Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation:
This adverse outcome pathway links inhibition of aromatase activity in teleost fish during gonadogenesis to increased differentiation to testis resulting in a male-biased sex ratio in the population, and ultimately, reduced population sustainability. Most gonochoristic fish species develop either as...
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | , , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2023
|
| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.34 |
| Schlagworte: | |
| Online-Zugang: | DE-862 DE-863 |
| Zusammenfassung: | This adverse outcome pathway links inhibition of aromatase activity in teleost fish during gonadogenesis to increased differentiation to testis resulting in a male-biased sex ratio in the population, and ultimately, reduced population sustainability. Most gonochoristic fish species develop either as males or females and do not change sex throughout their life span. However, in species where sexual differentiation is controlled at least to some degree by environmental factors, there can be a window of development during gonadal differentiation that is sensitive to a variety of exogenous conditions. During this window, endocrine active chemicals, aromatase inhibitors in particular, have the potential to alter gonad development and sex differentiation. This AOP is referred to as AOP 346 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). |
| Beschreibung: | 1 Online-Ressource (67 Seiten) 21 x 28cm. |
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| indexdate | 2025-03-18T14:28:58Z |
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| language | English |
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| physical | 1 Online-Ressource (67 Seiten) 21 x 28cm. |
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| series2 | OECD Series on Adverse Outcome Pathways |
| spelling | Santana Rodriguez, Kelvin J... VerfasserIn aut Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation Kelvin J., Santana Rodriguez ... [et al] Paris OECD Publishing 2023 1 Online-Ressource (67 Seiten) 21 x 28cm. Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.34 This adverse outcome pathway links inhibition of aromatase activity in teleost fish during gonadogenesis to increased differentiation to testis resulting in a male-biased sex ratio in the population, and ultimately, reduced population sustainability. Most gonochoristic fish species develop either as males or females and do not change sex throughout their life span. However, in species where sexual differentiation is controlled at least to some degree by environmental factors, there can be a window of development during gonadal differentiation that is sensitive to a variety of exogenous conditions. During this window, endocrine active chemicals, aromatase inhibitors in particular, have the potential to alter gonad development and sex differentiation. This AOP is referred to as AOP 346 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). Environment Villeneuve, Daniel L... MitwirkendeR ctb Jensen, Kathleen M... MitwirkendeR ctb Ankley, Gerald T... MitwirkendeR ctb Miller, David H... MitwirkendeR ctb |
| spellingShingle | Santana Rodriguez, Kelvin J.. Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation Environment |
| title | Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation |
| title_auth | Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation |
| title_exact_search | Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation |
| title_full | Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation Kelvin J., Santana Rodriguez ... [et al] |
| title_fullStr | Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation Kelvin J., Santana Rodriguez ... [et al] |
| title_full_unstemmed | Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation Kelvin J., Santana Rodriguez ... [et al] |
| title_short | Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation |
| title_sort | adverse outcome pathway on aromatase inhibition leading to male biased sex ratio via impacts on gonad differentiation |
| topic | Environment |
| topic_facet | Environment |
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