Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss:
The present AOP describes antagonistic chemical binding to the peroxisome proliferator-activated receptor α (PPARα), resulting in preferential binding a co-repressor to the overall PPARα signalling complex causing a chain of events that includes: antagonism of PPARα nuclear signalling, decreased tra...
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | , , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2019
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.10 |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | The present AOP describes antagonistic chemical binding to the peroxisome proliferator-activated receptor α (PPARα), resulting in preferential binding a co-repressor to the overall PPARα signalling complex causing a chain of events that includes: antagonism of PPARα nuclear signalling, decreased transcriptional expression of PPARα-regulated genes that support energy metabolism, inhibited metabolic energy production (decreased fatty acid beta oxidation and ketogenesis), and increase in catabolism of muscle protein, culminating with starvation-like weight loss. The AOP is likely to be synergised during fasting, starvation or malnutrition events. The adverse outcome of this AOP is body-weight loss, which within the context of dynamic energy budget theory, decreases energy allocations to organismal maturation and reproduction and has been demonstrated to negatively affect ecological fitness. |
| Beschreibung: | 1 Online-Ressource (83 p.) |
| DOI: | 10.1787/29d4e08d-en |
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| spelling | Gust, Kurt A... VerfasserIn aut Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss Kurt A., Gust ... [et al] Paris OECD Publishing 2019 1 Online-Ressource (83 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier OECD Series on Adverse Outcome Pathways no.10 The present AOP describes antagonistic chemical binding to the peroxisome proliferator-activated receptor α (PPARα), resulting in preferential binding a co-repressor to the overall PPARα signalling complex causing a chain of events that includes: antagonism of PPARα nuclear signalling, decreased transcriptional expression of PPARα-regulated genes that support energy metabolism, inhibited metabolic energy production (decreased fatty acid beta oxidation and ketogenesis), and increase in catabolism of muscle protein, culminating with starvation-like weight loss. The AOP is likely to be synergised during fasting, starvation or malnutrition events. The adverse outcome of this AOP is body-weight loss, which within the context of dynamic energy budget theory, decreases energy allocations to organismal maturation and reproduction and has been demonstrated to negatively affect ecological fitness. Environment Social Issues/Migration/Health Wilbanks, Mitchell S... MitwirkendeR ctb Collier, Zachary A... MitwirkendeR ctb Burgoon, Lyle D... MitwirkendeR ctb Perkins, Edward J... MitwirkendeR ctb FWS01 ZDB-13-SOC FWS_PDA_SOC https://doi.org/10.1787/29d4e08d-en Volltext |
| spellingShingle | Gust, Kurt A.. Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss Environment Social Issues/Migration/Health |
| title | Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss |
| title_auth | Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss |
| title_exact_search | Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss |
| title_full | Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss Kurt A., Gust ... [et al] |
| title_fullStr | Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss Kurt A., Gust ... [et al] |
| title_full_unstemmed | Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss Kurt A., Gust ... [et al] |
| title_short | Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss |
| title_sort | adverse outcome pathway on antagonist binding to pparα leading to body weight loss |
| topic | Environment Social Issues/Migration/Health |
| topic_facet | Environment Social Issues/Migration/Health |
| url | https://doi.org/10.1787/29d4e08d-en |
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