Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Freiburg im Breisgau
July, 2022
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Enthält Zeitschriftenaufsätze |
| Beschreibung: | xvi, 164 Seiten Illustrationen, Diagramme 30 cm |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV048916197 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 230427s2022 gw a||| m||| 00||| eng d | ||
| 015 | |a 23,H04 |2 dnb | ||
| 016 | 7 | |a 1280626208 |2 DE-101 | |
| 020 | |c Broschur | ||
| 035 | |a (OCoLC)1358406688 | ||
| 035 | |a (DE-599)KXP1830802097 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BW | ||
| 049 | |a DE-355 | ||
| 084 | |a 570 |2 sdnb | ||
| 084 | |8 2\p |a 610 |2 23sdnb | ||
| 084 | |8 1\p |a 616.994 |2 23ksdnb | ||
| 100 | 1 | |a Corrales Acuña, Eyleen |e Verfasser |0 (DE-588)1277767653 |4 aut | |
| 245 | 1 | 0 | |a Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment |c presented by Eyleen Vanessa Corrales Acuña |
| 264 | 1 | |a Freiburg im Breisgau |c July, 2022 | |
| 300 | |a xvi, 164 Seiten |b Illustrationen, Diagramme |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Enthält Zeitschriftenaufsätze | ||
| 502 | |b Dissertation |c Albert-Ludwigs-University Freiburg, Germany |d 2022 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u https://d-nb.info/1280626208/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034180324&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-034180324 | ||
| 883 | 0 | |8 1\p |a emakn |c 0,96906 |d 20230221 |q DE-101 |u https://d-nb.info/provenance/plan#emakn | |
| 883 | 2 | |8 2\p |a dnb |d 20230302 |q DE-101 |u https://d-nb.info/provenance/plan#dnb | |
Datensatz im Suchindex
| _version_ | 1804185092481875968 |
|---|---|
| adam_text | C
ONTENTS
DECLARATION
I
ABSTRACT
III
1
INTRODUCTION
1
1.1
GENERALITIES
OF
MALIGNANT
MELANOMA
....................................................
1
1.1.1
DIAGNOSE
.......................................................................................
2
1.1.2
CLASSIFICATION
..............................................................................
3
1.1.3
PROGNOSIS
....................................................................................
4
1.2
ETIOLOGY
AND
RISK
FACTORS
......................................................................
5
1.2.1
SUN
EXPOSURE
..............................................................................
6
1.2.2
MOLES
..........................................................................................
7
1.2.3
GENETIC
FACTORS
...........................................................................
7
1.3
DEVELOPMENT
AND
TRANSFORMATION
OF
MELANOCYTES
................................
8
1.3.1
EMBRYONIC
ORIGIN
OF
MELANOCYTES
..............................................
10
1.3.2
MELANOCYTE
BIOLOGY
.....................................................................
11
1.3.3
MALIGNANT
TRANSFORMATION
.........................................................
13
1.4
DEREGULATED
PATHWAYS
IN
MELANOMA
....................................................
14
1.4.1
MAPK/ERK
PATHWAY
...............................................................
14
1.4.2
PI3K/AKT
PATHWAY
..................................................................
16
1.5
AVAILABLE
THERAPIES
FOR
THE
TREATMENT
OF
MELANOMA
..............................
18
1.5.1
SURGICAL
RESECTION
........................................................................
19
1.5.2
CHEMOTHERAPIES
...............................................................................
20
1.5.3
TARGETED
THERAPIES
.........................................................................
20
1.5.4
IMMUNOTHERAPIES
............................................................................
23
1.5.5
ONCOLYTIC
VIRAL
THERAPIES
................................................................
25
1.6
DEVELOPMENT
OF
RESISTANCE
.......................................................................
26
2
THE
TUMOR
MICROENVIRONMENT
27
2.1
COMPONENTS
OF
THE
MELANOMA
MICROENVIRONMENT
....................................
28
2.1.1
IMMUNE
CELLS
.................................................................................
28
2.1.2
ADIPOCYTES
....................................................................................
29
2.1.3
FIBROBLASTS
....................................................................................
30
3
HIGH-THROUGHPUT
STRATEGIES
34
3.1
DATA
COLLECTION
.........................................................................................
34
3.1.1
DNA
MICROARRAYS
............................................................................
34
3.1.2
NEXT-GENERATION
SEQUENCING
..........................................................
35
3.2
DATA
NORMALIZATION
...................................................................................
36
3.3
DIMENSIONALITY
REDUCTION
..........................................................................
38
3.4
DATA
CLASSIFICATION
......................................................................................
39
3.4.1
DISTANCE
METRICS
............................................................................
39
3.4.2
CLUSTERING
ALGORITHMS
......................................................................
40
3.5
FUNCTIONAL
ANNOTATION
.............................................................................
43
3.5.1
OVER
REPRESENTATION
ANALYSIS
(ORA)
...........................................
43
3.5.2
GENE
SET
ENRICHMENT
ANALYSIS
(GSEA)
..........................................
44
4
RESULTS
45
4.1
MOLECULAR
AND
PHENOTYPIC
HETEROGENEITY
IN
MELANOMA
...........................
46
4.2
MODULATION
OF
THE
MELANOMA-STROMA
CROSSTALK
BY
TARGETED
INHIBITION
.
79
4.3
SIDE
EFFECTS
OF
TARGETED
INHIBITION
IN
THE
TUMOR
STROMA
..........................
105
5
GENERAL
DISCUSSION
128
5.1
MECHANISMS
OF
INTRINSIC
RESISTANCE
IN
MELANOMA
...................................
128
5.1.1
LOSS
OF
MELANOCYTIC
DIFFERENTIATION
..............................................
129
5.1.2
GAIN
OF
STEM-LIKE
PROPERTIES
.......................................................
130
5.1.3
ACTIVATION
OF
COMPENSATORY
SIGNALING
PATHWAYS
.......................
131
5.2
MELANOMA
POTENTIAL
TO
REMODEL
THE
STROMA
............................................
132
5.2.1
CROSSTALK
WITH
FIBROBLAST
.............................................................
132
5.2.2
MODULATION
BY
BRAF-TARGETED
INHIBITION
...................................
133
5.3
SIDE
EFFECTS
OF
BRAF-TARGETED
INHIBITION
IN
THE
STROMA
........................
135
5.3.1
PARADOXICAL
BRAF
ACTIVATION
IN
FIBROBLASTS
................................
136
5.3.2
PUTATIVE
IMPACT
ON
TUMOR
PROGRESSION
.....................................
137
5.3.3
THERAPEUTIC
ALTERNATIVES
.............................................................
138
6
CONCLUSION
AND
OUTLOOK
140
ACKNOWLEDGMENTS
142
A
PPENDIX
143
6.1
SUPPLEMENTARY
INFORMATION:
RESULTS
4.1
..............................................
143
6.2
SUPPLEMENTARY
INFORMATION: RESULTS
4.2
................................................
143
6.3
SUPPLEMENTARY
INFORMATION: RESULTS
4.3
................................................
147
REFERENCES
148
|
| adam_txt |
C
ONTENTS
DECLARATION
I
ABSTRACT
III
1
INTRODUCTION
1
1.1
GENERALITIES
OF
MALIGNANT
MELANOMA
.
1
1.1.1
DIAGNOSE
.
2
1.1.2
CLASSIFICATION
.
3
1.1.3
PROGNOSIS
.
4
1.2
ETIOLOGY
AND
RISK
FACTORS
.
5
1.2.1
SUN
EXPOSURE
.
6
1.2.2
MOLES
.
7
1.2.3
GENETIC
FACTORS
.
7
1.3
DEVELOPMENT
AND
TRANSFORMATION
OF
MELANOCYTES
.
8
1.3.1
EMBRYONIC
ORIGIN
OF
MELANOCYTES
.
10
1.3.2
MELANOCYTE
BIOLOGY
.
11
1.3.3
MALIGNANT
TRANSFORMATION
.
13
1.4
DEREGULATED
PATHWAYS
IN
MELANOMA
.
14
1.4.1
MAPK/ERK
PATHWAY
.
14
1.4.2
PI3K/AKT
PATHWAY
.
16
1.5
AVAILABLE
THERAPIES
FOR
THE
TREATMENT
OF
MELANOMA
.
18
1.5.1
SURGICAL
RESECTION
.
19
1.5.2
CHEMOTHERAPIES
.
20
1.5.3
TARGETED
THERAPIES
.
20
1.5.4
IMMUNOTHERAPIES
.
23
1.5.5
ONCOLYTIC
VIRAL
THERAPIES
.
25
1.6
DEVELOPMENT
OF
RESISTANCE
.
26
2
THE
TUMOR
MICROENVIRONMENT
27
2.1
COMPONENTS
OF
THE
MELANOMA
MICROENVIRONMENT
.
28
2.1.1
IMMUNE
CELLS
.
28
2.1.2
ADIPOCYTES
.
29
2.1.3
FIBROBLASTS
.
30
3
HIGH-THROUGHPUT
STRATEGIES
34
3.1
DATA
COLLECTION
.
34
3.1.1
DNA
MICROARRAYS
.
34
3.1.2
NEXT-GENERATION
SEQUENCING
.
35
3.2
DATA
NORMALIZATION
.
36
3.3
DIMENSIONALITY
REDUCTION
.
38
3.4
DATA
CLASSIFICATION
.
39
3.4.1
DISTANCE
METRICS
.
39
3.4.2
CLUSTERING
ALGORITHMS
.
40
3.5
FUNCTIONAL
ANNOTATION
.
43
3.5.1
OVER
REPRESENTATION
ANALYSIS
(ORA)
.
43
3.5.2
GENE
SET
ENRICHMENT
ANALYSIS
(GSEA)
.
44
4
RESULTS
45
4.1
MOLECULAR
AND
PHENOTYPIC
HETEROGENEITY
IN
MELANOMA
.
46
4.2
MODULATION
OF
THE
MELANOMA-STROMA
CROSSTALK
BY
TARGETED
INHIBITION
.
79
4.3
SIDE
EFFECTS
OF
TARGETED
INHIBITION
IN
THE
TUMOR
STROMA
.
105
5
GENERAL
DISCUSSION
128
5.1
MECHANISMS
OF
INTRINSIC
RESISTANCE
IN
MELANOMA
.
128
5.1.1
LOSS
OF
MELANOCYTIC
DIFFERENTIATION
.
129
5.1.2
GAIN
OF
STEM-LIKE
PROPERTIES
.
130
5.1.3
ACTIVATION
OF
COMPENSATORY
SIGNALING
PATHWAYS
.
131
5.2
MELANOMA
POTENTIAL
TO
REMODEL
THE
STROMA
.
132
5.2.1
CROSSTALK
WITH
FIBROBLAST
.
132
5.2.2
MODULATION
BY
BRAF-TARGETED
INHIBITION
.
133
5.3
SIDE
EFFECTS
OF
BRAF-TARGETED
INHIBITION
IN
THE
STROMA
.
135
5.3.1
PARADOXICAL
BRAF
ACTIVATION
IN
FIBROBLASTS
.
136
5.3.2
PUTATIVE
IMPACT
ON
TUMOR
PROGRESSION
.
137
5.3.3
THERAPEUTIC
ALTERNATIVES
.
138
6
CONCLUSION
AND
OUTLOOK
140
ACKNOWLEDGMENTS
142
A
PPENDIX
143
6.1
SUPPLEMENTARY
INFORMATION:
RESULTS
4.1
.
143
6.2
SUPPLEMENTARY
INFORMATION: RESULTS
4.2
.
143
6.3
SUPPLEMENTARY
INFORMATION: RESULTS
4.3
.
147
REFERENCES
148 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Corrales Acuña, Eyleen |
| author_GND | (DE-588)1277767653 |
| author_facet | Corrales Acuña, Eyleen |
| author_role | aut |
| author_sort | Corrales Acuña, Eyleen |
| author_variant | a e c ae aec |
| building | Verbundindex |
| bvnumber | BV048916197 |
| ctrlnum | (OCoLC)1358406688 (DE-599)KXP1830802097 |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01725nam a2200409 c 4500</leader><controlfield tag="001">BV048916197</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">230427s2022 gw a||| m||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">23,H04</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1280626208</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="c">Broschur</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1358406688</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)KXP1830802097</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BW</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">570</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="8">2\p</subfield><subfield code="a">610</subfield><subfield code="2">23sdnb</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="8">1\p</subfield><subfield code="a">616.994</subfield><subfield code="2">23ksdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Corrales Acuña, Eyleen</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1277767653</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment</subfield><subfield code="c">presented by Eyleen Vanessa Corrales Acuña</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Freiburg im Breisgau</subfield><subfield code="c">July, 2022</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xvi, 164 Seiten</subfield><subfield code="b">Illustrationen, Diagramme</subfield><subfield code="c">30 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Enthält Zeitschriftenaufsätze</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Albert-Ludwigs-University Freiburg, Germany</subfield><subfield code="d">2022</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">B:DE-101</subfield><subfield code="q">application/pdf</subfield><subfield code="u">https://d-nb.info/1280626208/04</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034180324&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-034180324</subfield></datafield><datafield tag="883" ind1="0" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">emakn</subfield><subfield code="c">0,96906</subfield><subfield code="d">20230221</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#emakn</subfield></datafield><datafield tag="883" ind1="2" ind2=" "><subfield code="8">2\p</subfield><subfield code="a">dnb</subfield><subfield code="d">20230302</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#dnb</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV048916197 |
| illustrated | Illustrated |
| index_date | 2024-07-03T21:54:42Z |
| indexdate | 2024-07-10T09:49:44Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034180324 |
| oclc_num | 1358406688 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | xvi, 164 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| record_format | marc |
| spelling | Corrales Acuña, Eyleen Verfasser (DE-588)1277767653 aut Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment presented by Eyleen Vanessa Corrales Acuña Freiburg im Breisgau July, 2022 xvi, 164 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält Zeitschriftenaufsätze Dissertation Albert-Ludwigs-University Freiburg, Germany 2022 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1280626208/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034180324&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p emakn 0,96906 20230221 DE-101 https://d-nb.info/provenance/plan#emakn 2\p dnb 20230302 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Corrales Acuña, Eyleen Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment |
| subject_GND | (DE-588)4113937-9 |
| title | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment |
| title_auth | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment |
| title_exact_search | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment |
| title_exact_search_txtP | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment |
| title_full | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment presented by Eyleen Vanessa Corrales Acuña |
| title_fullStr | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment presented by Eyleen Vanessa Corrales Acuña |
| title_full_unstemmed | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment presented by Eyleen Vanessa Corrales Acuña |
| title_short | Characterization of the impact of BRAF-targeted inhibition in the melanoma microenvironment |
| title_sort | characterization of the impact of braf targeted inhibition in the melanoma microenvironment |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1280626208/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034180324&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT corralesacunaeyleen characterizationoftheimpactofbraftargetedinhibitioninthemelanomamicroenvironment |
Es ist kein Print-Exemplar vorhanden.
Inhaltsverzeichnis