Photoswitchable acid-base equilibria: for the light-driven generation of proton gradients
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
[2023?]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Tag der mündlichen Prüfung: 11.12.2023 |
| Beschreibung: | V, 104 Seiten Illustrationen, Diagramme (teilweise farbig) |
Internformat
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| 100 | 1 | |a Römpp, Florian |e Verfasser |0 (DE-588)1337256579 |4 aut | |
| 245 | 1 | 0 | |a Photoswitchable acid-base equilibria |b for the light-driven generation of proton gradients |c von M. Sc., Florian Quirin Römpp |
| 264 | 1 | |a Berlin |c [2023?] | |
| 300 | |a V, 104 Seiten |b Illustrationen, Diagramme (teilweise farbig) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Tag der mündlichen Prüfung: 11.12.2023 | ||
| 502 | |b Dissertation |c Humboldt-Universität zu Berlin |d 2023 | ||
| 546 | |a Zusammenfassung englisch und deutsch | ||
| 650 | 0 | 7 | |a Molekularer Schalter |0 (DE-588)4444367-5 |2 gnd |9 rswk-swf |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-035141421 | |
Datensatz im Suchindex
| _version_ | 1822135309511426048 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
ABSTRACT
I
KURZZUSAMMENFASSUNG
II
DANKSAGUNG
III
SELBSTSTAENDIGKEITSERKLAERUNG
V
1
INTRODUCTION
1
2
THEORETICAL
BACKGROUND
4
2.1
PH
AND
PK
A
4
2.1.1
MATHEMATICAL
DERIVATION
4
2.1.2
MEANING
AND
SIGNIFICANCE
5
2.2
DIARYLETHENES
(DAES)
6
2.2.1
BASIC
STRUCTURE
AND
PROPERTIES
6
2.2.2
FUNCTIONALIZATION
INTO
EFFECTIVE
TOOLS
9
2.3
PHOTOACTIVE
PKA
MODULATORS
11
2.3.1
PHOTOACID
GENERATORS
(PAGS)
12
2.3.2
REVERSIBLE
PHOTOACTIVE
PK
A
MODULATORS
13
3
AIM
18
3.1
MOLECULAR
DESIGN
18
3.2
RETROSYNTHETIC
APPROACH
19
4
RESULTS
AND
DISCUSSION
21
4.1
SYNTHESES
OF
TARGET
MOLECULES
21
4.2
PHOTOCHEMICAL
PROPERTIES
IN
AQUEOUS
SOLUTION
26
4.2.1
SWITCHING
BEHAVIOR
AND
PROTONATION
RATIO
OF
PARENT
MOLECULE
1
IN
VARIOUS
BUFFERS
27
4.2.2
DETERMINATION
OF
QUANTUM
YIELDS
OF
1
33
4.2.3
PHOTOCHEMICAL
PROPERTIES
OF
DERIVATIVES
IN
PBS
SOLUTION
34
4.3
DETERMINATION
OF
PK
A
VALUES
41
4.4 TOWARDS
APPLICATIONS
OF
THE
DEVELOPED
PHOTOCHROMIC
PK
A
MODULATORS
45
4.4.1
ATTEMPTED
INCORPORATION
IN
MEMBRANES
45
4.4.2
ATTEMPTED
PK
A
MODULATION
WITHIN
MITOCHONDRIA
46
4.4.3
IMMOBILIZATION
ON
GLASS
SURFACES
46
4.4.4
ATTEMPTED
MODULATION
OF
BIOAVAILABILITY
48
4.4.5
CONTROL
OVER
ENZYMATIC
PROCESSES
49
5
CONCLUSION
AND
OUTLOOK
52
6
EXPERIMENTAL
SECTION
55
6.1
GENERAL
METHODS
55
6.2
SYNTHESIS
57
6.2.1
SYNTHETIC
ROUTE
57
6.2.2
SYNTHESIS
OF
METHYL
5-METHYLTHIOPHENE-2-CARBOXYLATE
(6):
[711
58
6.2.3
SYNTHESIS
OF
METHYL-4-(2-CHLOROACETYL)-5-METHYLTHIOPHENE-2-CARBOXYLATE
(7):YY
58
6.2.4
SYNTHESIS
OF
METHYL
5-METHYL-4-(2-PHENYLTHIAZOL-4-YL)THIOPHENE-2-CARBOXYLATE
(8):
[701
59
6.2.5
SYNTHESIS
OF
METHYL
4-(5-IODO-2-PHENYLTHIAZOL-4-YL)-5-METHYL-THIOPHENE-2
CARBOXYLATE
(4):
59
6.2.6
SYNTHESIS
OF
ETHYL
2-CHLORO-4,4,4-TRIFLUORO-3-OXOBUTANOATE
(9):
T73]
60
6.2.7
SYNTHESIS
OF
ETHYL
2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE
(10):
[73]
60
6.2.8
SYNTHESIS
OF
ETHYL
2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE
(11):
1741
61
6.2.9
SYNTHESIS
OF
2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC
ACID
(5):
1741
62
6.2.10
SYNTHESIS
OF
METHYL
4-(2'-CHLORO-2-PHENYL-4'-(TRIFLUOROMETHYL)-[5,5'-BITHIAZOL]-4-YL)-5
METHYLTHIOPHENE-2-CARBOXYLATE
(12):
1751
62
6.2.11
SYNTHESIS
OF
5-METHYL-4-(2'-OXO-2-PHENYL-4'-(TRIFLUOROMETHYL)-2',3'-DIHYDRO-[5,5'BITHIAZOL]
4-YL)THIOPHENE-2-CARBOXYLIC
ACID
(LOH):
63
6.2.12
SYNTHESIS
OF
PERFLUOROPHENYL
5-METHYL-4-(2'-OXO-2-PHENYL-4'-(TRIFLUOROMETHYL)-2',3'
DIHYDRO-[5,5
'
-BITHIAZOL]-4-YL)THIOPHENE-2-CARBOXYLATE
(13):YY
64
6.2.13
SYNTHESIS
OF
AMIDES:
791
64
N-BUTYL-5-METHYL-4-(2
'
-OXO-2-PHENYL-4
'
-TRIFLUOROMETHYL)-2
'
,3
'
-DIHYDRO-[5,5-BITHIAZOL]-4
YL)THIOPHENE-2-CARBOXAMIDE
(1OH-BUTYL),
64
N-(1,3-DIHYDROXY-2-(HYDROXYMETHYL)PROPAN-2-YL)-5-METHYL-4-(2
'
-OXO-2-PHENYL-4
'
-TRIFLUOROMETHYL)
2',3'-DIHYDRO-[5,5-BITHIAZOL]-4-YL)THIOPHENE-2-CARBOXAMIDE
(1OH-TRIS),
64
2-(5-METHYL-4-(2
'
-OXO-2-PHENYL-4
'
-(TRIFLUOROMETHYL)-2
'
,3
'
-DIHYDRO-[5,5
'
-BITHIAZOL]-4-YI)THIOPHENE
2-CARBOXAMIDO)ACETIC
ACID
(LOH-GLY),
64
2-(5-METHYL-4-(2
'
-OXO-2-PHENYL-4
'
-(TRIFLUOROMETHYL)-2
'
,3
'
-DIHYDRO-[5,5
'
-BITHIAZOL]-4-YL)THIOPHENE
2-CARBOXAMIDO)SUCCINIC
ACID
(LOH-ASP),
64
5-AMINO-2-(5-METHYL-4-(2
'
-OXO-2-PHENYL-4
'
-(TRIFLUOROMETHYL)-2
'
,3
'
-DIHYDRO-[5,5
'
-BITHIAZOL]-4
YL)THIOPHENE-2-CARBOXAMIDO)PENTANOIC
ACID
(LOH-LYS):
64
6.2.14
SYNTHESIS
OF
3-HYDROXY-2,2-BIS(HYDROXYMETHYL)PROPYL
5-METHYL-4-(2'-OXO-2-PHENYL-4'
(TRIFLUOROMETHYL)-2',3'-DIHYDRO-[5,5'-BITHIAZOL]-4-YL)THIOPHENE-2-CARBOXYLATE
(LOH-PE):
1771
68
6.2.15
SYNTHESIS
OF
METHYL
4-(2-ISOPROPYLTHIAZOL-4-YL)-5-METHYLTHIOPHENE-2-CARBOXYLATE
(8B):
[70)
68
6.2.16
SYNTHESIS
OF
METHYL
4-(2'-CHLORO-2-ISOPROPYL-4'-(TRIFLUOROMETHYL)-[5,5'-BITHIAZOL]-4-YL)-5
METHYLTHIOPHENE-2-CARBOXYLATE
(12B):
[761
69
6.2.17
SYNTHESIS
OF
4-(2-ISOPROPYL-2'-OXO-4'-(TRIFLUOROMETHYL)-2',3'-DIHYDRO-[5,5'-BITHIAZOL]-4-YL)-5
METHYLTHIOPHENE-2-CARBOXYLIC
ACID
(1OH-LSO):
69
6.2.18
SYNTHESIS
OF
(6-((5-METHYL-4-(2'-OXO-2-PHENYL-4'-(TRIFLUOROMETHYL)-2',3'-DIHYDRO-[5,5'
BITHIAZOL]-4-YL)THIOPHENE-2-CARBONYL)OXY)HEXYL)TRIPHENYLPHOSPHONIUM
BROMIDE
(LOH-MIT):
70
6.3
NMR
SPECTROSCOPY
71
6.4
UV/VIS
SPECTROSCOPY
94
6.4.1
DETERMINATION
OF
MOLAR
EXCTINCTION
COEFFICIENTS
(E)
94
6.4.2
DETERMINATION
OF
QUANTUM
YIELDS
()
95
6.5
DETERMINATION
OF
PKA
VALUES
98
6.6
CRYSTALLOGRAPHIC
DETAILS
99
7
ABBREVIATIONS
100
8
REFERENCES
102 |
| any_adam_object | 1 |
| author | Römpp, Florian |
| author_GND | (DE-588)1337256579 |
| author_facet | Römpp, Florian |
| author_role | aut |
| author_sort | Römpp, Florian |
| author_variant | f r fr |
| building | Verbundindex |
| bvnumber | BV049800793 |
| ctrlnum | (OCoLC)1454741866 (DE-599)DNB1333819587 |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV049800793 |
| illustrated | Illustrated |
| indexdate | 2025-01-24T13:00:45Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-035141421 |
| oclc_num | 1454741866 |
| open_access_boolean | |
| owner | DE-11 DE-706 |
| owner_facet | DE-11 DE-706 |
| physical | V, 104 Seiten Illustrationen, Diagramme (teilweise farbig) |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| record_format | marc |
| spelling | Römpp, Florian Verfasser (DE-588)1337256579 aut Photoswitchable acid-base equilibria for the light-driven generation of proton gradients von M. Sc., Florian Quirin Römpp Berlin [2023?] V, 104 Seiten Illustrationen, Diagramme (teilweise farbig) txt rdacontent n rdamedia nc rdacarrier Tag der mündlichen Prüfung: 11.12.2023 Dissertation Humboldt-Universität zu Berlin 2023 Zusammenfassung englisch und deutsch Molekularer Schalter (DE-588)4444367-5 gnd rswk-swf Säure-Base-Gleichgewicht (DE-588)4051270-8 gnd rswk-swf Invasive Technik (DE-588)4258105-9 gnd rswk-swf Proton (DE-588)4137643-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Invasive Technik (DE-588)4258105-9 s Säure-Base-Gleichgewicht (DE-588)4051270-8 s Molekularer Schalter (DE-588)4444367-5 s Proton (DE-588)4137643-2 s DE-604 B:DE-101 application/pdf https://d-nb.info/1333819587/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=035141421&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p dnb 20241029 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Römpp, Florian Photoswitchable acid-base equilibria for the light-driven generation of proton gradients Molekularer Schalter (DE-588)4444367-5 gnd Säure-Base-Gleichgewicht (DE-588)4051270-8 gnd Invasive Technik (DE-588)4258105-9 gnd Proton (DE-588)4137643-2 gnd |
| subject_GND | (DE-588)4444367-5 (DE-588)4051270-8 (DE-588)4258105-9 (DE-588)4137643-2 (DE-588)4113937-9 |
| title | Photoswitchable acid-base equilibria for the light-driven generation of proton gradients |
| title_auth | Photoswitchable acid-base equilibria for the light-driven generation of proton gradients |
| title_exact_search | Photoswitchable acid-base equilibria for the light-driven generation of proton gradients |
| title_full | Photoswitchable acid-base equilibria for the light-driven generation of proton gradients von M. Sc., Florian Quirin Römpp |
| title_fullStr | Photoswitchable acid-base equilibria for the light-driven generation of proton gradients von M. Sc., Florian Quirin Römpp |
| title_full_unstemmed | Photoswitchable acid-base equilibria for the light-driven generation of proton gradients von M. Sc., Florian Quirin Römpp |
| title_short | Photoswitchable acid-base equilibria |
| title_sort | photoswitchable acid base equilibria for the light driven generation of proton gradients |
| title_sub | for the light-driven generation of proton gradients |
| topic | Molekularer Schalter (DE-588)4444367-5 gnd Säure-Base-Gleichgewicht (DE-588)4051270-8 gnd Invasive Technik (DE-588)4258105-9 gnd Proton (DE-588)4137643-2 gnd |
| topic_facet | Molekularer Schalter Säure-Base-Gleichgewicht Invasive Technik Proton Hochschulschrift |
| url | https://d-nb.info/1333819587/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=035141421&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT romppflorian photoswitchableacidbaseequilibriaforthelightdrivengenerationofprotongradients |
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