Ancestral Genomics: African American Health in the Age of Precision Medicine
A leading evolutionary historian offers a radical solution to racial health disparities in the United States.Constance B. Hilliard was living in Japan when she began experiencing joint pain. Her doctor diagnosed osteoarthritis-a common ailment for someone her age. But her bloodwork showed something...
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Format: | Elektronisch E-Book |
Sprache: | English |
Veröffentlicht: |
Cambridge, MA
Harvard University Press
[2024]
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Schlagworte: | |
Online-Zugang: | DE-Aug4 URL des Erstveröffentlichers |
Zusammenfassung: | A leading evolutionary historian offers a radical solution to racial health disparities in the United States.Constance B. Hilliard was living in Japan when she began experiencing joint pain. Her doctor diagnosed osteoarthritis-a common ailment for someone her age. But her bloodwork showed something else: Hilliard, who had never had kidney problems, appeared to be suffering from renal failure. When she returned to Texas, however, a new round of tests showed that her kidneys were healthy. Unlike the Japanese doctor, her American primary care provider had checked a box on her lab report for "African American." As a scholar of scientific racism, Hilliard was perplexed. Why should race, which experts agree has no biological basis, matter for getting accurate test results?Ancestral Genomics is the result of Hilliard's decade-long quest to solve this puzzle. In a masterful synthesis of evolutionary history, population genetics, and public health research, she addresses the usefulness of race as a heuristic in genomic medicine. Built from European genetic data, the Human Genome Project and other databases have proven inadequate for identifying disease-causing gene variants in patients of African descent. Such databases, Hilliard argues, overlook crucial information about the environments to which their ancestors' bodies adapted prior to the transatlantic slave trade. Hilliard shows how, by analyzing "ecological niche populations," a classification model that combines family and ecological histories with genetic information, our increasingly advanced genomic technologies, including personalized medicine, can serve African Americans and other people of color, while avoiding racial essentialism.Forcefully argued and morally urgent, Ancestral Genomics is a clarion call for the US medical community to embrace our multigenomic society |
Beschreibung: | Description based on online resource; title from PDF title page (publisher's Web site, viewed 03. Jul 2024) |
Beschreibung: | 1 Online-Ressource (176 Seiten) |
ISBN: | 9780674296787 |
DOI: | 10.4159/9780674296787 |
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spelling | Hilliard, Constance B. Verfasser aut Ancestral Genomics African American Health in the Age of Precision Medicine Constance B. Hilliard Cambridge, MA Harvard University Press [2024] © 2024 1 Online-Ressource (176 Seiten) txt rdacontent c rdamedia cr rdacarrier Description based on online resource; title from PDF title page (publisher's Web site, viewed 03. Jul 2024) A leading evolutionary historian offers a radical solution to racial health disparities in the United States.Constance B. Hilliard was living in Japan when she began experiencing joint pain. Her doctor diagnosed osteoarthritis-a common ailment for someone her age. But her bloodwork showed something else: Hilliard, who had never had kidney problems, appeared to be suffering from renal failure. When she returned to Texas, however, a new round of tests showed that her kidneys were healthy. Unlike the Japanese doctor, her American primary care provider had checked a box on her lab report for "African American." As a scholar of scientific racism, Hilliard was perplexed. Why should race, which experts agree has no biological basis, matter for getting accurate test results?Ancestral Genomics is the result of Hilliard's decade-long quest to solve this puzzle. In a masterful synthesis of evolutionary history, population genetics, and public health research, she addresses the usefulness of race as a heuristic in genomic medicine. Built from European genetic data, the Human Genome Project and other databases have proven inadequate for identifying disease-causing gene variants in patients of African descent. Such databases, Hilliard argues, overlook crucial information about the environments to which their ancestors' bodies adapted prior to the transatlantic slave trade. Hilliard shows how, by analyzing "ecological niche populations," a classification model that combines family and ecological histories with genetic information, our increasingly advanced genomic technologies, including personalized medicine, can serve African Americans and other people of color, while avoiding racial essentialism.Forcefully argued and morally urgent, Ancestral Genomics is a clarion call for the US medical community to embrace our multigenomic society In English SOCIAL SCIENCE / Ethnic Studies / African American Studies bisacsh https://doi.org/10.4159/9780674296787?locatt=mode:legacy Verlag URL des Erstveröffentlichers Volltext |
spellingShingle | Hilliard, Constance B. Ancestral Genomics African American Health in the Age of Precision Medicine SOCIAL SCIENCE / Ethnic Studies / African American Studies bisacsh |
title | Ancestral Genomics African American Health in the Age of Precision Medicine |
title_auth | Ancestral Genomics African American Health in the Age of Precision Medicine |
title_exact_search | Ancestral Genomics African American Health in the Age of Precision Medicine |
title_full | Ancestral Genomics African American Health in the Age of Precision Medicine Constance B. Hilliard |
title_fullStr | Ancestral Genomics African American Health in the Age of Precision Medicine Constance B. Hilliard |
title_full_unstemmed | Ancestral Genomics African American Health in the Age of Precision Medicine Constance B. Hilliard |
title_short | Ancestral Genomics |
title_sort | ancestral genomics african american health in the age of precision medicine |
title_sub | African American Health in the Age of Precision Medicine |
topic | SOCIAL SCIENCE / Ethnic Studies / African American Studies bisacsh |
topic_facet | SOCIAL SCIENCE / Ethnic Studies / African American Studies |
url | https://doi.org/10.4159/9780674296787?locatt=mode:legacy |
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