Oxidative DNA damage leading to chromosomal aberrations and mutations:
This Adverse Outcome Pathway (AOP) describes the linkage between oxidative DNA damage and irreversible genomic damage (chromosomal aberrations and mutations). DNA damage is considered an important contributor to the adverse health effects of many environmental toxicants and this AOP may thus be of w...
Gespeichert in:
| 1. Verfasser: | |
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| Weitere Verfasser: | , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2023
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| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | This Adverse Outcome Pathway (AOP) describes the linkage between oxidative DNA damage and irreversible genomic damage (chromosomal aberrations and mutations). DNA damage is considered an important contributor to the adverse health effects of many environmental toxicants and this AOP may thus be of widespread use to the regulatory community. Although increase in oxidative DNA damage is the molecular initiating event for this AOP, there are numerous upstream key events that can also lead to DNA oxidation. Thus, this AOP may be expanded upstream, and could be incorporated into a variety of AOP networks. Furthermore, the AOP points to critical research gaps required to establish the quantitative associations and modulating factors that connect KEs across the AOP, and highlights the utility of novel test methods in understanding and evaluating the implications of oxidative DNA damage. This AOP is referred to as AOP 296 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki) |
| Beschreibung: | 1 Online-Ressource (154 Seiten) 21 x 28cm |
| DOI: | 10.1787/399d2c34-en |
Internformat
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Datensatz im Suchindex
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| author | Cho, Eunnara |
| author2 | Allemang, Ashley Audebert, Marc Chauhan, Vinita |
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| author_facet | Cho, Eunnara Allemang, Ashley Audebert, Marc Chauhan, Vinita |
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| doi_str_mv | 10.1787/399d2c34-en |
| format | Electronic eBook |
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| illustrated | Not Illustrated |
| indexdate | 2024-12-09T19:00:24Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-035411826 |
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| physical | 1 Online-Ressource (154 Seiten) 21 x 28cm |
| psigel | ZDB-13-SOC |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| publisher | OECD Publishing |
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| series2 | OECD Series on Adverse Outcome Pathways |
| spelling | Cho, Eunnara Verfasser aut Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] Paris OECD Publishing 2023 1 Online-Ressource (154 Seiten) 21 x 28cm txt rdacontent c rdamedia cr rdacarrier OECD Series on Adverse Outcome Pathways This Adverse Outcome Pathway (AOP) describes the linkage between oxidative DNA damage and irreversible genomic damage (chromosomal aberrations and mutations). DNA damage is considered an important contributor to the adverse health effects of many environmental toxicants and this AOP may thus be of widespread use to the regulatory community. Although increase in oxidative DNA damage is the molecular initiating event for this AOP, there are numerous upstream key events that can also lead to DNA oxidation. Thus, this AOP may be expanded upstream, and could be incorporated into a variety of AOP networks. Furthermore, the AOP points to critical research gaps required to establish the quantitative associations and modulating factors that connect KEs across the AOP, and highlights the utility of novel test methods in understanding and evaluating the implications of oxidative DNA damage. This AOP is referred to as AOP 296 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki) Environment Allemang, Ashley ctb Audebert, Marc ctb Chauhan, Vinita ctb https://doi.org/10.1787/399d2c34-en Verlag kostenfrei Volltext |
| spellingShingle | Cho, Eunnara Oxidative DNA damage leading to chromosomal aberrations and mutations Environment |
| title | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_auth | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_exact_search | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_full | Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] |
| title_fullStr | Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] |
| title_full_unstemmed | Oxidative DNA damage leading to chromosomal aberrations and mutations Eunnara, Cho ... [et al] |
| title_short | Oxidative DNA damage leading to chromosomal aberrations and mutations |
| title_sort | oxidative dna damage leading to chromosomal aberrations and mutations |
| topic | Environment |
| topic_facet | Environment |
| url | https://doi.org/10.1787/399d2c34-en |
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