Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy:
The present AOP describes inhibition of histone deacetylase resulting in testicular atrophy. Histone deacetylase inhibitors (HDIs) are approved as anti-cancer drugs since HDIs have apoptotic effects in cancer cells. The intracellular mechanisms of induction of the spermatocyte apoptosis by HDIs are...
Gespeichert in:
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| Weitere Verfasser: | , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2021
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.17 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The present AOP describes inhibition of histone deacetylase resulting in testicular atrophy. Histone deacetylase inhibitors (HDIs) are approved as anti-cancer drugs since HDIs have apoptotic effects in cancer cells. The intracellular mechanisms of induction of the spermatocyte apoptosis by HDIs are suggested as histone deacetylase (HDAC) inhibition as MIE, histone acetylation increase, disrupted cell cycle, apoptosis, and spermatocyte depletion as KEs. The adverse outcome has been defined as testicular atrophy. The HDIs inhibit deacetylation of the histone, leading to an increase in histone acetylation. The apoptosis induced by disrupted cell cycle leads to spermatocyte depletion and testis atrophy. Testicular toxicity is of interest for human health risk assessment especially in terms of reproductive and developmental toxicity, however, the testicular toxicity has not been fully elucidated. This AOP may be one of the pathways induced by HDIs, which suggests the pathway networks of protein hyperacetylations. |
| Beschreibung: | 1 Online-Ressource (64 p.) |
| DOI: | 10.1787/b9c4bdb2-en |
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| spelling | Tanabe, Shihori VerfasserIn aut Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy Shihori, Tanabe, Akihiko, Hirose and Takashi, Yamada Paris OECD Publishing 2021 1 Online-Ressource (64 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.17 The present AOP describes inhibition of histone deacetylase resulting in testicular atrophy. Histone deacetylase inhibitors (HDIs) are approved as anti-cancer drugs since HDIs have apoptotic effects in cancer cells. The intracellular mechanisms of induction of the spermatocyte apoptosis by HDIs are suggested as histone deacetylase (HDAC) inhibition as MIE, histone acetylation increase, disrupted cell cycle, apoptosis, and spermatocyte depletion as KEs. The adverse outcome has been defined as testicular atrophy. The HDIs inhibit deacetylation of the histone, leading to an increase in histone acetylation. The apoptosis induced by disrupted cell cycle leads to spermatocyte depletion and testis atrophy. Testicular toxicity is of interest for human health risk assessment especially in terms of reproductive and developmental toxicity, however, the testicular toxicity has not been fully elucidated. This AOP may be one of the pathways induced by HDIs, which suggests the pathway networks of protein hyperacetylations. Environment Social Issues/Migration/Health Hirose, Akihiko MitwirkendeR ctb Yamada, Takashi MitwirkendeR ctb FWS01 ZDB-13-SOC FWS_PDA_SOC https://doi.org/10.1787/b9c4bdb2-en Volltext |
| spellingShingle | Tanabe, Shihori Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy Environment Social Issues/Migration/Health |
| title | Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy |
| title_auth | Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy |
| title_exact_search | Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy |
| title_full | Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy Shihori, Tanabe, Akihiko, Hirose and Takashi, Yamada |
| title_fullStr | Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy Shihori, Tanabe, Akihiko, Hirose and Takashi, Yamada |
| title_full_unstemmed | Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy Shihori, Tanabe, Akihiko, Hirose and Takashi, Yamada |
| title_short | Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy |
| title_sort | adverse outcome pathway on histone deacetylase inhibition leading to testicular atrophy |
| topic | Environment Social Issues/Migration/Health |
| topic_facet | Environment Social Issues/Migration/Health |
| url | https://doi.org/10.1787/b9c4bdb2-en |
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