The role of microRNA-100 in abdominal aortic aneurysms:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Freiburg im Breisgau
2022
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| Schlagworte: | |
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| Beschreibung: | X, 88, xxii Seiten Illustrationen 30 cm |
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MARC
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| 020 | |c Broschur | ||
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| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Schneider, Laura Anna |e Verfasser |0 (DE-588)1270003054 |4 aut | |
| 245 | 1 | 0 | |a The role of microRNA-100 in abdominal aortic aneurysms |c von Laura Anna Schneider |
| 264 | 1 | |a Freiburg im Breisgau |c 2022 | |
| 300 | |a X, 88, xxii Seiten |b Illustrationen |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Albert-Ludwigs-Universität Freiburg im Breisgau |d 2022 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u https://d-nb.info/1272265765/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034565466&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-034565466 | ||
| 883 | 0 | |8 1\p |a emakn |c 0,17258 |d 20230313 |q DE-101 |u https://d-nb.info/provenance/plan#emakn | |
Datensatz im Suchindex
| _version_ | 1804185803206688768 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
....................................................................................................................
I
LIST
OF
FIGURES........................................................................................................................
V
LIST
OF
TABLES
........................................................................................................................
VI
ABBREVIATIONS
......................................................................................................................
VII
INTRODUCTION
............................................................................................................................
1
1.
ABDOMINAL
AORTIC
ANEURYSM
.........................................................................................
1
1.1.
DEFINITION
.........................................................................................................
1
1.2.
EPIDEMIOLOGY
..................................................................................................
2
1.3.
CLINICAL
PRESENTATION
.......................................................................................
3
1.4.
RISK
FACTORS
.....................................................................................................
4
1.5.
PATHOPHYSIOLOGY
.............................................................................................
6
1.5.1.
BASICS
........................................................................................................
6
1.5.2.
MACROSCOPIC
CHANGES
...............................................................................
6
1.5.3.
MICROSCOPIC
CHANGES:
DEFINING
HALLMARKS
FOR
ABDOMINAL
AORTIC
ANEURYSMS
...................................................................................................................
9
1.5.4.
CELLULAR
MECHANISMS:
THE
PIVOTAL
ROLE
OF
VASCULAR
SMOOTH
MUSCLE
CELLS
.
10
1.5.5.
MOLECULAR
MECHANISMS
IN
ABDOMINAL
AORTIC
ANEURYSM
FORMATION
AND
PROGRESSION
..............................................................................................
12
1.5.5.1.
PROGRESSIVE
INFLAMMATION
........................................................................
12
1.5.5.2.
OXIDATIVE
STRESS
.......................................................................................
13
1.5.5.3.
INTERCELLULAR
ADHESION
MOLECULE-1
(ICAM-1
)
.............................................
13
1.5.5.4.
TRANSGELIN/SM22-A
...................................................................................
13
1.5.5.5.
MECHANISTIC
TARGET
OF
RAPAMYCIN
(MTOR)
..............................................
14
1.5.5.6.
SMOOTH
MUSCLE
A-ACTIN
(SMA)
..................................................................
14
1.5.5.7.
SMOOTHELIN
...............................................................................................
15
1.5.5.8.
CALPONIN
...................................................................................................
15
1.5.5.9.
MATRIX
METALLOPROTEINASES
.......................................................................
15
1.5.5.9.1.
MATRIX
METALLOPROTEINASE-2
(MMP-2,
GELATINASE-A)
...........................
16
1.5.5.9.2.
MATRIX
METALLOPROTEINASE-9
(MMP-9,
GELATINASE-B)
...........................
17
1.5.5.10.
INSULIN-LIKE
GROWTH
FACTOR-1
RECEPTOR
3
(IGF1RP)
.....................................
17
1.5.5.11.
RAS-RELATED
C3
BOTULINUM
TOXIN
SUBSTRATE
1
(RAC1
)
................................
17
1.5.6.
GENETIC
BACKGROUND
OF
ABDOMINAL
AORTIC
ANEURYSMS
..............................
18
1.6.
DIAGNOSTICS
...................................................................................................
19
1.7.
TREATMENT
19
1.7.
1.
CONSERVATIVE
THERAPY
........................................................
19
1.7.
2.
INTERVENTIONAL
THERAPY
......................................................
20
1.8.
PROGNOSIS
.....................................................................................................
20
2.
CHOOSING
A
MURINE
MODEL
..........................................................................................
21
3.
MICRO-RNAS
................................................................................................................
23
3.1.
MICRORNAS
IN
ABDOMINAL
AORTIC
ANEURYSMS
.................................................
23
3.2.
MICRORNAS
AS
BIOMARKERS
FOR
ABDOMINAL
AORTIC
ANEURYSMS
........................
24
3.3.
MICRORNAS
AS
THERAPEUTICS
..........................................................................
24
3.4.
MICRORNA-100
25
MATERIALS
AND
METHODS
........................................................................................................
27
1.
MATERIALS
.....................................................................................................................
27
1.1.
STATIONARY
LABORATORY
EQUIPMENT
..................................................................
27
1.2.
DISPOSABLES
..................................................................................................
28
1.3.
CHEMICALS,
ENZYMES,
COMPOUNDS
AND
PROTEINS
............................................
29
1.4.
KITS
................................................................................................................
31
1.5.
CELL
CULTURE
..................................................................................................
31
1.6.
OLIGONUCLEOTIDES
..........................................................................................
31
1.7.
TRANSFECTION
REAGENTS
32
1.8.
WESTERN
BLOT
ANTIBODIES
................................................................................
32
1.9.
STAINING
33
1.10.
MURINE
EXPERIMENTS
......................................................................................
33
ILL
2.
METHODS
......................................................................................................................
34
2.1.
CELL
CULTURE
OF
VASCULAR
SMOOTH
MUSCLE
CELLS
................................................
34
2.2.
TRANSFECTION
OF
VASCULAR
SMOOTH
MUSCLE
CELLS
..............................................
34
2.3.
STAINING
FOR
CONFOCAL
MICROSCOPY
...................................................................
34
2.4.
RNA
ISOLATION
................................................................................................
35
2.5.
TAQMAN
RT/Q-PCR
PROTOCOL
........................................................................
36
2.6.
PROTEIN
ISOLATION
............................................................................................
37
2.7.
WESTERN
BLOT
.................................................................................................
38
2.8.
PROLIFERATION
ASSAY
........................................................................................
40
2.9.
APOPTOSIS
ASSAY
............................................................................................
40
2.10.
RT
2
PROFILERYY
PCR
ARRAY
..............................................................................
40
2.11.
GENERATING
A
MURINE
MODEL
..........................................................................
41
2.12.
PREPARATION
AND
INSERTION
OF
OSMOTIC
PUMPS
.................................................
42
2.13.
MURINE
AORTIC
SONOGRAPHY
.............................................................................
42
2.14.
HARVESTING
AND
SAMPLE
PREPARATION
.............................................................
44
2.15.
ELASTICA
VAN
GIESON
STAINING
........................................................................
45
2.16.
TUNEL
ASSAY
................................................................................................
45
2.17.
STATISTICAL
ANALYSIS
........................................................................................
46
RESULTS
..........................................
47
1.
ANGIOTENSIN
II
PERFUSION
RESULTS
IN
AN
INCREASED
SUPRARENAL
AORTIC
DIAMETER
IN
VIVO...
47
2.
ANEURYSM
FORMATION
IS
LIMITED
BY
MIR-1
00
UPREGULATION
IN
VIVO
.................................
50
3.
MEDIAL
THICKNESS
IN
ANEURYSM
IS
PRESERVED
THROUGH
MIR-1
00
LEVEL
INCREASE
............
54
4.
DIFFERENCES
IN
NUMBER
OF
APOPTOTIC
EVENTS
COULD
NOT
BE
QUANTIFIED
VIA
TUNEL
ASSAY
4
WEEKS
AFTER
ANEURYSM
INDUCTION
...................................................................
58
5.
PATHWAY
EXPRESSION
ANALYSIS
OF
MURINE
VSMCS
WITH
GENETICALLY
INDUCED
ELEVATED
MIR-1
00
LEVELS
USING
THE
RT
2
PROFILER
ARRAY
MOUSE
CELL
MOTILITY
OPENS
FURTHER
RESEARCH
POSSIBILITIES
..................................................................................................
60
6.
CATIONIC
LIPID-MEDIATED
TRANSFECTION
DOES
NOT AFFECT
CELL
VIABILITY
...............................
63
7.
MIR-1
00
LEVEL
MODULATION
SEEMS
TO
CHANGE
CYTOSKELETAL
STRUCTURES
IN
HAOVSMCS
....................................................................................................................................
64
8.
MIR-1
00
MODULATION
HAS
NO
DETERMINABLE
IMPACT
ON
PHENOTYPE
MARKERS
IN
HAO
VSMCS
................................................................................................................
67
9.
MIR
MODULATION
DOES
NOT
AFFECT
EXPRESSION
OF
ELASTOLYTIC
ENZYMES
IN
VITRO...............
70
10.
MIR-1
00
MODULATION
AFFECTS
APOPTOSIS
........................................................................
72
11.
MIR-1
00
MODULATION
TARGETS
MTOR
SIGNALING
.............................................................
74
12.
MIR-1
00
MODULATION
DOES
NOT
AFFECT
IGF1
RB
OR
RAC1
-EXPRESSION
.............................
76
DISCUSSION
............................................................................................................................
80
1.
MIR-1
00
AND
VSMC
PHENOTYPE
...................................................................................
81
2.
MIR-1
00
AND
PATHWAY
ANALYSIS
....................................................................................
83
3.
MIR-1
00
AND
VSMC
APOPTOSIS
....................................................................................
85
SUMMARY
...............................................................................................................................
87
ZUSAMMENFASSUNG
..............................................................................................................
88
SUPPLEMENT
..............................................................................................................................
I
1.
RT
2
PROFILER
ARRAY
MOUSE
CELL
MOTILITY
...........................................................................
I
2.
BIBLIOGRAPHY
..................................................................................................................
IV
3.
PUBLICATIONS
...............................................................................................................
XVIII
4.
CURRICULUM
VITAE
..........................................................................................................XIX
5.
EIDESSTATTLICHE
VERSICHERUNG
.......................................................................................
XX
6.
ERKLARUNGEN
ZUM
EIGENANTEIL
......................................................................................
XXI
7.
DANKSAGUNG
...............................................................................................................
XXII
|
| adam_txt |
TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
.
I
LIST
OF
FIGURES.
V
LIST
OF
TABLES
.
VI
ABBREVIATIONS
.
VII
INTRODUCTION
.
1
1.
ABDOMINAL
AORTIC
ANEURYSM
.
1
1.1.
DEFINITION
.
1
1.2.
EPIDEMIOLOGY
.
2
1.3.
CLINICAL
PRESENTATION
.
3
1.4.
RISK
FACTORS
.
4
1.5.
PATHOPHYSIOLOGY
.
6
1.5.1.
BASICS
.
6
1.5.2.
MACROSCOPIC
CHANGES
.
6
1.5.3.
MICROSCOPIC
CHANGES:
DEFINING
HALLMARKS
FOR
ABDOMINAL
AORTIC
ANEURYSMS
.
9
1.5.4.
CELLULAR
MECHANISMS:
THE
PIVOTAL
ROLE
OF
VASCULAR
SMOOTH
MUSCLE
CELLS
.
10
1.5.5.
MOLECULAR
MECHANISMS
IN
ABDOMINAL
AORTIC
ANEURYSM
FORMATION
AND
PROGRESSION
.
12
1.5.5.1.
PROGRESSIVE
INFLAMMATION
.
12
1.5.5.2.
OXIDATIVE
STRESS
.
13
1.5.5.3.
INTERCELLULAR
ADHESION
MOLECULE-1
(ICAM-1
)
.
13
1.5.5.4.
TRANSGELIN/SM22-A
.
13
1.5.5.5.
MECHANISTIC
TARGET
OF
RAPAMYCIN
(MTOR)
.
14
1.5.5.6.
SMOOTH
MUSCLE
A-ACTIN
(SMA)
.
14
1.5.5.7.
SMOOTHELIN
.
15
1.5.5.8.
CALPONIN
.
15
1.5.5.9.
MATRIX
METALLOPROTEINASES
.
15
1.5.5.9.1.
MATRIX
METALLOPROTEINASE-2
(MMP-2,
GELATINASE-A)
.
16
1.5.5.9.2.
MATRIX
METALLOPROTEINASE-9
(MMP-9,
GELATINASE-B)
.
17
1.5.5.10.
INSULIN-LIKE
GROWTH
FACTOR-1
RECEPTOR
3
(IGF1RP)
.
17
1.5.5.11.
RAS-RELATED
C3
BOTULINUM
TOXIN
SUBSTRATE
1
(RAC1
)
.
17
1.5.6.
GENETIC
BACKGROUND
OF
ABDOMINAL
AORTIC
ANEURYSMS
.
18
1.6.
DIAGNOSTICS
.
19
1.7.
TREATMENT
19
1.7.
1.
CONSERVATIVE
THERAPY
.
19
1.7.
2.
INTERVENTIONAL
THERAPY
.
20
1.8.
PROGNOSIS
.
20
2.
CHOOSING
A
MURINE
MODEL
.
21
3.
MICRO-RNAS
.
23
3.1.
MICRORNAS
IN
ABDOMINAL
AORTIC
ANEURYSMS
.
23
3.2.
MICRORNAS
AS
BIOMARKERS
FOR
ABDOMINAL
AORTIC
ANEURYSMS
.
24
3.3.
MICRORNAS
AS
THERAPEUTICS
.
24
3.4.
MICRORNA-100
25
MATERIALS
AND
METHODS
.
27
1.
MATERIALS
.
27
1.1.
STATIONARY
LABORATORY
EQUIPMENT
.
27
1.2.
DISPOSABLES
.
28
1.3.
CHEMICALS,
ENZYMES,
COMPOUNDS
AND
PROTEINS
.
29
1.4.
KITS
.
31
1.5.
CELL
CULTURE
.
31
1.6.
OLIGONUCLEOTIDES
.
31
1.7.
TRANSFECTION
REAGENTS
32
1.8.
WESTERN
BLOT
ANTIBODIES
.
32
1.9.
STAINING
33
1.10.
MURINE
EXPERIMENTS
.
33
ILL
2.
METHODS
.
34
2.1.
CELL
CULTURE
OF
VASCULAR
SMOOTH
MUSCLE
CELLS
.
34
2.2.
TRANSFECTION
OF
VASCULAR
SMOOTH
MUSCLE
CELLS
.
34
2.3.
STAINING
FOR
CONFOCAL
MICROSCOPY
.
34
2.4.
RNA
ISOLATION
.
35
2.5.
TAQMAN
RT/Q-PCR
PROTOCOL
.
36
2.6.
PROTEIN
ISOLATION
.
37
2.7.
WESTERN
BLOT
.
38
2.8.
PROLIFERATION
ASSAY
.
40
2.9.
APOPTOSIS
ASSAY
.
40
2.10.
RT
2
PROFILERYY
PCR
ARRAY
.
40
2.11.
GENERATING
A
MURINE
MODEL
.
41
2.12.
PREPARATION
AND
INSERTION
OF
OSMOTIC
PUMPS
.
42
2.13.
MURINE
AORTIC
SONOGRAPHY
.
42
2.14.
HARVESTING
AND
SAMPLE
PREPARATION
.
44
2.15.
ELASTICA
VAN
GIESON
STAINING
.
45
2.16.
TUNEL
ASSAY
.
45
2.17.
STATISTICAL
ANALYSIS
.
46
RESULTS
.
47
1.
ANGIOTENSIN
II
PERFUSION
RESULTS
IN
AN
INCREASED
SUPRARENAL
AORTIC
DIAMETER
IN
VIVO.
47
2.
ANEURYSM
FORMATION
IS
LIMITED
BY
MIR-1
00
UPREGULATION
IN
VIVO
.
50
3.
MEDIAL
THICKNESS
IN
ANEURYSM
IS
PRESERVED
THROUGH
MIR-1
00
LEVEL
INCREASE
.
54
4.
DIFFERENCES
IN
NUMBER
OF
APOPTOTIC
EVENTS
COULD
NOT
BE
QUANTIFIED
VIA
TUNEL
ASSAY
4
WEEKS
AFTER
ANEURYSM
INDUCTION
.
58
5.
PATHWAY
EXPRESSION
ANALYSIS
OF
MURINE
VSMCS
WITH
GENETICALLY
INDUCED
ELEVATED
MIR-1
00
LEVELS
USING
THE
RT
2
PROFILER
ARRAY
'
MOUSE
CELL
MOTILITY
'
OPENS
FURTHER
RESEARCH
POSSIBILITIES
.
60
6.
CATIONIC
LIPID-MEDIATED
TRANSFECTION
DOES
NOT AFFECT
CELL
VIABILITY
.
63
7.
MIR-1
00
LEVEL
MODULATION
SEEMS
TO
CHANGE
CYTOSKELETAL
STRUCTURES
IN
HAOVSMCS
.
64
8.
MIR-1
00
MODULATION
HAS
NO
DETERMINABLE
IMPACT
ON
PHENOTYPE
MARKERS
IN
HAO
VSMCS
.
67
9.
MIR
MODULATION
DOES
NOT
AFFECT
EXPRESSION
OF
ELASTOLYTIC
ENZYMES
IN
VITRO.
70
10.
MIR-1
00
MODULATION
AFFECTS
APOPTOSIS
.
72
11.
MIR-1
00
MODULATION
TARGETS
MTOR
SIGNALING
.
74
12.
MIR-1
00
MODULATION
DOES
NOT
AFFECT
IGF1
RB
OR
RAC1
-EXPRESSION
.
76
DISCUSSION
.
80
1.
MIR-1
00
AND
VSMC
PHENOTYPE
.
81
2.
MIR-1
00
AND
PATHWAY
ANALYSIS
.
83
3.
MIR-1
00
AND
VSMC
APOPTOSIS
.
85
SUMMARY
.
87
ZUSAMMENFASSUNG
.
88
SUPPLEMENT
.
I
1.
RT
2
PROFILER
ARRAY
'MOUSE
CELL
MOTILITY
'
.
I
2.
BIBLIOGRAPHY
.
IV
3.
PUBLICATIONS
.
XVIII
4.
CURRICULUM
VITAE
.XIX
5.
EIDESSTATTLICHE
VERSICHERUNG
.
XX
6.
ERKLARUNGEN
ZUM
EIGENANTEIL
.
XXI
7.
DANKSAGUNG
.
XXII |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Schneider, Laura Anna |
| author_GND | (DE-588)1270003054 |
| author_facet | Schneider, Laura Anna |
| author_role | aut |
| author_sort | Schneider, Laura Anna |
| author_variant | l a s la las |
| building | Verbundindex |
| bvnumber | BV049304258 |
| classification_rvk | YC 1104 |
| ctrlnum | (OCoLC)1347225387 (DE-599)KXP1818592347 |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Thesis Book |
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| id | DE-604.BV049304258 |
| illustrated | Illustrated |
| index_date | 2024-07-03T22:39:30Z |
| indexdate | 2024-07-10T10:01:02Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034565466 |
| oclc_num | 1347225387 |
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| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | X, 88, xxii Seiten Illustrationen 30 cm |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| record_format | marc |
| spelling | Schneider, Laura Anna Verfasser (DE-588)1270003054 aut The role of microRNA-100 in abdominal aortic aneurysms von Laura Anna Schneider Freiburg im Breisgau 2022 X, 88, xxii Seiten Illustrationen 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2022 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1272265765/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034565466&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p emakn 0,17258 20230313 DE-101 https://d-nb.info/provenance/plan#emakn |
| spellingShingle | Schneider, Laura Anna The role of microRNA-100 in abdominal aortic aneurysms |
| subject_GND | (DE-588)4113937-9 |
| title | The role of microRNA-100 in abdominal aortic aneurysms |
| title_auth | The role of microRNA-100 in abdominal aortic aneurysms |
| title_exact_search | The role of microRNA-100 in abdominal aortic aneurysms |
| title_exact_search_txtP | The role of microRNA-100 in abdominal aortic aneurysms |
| title_full | The role of microRNA-100 in abdominal aortic aneurysms von Laura Anna Schneider |
| title_fullStr | The role of microRNA-100 in abdominal aortic aneurysms von Laura Anna Schneider |
| title_full_unstemmed | The role of microRNA-100 in abdominal aortic aneurysms von Laura Anna Schneider |
| title_short | The role of microRNA-100 in abdominal aortic aneurysms |
| title_sort | the role of microrna 100 in abdominal aortic aneurysms |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1272265765/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034565466&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schneiderlauraanna theroleofmicrorna100inabdominalaorticaneurysms |
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