X-Ray Structure Analysis of Bio-Macromolecular Crystals: Practical Methods and Basic Theory
Since the late 19th century, X-ray structural studies have forged ahead through technological progress and the creative ingenuity of researchers. As high intensity X-ray sources and increased speed and sensitivity of the detectors have emerged, it's now possible to image the atomic structure of...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Oxford University Press
2025
|
| Schriftenreihe: | International Union of Crystallography Texts on Crystallography
23 |
| Schlagworte: | |
| Zusammenfassung: | Since the late 19th century, X-ray structural studies have forged ahead through technological progress and the creative ingenuity of researchers. As high intensity X-ray sources and increased speed and sensitivity of the detectors have emerged, it's now possible to image the atomic structure of complex bio-macromolecules, the orbital electron density of small molecules, and to even follow the dynamical behavior of bio-macromolecules.Textbooks from which junior researchers can grasp the current art have not kept pace with the technological developments and diversification of the field. X-ray studies of bio-macromolecules require a broad understanding of the theory and practical methodologies. A project can include isolating, crystalizing, and adjudicating suitable samples, obtaining and analysing the X-ray data, and finally publishing the results in a standard format. Early decisions in a project can become pitfalls that swallow the unwary. It is increasingly essential to become adept at managing both proteins and nucleic acids. Whereas software is available to help in the critical problem of resolving the phase, expedience often encourages treating such tools as a black-box. The aim here is to help navigate the researcher through these multifarious issues. The book is intended to serve as a "companion" to experimentalists. It is divided into a general overview of X-ray structural analysis techniques (chapters 1-2) and a detailed discussion (chapters 3-16) that begins with the preparation of proteins and (uniquely) nucleic acids and ends with publishing the results and is organized to lead the reader through the whole process |
| Beschreibung: | 259 Figues and 39 Tables |
| Beschreibung: | 400 Seiten 246 mm |
| ISBN: | 9780198933601 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV050123933 | ||
| 003 | DE-604 | ||
| 007 | t| | ||
| 008 | 250115s2025 xx |||| 00||| eng d | ||
| 020 | |a 9780198933601 |9 978-0-19-893360-1 | ||
| 024 | 3 | |a 9780198933601 | |
| 035 | |a (DE-599)BVBBV050123933 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-29T | ||
| 100 | 0 | |a Takenaka, Akio |a Dr |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a X-Ray Structure Analysis of Bio-Macromolecular Crystals |b Practical Methods and Basic Theory |
| 264 | 1 | |a Oxford |b Oxford University Press |c 2025 | |
| 300 | |a 400 Seiten |c 246 mm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a International Union of Crystallography Texts on Crystallography |v 23 | |
| 500 | |a 259 Figues and 39 Tables | ||
| 520 | |a Since the late 19th century, X-ray structural studies have forged ahead through technological progress and the creative ingenuity of researchers. As high intensity X-ray sources and increased speed and sensitivity of the detectors have emerged, it's now possible to image the atomic structure of complex bio-macromolecules, the orbital electron density of small molecules, and to even follow the dynamical behavior of bio-macromolecules.Textbooks from which junior researchers can grasp the current art have not kept pace with the technological developments and diversification of the field. X-ray studies of bio-macromolecules require a broad understanding of the theory and practical methodologies. A project can include isolating, crystalizing, and adjudicating suitable samples, obtaining and analysing the X-ray data, and finally publishing the results in a standard format. Early decisions in a project can become pitfalls that swallow the unwary. It is increasingly essential to become adept at managing both proteins and nucleic acids. Whereas software is available to help in the critical problem of resolving the phase, expedience often encourages treating such tools as a black-box. The aim here is to help navigate the researcher through these multifarious issues. The book is intended to serve as a "companion" to experimentalists. It is divided into a general overview of X-ray structural analysis techniques (chapters 1-2) and a detailed discussion (chapters 3-16) that begins with the preparation of proteins and (uniquely) nucleic acids and ends with publishing the results and is organized to lead the reader through the whole process | ||
| 650 | 4 | |a bicssc / Crystallography | |
| 650 | 4 | |a bicssc / Condensed matter physics (liquid state & solid state physics) | |
| 650 | 4 | |a bicssc / Biochemistry | |
| 700 | 1 | |a Kumasaka, Takashi |e Sonstige |4 oth | |
| 700 | 1 | |a Chatake, Toshiyuki |e Sonstige |4 oth | |
| 700 | 1 | |a Sunami, Tomoko |e Sonstige |4 oth | |
| 700 | 1 | |a Kondo, Jiro |e Sonstige |4 oth | |
| 700 | 1 | |a Morishita, Ella |e Sonstige |4 oth | |
| 700 | 1 | |a Dawson, Wayne |e Sonstige |4 oth | |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-035460778 | |
Datensatz im Suchindex
| _version_ | 1821357649662312448 |
|---|---|
| adam_text | |
| any_adam_object | |
| author | Takenaka, Akio Dr |
| author_facet | Takenaka, Akio Dr |
| author_role | aut |
| author_sort | Takenaka, Akio Dr |
| author_variant | a d t ad adt |
| building | Verbundindex |
| bvnumber | BV050123933 |
| ctrlnum | (DE-599)BVBBV050123933 |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV050123933</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="007">t|</controlfield><controlfield tag="008">250115s2025 xx |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780198933601</subfield><subfield code="9">978-0-19-893360-1</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9780198933601</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV050123933</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29T</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Takenaka, Akio</subfield><subfield code="a">Dr</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">X-Ray Structure Analysis of Bio-Macromolecular Crystals</subfield><subfield code="b">Practical Methods and Basic Theory</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford</subfield><subfield code="b">Oxford University Press</subfield><subfield code="c">2025</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">400 Seiten</subfield><subfield code="c">246 mm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">International Union of Crystallography Texts on Crystallography</subfield><subfield code="v">23</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">259 Figues and 39 Tables</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Since the late 19th century, X-ray structural studies have forged ahead through technological progress and the creative ingenuity of researchers. As high intensity X-ray sources and increased speed and sensitivity of the detectors have emerged, it's now possible to image the atomic structure of complex bio-macromolecules, the orbital electron density of small molecules, and to even follow the dynamical behavior of bio-macromolecules.Textbooks from which junior researchers can grasp the current art have not kept pace with the technological developments and diversification of the field. X-ray studies of bio-macromolecules require a broad understanding of the theory and practical methodologies. A project can include isolating, crystalizing, and adjudicating suitable samples, obtaining and analysing the X-ray data, and finally publishing the results in a standard format. Early decisions in a project can become pitfalls that swallow the unwary. It is increasingly essential to become adept at managing both proteins and nucleic acids. Whereas software is available to help in the critical problem of resolving the phase, expedience often encourages treating such tools as a black-box. The aim here is to help navigate the researcher through these multifarious issues. The book is intended to serve as a "companion" to experimentalists. It is divided into a general overview of X-ray structural analysis techniques (chapters 1-2) and a detailed discussion (chapters 3-16) that begins with the preparation of proteins and (uniquely) nucleic acids and ends with publishing the results and is organized to lead the reader through the whole process</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bicssc / Crystallography</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bicssc / Condensed matter physics (liquid state & solid state physics)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bicssc / Biochemistry</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kumasaka, Takashi</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chatake, Toshiyuki</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sunami, Tomoko</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kondo, Jiro</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morishita, Ella</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dawson, Wayne</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-035460778</subfield></datafield></record></collection> |
| id | DE-604.BV050123933 |
| illustrated | Not Illustrated |
| indexdate | 2025-01-15T23:00:11Z |
| institution | BVB |
| isbn | 9780198933601 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-035460778 |
| open_access_boolean | |
| owner | DE-29T |
| owner_facet | DE-29T |
| physical | 400 Seiten 246 mm |
| publishDate | 2025 |
| publishDateSearch | 2025 |
| publishDateSort | 2025 |
| publisher | Oxford University Press |
| record_format | marc |
| series2 | International Union of Crystallography Texts on Crystallography |
| spelling | Takenaka, Akio Dr Verfasser aut X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory Oxford Oxford University Press 2025 400 Seiten 246 mm txt rdacontent n rdamedia nc rdacarrier International Union of Crystallography Texts on Crystallography 23 259 Figues and 39 Tables Since the late 19th century, X-ray structural studies have forged ahead through technological progress and the creative ingenuity of researchers. As high intensity X-ray sources and increased speed and sensitivity of the detectors have emerged, it's now possible to image the atomic structure of complex bio-macromolecules, the orbital electron density of small molecules, and to even follow the dynamical behavior of bio-macromolecules.Textbooks from which junior researchers can grasp the current art have not kept pace with the technological developments and diversification of the field. X-ray studies of bio-macromolecules require a broad understanding of the theory and practical methodologies. A project can include isolating, crystalizing, and adjudicating suitable samples, obtaining and analysing the X-ray data, and finally publishing the results in a standard format. Early decisions in a project can become pitfalls that swallow the unwary. It is increasingly essential to become adept at managing both proteins and nucleic acids. Whereas software is available to help in the critical problem of resolving the phase, expedience often encourages treating such tools as a black-box. The aim here is to help navigate the researcher through these multifarious issues. The book is intended to serve as a "companion" to experimentalists. It is divided into a general overview of X-ray structural analysis techniques (chapters 1-2) and a detailed discussion (chapters 3-16) that begins with the preparation of proteins and (uniquely) nucleic acids and ends with publishing the results and is organized to lead the reader through the whole process bicssc / Crystallography bicssc / Condensed matter physics (liquid state & solid state physics) bicssc / Biochemistry Kumasaka, Takashi Sonstige oth Chatake, Toshiyuki Sonstige oth Sunami, Tomoko Sonstige oth Kondo, Jiro Sonstige oth Morishita, Ella Sonstige oth Dawson, Wayne Sonstige oth |
| spellingShingle | Takenaka, Akio Dr X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory bicssc / Crystallography bicssc / Condensed matter physics (liquid state & solid state physics) bicssc / Biochemistry |
| title | X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory |
| title_auth | X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory |
| title_exact_search | X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory |
| title_full | X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory |
| title_fullStr | X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory |
| title_full_unstemmed | X-Ray Structure Analysis of Bio-Macromolecular Crystals Practical Methods and Basic Theory |
| title_short | X-Ray Structure Analysis of Bio-Macromolecular Crystals |
| title_sort | x ray structure analysis of bio macromolecular crystals practical methods and basic theory |
| title_sub | Practical Methods and Basic Theory |
| topic | bicssc / Crystallography bicssc / Condensed matter physics (liquid state & solid state physics) bicssc / Biochemistry |
| topic_facet | bicssc / Crystallography bicssc / Condensed matter physics (liquid state & solid state physics) bicssc / Biochemistry |
| work_keys_str_mv | AT takenakaakiodr xraystructureanalysisofbiomacromolecularcrystalspracticalmethodsandbasictheory AT kumasakatakashi xraystructureanalysisofbiomacromolecularcrystalspracticalmethodsandbasictheory AT chataketoshiyuki xraystructureanalysisofbiomacromolecularcrystalspracticalmethodsandbasictheory AT sunamitomoko xraystructureanalysisofbiomacromolecularcrystalspracticalmethodsandbasictheory AT kondojiro xraystructureanalysisofbiomacromolecularcrystalspracticalmethodsandbasictheory AT morishitaella xraystructureanalysisofbiomacromolecularcrystalspracticalmethodsandbasictheory AT dawsonwayne xraystructureanalysisofbiomacromolecularcrystalspracticalmethodsandbasictheory |