Musik & politischer Konflikt aus der Türkei: kurdische, alevitische und linke Musik in Deutschland
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Elektronisch E-Book |
| Sprache: | German |
| Veröffentlicht: |
Bielefeld
transcript
2020
|
| Schriftenreihe: | Kultur und soziale Praxis
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei kostenfrei kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource (232 Seiten) |
| ISBN: | 9783839454763 |
| DOI: | 10.14361/9783839454763 |
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| 246 | 1 | 3 | |a Musik und politischer Konflikt aus der Türkei |
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Datensatz im Suchindex
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| adam_text |
TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
.
ILL
LIST
OF
FIGURES
.
VII
LIST
OF
TABLES
.
IX
LIST
OF
ABBREVIATIONS
.10
1
INTRODUCTION
.
15
1.1
AMYOTROPHIC
LATERAL
SCLEROSIS
.
15
1.1.1
EPIDEMIOLOGY
.
15
1.1.2
CLINICAL
MANIFESTATION
AND
DIAGNOSIS
.
16
1.1.3
THERAPIES
.
17
1.1.4
GENETICS
OF
AMYOTROPHIC
LATERAL
SCLEROSIS
.
18
1.2
FUS
MEDIATED
AMYOTROPHIC
LATERAL
SCLEROSIS
.
20
1.2.1
STRUCTURE
AND
PHYSIOLOGICAL
FUNCTION
.
20
1.2.2
LIQUID-LIKE
COMPARTMENTS
AND
LIQUID-TO-SOLID
PHASE
TRANSITION
.
22
1.2.3
LOSS-OF-FUNCTION
AND
TOXIC
GAIN-OF-FUNCTION
MECHANISMS
IN
PATHOGENESIS
OF
FUS-ALS
24
1.3
ENVIRONMENTAL
RISK
FACTORS
OF
AMYOTROPHIC
LATERAL
SCLEROSIS
.
26
1.3.1
ASSOCIATION
OF
VIRUSES
IN
ALS
.
27
1.3.2
SHARED
MECHANISM
DURING
VIRUS
INFECTIONS
AND
ALS
PATHOLOGY
.
28
1.3.3
ALS
ASSOCIATED
RNA-BINDING
PROTEINS
ARE
LINKED
TO
THE
PATHOGENESIS
OF
MULTIPLE
VIRUSES,
INCLUDING
HIV1
.
29
1.4
ALS
DISEASE
MODELS.
31
1.4.1
HUMAN
STEM
CELL-BASED
MODELS.
31
1.4.2
RECENT
FINDINGS
USING
FUS-IPSC
ALS
DISEASE
MODELS
.
32
1.5
MOTOR
UNIT
MODELS
OF
ALS
.
34
1.5.1
LOWER
MNS.
35
1.5.2
SKELETAL
MYOTUBES
.
36
1.5.3
NEUROMUSCULAR
JUNCTION
.
37
1.5.4
CURRENT
IN
VITRO
MODELS
OF
THE
MOTOR
UNIT
.
39
1.6
ASSAYS
OF
NMJ
FUNCTION
.
41
1.6.1
ELECTROPHYSIOLOGY.
41
1.6.2
OPTOGENETICS.
42
1.6.3
VIRUS-MEDIATED
TRACING
OF
SYNAPTIC
CONNECTIONS:
A
POSSIBLE
TOOL
FOR
ASSESSING
MOTOR
UNITS
.
43
2
AIMS
.
46
3
MATERIALS
.
47
3.1
CELL
LINES
.
47
3.2
CELL
CULTURE
.
47
3.3
COMPOUND.
48
3.4
VECTORS
.
49
3.5
IMMUNOCYTOCHEMISTRY
/
FISH
.
49
3.6
QRT-PCR
AND
PCR
.
50
3.7
WESTERN
BLOT
.
51
3.8
CYTOTOXICITY
.
51
3.9
DEVICE
FABRICATION
.
52
4
METHODS
.
53
4.1
ETHICAL
APPROVAL.
53
4.2
BIOSAFETY
.
53
4.3
CELL
CULTURE
.
53
4.3.1
CELL
LINES.
53
4.3.2
MATRIGEL
COATING
.
54
4.3.3
PASSAGING
.
54
4.3.4
IPSC
CULTURE
.
55
4.3.5
PREPERATION
OF
MEF
CONDITION
MEDIUM
.
55
4.3.6
MN
PRECURSOR
CELL
DERIVATION
.
55
4.3.7
MNS
DIFFERENTIATION
.
56
4.3.8
SKELETAL
MYOTUBE
DIFFERENTIATION
.
57
4.4
MICROFLUIDIC
PLATFORM
.
58
4.4.1
MASTER
FABRICATION
.
58
4.4.2
PDMS
REPLICA
MOLDING
.
58
4.4.3
PLO-COATING
AND
PLO-PDMS
MFP
PREPARATION
.
58
4.4.4
PEMA
COATING
.
59
4.4.5
PEMA-PDMS
MFP
BONDING
.
59
4.4.6
SURFACE
COATING
ON
GLASS
SLIDES
.
59
4.4.7
PEMA-MFP
CHARACTERIZATION
.
60
4.5
IMMUNOFLUORESCENCE
AND
FISH
.
60
4.6
AXONAL
OUTGROWTH
.
62
4.7
CELL
ADHERENCE
.
62
IV
4.8
OPTOGENETICS
.
63
4.9
ELECTROPHYSIOLOGY
.
63
4.10
RNA
ISOLATION
AND
QPCR
ANALYSIS
.
64
4.11
WESTERN
BLOT
.
64
4.12
VIRUS
PRODUCTION
.
66
4.13
MONOSYNAPTIC
TRACING
.
67
4.14
CYTOTOXICITY
.
68
4.15
TRANSCRIPTOME
ANALYSIS
.
69
4.16
STRESS
GRANULE
AND
TRANSLOCATION
ANALYSIS
.
69
5
RESULTS
.
70
5.1
DEVELOPMENT
OF
A
CUSTOMIZABLE
MICROFLUIDIC
PLATFORM
FOR
MEDIUM-THROUGHPUT
MODELLING
OF
MOTOR
UNITS.
70
5.1.1
DESIGN
OF
THE
MICROFLUIDIC
PLATFORM
FOR
IN
VITRO
MOTOR
UNIT
MODELS
.
70
5.1.2
DERIVATION
OF
MNS
AND
SKELETAL
MYOTUBES
FROM
IPSCS
.
71
5.1.3
MNS
AND
SKELETAL
MYOTUBES
HAVE
DIFFERENT
ADHESION
REQUIREMENTS
.
75
5.1.4
PEMA
FUNCTIONALIZATION
ALLOWS
CO-CULTIVATION
OF
HUMAN
IPSC-DERIVED
SKELETAL
MYOTUBES
AND
MNS
.
77
5.1.5
PEMA
FUNCTIONALIZED
MICROFLUIDIC
DEVICES
ARE
FABRICATED
USING
PDMS
SILINIZATION
AND
PLASMA
TREATMENT
.
80
5.1.6
THE
NOVEL
PEMA
FUNCTIONALIZED
MICROFLUIDIC
PLATFORM
CAN
BE
USED
TO
MODEL
THE
MOTOR
UNIT
.
82
5.2
MONOSYNAPTIC
TRACING
AS
AN
ASSAY
OF
SYNAPTIC
FUNCTION
FOR
MEDIUM-THROUGHPUT
APPLICATIONS
.
85
5.2.1
A
RECOMBINANT
RABIES
VIRUS
CAN
BE
USED
TO
TRACE
SYNAPTIC
CONNECTIONS
BETWEEN
HUMAN
IPSC-DERIVED
NEURONS
INSIDE
THE
MICROFLUIDIC
PLATFORM
.
85
5.2.2
MONOSYNAPTIC
RABIES
TRACING
CAN
BE
USED
TO
ASSESS
NMJS
INSIDE
THE
PEMA
FUNCTIONALIZED
MICROFLUIDIC
PLATFORM
.
88
5.3
APPLICATION
OF
RECOMBINANT
RABV
REVEALS
NOVEL
ROLE
FOR
VIRUSES
IN
ALS
.
91
5.3.1
MODELING
FUS-ALS
PATHOGENESIS
USING
MONOSYNAPTIC
RABIES
TRACING
.
91
5.3.2
RABIES
VIRUS
INFECTION
INDUCES
FUS-ALS
PHENOTYPES
IN
FUS
P525L
MNS
.
95
5.3.3
FUS-ALS
PHENOTYPES
CAN
BE
DIMINISHED
BY
INTERVENING
IN
THE
RABV
LIFE
CYCLE
.
99
5.3.4
HIV-1
AND
ZIKV
INDUCE
FUS-ALS
PHENOTYPES
INDEPENDENT
OF
STRESS
GRANULE
FORMATION
.
100
5.3.5
RABIES
VIRUS
AND
HIV-1
EXACERBATE
CYTOPLASMIC
MISLOCOLIZATION
OF
FUS
PROTEIN
.
104
V
6
DISCUSSION.107
6.1
A
MEDIUM-THROUGHPUT
MICROFLUIDIC
PLATFORM
.
107
6.1.1
CRITICAL
EVALUATION
AND
FURTHER
IMPROVEMENTS
.
109
6.2
MONOSYNAPTIC
RABV
TRACING
ASSAY
FOR
MEDIUM-THROUGHPUT
APPLICATIONS
.
110
6.2.1
CRITICAL
EVALUATION
AND
FURTHER
IMPROVEMENTS
.
ILL
6.3
APPLICATION
OF
RECOMBINANT
RABV
REVEALS
NOVEL
ROLE
FOR
VIRUSES
IN
ALS
.
113
6.3.1
A
POTENTIAL
ROLE
OF
VIRUSES
IN
THE
PRION-LIKE
DISEASE
ONSET
AND
PROGRESSION
.
113
6.3.2
OTHER
MECHANISMS
WHICH
MIGHT
BE
INVOLVED
IN
VIRUS
MEDIATED
ALS
PATHOLOGY
.
115
6.4
IMPLEMENTATION
OF
FINDINGS
FOR
THE
DEVELOPMENT
OF
NEW
ALS
THERAPEUTICS
.
116
6.4.1
IMPLEMENTATION
OF
MEDIUM-THROUGHPUT
SCREENING
ASSAYS
.
117
7
SUMMARY
.119
8
ZUSAMMENFASSUNG
.121
9
BIBLIOGRAPHY
.
123
10
ACKNOWLEDGEMENT
.
150
11
SUPPLEMENTARY
.152
12
EIDESSTATTLICHE
ERKLARUNGEN
.157
VI |
| adam_txt | |
| any_adam_object | 1 |
| any_adam_object_boolean | |
| author | Seidlitz, Kirsten 1988- |
| author_GND | (DE-588)1221678876 |
| author_facet | Seidlitz, Kirsten 1988- |
| author_role | aut |
| author_sort | Seidlitz, Kirsten 1988- |
| author_variant | k s ks |
| building | Verbundindex |
| bvnumber | BV049604074 |
| classification_rvk | LS 38550 |
| collection | ZDB-94-OAB ZDB-23-DGG ZDB-23-GOA ZDB-23-SEW |
| ctrlnum | (OCoLC)1427318652 (DE-599)BVBBV049604074 |
| discipline | Musikwissenschaft |
| discipline_str_mv | Musikwissenschaft |
| doi_str_mv | 10.14361/9783839454763 10.1515/9783839454763 |
| format | Thesis Electronic eBook |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| geographic | Deutschland (DE-588)4011882-4 gnd Türkei (DE-588)4061163-2 gnd |
| geographic_facet | Deutschland Türkei |
| id | DE-604.BV049604074 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T23:35:08Z |
| indexdate | 2025-01-24T23:03:01Z |
| institution | BVB |
| isbn | 9783839454763 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034948441 |
| oclc_num | 1427318652 |
| open_access_boolean | 1 |
| owner | DE-B1533 DE-M100 DE-12 DE-634 DE-210 DE-1052 DE-521 DE-1043 DE-1102 DE-1046 DE-1047 DE-858 DE-1028 DE-Aug4 DE-1050 DE-573 DE-M347 DE-92 DE-1051 DE-898 DE-BY-UBR DE-859 DE-860 DE-1049 DE-861 DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-523 DE-Re13 DE-BY-UBR DE-Y3 DE-255 DE-Y7 DE-Y2 DE-70 DE-2174 DE-127 DE-22 DE-BY-UBG DE-155 DE-BY-UBR DE-150 DE-154 DE-91 DE-BY-TUM DE-384 DE-473 DE-BY-UBG DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-703 DE-20 DE-706 DE-824 DE-29 DE-739 |
| owner_facet | DE-B1533 DE-M100 DE-12 DE-634 DE-210 DE-1052 DE-521 DE-1043 DE-1102 DE-1046 DE-1047 DE-858 DE-1028 DE-Aug4 DE-1050 DE-573 DE-M347 DE-92 DE-1051 DE-898 DE-BY-UBR DE-859 DE-860 DE-1049 DE-861 DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-523 DE-Re13 DE-BY-UBR DE-Y3 DE-255 DE-Y7 DE-Y2 DE-70 DE-2174 DE-127 DE-22 DE-BY-UBG DE-155 DE-BY-UBR DE-150 DE-154 DE-91 DE-BY-TUM DE-384 DE-473 DE-BY-UBG DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-703 DE-20 DE-706 DE-824 DE-29 DE-739 |
| physical | 1 Online-Ressource (232 Seiten) |
| psigel | ZDB-94-OAB ZDB-23-DGG ZDB-23-GOA ZDB-23-SEW ZDB-23-SEW20 |
| publishDate | 2020 |
| publishDateSearch | 2020 |
| publishDateSort | 2020 |
| publisher | transcript |
| record_format | marc |
| series2 | Kultur und soziale Praxis |
| spelling | Seidlitz, Kirsten 1988- Verfasser (DE-588)1221678876 aut Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland Kirsten Seidlitz Musik und politischer Konflikt aus der Türkei Bielefeld transcript 2020 1 Online-Ressource (232 Seiten) txt rdacontent c rdamedia cr rdacarrier Kultur und soziale Praxis Dissertation Universität zu Köln 2018 Protest (DE-588)4157835-1 gnd rswk-swf Türken (DE-588)4061165-6 gnd rswk-swf Politischer Konflikt (DE-588)4115589-0 gnd rswk-swf Aleviten (DE-588)4232727-1 gnd rswk-swf Kurden (DE-588)4033792-3 gnd rswk-swf Musik (DE-588)4040802-4 gnd rswk-swf Protestbewegung (DE-588)4226404-2 gnd rswk-swf Deutschland (DE-588)4011882-4 gnd rswk-swf Türkei (DE-588)4061163-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Deutschland (DE-588)4011882-4 g Aleviten (DE-588)4232727-1 s Kurden (DE-588)4033792-3 s Musik (DE-588)4040802-4 s Politischer Konflikt (DE-588)4115589-0 s Protest (DE-588)4157835-1 s Türken (DE-588)4061165-6 s DE-604 Türkei (DE-588)4061163-2 g Protestbewegung (DE-588)4226404-2 s Erscheint auch als Druck-Ausgabe 978-3-8376-5476-9 https://doi.org/10.14361/9783839454763 Verlag kostenfrei Volltext https://doi.org/10.1515/9783839454763 Verlag kostenfrei Volltext https://directory.doabooks.org/handle/20.500.12854/136358 Verlag kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034948441&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Seidlitz, Kirsten 1988- Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland Protest (DE-588)4157835-1 gnd Türken (DE-588)4061165-6 gnd Politischer Konflikt (DE-588)4115589-0 gnd Aleviten (DE-588)4232727-1 gnd Kurden (DE-588)4033792-3 gnd Musik (DE-588)4040802-4 gnd Protestbewegung (DE-588)4226404-2 gnd |
| subject_GND | (DE-588)4157835-1 (DE-588)4061165-6 (DE-588)4115589-0 (DE-588)4232727-1 (DE-588)4033792-3 (DE-588)4040802-4 (DE-588)4226404-2 (DE-588)4011882-4 (DE-588)4061163-2 (DE-588)4113937-9 |
| title | Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland |
| title_alt | Musik und politischer Konflikt aus der Türkei |
| title_auth | Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland |
| title_exact_search | Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland |
| title_exact_search_txtP | Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland |
| title_full | Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland Kirsten Seidlitz |
| title_fullStr | Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland Kirsten Seidlitz |
| title_full_unstemmed | Musik & politischer Konflikt aus der Türkei kurdische, alevitische und linke Musik in Deutschland Kirsten Seidlitz |
| title_short | Musik & politischer Konflikt aus der Türkei |
| title_sort | musik politischer konflikt aus der turkei kurdische alevitische und linke musik in deutschland |
| title_sub | kurdische, alevitische und linke Musik in Deutschland |
| topic | Protest (DE-588)4157835-1 gnd Türken (DE-588)4061165-6 gnd Politischer Konflikt (DE-588)4115589-0 gnd Aleviten (DE-588)4232727-1 gnd Kurden (DE-588)4033792-3 gnd Musik (DE-588)4040802-4 gnd Protestbewegung (DE-588)4226404-2 gnd |
| topic_facet | Protest Türken Politischer Konflikt Aleviten Kurden Musik Protestbewegung Deutschland Türkei Hochschulschrift |
| url | https://doi.org/10.14361/9783839454763 https://doi.org/10.1515/9783839454763 https://directory.doabooks.org/handle/20.500.12854/136358 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034948441&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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