G protein-coupled receptors: immobilization and applications in drug discovery
This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor res...
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| Main Authors: | , , , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Singapore
Springer
[2023]
|
| Series: | SpringerBriefs in molecular science
|
| Subjects: | |
| Summary: | This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities |
| Item Description: | G Protein-Coupled Receptors.- Purification of G Protein-Coupled Receptors.- Oriented Immobilization of G Protein-Coupled Receptors.- Key Biochemical Aspects of Drug-Target Interactions.- Immobilized GPCRs in Drug-Receptor Interaction Analysis.- Immobilized GPCRs in Compound Screening |
| Physical Description: | xii, 91 Seiten Illustrationen 174 grams |
| ISBN: | 9789819900770 |
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| id | DE-604.BV048996535 |
| illustrated | Illustrated |
| index_date | 2024-07-03T22:08:39Z |
| indexdate | 2024-07-10T09:52:21Z |
| institution | BVB |
| isbn | 9789819900770 |
| language | English |
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| physical | xii, 91 Seiten Illustrationen 174 grams |
| publishDate | 2023 |
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| publisher | Springer |
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| spelling | Zhao, Xinfeng Verfasser aut G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang Singapore Springer [2023] xii, 91 Seiten Illustrationen 174 grams txt rdacontent n rdamedia nc rdacarrier SpringerBriefs in molecular science G Protein-Coupled Receptors.- Purification of G Protein-Coupled Receptors.- Oriented Immobilization of G Protein-Coupled Receptors.- Key Biochemical Aspects of Drug-Target Interactions.- Immobilized GPCRs in Drug-Receptor Interaction Analysis.- Immobilized GPCRs in Compound Screening This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry Hardcover, Softcover / Chemie/Theoretische Chemie Li, Qian Verfasser aut Wang, Jing Verfasser aut Liang, Qi Verfasser aut Quan, Jia Verfasser aut Erscheint auch als Online-Ausgabe 978-981-99-0078-7 |
| spellingShingle | Zhao, Xinfeng Li, Qian Wang, Jing Liang, Qi Quan, Jia G protein-coupled receptors immobilization and applications in drug discovery bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry |
| title | G protein-coupled receptors immobilization and applications in drug discovery |
| title_auth | G protein-coupled receptors immobilization and applications in drug discovery |
| title_exact_search | G protein-coupled receptors immobilization and applications in drug discovery |
| title_exact_search_txtP | G protein-coupled receptors immobilization and applications in drug discovery |
| title_full | G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang |
| title_fullStr | G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang |
| title_full_unstemmed | G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang |
| title_short | G protein-coupled receptors |
| title_sort | g protein coupled receptors immobilization and applications in drug discovery |
| title_sub | immobilization and applications in drug discovery |
| topic | bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry |
| topic_facet | bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry |
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