Reproducibility in biomedical research: epistemological and statistical problems and the future

Front Cover -- Reproducibility in Biomedical Research -- Copyright Page -- Dedication -- Quotes -- Contents -- Preface to the second edition -- Looking just over the horizon -- Machine learning artificial intelligence -- Translational research -- Biological realism and Chaos and Complexity -- Probab...

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1. Verfasser: Montgomery, Erwin B. Jr (VerfasserIn)
Format: Buch
Sprache:English
Veröffentlicht: London ; San Diego ; Cambridge, MA Academic Press, Elsevier [2024]
Ausgabe:Second edition
Zusammenfassung:Front Cover -- Reproducibility in Biomedical Research -- Copyright Page -- Dedication -- Quotes -- Contents -- Preface to the second edition -- Looking just over the horizon -- Machine learning artificial intelligence -- Translational research -- Biological realism and Chaos and Complexity -- Probability and statistical epistemology -- Randomness as fundamental and foundational -- Finally… -- Preface to the first edition -- 1 Introduction -- Productive irreproducibility -- The multifaceted notion of reproducibility and irreproducibility -- Beyond "stamp collecting" -- Replication reproducibility -- Within-experiment reproducibility -- Narrow, broad, conceptual, and translational reproducibility -- Turning from the past with an eye to the future -- Machine learning artificial intelligence -- A challenge to clinical research posed by a new notion of translational research -- Toward more realistic experimental designs and analyses -- The fundamental causes of unproductive irreproducibility -- Illogic -- The paradox and dilemma of the "population" -- The logic of population and sample -- The proof of the pudding, in this case sample/population biomedical research -- Wrestling with the fundamental problem -- Proceeding from what is certain but not useful to what is uncertain but useful -- Precision versus accuracy -- Precision and statistical distributions -- Combinatorics -- Dynamics -- Machine learning artificial intelligence and the emperor's new clothes -- Knowledge is prediction, prediction is reproducibility or productive irreproducibility -- The ascendancy of experimental science -- Challenges to prediction and thus biomedical research -- Predicting to the unknowable population -- Hume's Problem of Induction -- When traditional experimental design and statistics breed unproductive irreproducibility -- Data do not and cannot speak for themselves
Beschreibung:Literaturverzeichnis Seite 397-411
Beschreibung:xxxv, 426 Seiten Illustrationen, Diagramme
ISBN:9780443138294

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