Cover -- Title Page -- Copyright -- Contents -- A Personal Foreword -- Preface -- Chapter 1 Basics of Targeted Drug Delivery -- 1.1 Introduction -- 1.1.1 Concept of Bioavailability and Therapeutic Index -- 1.2 Targeted Drug Delivery -- 1.3 Strategies for Drug Targeting -- 1.3.1 Passive Targeting --...

Ausführliche Beschreibung

Bibliographische Detailangaben

Weitere Verfasser:	Bachhav, Yogeshwar G. (HerausgeberIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Weinheim Wiley-VCH [2023]
Schriftenreihe:	Methods and principles in medicinal chemistry volume 82
Schlagworte:	Targeted drug delivery Electronic books Aufsatzsammlung
Online-Zugang:	Volltext
Zusammenfassung:	Cover -- Title Page -- Copyright -- Contents -- A Personal Foreword -- Preface -- Chapter 1 Basics of Targeted Drug Delivery -- 1.1 Introduction -- 1.1.1 Concept of Bioavailability and Therapeutic Index -- 1.2 Targeted Drug Delivery -- 1.3 Strategies for Drug Targeting -- 1.3.1 Passive Targeting -- 1.3.1.1 Reticuloendothelial System (RES) System -- 1.3.1.2 Enhanced Permeability and Retention (EPR) Effect -- 1.3.1.3 Localized Delivery -- 1.3.2 Active Targeting -- 1.3.3 Physical Targeting -- 1.3.3.1 Ultrasound for Targeting -- 1.3.3.2 Magnetic Field for Targeting -- 1.4 Therapeutic Applications of Targeted Drug Delivery -- 1.4.1 Diabetes Management -- 1.4.2 Neurological Diseases -- 1.4.3 Cardiovascular Diseases -- 1.4.4 Respiratory Diseases -- 1.4.5 Cancer Indications -- 1.5 Targeted DugDelivery Products -- 1.6 Challenges -- 1.6.1 Passive Targeting and EPR Effect -- 1.6.2 Active Targeting -- 1.7 Scaleup and Challenges -- 1.8 Current Status -- 1.9 Conclusion and Prospects -- References -- Chapter 2 Addressing Unmet Medical Needs Using Targeted DrugDelivery Systems: Emphasis on NanomedicineBased Applications -- 2.1 Introduction -- 2.2 Targeted DrugDelivery Systems for Unmet Medical Needs -- 2.2.1 Targeting Ligands -- 2.2.1.1 Small Molecules as Targeting Ligands -- 2.2.1.2 Aptamers as Targeting Ligands -- 2.2.1.3 Antibodies as Targeting Ligands -- 2.2.1.4 Lectins as Targeting Ligands -- 2.2.1.5 Lactoferrins as Targeting Ligands -- 2.2.2 Targeting Approaches -- 2.2.2.1 DiseaseBased Targeting -- 2.2.2.2 LocationBased Targeting -- 2.3 Regulatory Aspects and Clinical Perspectives -- 2.4 Conclusion and Future Outlook -- References -- Chapter 3 NanocarriersBased Targeted Drug Delivery Systems: Small and Macromolecules -- 3.1 Nanocarriers (Nanomedicine) - Overview and Role in Targeted Drug Delivery -- 3.2 Passive Targeting Approaches.
Beschreibung:	1 Online-Ressource (xvii, 438 Seiten) Illustrationen
ISBN:	9783527827862 9783527827879 9783527827855