Transporters and drug-metabolizing enzymes in drug toxicity:
Overview. Overview / Albert P Li -- Transporter, Drug Metabolism, and Drug-Induced Liver Injury in Marketed Drugs / Minjun Chen, Kristin Ashby, Yue Wu -- Drug-Metabolism Enzymes and Transporter Activities as Risk Factors of Selected Marketed Drugs Associated with Drug-Induced Fatalities / Albert P L...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2021
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Overview. Overview / Albert P Li -- Transporter, Drug Metabolism, and Drug-Induced Liver Injury in Marketed Drugs / Minjun Chen, Kristin Ashby, Yue Wu -- Drug-Metabolism Enzymes and Transporter Activities as Risk Factors of Selected Marketed Drugs Associated with Drug-Induced Fatalities / Albert P Li -- Drug Metabolizing Enzymes and Drug Toxicity. Drug-Metabolizing Enzymes and Drug Toxicity / Albert P Li -- Genetic Polymorphism of Drug-Metabolizing Enzymes and Drug Transporters in Drug Toxicity / Ann K Daly -- Acyl Glucuronidation and Acyl-CoA Formation Mechanisms Mediating the Bioactivation and Potential Toxicity of Carboxylic Acid-containing Drugs / Mark P Grillo -- Liquid Chromatography-Mass Spectrometry (LC-MS) Quantification of Reactive Metabolites / Qingping Wang, Chuang Lu -- Human-Based In Vitro Experimental Approaches for the Evaluation of Metabolism-Dependent Drug Toxicity / Albert P Li -- Drug Transporters and Drug Toxicity. Mechanism-Based Experimental Models for the Evaluation of BSEP Inhibition and DILI / William A Murphy, Chitra Saran, Paavo Honkakoski, Kim LR Brouwer -- Hepatic Bile Acid Transporters in Drug-Induced Cholestasis / Tao Hu, Hongbing Wang -- Role of Renal Transporters in Drug-Drug Interactions and Nephrotoxicity / Yan Zhang, Donald Miller -- Blood-Brain Barrier Transporters and Central Nervous System Drug Response and Toxicity / Donald W Miller, Stacey Line, Nur A Safa, Yan Zhang -- Ototoxicity and Drug Transport in the Cochlea / Stefanie Kennon-McGill, Mitchell R McGill -- Modeling Drug Metabolizing Enzymes-Transporters Interplay for The Prediction of Drug Toxicity. Application of a PBPK Model Incorporating the Interplay Between Transporters and Drug-Metabolizing Enzymes for the Precise Prediction of Drug Toxicity / Kazuya Maeda -- The Extended Clearance Model / Birk Poller, Felix Huth, Vlasia Kastrinou-Lampou, Gerd A Kullak-Ublick, Michael Arand, Gian Camenisch. |
| Beschreibung: | 1 Online-Ressource (1 online resource) |
| ISBN: | 9781119170914 1119170915 |
| DOI: | 10.1002/9781119171003 |
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| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.7/042 |
| dewey-search | 615.7/042 |
| dewey-sort | 3615.7 242 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1002/9781119171003 |
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| illustrated | Not Illustrated |
| index_date | 2024-07-03T23:21:44Z |
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| isbn | 9781119170914 1119170915 |
| language | English |
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| spelling | Li, Albert P. Verfasser aut Transporters and drug-metabolizing enzymes in drug toxicity Hoboken, NJ Wiley 2021 1 Online-Ressource (1 online resource) txt rdacontent c rdamedia cr rdacarrier Overview. Overview / Albert P Li -- Transporter, Drug Metabolism, and Drug-Induced Liver Injury in Marketed Drugs / Minjun Chen, Kristin Ashby, Yue Wu -- Drug-Metabolism Enzymes and Transporter Activities as Risk Factors of Selected Marketed Drugs Associated with Drug-Induced Fatalities / Albert P Li -- Drug Metabolizing Enzymes and Drug Toxicity. Drug-Metabolizing Enzymes and Drug Toxicity / Albert P Li -- Genetic Polymorphism of Drug-Metabolizing Enzymes and Drug Transporters in Drug Toxicity / Ann K Daly -- Acyl Glucuronidation and Acyl-CoA Formation Mechanisms Mediating the Bioactivation and Potential Toxicity of Carboxylic Acid-containing Drugs / Mark P Grillo -- Liquid Chromatography-Mass Spectrometry (LC-MS) Quantification of Reactive Metabolites / Qingping Wang, Chuang Lu -- Human-Based In Vitro Experimental Approaches for the Evaluation of Metabolism-Dependent Drug Toxicity / Albert P Li -- Drug Transporters and Drug Toxicity. Mechanism-Based Experimental Models for the Evaluation of BSEP Inhibition and DILI / William A Murphy, Chitra Saran, Paavo Honkakoski, Kim LR Brouwer -- Hepatic Bile Acid Transporters in Drug-Induced Cholestasis / Tao Hu, Hongbing Wang -- Role of Renal Transporters in Drug-Drug Interactions and Nephrotoxicity / Yan Zhang, Donald Miller -- Blood-Brain Barrier Transporters and Central Nervous System Drug Response and Toxicity / Donald W Miller, Stacey Line, Nur A Safa, Yan Zhang -- Ototoxicity and Drug Transport in the Cochlea / Stefanie Kennon-McGill, Mitchell R McGill -- Modeling Drug Metabolizing Enzymes-Transporters Interplay for The Prediction of Drug Toxicity. Application of a PBPK Model Incorporating the Interplay Between Transporters and Drug-Metabolizing Enzymes for the Precise Prediction of Drug Toxicity / Kazuya Maeda -- The Extended Clearance Model / Birk Poller, Felix Huth, Vlasia Kastrinou-Lampou, Gerd A Kullak-Ublick, Michael Arand, Gian Camenisch. Drugs / Toxicology 1119170842 9781119170846 Erscheint auch als Druck-Ausgabe 1119170842 9781119170846 https://doi.org/10.1002/9781119171003 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Li, Albert P. Transporters and drug-metabolizing enzymes in drug toxicity |
| title | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_auth | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_exact_search | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_exact_search_txtP | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_full | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_fullStr | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_full_unstemmed | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_short | Transporters and drug-metabolizing enzymes in drug toxicity |
| title_sort | transporters and drug metabolizing enzymes in drug toxicity |
| url | https://doi.org/10.1002/9781119171003 |
| work_keys_str_mv | AT lialbertp transportersanddrugmetabolizingenzymesindrugtoxicity |