Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Aachen
Apprimus Verlag
2023
|
| Ausgabe: | 1. Auflage |
| Schriftenreihe: | Applied Microbiology
Volume 32 |
| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | XVIII, 201 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 342 g |
| ISBN: | 9783985551767 3985551766 |
| DOI: | 10.18154/RWTH-2023-09908 |
Internformat
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| 100 | 1 | |a Ullmann, Lena |d 1991- |e Verfasser |0 (DE-588)1255245964 |4 aut | |
| 245 | 1 | 0 | |a Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates |c Lena Ullmann |
| 250 | |a 1. Auflage | ||
| 264 | 1 | |a Aachen |b Apprimus Verlag |c 2023 | |
| 300 | |a XVIII, 201 Seiten |b Illustrationen, Diagramme |c 21 cm x 14.8 cm, 342 g | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Applied Microbiology |v Volume 32 | |
| 502 | |b Dissertation |c RWTH Aachen University |d 2023 | ||
| 650 | 0 | 7 | |a Formiate |0 (DE-588)4226475-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Acetate |0 (DE-588)4141236-9 |2 gnd |9 rswk-swf |
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| 650 | 0 | 7 | |a Brandpilze |0 (DE-588)4139860-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Itaconsäure |0 (DE-588)4338677-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biokonversion |0 (DE-588)4145610-5 |2 gnd |9 rswk-swf |
| 653 | |a Mikrobiologie | ||
| 653 | |a Naturwissenschaft | ||
| 653 | |a Biotechnologie | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Itaconsäure |0 (DE-588)4338677-5 |D s |
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| 689 | 0 | 3 | |a Formiate |0 (DE-588)4226475-3 |D s |
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| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |o https://doi.org/10.18154/RWTH-2023-09908 |
| 830 | 0 | |a Applied Microbiology |v Volume 32 |w (DE-604)BV042644516 |9 32 | |
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Datensatz im Suchindex
| _version_ | 1804186243713466368 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
CONTENTS
EIDESSTATTLICHE
ERKLARUNG
.................................................................................................
ILL
FUNDING
..............................................................................................................................
V
DANKSAGUNG
.....................................................................................................................
VII
SUMMARY
............................................................................................................................
V
ZUSAMMENFASSUNG
.........................................................................................................
VII
LIST
OF
ABBREVIATIONS
.........................................................................................................
IX
LIST
OF
FIGURES
...................................................................................................................XIII
LIST
OF
TABLES
..................................................................................................................
XVII
1
GENERAL
INTRODUCTION
......................................................................................................
3
1.1
BIOECONOMY
-
A
SUSTAINABLE
BIO-BASED
PRODUCTION
OF
CHEMICALS
.........................
3
1.1.1
PRODUCTION
OF
FUELS
FROM
BIO-BASED
FEEDSTOCKS
..............................................
4
1.2
ITACONIC
ACID
AS
A
PLATFORM
CHEMICAL
.....................................................................
6
1.2.1
APPLICATION
FIELDS
OF
ITACONATE
..........................................................................
8
1.2.2
MARKET
POTENTIAL
OF
ITACONATE
............................................................................
9
1.2.3
INDUSTRIAL
PRODUCTION
OF
ITACONATE
...................................................................
10
1.3
USTILAGINACEAE
AS
ALTERNATIVE
PRODUCTIONS
HOSTS
................................................
13
1.4
ALTERNATIVE
FEEDSTOCKS
FOR
ITACONIC
ACID
PRODUCTION
.............................................
14
1.4.1
ACETATE
.............................................................................................................
15
1.4.2
FORMATE
............................................................................................................
17
1.5
SCOPE
AND
OUTLINE
OF
THIS
THESIS
............................................................................
19
2
MATERIAL
AND
METHODS
................................................................................................23
2.1
CHEMICALS
..............................................................................................................
23
2.2
STRAINS,
MEDIA,
AND
CULTURE
CONDITIONS
...............................................................
23
2.3
MEMBRANE
SET-UP
.................................................................................................
27
2.4
ANALYTICAL
METHODS
...............................................................................................
29
2.4.1
CELL
GROWTH
MEASUREMENT
..............................................................................29
2.4.2
LC-RI/UV-MS/MS
.............................................................................................
30
2.4.3
13
C-LABELING
VIA
GC-MS
...................................................................................
30
2.4.4
DESIGN
OF
EXPERIMENT
(DOE)
APPROACH
..........................................................
31
2.5
STATISTICAL
ANALYSIS
................................................................................................
32
2.6
GENOME
SEQUENCING
............................................................................................
32
2.6.1
GENOMIC
DNA
ISOLATION
....................................................................................
32
2.6.2
NANOPORE
LIBRARY
PREPARATION
AND
GRIDION
SEQUENCING
...........................
33
2.6.3
ILLUMINA
LIBRARY
PREPARATION
AND
MISEQ
SEQUENCING
......................................33
2.6.4
BASE
CALLING,
READS
PROCESSING,
AND
ASSEMBLY
............................................33
2.6.5
GENE
PREDICTION
AND
GENOME
ANNOTATION
.......................................................
33
TABLE
OF
CONTENTS
2.6.6
COMPARATIVE
GENOME
ANALYSES
AND
PHYLOGENETIC
ANALYSES
........................
34
2.6.7
CO2
HYDROGENATION
IN
PRESENCE
OF
NAOH
AND
CIS-[RUCL2(CI2-DPPM)2]IN
APOLAR
SOLVENT/
H2O
..................................................................................................................
35
3
RESULTS
..........................................................................................................................
41
3.1
USTILAGINACEAE
BIOCATALYST
FOR
CO-METABOLISM
OF
CO2-DERIVED
SUBSTRATES
TOWARD
CARBON-NEUTRAL
ITACONATE
PRODUCTION
....................................................................
41
3.1.1
SUMMARY
...........................................................................................................
41
3.1.2
INTRODUCTION
......................................................................................................
41
3.1.3
RESULTS
AND
DISCUSSION
...................................................................................
45
3.1.4
CONCLUSION
........................................................................................................64
3.2
ACETATE
CO-FEEDING
TOWARD
CARBON-NEUTRAL
ITACONATE
PRODUCTION
BY
USTILAGO
MAYDIS
.....................................................................................................
69
3.2.1
SUMMARY
...........................................................................................................
69
3.2.2
INTRODUCTION
.......................................................................................................
69
3.2.3
RESULTS
AND
DISCUSSION
...................................................................................
71
3.2.4
CONCLUSION
........................................................................................................
90
3.3
IMPROVED
ITACONATE
PRODUCTION
WITH
U.
CYNODONTIS
VIA
CO-METABOLISM
OF
CO2
DERIVED
FORMATE
..................................................................................................
95
3.3.1
SUMMARY
...........................................................................................................
95
3.3.2
INTRODUCTION
.......................................................................................................
95
3.3.3
RESULTS
AND
DISCUSSION
...................................................................................
98
3.3.4
OPTIMIZATION
OF
FORMATE
CO-METABOLIZATION
VIA
DESIGN
OF
EXPERIMENT
(DOE)
APPROACH
....................................................................................................................
100
3.3.5
IMPLEMENTING
CO2-DERIVED
FORMATE
..............................................................
107
3.3.6
CONCLUSION
AND
OUTLOOK
..................................................................................
116
3.4
SEVENTEEN
USTILAGINACEAE
HIGH-QUALITY
GENOME
SEQUENCES
ALLOW
PHYLOGENOMIC
ANALYSIS
AND
PROVIDE
INSIGHTS
INTO
SECONDARY
METABOLITE
SYNTHESIS
...............
121
3.4.1
SUMMARY
.........................................................................................................
121
3.4.2
INTRODUCTION
.....................................................................................................
121
3.4.3
RESULTS
............................................................................................................
122
3.4.4
CONCLUSION
......................................................................................................
138
4
GENERAL
DISCUSSION
AND
OUTLOOK
................................................................................
143
4.1
PROCESS
OPTIMIZATION
..........................................................................................
143
4.2
CO2-DERIVED
SUBSTRATES
......................................................................................
145
4.3
OPTIMIZATION
VIA
METABOLIC
ENGINEERING
............................................................
147
4.4
CONCLUDING
REMARKS
AND
OUTLOOK
.......................................................................
150
APPENDIX
..........................................................................................................................
151
4.5
APPENDIX
.............................................................................................................
153
4.5.1
SUPPLEMENTARY
TABLES
....................................................................................
153
4.5.2
SUPPLEMENTARY
FIGURES
...................................................................................
167
II
TABLE
OF
CONTENTS
REFERENCES
....................................................................................................................
173
CURRICULUM
VITAE
............................................................................................................
197
|
| adam_txt |
TABLE
OF
CONTENTS
CONTENTS
EIDESSTATTLICHE
ERKLARUNG
.
ILL
FUNDING
.
V
DANKSAGUNG
.
VII
SUMMARY
.
V
ZUSAMMENFASSUNG
.
VII
LIST
OF
ABBREVIATIONS
.
IX
LIST
OF
FIGURES
.XIII
LIST
OF
TABLES
.
XVII
1
GENERAL
INTRODUCTION
.
3
1.1
BIOECONOMY
-
A
SUSTAINABLE
BIO-BASED
PRODUCTION
OF
CHEMICALS
.
3
1.1.1
PRODUCTION
OF
FUELS
FROM
BIO-BASED
FEEDSTOCKS
.
4
1.2
ITACONIC
ACID
AS
A
PLATFORM
CHEMICAL
.
6
1.2.1
APPLICATION
FIELDS
OF
ITACONATE
.
8
1.2.2
MARKET
POTENTIAL
OF
ITACONATE
.
9
1.2.3
INDUSTRIAL
PRODUCTION
OF
ITACONATE
.
10
1.3
USTILAGINACEAE
AS
ALTERNATIVE
PRODUCTIONS
HOSTS
.
13
1.4
ALTERNATIVE
FEEDSTOCKS
FOR
ITACONIC
ACID
PRODUCTION
.
14
1.4.1
ACETATE
.
15
1.4.2
FORMATE
.
17
1.5
SCOPE
AND
OUTLINE
OF
THIS
THESIS
.
19
2
MATERIAL
AND
METHODS
.23
2.1
CHEMICALS
.
23
2.2
STRAINS,
MEDIA,
AND
CULTURE
CONDITIONS
.
23
2.3
MEMBRANE
SET-UP
.
27
2.4
ANALYTICAL
METHODS
.
29
2.4.1
CELL
GROWTH
MEASUREMENT
.29
2.4.2
LC-RI/UV-MS/MS
.
30
2.4.3
13
C-LABELING
VIA
GC-MS
.
30
2.4.4
DESIGN
OF
EXPERIMENT
(DOE)
APPROACH
.
31
2.5
STATISTICAL
ANALYSIS
.
32
2.6
GENOME
SEQUENCING
.
32
2.6.1
GENOMIC
DNA
ISOLATION
.
32
2.6.2
NANOPORE
LIBRARY
PREPARATION
AND
GRIDION
SEQUENCING
.
33
2.6.3
ILLUMINA
LIBRARY
PREPARATION
AND
MISEQ
SEQUENCING
.33
2.6.4
BASE
CALLING,
READS
PROCESSING,
AND
ASSEMBLY
.33
2.6.5
GENE
PREDICTION
AND
GENOME
ANNOTATION
.
33
TABLE
OF
CONTENTS
2.6.6
COMPARATIVE
GENOME
ANALYSES
AND
PHYLOGENETIC
ANALYSES
.
34
2.6.7
CO2
HYDROGENATION
IN
PRESENCE
OF
NAOH
AND
CIS-[RUCL2(CI2-DPPM)2]IN
APOLAR
SOLVENT/
H2O
.
35
3
RESULTS
.
41
3.1
USTILAGINACEAE
BIOCATALYST
FOR
CO-METABOLISM
OF
CO2-DERIVED
SUBSTRATES
TOWARD
CARBON-NEUTRAL
ITACONATE
PRODUCTION
.
41
3.1.1
SUMMARY
.
41
3.1.2
INTRODUCTION
.
41
3.1.3
RESULTS
AND
DISCUSSION
.
45
3.1.4
CONCLUSION
.64
3.2
ACETATE
CO-FEEDING
TOWARD
CARBON-NEUTRAL
ITACONATE
PRODUCTION
BY
USTILAGO
MAYDIS
.
69
3.2.1
SUMMARY
.
69
3.2.2
INTRODUCTION
.
69
3.2.3
RESULTS
AND
DISCUSSION
.
71
3.2.4
CONCLUSION
.
90
3.3
IMPROVED
ITACONATE
PRODUCTION
WITH
U.
CYNODONTIS
VIA
CO-METABOLISM
OF
CO2
DERIVED
FORMATE
.
95
3.3.1
SUMMARY
.
95
3.3.2
INTRODUCTION
.
95
3.3.3
RESULTS
AND
DISCUSSION
.
98
3.3.4
OPTIMIZATION
OF
FORMATE
CO-METABOLIZATION
VIA
DESIGN
OF
EXPERIMENT
(DOE)
APPROACH
.
100
3.3.5
IMPLEMENTING
CO2-DERIVED
FORMATE
.
107
3.3.6
CONCLUSION
AND
OUTLOOK
.
116
3.4
SEVENTEEN
USTILAGINACEAE
HIGH-QUALITY
GENOME
SEQUENCES
ALLOW
PHYLOGENOMIC
ANALYSIS
AND
PROVIDE
INSIGHTS
INTO
SECONDARY
METABOLITE
SYNTHESIS
.
121
3.4.1
SUMMARY
.
121
3.4.2
INTRODUCTION
.
121
3.4.3
RESULTS
.
122
3.4.4
CONCLUSION
.
138
4
GENERAL
DISCUSSION
AND
OUTLOOK
.
143
4.1
PROCESS
OPTIMIZATION
.
143
4.2
CO2-DERIVED
SUBSTRATES
.
145
4.3
OPTIMIZATION
VIA
METABOLIC
ENGINEERING
.
147
4.4
CONCLUDING
REMARKS
AND
OUTLOOK
.
150
APPENDIX
.
151
4.5
APPENDIX
.
153
4.5.1
SUPPLEMENTARY
TABLES
.
153
4.5.2
SUPPLEMENTARY
FIGURES
.
167
II
TABLE
OF
CONTENTS
REFERENCES
.
173
CURRICULUM
VITAE
.
197 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Ullmann, Lena 1991- |
| author_GND | (DE-588)1255245964 |
| author_facet | Ullmann, Lena 1991- |
| author_role | aut |
| author_sort | Ullmann, Lena 1991- |
| author_variant | l u lu |
| building | Verbundindex |
| bvnumber | BV049466327 |
| collection | ebook |
| ctrlnum | (OCoLC)1420153682 (DE-599)DNB1305546725 |
| doi_str_mv | 10.18154/RWTH-2023-09908 |
| edition | 1. Auflage |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV049466327 |
| illustrated | Illustrated |
| index_date | 2024-07-03T23:15:53Z |
| indexdate | 2024-07-10T10:08:02Z |
| institution | BVB |
| institution_GND | (DE-588)1068101474 |
| isbn | 9783985551767 3985551766 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034811983 |
| oclc_num | 1420153682 |
| open_access_boolean | 1 |
| owner | DE-29T |
| owner_facet | DE-29T |
| physical | XVIII, 201 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 342 g |
| psigel | ebook |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| publisher | Apprimus Verlag |
| record_format | marc |
| series | Applied Microbiology |
| series2 | Applied Microbiology |
| spelling | Ullmann, Lena 1991- Verfasser (DE-588)1255245964 aut Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates Lena Ullmann 1. Auflage Aachen Apprimus Verlag 2023 XVIII, 201 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 342 g txt rdacontent n rdamedia nc rdacarrier Applied Microbiology Volume 32 Dissertation RWTH Aachen University 2023 Formiate (DE-588)4226475-3 gnd rswk-swf Acetate (DE-588)4141236-9 gnd rswk-swf Herstellung (DE-588)4159653-5 gnd rswk-swf Brandpilze (DE-588)4139860-9 gnd rswk-swf Itaconsäure (DE-588)4338677-5 gnd rswk-swf Biokonversion (DE-588)4145610-5 gnd rswk-swf Mikrobiologie Naturwissenschaft Biotechnologie (DE-588)4113937-9 Hochschulschrift gnd-content Itaconsäure (DE-588)4338677-5 s Herstellung (DE-588)4159653-5 s Acetate (DE-588)4141236-9 s Formiate (DE-588)4226475-3 s Biokonversion (DE-588)4145610-5 s Brandpilze (DE-588)4139860-9 s DE-604 Apprimus Verlag (DE-588)1068101474 pbl Erscheint auch als Online-Ausgabe, PDF https://doi.org/10.18154/RWTH-2023-09908 Applied Microbiology Volume 32 (DE-604)BV042644516 32 https://doi.org/10.18154/RWTH-2023-09908 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034811983&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p vlb 20231010 DE-101 https://d-nb.info/provenance/plan#vlb |
| spellingShingle | Ullmann, Lena 1991- Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates Applied Microbiology Formiate (DE-588)4226475-3 gnd Acetate (DE-588)4141236-9 gnd Herstellung (DE-588)4159653-5 gnd Brandpilze (DE-588)4139860-9 gnd Itaconsäure (DE-588)4338677-5 gnd Biokonversion (DE-588)4145610-5 gnd |
| subject_GND | (DE-588)4226475-3 (DE-588)4141236-9 (DE-588)4159653-5 (DE-588)4139860-9 (DE-588)4338677-5 (DE-588)4145610-5 (DE-588)4113937-9 |
| title | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates |
| title_auth | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates |
| title_exact_search | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates |
| title_exact_search_txtP | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates |
| title_full | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates Lena Ullmann |
| title_fullStr | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates Lena Ullmann |
| title_full_unstemmed | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates Lena Ullmann |
| title_short | Toward a CO2-neutral biotechnology: itaconate production using CO2 derived co-substrates |
| title_sort | toward a co2 neutral biotechnology itaconate production using co2 derived co substrates |
| topic | Formiate (DE-588)4226475-3 gnd Acetate (DE-588)4141236-9 gnd Herstellung (DE-588)4159653-5 gnd Brandpilze (DE-588)4139860-9 gnd Itaconsäure (DE-588)4338677-5 gnd Biokonversion (DE-588)4145610-5 gnd |
| topic_facet | Formiate Acetate Herstellung Brandpilze Itaconsäure Biokonversion Hochschulschrift |
| url | https://doi.org/10.18154/RWTH-2023-09908 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034811983&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV042644516 |
| work_keys_str_mv | AT ullmannlena towardaco2neutralbiotechnologyitaconateproductionusingco2derivedcosubstrates AT apprimusverlag towardaco2neutralbiotechnologyitaconateproductionusingco2derivedcosubstrates |