Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory:
This Adverse Outcome Pathway (AOP) describes the linkage between binding to proteins involved in protection against oxidative stress and impairment in learning and memory. Production, binding and degradation of Reactive Oxygen Radicals are tightly regulated in the body, and an imbalance between prod...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Weitere Verfasser: | , , , , , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Paris
OECD Publishing
2022
|
| Schriftenreihe: | OECD Series on Adverse Outcome Pathways
no.20 |
| Schlagworte: | |
| Online-Zugang: | kostenfrei |
| Zusammenfassung: | This Adverse Outcome Pathway (AOP) describes the linkage between binding to proteins involved in protection against oxidative stress and impairment in learning and memory. Production, binding and degradation of Reactive Oxygen Radicals are tightly regulated in the body, and an imbalance between production and protection may cause oxidative stress, which is common to many toxicity pathways. Oxidative stress may lead to an imbalance in glutamate neurotransmission, which is involved in learning and memory. Oxidative stress may also cause cellular injury and death. During brain development and in particular during the establishment of neuronal connections and networks, such perturbations may lead to functional impairment in learning and memory. The weight-of-evidence supporting the relationship between the key events described in this AOP is based mainly on developmental effects observed after an exposure to mercury, a heavy metal known for its strong affinity to many proteins having anti-oxidant properties. This AOP is referred to as AOP 17 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki) |
| Beschreibung: | 1 Online-Ressource (190 Seiten) |
| DOI: | 10.1787/4df0e9e4-en |
Internformat
MARC
| LEADER | 00000nam a22000001cb4500 | ||
|---|---|---|---|
| 001 | BV048943170 | ||
| 003 | DE-604 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 230510s2022 xx o|||| 00||| eng d | ||
| 024 | 7 | |a 10.1787/4df0e9e4-en |2 doi | |
| 035 | |a (ZDB-13-SOC)084084111 | ||
| 035 | |a (OCoLC)1379407818 | ||
| 035 | |a (DE-599)KEP084084111 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-521 |a DE-1028 |a DE-573 |a DE-92 |a DE-898 |a DE-1049 |a DE-861 |a DE-91 |a DE-384 |a DE-473 |a DE-355 |a DE-20 |a DE-824 |a DE-29 |a DE-739 |a DE-188 |a DE-19 | ||
| 100 | 1 | |a Tschudi-Monnet, Florianne |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory |c Florianne, Tschudi-Monnet ... [et al] |
| 264 | 1 | |a Paris |b OECD Publishing |c 2022 | |
| 300 | |a 1 Online-Ressource (190 Seiten) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a OECD Series on Adverse Outcome Pathways |v no.20 | |
| 520 | 3 | |a This Adverse Outcome Pathway (AOP) describes the linkage between binding to proteins involved in protection against oxidative stress and impairment in learning and memory. Production, binding and degradation of Reactive Oxygen Radicals are tightly regulated in the body, and an imbalance between production and protection may cause oxidative stress, which is common to many toxicity pathways. Oxidative stress may lead to an imbalance in glutamate neurotransmission, which is involved in learning and memory. Oxidative stress may also cause cellular injury and death. During brain development and in particular during the establishment of neuronal connections and networks, such perturbations may lead to functional impairment in learning and memory. The weight-of-evidence supporting the relationship between the key events described in this AOP is based mainly on developmental effects observed after an exposure to mercury, a heavy metal known for its strong affinity to many proteins having anti-oxidant properties. This AOP is referred to as AOP 17 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki) | |
| 650 | 4 | |a Environment | |
| 700 | 1 | |a Zurich, Marie-Gabrielle |4 MitwirkendeR |4 ctb | |
| 700 | 1 | |a Nunes, Carolina |4 MitwirkendeR |4 ctb | |
| 700 | 1 | |a Sandström, Jenny |4 MitwirkendeR |4 ctb | |
| 700 | 1 | |a FitzGerald, Rex |4 MitwirkendeR |4 ctb | |
| 700 | 1 | |a Aschner, Michael |4 MitwirkendeR |4 ctb | |
| 700 | 1 | |a Rocha, Joao |4 MitwirkendeR |4 ctb | |
| 856 | 4 | 0 | |u https://doi.org/10.1787/4df0e9e4-en |x Verlag |z kostenfrei |3 Volltext |
| 912 | |a ZDB-13-SOC | ||
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-034207017 | |
Datensatz im Suchindex
| _version_ | 1822611093852258304 |
|---|---|
| adam_text | |
| adam_txt | |
| any_adam_object | |
| any_adam_object_boolean | |
| author | Tschudi-Monnet, Florianne |
| author2 | Zurich, Marie-Gabrielle Nunes, Carolina Sandström, Jenny FitzGerald, Rex Aschner, Michael Rocha, Joao |
| author2_role | ctb ctb ctb ctb ctb ctb |
| author2_variant | m g z mgz c n cn j s js r f rf m a ma j r jr |
| author_facet | Tschudi-Monnet, Florianne Zurich, Marie-Gabrielle Nunes, Carolina Sandström, Jenny FitzGerald, Rex Aschner, Michael Rocha, Joao |
| author_role | aut |
| author_sort | Tschudi-Monnet, Florianne |
| author_variant | f t m ftm |
| building | Verbundindex |
| bvnumber | BV048943170 |
| collection | ZDB-13-SOC |
| ctrlnum | (ZDB-13-SOC)084084111 (OCoLC)1379407818 (DE-599)KEP084084111 |
| discipline | Wirtschaftswissenschaften |
| discipline_str_mv | Wirtschaftswissenschaften |
| doi_str_mv | 10.1787/4df0e9e4-en |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a22000001cb4500</leader><controlfield tag="001">BV048943170</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">230510s2022 xx o|||| 00||| eng d</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1787/4df0e9e4-en</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-13-SOC)084084111</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1379407818</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)KEP084084111</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-521</subfield><subfield code="a">DE-1028</subfield><subfield code="a">DE-573</subfield><subfield code="a">DE-92</subfield><subfield code="a">DE-898</subfield><subfield code="a">DE-1049</subfield><subfield code="a">DE-861</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-384</subfield><subfield code="a">DE-473</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-824</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-739</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Tschudi-Monnet, Florianne</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory</subfield><subfield code="c">Florianne, Tschudi-Monnet ... [et al]</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Paris</subfield><subfield code="b">OECD Publishing</subfield><subfield code="c">2022</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (190 Seiten)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">OECD Series on Adverse Outcome Pathways</subfield><subfield code="v">no.20</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">This Adverse Outcome Pathway (AOP) describes the linkage between binding to proteins involved in protection against oxidative stress and impairment in learning and memory. Production, binding and degradation of Reactive Oxygen Radicals are tightly regulated in the body, and an imbalance between production and protection may cause oxidative stress, which is common to many toxicity pathways. Oxidative stress may lead to an imbalance in glutamate neurotransmission, which is involved in learning and memory. Oxidative stress may also cause cellular injury and death. During brain development and in particular during the establishment of neuronal connections and networks, such perturbations may lead to functional impairment in learning and memory. The weight-of-evidence supporting the relationship between the key events described in this AOP is based mainly on developmental effects observed after an exposure to mercury, a heavy metal known for its strong affinity to many proteins having anti-oxidant properties. This AOP is referred to as AOP 17 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Environment</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zurich, Marie-Gabrielle</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nunes, Carolina</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sandström, Jenny</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">FitzGerald, Rex</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Aschner, Michael</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rocha, Joao</subfield><subfield code="4">MitwirkendeR</subfield><subfield code="4">ctb</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1787/4df0e9e4-en</subfield><subfield code="x">Verlag</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-13-SOC</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-034207017</subfield></datafield></record></collection> |
| id | DE-604.BV048943170 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T21:58:30Z |
| indexdate | 2025-01-29T19:03:08Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034207017 |
| oclc_num | 1379407818 |
| open_access_boolean | 1 |
| owner | DE-521 DE-1028 DE-573 DE-92 DE-898 DE-BY-UBR DE-1049 DE-861 DE-91 DE-BY-TUM DE-384 DE-473 DE-BY-UBG DE-355 DE-BY-UBR DE-20 DE-824 DE-29 DE-739 DE-188 DE-19 DE-BY-UBM |
| owner_facet | DE-521 DE-1028 DE-573 DE-92 DE-898 DE-BY-UBR DE-1049 DE-861 DE-91 DE-BY-TUM DE-384 DE-473 DE-BY-UBG DE-355 DE-BY-UBR DE-20 DE-824 DE-29 DE-739 DE-188 DE-19 DE-BY-UBM |
| physical | 1 Online-Ressource (190 Seiten) |
| psigel | ZDB-13-SOC |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | OECD Publishing |
| record_format | marc |
| series2 | OECD Series on Adverse Outcome Pathways |
| spelling | Tschudi-Monnet, Florianne Verfasser aut Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory Florianne, Tschudi-Monnet ... [et al] Paris OECD Publishing 2022 1 Online-Ressource (190 Seiten) txt rdacontent c rdamedia cr rdacarrier OECD Series on Adverse Outcome Pathways no.20 This Adverse Outcome Pathway (AOP) describes the linkage between binding to proteins involved in protection against oxidative stress and impairment in learning and memory. Production, binding and degradation of Reactive Oxygen Radicals are tightly regulated in the body, and an imbalance between production and protection may cause oxidative stress, which is common to many toxicity pathways. Oxidative stress may lead to an imbalance in glutamate neurotransmission, which is involved in learning and memory. Oxidative stress may also cause cellular injury and death. During brain development and in particular during the establishment of neuronal connections and networks, such perturbations may lead to functional impairment in learning and memory. The weight-of-evidence supporting the relationship between the key events described in this AOP is based mainly on developmental effects observed after an exposure to mercury, a heavy metal known for its strong affinity to many proteins having anti-oxidant properties. This AOP is referred to as AOP 17 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki) Environment Zurich, Marie-Gabrielle MitwirkendeR ctb Nunes, Carolina MitwirkendeR ctb Sandström, Jenny MitwirkendeR ctb FitzGerald, Rex MitwirkendeR ctb Aschner, Michael MitwirkendeR ctb Rocha, Joao MitwirkendeR ctb https://doi.org/10.1787/4df0e9e4-en Verlag kostenfrei Volltext |
| spellingShingle | Tschudi-Monnet, Florianne Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory Environment |
| title | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory |
| title_auth | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory |
| title_exact_search | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory |
| title_exact_search_txtP | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory |
| title_full | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory Florianne, Tschudi-Monnet ... [et al] |
| title_fullStr | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory Florianne, Tschudi-Monnet ... [et al] |
| title_full_unstemmed | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory Florianne, Tschudi-Monnet ... [et al] |
| title_short | Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory |
| title_sort | binding of electrophilic chemicals to sh thiol group of proteins and or to seleno proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory |
| topic | Environment |
| topic_facet | Environment |
| url | https://doi.org/10.1787/4df0e9e4-en |
| work_keys_str_mv | AT tschudimonnetflorianne bindingofelectrophilicchemicalstoshthiolgroupofproteinsandortoselenoproteinsinvolvedinprotectionagainstoxidativestressduringbraindevelopmentleadingtoimpairmentoflearningandmemory AT zurichmariegabrielle bindingofelectrophilicchemicalstoshthiolgroupofproteinsandortoselenoproteinsinvolvedinprotectionagainstoxidativestressduringbraindevelopmentleadingtoimpairmentoflearningandmemory AT nunescarolina bindingofelectrophilicchemicalstoshthiolgroupofproteinsandortoselenoproteinsinvolvedinprotectionagainstoxidativestressduringbraindevelopmentleadingtoimpairmentoflearningandmemory AT sandstromjenny bindingofelectrophilicchemicalstoshthiolgroupofproteinsandortoselenoproteinsinvolvedinprotectionagainstoxidativestressduringbraindevelopmentleadingtoimpairmentoflearningandmemory AT fitzgeraldrex bindingofelectrophilicchemicalstoshthiolgroupofproteinsandortoselenoproteinsinvolvedinprotectionagainstoxidativestressduringbraindevelopmentleadingtoimpairmentoflearningandmemory AT aschnermichael bindingofelectrophilicchemicalstoshthiolgroupofproteinsandortoselenoproteinsinvolvedinprotectionagainstoxidativestressduringbraindevelopmentleadingtoimpairmentoflearningandmemory AT rochajoao bindingofelectrophilicchemicalstoshthiolgroupofproteinsandortoselenoproteinsinvolvedinprotectionagainstoxidativestressduringbraindevelopmentleadingtoimpairmentoflearningandmemory |