature as it pertains to Gulf War illnesses ; Gulf War illnesses series |
| spelling | Golomb, Beatrice Alexandra. Pyridostigmine bromide : executive summary / Beatrice Alexandra Golomb. Santa Monica, Calif. : National Defense Research Institute, RAND, 1999. 1 online resource (xxi (21) pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier A review of the scientific literature as it pertains to Gulf War illnesses ; v. 2 Gulf War illnesses series "Prepared for the Office of the Secretary of Defense." "This executive summary reproduces the preface and summary from Pyridostigmine bromide by Beatrice Alexandra Golomb, MR-1018/2-OSD"--Title page verso "MR-1018/2/1-OSD"--Page 4 of cover Includes bibliographical references. Ch. 1. Introduction -- Ch. 2. Fact Sheet: PB Pretreatment for Soman Exposure -- Ch. 3. Characteristics of PB -- Ch. 4. PB Use in the Persian Gulf War -- Ch. 5. Health Problems in PGW Veterans -- Ch. 6. Theories Linking PB to Illness in PGW Veterans -- Ch. 7. Blood-Brain Barrier Passage -- Ch. 8. Individual Differences in Reactions to PB -- Ch. 9. Interactions between PB and other Exposures -- Ch. 10. Bromism -- Ch. 11. Multiple Chemical Sensitivity -- Ch. 12. Neuromuscular Junction Effects -- Ch. 13. Neurotransmitter Dysregulation -- Ch. 14. Chronic Effects -- Ch. 15. Other Considerations -- Ch. 16. Conclusions -- Addendum: Evidence for Neurotransmitter Dysregulation Identified or Published Since the Review Process -- App. A. Pyridostigmine Pharmacokinetic Data -- App. B. Effects of PB in Humans -- App. C. Further Discussion of the Acetylcholine-Serotonin Relationship. The United States and its allies in the Persian Gulf War (PGW) knew that Iraq had used nerve agents and chemical weapons in its previous conflicts and so took steps to protect their troops. Pyridostigmine bromide (PB) was distributed as a pretreatment that would enhance the effectiveness of postexposure treatments in the event that the nerve agent soman was used. This report examines the role that PB played in the ongoing chronic health problems documented in PGW veterans. After careful examination of the known effects of PB on the central and peripheral nervous systems, the author finds the evidence consistent with a possible role for PB as a contributor to the health complaints of some PGW veterans and calls for immediate attention in the form of additional investigation to clarify the role of PB. -- Provided by publisher. Print version record. Persian Gulf syndrome. http://id.loc.gov/authorities/subjects/sh98000483 Chemical agents (Munitions) http://id.loc.gov/authorities/subjects/sh90001356 Chemical warfare. http://id.loc.gov/authorities/subjects/sh85022958 Perisan Gulf Syndrome Chemical Warfare Persian Gulf Syndrome https://id.nlm.nih.gov/mesh/D018923 Chemical Warfare Agents https://id.nlm.nih.gov/mesh/D002619 Syndrome de la guerre du Golfe. Agents chimiques (Munitions) Guerre chimique. MEDICAL Infectious Diseases. bisacsh HEALTH & FITNESS Diseases Contagious. bisacsh Chemical warfare fast Chemical agents (Munitions) fast Persian Gulf syndrome fast National Defense Research Institute (U.S.) http://id.loc.gov/authorities/names/n91060525 has work: Pyridostigmine bromide (Text) https://id.oclc.org/worldcat/entity/E39PD37jBbQkjbGGHH6MP3Ggpd https://id.oclc.org/worldcat/ontology/hasWork Print version: Golomb, Beatrice Alexandra. Pyridostigmine bromide. Santa Monica, Calif. : National Defense Research Institute, RAND, 1999 0833027956 Review of the scientific literature as it pertains to Gulf War illnesses ; v. 2. http://id.loc.gov/authorities/names/n99802652 Gulf War illnesses series. http://id.loc.gov/authorities/names/n99007612 FWS01 ZDB-4-EBA FWS_PDA_EBA https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=20474 Volltext |
| spellingShingle | Golomb, Beatrice Alexandra Pyridostigmine bromide : executive summary / Review of the scientific literature as it pertains to Gulf War illnesses ; Gulf War illnesses series. Ch. 1. Introduction -- Ch. 2. Fact Sheet: PB Pretreatment for Soman Exposure -- Ch. 3. Characteristics of PB -- Ch. 4. PB Use in the Persian Gulf War -- Ch. 5. Health Problems in PGW Veterans -- Ch. 6. Theories Linking PB to Illness in PGW Veterans -- Ch. 7. Blood-Brain Barrier Passage -- Ch. 8. Individual Differences in Reactions to PB -- Ch. 9. Interactions between PB and other Exposures -- Ch. 10. Bromism -- Ch. 11. Multiple Chemical Sensitivity -- Ch. 12. Neuromuscular Junction Effects -- Ch. 13. Neurotransmitter Dysregulation -- Ch. 14. Chronic Effects -- Ch. 15. Other Considerations -- Ch. 16. Conclusions -- Addendum: Evidence for Neurotransmitter Dysregulation Identified or Published Since the Review Process -- App. A. Pyridostigmine Pharmacokinetic Data -- App. B. Effects of PB in Humans -- App. C. Further Discussion of the Acetylcholine-Serotonin Relationship. Persian Gulf syndrome. http://id.loc.gov/authorities/subjects/sh98000483 Chemical agents (Munitions) http://id.loc.gov/authorities/subjects/sh90001356 Chemical warfare. http://id.loc.gov/authorities/subjects/sh85022958 Perisan Gulf Syndrome Chemical Warfare Persian Gulf Syndrome https://id.nlm.nih.gov/mesh/D018923 Chemical Warfare Agents https://id.nlm.nih.gov/mesh/D002619 Syndrome de la guerre du Golfe. Agents chimiques (Munitions) Guerre chimique. MEDICAL Infectious Diseases. bisacsh HEALTH & FITNESS Diseases Contagious. bisacsh Chemical warfare fast Chemical agents (Munitions) fast Persian Gulf syndrome fast |
| subject_GND | http://id.loc.gov/authorities/subjects/sh98000483 http://id.loc.gov/authorities/subjects/sh90001356 http://id.loc.gov/authorities/subjects/sh85022958 https://id.nlm.nih.gov/mesh/D018923 https://id.nlm.nih.gov/mesh/D002619 |
| title | Pyridostigmine bromide : executive summary / |
| title_auth | Pyridostigmine bromide : executive summary / |
| title_exact_search | Pyridostigmine bromide : executive summary / |
| title_full | Pyridostigmine bromide : executive summary / Beatrice Alexandra Golomb. |
| title_fullStr | Pyridostigmine bromide : executive summary / Beatrice Alexandra Golomb. |
| title_full_unstemmed | Pyridostigmine bromide : executive summary / Beatrice Alexandra Golomb. |
| title_short | Pyridostigmine bromide : |
| title_sort | pyridostigmine bromide executive summary |
| title_sub | executive summary / |
| topic | Persian Gulf syndrome. http://id.loc.gov/authorities/subjects/sh98000483 Chemical agents (Munitions) http://id.loc.gov/authorities/subjects/sh90001356 Chemical warfare. http://id.loc.gov/authorities/subjects/sh85022958 Perisan Gulf Syndrome Chemical Warfare Persian Gulf Syndrome https://id.nlm.nih.gov/mesh/D018923 Chemical Warfare Agents https://id.nlm.nih.gov/mesh/D002619 Syndrome de la guerre du Golfe. Agents chimiques (Munitions) Guerre chimique. MEDICAL Infectious Diseases. bisacsh HEALTH & FITNESS Diseases Contagious. bisacsh Chemical warfare fast Chemical agents (Munitions) fast Persian Gulf syndrome fast |
| topic_facet | Persian Gulf syndrome. Chemical agents (Munitions) Chemical warfare. Perisan Gulf Syndrome Chemical Warfare Persian Gulf Syndrome Chemical Warfare Agents Syndrome de la guerre du Golfe. Agents chimiques (Munitions) Guerre chimique. MEDICAL Infectious Diseases. HEALTH & FITNESS Diseases Contagious. Chemical warfare Persian Gulf syndrome |
| url | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=20474 |
| work_keys_str_mv | AT golombbeatricealexandra pyridostigminebromideexecutivesummary AT nationaldefenseresearchinstituteus pyridostigminebromideexecutivesummary |