The extracellular matrix and the tumor microenvironment:
This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression.Twelve chapters deal with the biochemical and biophysical background of extrace...
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer
[2022]
|
| Schriftenreihe: | Biology of extracellular matrix
Volume 11 |
| Schlagworte: | |
| Zusammenfassung: | This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression.Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression.Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors.The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology |
| Beschreibung: | Table of Contents; Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation. ; Dragana Nikitovits, George Tzanakakis; The role of decorin in cancer; Kornélia Baghy, Andrea Reszegi, Zsolt Horváth, Ilona Kovalszky; The mystery of syndecan-1 in tumor development and progression; Ilona Kovalszky, Kornélia Baghy, Andrea Reszegi, Péter Hollósi, Anders Hjerpe, Katalin Dobra; Syndecan-2 Biology and its Role in Colorectal Carcinoma; Eok-Soo Oh and John R. Couchman; Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy; Athanasios Papadas, Alexander Cicala, Sean G. Kraus, Garrett Arauz, Gauri Deb, Dustin Deming, and Fotis Asimakopoulos; Circulating proteoglycans/glycosaminoglycans as cancer biomarkers; Antonio Junior Lepedda, Gabriele Nieddu, Nikos Karamanos, Marilena Formato; Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects"; Antonella Icardi, Silvina L Lompardia, Daniela L. Papademetrio, Paolo Rosales, Mariángeles Díaz, Matías A. Pibuel Laura Alaniz, Elida Alvarez. ; Heparanase: a paramount enzyme for cancer initiation, progression and metastasis; Valentina Masola, Nicola Greco, Giovanni Gambaro, Marco Franchi and Maurizio Onisto; Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved; Patricia Rousselle and Konrad Beck; Basement membrane, collagen, and fibronectin: physical interactions with cancer cells. ; Franchi Marco, Valentina Masola, Konstantinos-Athanasios Karamanos, Leonardo Franchi, Konstantina Kyriakopoulou, Maurizio Onisto, Concettina Cappadone.; Integrins in cancer: re-focusing on the tumor microenvironment; Cédric Zeltz, Ning Lu, Ritva He |
| Beschreibung: | x, 494 Seiten Illustrationen 765 grams |
| ISBN: | 9783030997106 |
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Datensatz im Suchindex
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| id | DE-604.BV049097711 |
| illustrated | Illustrated |
| index_date | 2024-07-03T22:31:47Z |
| indexdate | 2024-07-10T09:55:15Z |
| institution | BVB |
| isbn | 9783030997106 |
| language | English |
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| series | Biology of extracellular matrix |
| series2 | Biology of extracellular matrix |
| spelling | The extracellular matrix and the tumor microenvironment Ilona Kovalszky, Marco Franchi, Laura D. Alaniz, editors Cham Springer [2022] x, 494 Seiten Illustrationen 765 grams txt rdacontent n rdamedia nc rdacarrier Biology of extracellular matrix Volume 11 Table of Contents; Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation. ; Dragana Nikitovits, George Tzanakakis; The role of decorin in cancer; Kornélia Baghy, Andrea Reszegi, Zsolt Horváth, Ilona Kovalszky; The mystery of syndecan-1 in tumor development and progression; Ilona Kovalszky, Kornélia Baghy, Andrea Reszegi, Péter Hollósi, Anders Hjerpe, Katalin Dobra; Syndecan-2 Biology and its Role in Colorectal Carcinoma; Eok-Soo Oh and John R. Couchman; Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy; Athanasios Papadas, Alexander Cicala, Sean G. Kraus, Garrett Arauz, Gauri Deb, Dustin Deming, and Fotis Asimakopoulos; Circulating proteoglycans/glycosaminoglycans as cancer biomarkers; Antonio Junior Lepedda, Gabriele Nieddu, Nikos Karamanos, Marilena Formato; Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects"; Antonella Icardi, Silvina L Lompardia, Daniela L. Papademetrio, Paolo Rosales, Mariángeles Díaz, Matías A. Pibuel Laura Alaniz, Elida Alvarez. ; Heparanase: a paramount enzyme for cancer initiation, progression and metastasis; Valentina Masola, Nicola Greco, Giovanni Gambaro, Marco Franchi and Maurizio Onisto; Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved; Patricia Rousselle and Konrad Beck; Basement membrane, collagen, and fibronectin: physical interactions with cancer cells. ; Franchi Marco, Valentina Masola, Konstantinos-Athanasios Karamanos, Leonardo Franchi, Konstantina Kyriakopoulou, Maurizio Onisto, Concettina Cappadone.; Integrins in cancer: re-focusing on the tumor microenvironment; Cédric Zeltz, Ning Lu, Ritva He This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression.Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression.Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors.The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology bicssc bisacsh Cytology Clinical biochemistry Cancer Hardcover, Softcover / Medizin/Nichtklinische Fächer Kovalszky, Ilona edt Franchi, Marco edt Alaniz, Laura D. edt Erscheint auch als Online-Ausgabe 978-3-030-99708-3 Biology of extracellular matrix Volume 11 (DE-604)BV049315745 11 |
| spellingShingle | The extracellular matrix and the tumor microenvironment Biology of extracellular matrix bicssc bisacsh Cytology Clinical biochemistry Cancer |
| title | The extracellular matrix and the tumor microenvironment |
| title_auth | The extracellular matrix and the tumor microenvironment |
| title_exact_search | The extracellular matrix and the tumor microenvironment |
| title_exact_search_txtP | The extracellular matrix and the tumor microenvironment |
| title_full | The extracellular matrix and the tumor microenvironment Ilona Kovalszky, Marco Franchi, Laura D. Alaniz, editors |
| title_fullStr | The extracellular matrix and the tumor microenvironment Ilona Kovalszky, Marco Franchi, Laura D. Alaniz, editors |
| title_full_unstemmed | The extracellular matrix and the tumor microenvironment Ilona Kovalszky, Marco Franchi, Laura D. Alaniz, editors |
| title_short | The extracellular matrix and the tumor microenvironment |
| title_sort | the extracellular matrix and the tumor microenvironment |
| topic | bicssc bisacsh Cytology Clinical biochemistry Cancer |
| topic_facet | bicssc bisacsh Cytology Clinical biochemistry Cancer |
| volume_link | (DE-604)BV049315745 |
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