Disruption of VEGFR signaling leading to developmental defects:
The cardiovascular system is the first functional organ system to develop in the vertebrate embryo, reflecting its critical role during normal development and pregnancy. This Adverse Outcome Pathway focuses on the regulation and disruption of vasculogenesis-angiogenesis during embryonic development...
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | , , , , , , , , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2023
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.31 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The cardiovascular system is the first functional organ system to develop in the vertebrate embryo, reflecting its critical role during normal development and pregnancy. This Adverse Outcome Pathway focuses on the regulation and disruption of vasculogenesis-angiogenesis during embryonic development via disruption of the Vascular Endothelial Growth Factor (VEGF) signaling pathway. This pathway is a critical regulatory system for assembly of embryonic blood vessels. Genetic studies have shown that perturbing the VEGF signaling system can invoke varying degrees of adverse consequences, ranging from congenital angiodysplasia to fetal malformations and embryolethality. This AOP is referred to as AOP 43 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). |
| Beschreibung: | 1 Online-Ressource (61 p.) 21 x 28cm. |
| DOI: | 10.1787/c1116a35-en |
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| author | Knudsen, Thomas B.. |
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| discipline | Wirtschaftswissenschaften |
| doi_str_mv | 10.1787/c1116a35-en |
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| indexdate | 2024-11-26T14:55:35Z |
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| physical | 1 Online-Ressource (61 p.) 21 x 28cm. |
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| publishDate | 2023 |
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| spelling | Knudsen, Thomas B... VerfasserIn aut Disruption of VEGFR signaling leading to developmental defects Thomas B., Knudsen ... [et al] Paris OECD Publishing 2023 1 Online-Ressource (61 p.) 21 x 28cm. Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.31 The cardiovascular system is the first functional organ system to develop in the vertebrate embryo, reflecting its critical role during normal development and pregnancy. This Adverse Outcome Pathway focuses on the regulation and disruption of vasculogenesis-angiogenesis during embryonic development via disruption of the Vascular Endothelial Growth Factor (VEGF) signaling pathway. This pathway is a critical regulatory system for assembly of embryonic blood vessels. Genetic studies have shown that perturbing the VEGF signaling system can invoke varying degrees of adverse consequences, ranging from congenital angiodysplasia to fetal malformations and embryolethality. This AOP is referred to as AOP 43 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki). Environment Saili, Katerine MitwirkendeR ctb Franzosa, Jill MitwirkendeR ctb Baker, Nancy MitwirkendeR ctb Spencer, Richard MitwirkendeR ctb Tal, Tamara MitwirkendeR ctb Kleinstreuer, Nicole MitwirkendeR ctb Heinonen, Tuula MitwirkendeR ctb Ellis-Hutchings, Rob MitwirkendeR ctb Vargesson, Neil MitwirkendeR ctb Bondesson, Maria MitwirkendeR ctb FWS01 ZDB-13-SOC FWS_PDA_SOC https://doi.org/10.1787/c1116a35-en Volltext |
| spellingShingle | Knudsen, Thomas B.. Disruption of VEGFR signaling leading to developmental defects Environment |
| title | Disruption of VEGFR signaling leading to developmental defects |
| title_auth | Disruption of VEGFR signaling leading to developmental defects |
| title_exact_search | Disruption of VEGFR signaling leading to developmental defects |
| title_full | Disruption of VEGFR signaling leading to developmental defects Thomas B., Knudsen ... [et al] |
| title_fullStr | Disruption of VEGFR signaling leading to developmental defects Thomas B., Knudsen ... [et al] |
| title_full_unstemmed | Disruption of VEGFR signaling leading to developmental defects Thomas B., Knudsen ... [et al] |
| title_short | Disruption of VEGFR signaling leading to developmental defects |
| title_sort | disruption of vegfr signaling leading to developmental defects |
| topic | Environment |
| topic_facet | Environment |
| url | https://doi.org/10.1787/c1116a35-en |
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