G protein-coupled receptors: immobilization and applications in drug discovery
This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor res...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Singapore
Springer
[2023]
|
| Schriftenreihe: | SpringerBriefs in molecular science
|
| Schlagworte: | |
| Zusammenfassung: | This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities |
| Beschreibung: | G Protein-Coupled Receptors.- Purification of G Protein-Coupled Receptors.- Oriented Immobilization of G Protein-Coupled Receptors.- Key Biochemical Aspects of Drug-Target Interactions.- Immobilized GPCRs in Drug-Receptor Interaction Analysis.- Immobilized GPCRs in Compound Screening |
| Beschreibung: | xii, 91 Seiten Illustrationen 174 grams |
| ISBN: | 9789819900770 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV048996535 | ||
| 003 | DE-604 | ||
| 005 | 20230717 | ||
| 007 | t | ||
| 008 | 230612s2023 a||| |||| 00||| eng d | ||
| 020 | |a 9789819900770 |9 978-981-99-0077-0 | ||
| 024 | 3 | |a 9789819900770 | |
| 035 | |a (OCoLC)1390809918 | ||
| 035 | |a (DE-599)BVBBV048996535 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-29T | ||
| 100 | 1 | |a Zhao, Xinfeng |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a G protein-coupled receptors |b immobilization and applications in drug discovery |c Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang |
| 264 | 1 | |a Singapore |b Springer |c [2023] | |
| 300 | |a xii, 91 Seiten |b Illustrationen |c 174 grams | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a SpringerBriefs in molecular science | |
| 500 | |a G Protein-Coupled Receptors.- Purification of G Protein-Coupled Receptors.- Oriented Immobilization of G Protein-Coupled Receptors.- Key Biochemical Aspects of Drug-Target Interactions.- Immobilized GPCRs in Drug-Receptor Interaction Analysis.- Immobilized GPCRs in Compound Screening | ||
| 520 | |a This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities | ||
| 650 | 4 | |a bicssc | |
| 650 | 4 | |a bicssc | |
| 650 | 4 | |a bicssc | |
| 650 | 4 | |a bisacsh | |
| 650 | 4 | |a bisacsh | |
| 650 | 4 | |a bisacsh | |
| 650 | 4 | |a Biochemistry | |
| 650 | 4 | |a Medicinal chemistry | |
| 650 | 4 | |a Pharmaceutical chemistry | |
| 650 | 4 | |a Analytical chemistry | |
| 653 | |a Hardcover, Softcover / Chemie/Theoretische Chemie | ||
| 700 | 1 | |a Li, Qian |e Verfasser |4 aut | |
| 700 | 1 | |a Wang, Jing |e Verfasser |4 aut | |
| 700 | 1 | |a Liang, Qi |e Verfasser |4 aut | |
| 700 | 1 | |a Quan, Jia |e Verfasser |4 aut | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-981-99-0078-7 |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-034259776 | ||
Datensatz im Suchindex
| _version_ | 1804185256607088640 |
|---|---|
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| author | Zhao, Xinfeng Li, Qian Wang, Jing Liang, Qi Quan, Jia |
| author_facet | Zhao, Xinfeng Li, Qian Wang, Jing Liang, Qi Quan, Jia |
| author_role | aut aut aut aut aut |
| author_sort | Zhao, Xinfeng |
| author_variant | x z xz q l ql j w jw q l ql j q jq |
| building | Verbundindex |
| bvnumber | BV048996535 |
| ctrlnum | (OCoLC)1390809918 (DE-599)BVBBV048996535 |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03065nam a2200493 c 4500</leader><controlfield tag="001">BV048996535</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20230717 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">230612s2023 a||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9789819900770</subfield><subfield code="9">978-981-99-0077-0</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9789819900770</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1390809918</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV048996535</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29T</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Zhao, Xinfeng</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">G protein-coupled receptors</subfield><subfield code="b">immobilization and applications in drug discovery</subfield><subfield code="c">Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Singapore</subfield><subfield code="b">Springer</subfield><subfield code="c">[2023]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xii, 91 Seiten</subfield><subfield code="b">Illustrationen</subfield><subfield code="c">174 grams</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">SpringerBriefs in molecular science</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">G Protein-Coupled Receptors.- Purification of G Protein-Coupled Receptors.- Oriented Immobilization of G Protein-Coupled Receptors.- Key Biochemical Aspects of Drug-Target Interactions.- Immobilized GPCRs in Drug-Receptor Interaction Analysis.- Immobilized GPCRs in Compound Screening</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bicssc</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bicssc</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bicssc</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicinal chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmaceutical chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Analytical chemistry</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Hardcover, Softcover / Chemie/Theoretische Chemie</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Qian</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Jing</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liang, Qi</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Quan, Jia</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="z">978-981-99-0078-7</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-034259776</subfield></datafield></record></collection> |
| id | DE-604.BV048996535 |
| illustrated | Illustrated |
| index_date | 2024-07-03T22:08:39Z |
| indexdate | 2024-07-10T09:52:21Z |
| institution | BVB |
| isbn | 9789819900770 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034259776 |
| oclc_num | 1390809918 |
| open_access_boolean | |
| owner | DE-29T |
| owner_facet | DE-29T |
| physical | xii, 91 Seiten Illustrationen 174 grams |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| publisher | Springer |
| record_format | marc |
| series2 | SpringerBriefs in molecular science |
| spelling | Zhao, Xinfeng Verfasser aut G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang Singapore Springer [2023] xii, 91 Seiten Illustrationen 174 grams txt rdacontent n rdamedia nc rdacarrier SpringerBriefs in molecular science G Protein-Coupled Receptors.- Purification of G Protein-Coupled Receptors.- Oriented Immobilization of G Protein-Coupled Receptors.- Key Biochemical Aspects of Drug-Target Interactions.- Immobilized GPCRs in Drug-Receptor Interaction Analysis.- Immobilized GPCRs in Compound Screening This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry Hardcover, Softcover / Chemie/Theoretische Chemie Li, Qian Verfasser aut Wang, Jing Verfasser aut Liang, Qi Verfasser aut Quan, Jia Verfasser aut Erscheint auch als Online-Ausgabe 978-981-99-0078-7 |
| spellingShingle | Zhao, Xinfeng Li, Qian Wang, Jing Liang, Qi Quan, Jia G protein-coupled receptors immobilization and applications in drug discovery bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry |
| title | G protein-coupled receptors immobilization and applications in drug discovery |
| title_auth | G protein-coupled receptors immobilization and applications in drug discovery |
| title_exact_search | G protein-coupled receptors immobilization and applications in drug discovery |
| title_exact_search_txtP | G protein-coupled receptors immobilization and applications in drug discovery |
| title_full | G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang |
| title_fullStr | G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang |
| title_full_unstemmed | G protein-coupled receptors immobilization and applications in drug discovery Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang |
| title_short | G protein-coupled receptors |
| title_sort | g protein coupled receptors immobilization and applications in drug discovery |
| title_sub | immobilization and applications in drug discovery |
| topic | bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry |
| topic_facet | bicssc bisacsh Biochemistry Medicinal chemistry Pharmaceutical chemistry Analytical chemistry |
| work_keys_str_mv | AT zhaoxinfeng gproteincoupledreceptorsimmobilizationandapplicationsindrugdiscovery AT liqian gproteincoupledreceptorsimmobilizationandapplicationsindrugdiscovery AT wangjing gproteincoupledreceptorsimmobilizationandapplicationsindrugdiscovery AT liangqi gproteincoupledreceptorsimmobilizationandapplicationsindrugdiscovery AT quanjia gproteincoupledreceptorsimmobilizationandapplicationsindrugdiscovery |