Modular modification of chimeric antigen receptors sheds light on T cell activation:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Freiburg im Breisgau
Dezember 2022
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | V, 156 Seiten Illustrationen, Diagramme 30 cm |
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MARC
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| 245 | 1 | 0 | |a Modular modification of chimeric antigen receptors sheds light on T cell activation |c vorgelegt von Rubí Misol-Há Velasco Cárdenas |
| 264 | 1 | |a Freiburg im Breisgau |c Dezember 2022 | |
| 300 | |a V, 156 Seiten |b Illustrationen, Diagramme |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 502 | |b Dissertation |c Albert-Ludwigs-Universität Freiburg |d 2023 | ||
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Datensatz im Suchindex
| _version_ | 1804186458636943360 |
|---|---|
| adam_text | I.
TABLE
OF
CONTENTS
I.
TABLE
OF
CONTENTS
IL
ABSTRACT
......................................................................................................................................
II
III.
ZUSAMMENFASSUNG
...................................................................................................................
IV
1.
INTRODUCTION
....................................................................................................................................
1
1.1.
THE
IMMUNE
SYSTEM
.............................................................................................................
1
1.1.1.
INNATE
AND
ADAPTIVE
IMMUNITY
..............................................................................................
1
1.1.2.
T
CELLS
.......................................................................................................................................
1
2
1.1.3.
THE
T
CELL
RECEPTOR
(TCR)
AND
THE
THREE
SIGNAL
MODEL
FOR
T
CELL
ACTIVATION
1.2.
CANCER
IMMUNOTHERAPY
...................................................................................
1.2.1.
TYPES
OF
CANCER
IMMUNOTHERAPY
.....................................................................
1.3.
CHIMERIC
ANTIGEN
RECEPTORS
(CAR)
T
CELLS
..................................................
1.3.1.
REGULATORY
COMPONENTS
OF
CARS
.....................................................................
1.3.2.
CAR
SIGNALLING
AND
OPTIMIZATION
.......................
1.3.3.
CAR
TOXICITIES
AND
CHALLENGES
..........................................................................
2.
OBJECTIVES
...................................................................................................................
3.
RESULTS
........................................................................................................................
10
12
12
14
15
5
6
9
3.1.
HARNESSING
CD3
DIVERSITY
TO
REDESIGN
CAR
T
CELLS
........................................................
15
3.2.
NONCANONICAL
BINDING
OF
LCK
TO
CD3S
PROMOTES
TCR
SIGNALING
AND
CAR
FUNCTION
..
59
3.3.
NOVEL
LECTIN-BASED
CHIMERIC
ANTIGEN
RECEPTORS
TARGET
GB3-POSITIVE
TUMOUR
CELLS
........
87
3.4.
RATIONAL
DESIGN
OF
A
TRIMERIC
APRIL-BASED
CAR-BINDING
DOMAIN
ENABLES
EFFICIENT
TARGETING
OF
MULTIPLE
MYELOMA
...............................................................................................
113
4.
DISCUSSION
AND
FUTURE
PERSPECTIVES
........................................................................................
127
5.
ABBREVIATIONS
............................................................................................................................
132
6.
LIST
OF
FIGURES
...........................................................................................................................
135
7.
REFERENCES
.................................................................................................................................
136
8.
LIST
OF
PUBLICATIONS
...................................................................................................................
152
9.
ACKNOWLEDGMENTS
....................................................................................................................
154
|
| adam_txt |
I.
TABLE
OF
CONTENTS
I.
TABLE
OF
CONTENTS
IL
ABSTRACT
.
II
III.
ZUSAMMENFASSUNG
.
IV
1.
INTRODUCTION
.
1
1.1.
THE
IMMUNE
SYSTEM
.
1
1.1.1.
INNATE
AND
ADAPTIVE
IMMUNITY
.
1
1.1.2.
T
CELLS
.
1
2
1.1.3.
THE
T
CELL
RECEPTOR
(TCR)
AND
THE
THREE
SIGNAL
MODEL
FOR
T
CELL
ACTIVATION
1.2.
CANCER
IMMUNOTHERAPY
.
1.2.1.
TYPES
OF
CANCER
IMMUNOTHERAPY
.
1.3.
CHIMERIC
ANTIGEN
RECEPTORS
(CAR)
T
CELLS
.
1.3.1.
REGULATORY
COMPONENTS
OF
CARS
.
1.3.2.
CAR
SIGNALLING
AND
OPTIMIZATION
.
1.3.3.
CAR
TOXICITIES
AND
CHALLENGES
.
2.
OBJECTIVES
.
3.
RESULTS
.
10
12
12
14
15
5
6
9
3.1.
HARNESSING
CD3
DIVERSITY
TO
REDESIGN
CAR
T
CELLS
.
15
3.2.
NONCANONICAL
BINDING
OF
LCK
TO
CD3S
PROMOTES
TCR
SIGNALING
AND
CAR
FUNCTION
.
59
3.3.
NOVEL
LECTIN-BASED
CHIMERIC
ANTIGEN
RECEPTORS
TARGET
GB3-POSITIVE
TUMOUR
CELLS
.
87
3.4.
RATIONAL
DESIGN
OF
A
TRIMERIC
APRIL-BASED
CAR-BINDING
DOMAIN
ENABLES
EFFICIENT
TARGETING
OF
MULTIPLE
MYELOMA
.
113
4.
DISCUSSION
AND
FUTURE
PERSPECTIVES
.
127
5.
ABBREVIATIONS
.
132
6.
LIST
OF
FIGURES
.
135
7.
REFERENCES
.
136
8.
LIST
OF
PUBLICATIONS
.
152
9.
ACKNOWLEDGMENTS
.
154 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Velasco Cárdenas, Rubí Misol-Há |
| author_GND | (DE-588)1201780810 |
| author_facet | Velasco Cárdenas, Rubí Misol-Há |
| author_role | aut |
| author_sort | Velasco Cárdenas, Rubí Misol-Há |
| author_variant | c r m h v crmh crmhv |
| building | Verbundindex |
| bvnumber | BV049588518 |
| ctrlnum | (OCoLC)1393207101 (DE-599)DNB1303851237 |
| format | Thesis Book |
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| illustrated | Illustrated |
| index_date | 2024-07-03T23:33:00Z |
| indexdate | 2024-07-10T10:11:27Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034933246 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | V, 156 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2022 |
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| publishDateSort | 2022 |
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| spelling | Velasco Cárdenas, Rubí Misol-Há Verfasser (DE-588)1201780810 aut Modular modification of chimeric antigen receptors sheds light on T cell activation vorgelegt von Rubí Misol-Há Velasco Cárdenas Freiburg im Breisgau Dezember 2022 V, 156 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Albert-Ludwigs-Universität Freiburg 2023 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1303851237/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034933246&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p dnb 20231214 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Velasco Cárdenas, Rubí Misol-Há Modular modification of chimeric antigen receptors sheds light on T cell activation |
| subject_GND | (DE-588)4113937-9 |
| title | Modular modification of chimeric antigen receptors sheds light on T cell activation |
| title_auth | Modular modification of chimeric antigen receptors sheds light on T cell activation |
| title_exact_search | Modular modification of chimeric antigen receptors sheds light on T cell activation |
| title_exact_search_txtP | Modular modification of chimeric antigen receptors sheds light on T cell activation |
| title_full | Modular modification of chimeric antigen receptors sheds light on T cell activation vorgelegt von Rubí Misol-Há Velasco Cárdenas |
| title_fullStr | Modular modification of chimeric antigen receptors sheds light on T cell activation vorgelegt von Rubí Misol-Há Velasco Cárdenas |
| title_full_unstemmed | Modular modification of chimeric antigen receptors sheds light on T cell activation vorgelegt von Rubí Misol-Há Velasco Cárdenas |
| title_short | Modular modification of chimeric antigen receptors sheds light on T cell activation |
| title_sort | modular modification of chimeric antigen receptors sheds light on t cell activation |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1303851237/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034933246&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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