Development of synthetic mucus with physiological viscoelasticity and its impact on phonation:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Düren
Shaker
2023
|
| Ausgabe: | 1. Auflage |
| Schriftenreihe: | Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie
Band 31 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xx, 158 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 270 g |
| ISBN: | 9783844089943 3844089942 |
Internformat
MARC
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| 245 | 1 | 0 | |a Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |c Gregor Peters |
| 250 | |a 1. Auflage | ||
| 263 | |a 202303 | ||
| 264 | 1 | |a Düren |b Shaker |c 2023 | |
| 300 | |a xx, 158 Seiten |b Illustrationen, Diagramme |c 21 cm x 14.8 cm, 270 g | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie |v Band 31 | |
| 502 | |b Dissertation |c Friedrich-Alexander-Universität Erlangen-Nürnberg |d 2022 | ||
| 650 | 0 | 7 | |a Schleim |0 (DE-588)4179715-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Stimmbildung |0 (DE-588)4057583-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Viskoelastizität |0 (DE-588)4063621-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Chemische Synthese |0 (DE-588)4133806-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Kehlkopf |0 (DE-588)4139922-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Ersatzstoff |0 (DE-588)4131298-3 |2 gnd |9 rswk-swf |
| 653 | |a laryngeal mucus | ||
| 653 | |a Phoniatrie | ||
| 653 | |a voice disorders | ||
| 653 | |a ex vivo experiments | ||
| 653 | |a viscoelasticity | ||
| 653 | |a phonation | ||
| 653 | |a rheology | ||
| 653 | |a voice | ||
| 653 | |a vocal folds | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| 689 | 0 | 1 | |a Schleim |0 (DE-588)4179715-2 |D s |
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Datensatz im Suchindex
| _version_ | 1806775595884871680 |
|---|---|
| adam_text |
CONTENTS
NOMENCLATURE
XVII
1
INTRODUCTION
1
2
FUNDAMENTALS
5
2.1
LARYNX
ANATOMY
AND
HUMAN
VOICE
PRODUCTION
.
5
2.1.1
LARYNGEAL
STRUCTURES
INVOLVED
IN
THE
PHONATORY
PROCESS
.
5
2.1.2
MORPHOLOGY
OF
THE
VOCAL
FOLDS
.
6
2.1.3
PRINCIPLE
OF
HUMAN
PHONATION
.
8
2.2
HUMAN
MUCUS
.
8
2.2.1
ROLE
OF
MUCUS
IN
THE
BODY
AND
LARYNX
.
8
2.2.2
COMPOSITION
AND
CHEMICAL
STRUCTURE
OF
MUCUS
.
9
2.3
BASICS
OF
RHEOMETRY
AND
RHEOLOGY
.
9
2.3.1
SHEAR
RHEOMETRY
AND
RHEOLOGY
.
10
2.3.2
PARTICLE
TRACKING
MICRORHEOLOGY
.
17
3
RHEOLOGY
OF
HUMAN
LARYNGEAL
MUCUS
23
3.1
RESEARCH
ON
THE
RHEOLOGY
OF
HUMAN
MUCUS
.
23
3.2
MUCUS
SAMPLES
.
25
3.2.1
COLLECTION
OF
LARYNGEAL
MUCUS
SAMPLES
.
25
3.2.2
QUALITY
AND
PROPERTIES
OF
THE
MUCUS
SAMPLES
.
26
3.3
MEASUREMENT
PROCEDURES
.
29
3.3.1
PARTICLE
TRACKING
MICRORHEOLOGY
.
29
3.3.2
OSCILLATORY
SHEAR
RHEOMETRY
.
31
3.4
VISCOELASTICITY
OF
HUMAN
LARYNGEAL
MUCUS
.
31
3.4.1
VISCOELASTICITY
DETERMINED
BY
PTM
.
31
3.4.2
VISCOELASTICITY
DETERMINED
BY
OSR
.
41
3.5
SUMMARY
OF
THE
RHEOLOGICAL
PROPERTIES
OF
MUCUS
.
43
4
CREATION
OF
SYNTHETIC
MUCUS
WITH
PHYSIOLOGICAL
VISCOELASTICITY
45
4.1
MUCUS
SUBSTITUTES
IN
CURRENT
RESEARCH
.
45
4.2
RHEOLOGY
OF
SYNTHETIC
MUCUS
CANDIDATES
.
46
4.2.1
CARBOMER
.
47
4.2.2
HYDROXYETHYL
CELLULOSE
.
48
4.2.3
XANTHAN
.
49
4.3
SUMMARY
OF
THE
CREATION
OF
SYNTHETIC
MUCUS
.
54
5
EX
VIVO
PHONATION
EXPERIMENTS
55
5.1
EXPERIMENTAL
SETUP
FOR
PORCINE
LARYNGES
.
55
5.1.1
PREPARATION
OF
THE
PORCINE
CADAVER
LARYNGES
.
56
5.1.2
AUTOMATED
MEASUREMENT
SETUP
.
57
5.1.3
MUCUS
APPLICATION
.
59
5.2
MEASUREMENT
PROCEDURE
.
61
5.3
DATA
ANALYSIS
.
63
5.3.1
AERODYNAMIC
PARAMETERS
.
63
5.3.2
GLOTTAL
DYNAMIC
PARAMETERS
.
65
5.3.3
SUBGLOTTAL
PRESSURE
AND
ACOUSTIC
PARAMETERS
.
66
5.3.4
DATA
EXCLUSION
.
66
6
IMPACT
OF
MUCUS
RHEOLOGY
AND
MUCINS
ON
PHONATION
69
6.1
RESEARCH
ON
THE
PHONATORY
PROCESS
.
70
6.2
STUDY
DESIGN
.
70
6.3
GENERAL
PHONATION
PARAMETERS
.
71
6.4
IMPACT
OF
RHEOLOGY
ON
PHONATORY
PARAMETERS
.
72
6.4.1
AERODYNAMIC
PARAMETERS
.
73
6.4.2
GLOTTAL
DYNAMIC
PARAMETERS
.
75
6.4.3
SUBGLOTTAL
PRESSURE
PARAMETERS
.
80
6.4.4
ACOUSTIC
PARAMETERS
.
83
6.5
IMPACT
OF
MUCINS
ON
PHONATORY
PARAMETERS
.
85
6.6
SUMMARY
OF
THE
IMPACT
OF
RHEOLOGY
AND
MUCINS
.
87
7
CLUSTERING
AND
PAIRWISE
ANALYSIS
OF
THE
MEASUREMENT
DATA
89
7.1
CLUSTERING
OF
THE
MEASUREMENT
DATA
.
89
7.2
GRAPHIC
ANALYSIS
OF
THE
PHONATORY
PARAMETERS
.
90
7.2.1
AERODYNAMIC
PARAMETERS
.
90
7.2.2
GLOTTAL
DYNAMIC
PARAMETERS
.
93
7.2.3
SUBGLOTTAL
PRESSURE
PARAMETERS
.
97
7.2.4
ACOUSTIC
PARAMETERS
.
100
7.3
STATISTICAL
ANALYSIS
BY
PAIRWISE
TESTS
.
103
7.3.1
IMPACT
OF
GLOTTIS
CLOSURE
.
103
7.3.2
GLOTTIS
CLOSURE
DEPENDENT
INFLUENCE
OF
RHEOLOGY
.
106
7.4
SUMMARY
OF
THE
CLUSTERED
DATA
ANALYSIS
.
109
8
CONCLUSION
AND
OUTLOOK
111
8.1
PROJECT
STATUS
.
ILL
8.2
PROJECT
LIMITATIONS
AND
OUTLOOK
.
114
8.2.1
INVESTIGATIONS
ON
HUMAN
LARYNGEAL
MUCUS
.
114
8.2.2
EXPERIMENTAL
ADVANCES
.
115
8.2.3
THERAPEUTICAL
OPTIONS
.
116
8.3
IMPACT
OF
THE
PROJECT
.
116
BIBLIOGRAPHY
117
A
FURTHER
INFORMATION
ON
PARTICLE
TRACKING
MICRORHEOLOGY
133
B
FURTHER
INFORMATION
ON
GAT
AND
THE
GAW
135
C
ADDITIONAL
DATA
141
LIST
OF
FIGURES
142
LIST
OF
TABLES
154 |
| adam_txt |
CONTENTS
NOMENCLATURE
XVII
1
INTRODUCTION
1
2
FUNDAMENTALS
5
2.1
LARYNX
ANATOMY
AND
HUMAN
VOICE
PRODUCTION
.
5
2.1.1
LARYNGEAL
STRUCTURES
INVOLVED
IN
THE
PHONATORY
PROCESS
.
5
2.1.2
MORPHOLOGY
OF
THE
VOCAL
FOLDS
.
6
2.1.3
PRINCIPLE
OF
HUMAN
PHONATION
.
8
2.2
HUMAN
MUCUS
.
8
2.2.1
ROLE
OF
MUCUS
IN
THE
BODY
AND
LARYNX
.
8
2.2.2
COMPOSITION
AND
CHEMICAL
STRUCTURE
OF
MUCUS
.
9
2.3
BASICS
OF
RHEOMETRY
AND
RHEOLOGY
.
9
2.3.1
SHEAR
RHEOMETRY
AND
RHEOLOGY
.
10
2.3.2
PARTICLE
TRACKING
MICRORHEOLOGY
.
17
3
RHEOLOGY
OF
HUMAN
LARYNGEAL
MUCUS
23
3.1
RESEARCH
ON
THE
RHEOLOGY
OF
HUMAN
MUCUS
.
23
3.2
MUCUS
SAMPLES
.
25
3.2.1
COLLECTION
OF
LARYNGEAL
MUCUS
SAMPLES
.
25
3.2.2
QUALITY
AND
PROPERTIES
OF
THE
MUCUS
SAMPLES
.
26
3.3
MEASUREMENT
PROCEDURES
.
29
3.3.1
PARTICLE
TRACKING
MICRORHEOLOGY
.
29
3.3.2
OSCILLATORY
SHEAR
RHEOMETRY
.
31
3.4
VISCOELASTICITY
OF
HUMAN
LARYNGEAL
MUCUS
.
31
3.4.1
VISCOELASTICITY
DETERMINED
BY
PTM
.
31
3.4.2
VISCOELASTICITY
DETERMINED
BY
OSR
.
41
3.5
SUMMARY
OF
THE
RHEOLOGICAL
PROPERTIES
OF
MUCUS
.
43
4
CREATION
OF
SYNTHETIC
MUCUS
WITH
PHYSIOLOGICAL
VISCOELASTICITY
45
4.1
MUCUS
SUBSTITUTES
IN
CURRENT
RESEARCH
.
45
4.2
RHEOLOGY
OF
SYNTHETIC
MUCUS
CANDIDATES
.
46
4.2.1
CARBOMER
.
47
4.2.2
HYDROXYETHYL
CELLULOSE
.
48
4.2.3
XANTHAN
.
49
4.3
SUMMARY
OF
THE
CREATION
OF
SYNTHETIC
MUCUS
.
54
5
EX
VIVO
PHONATION
EXPERIMENTS
55
5.1
EXPERIMENTAL
SETUP
FOR
PORCINE
LARYNGES
.
55
5.1.1
PREPARATION
OF
THE
PORCINE
CADAVER
LARYNGES
.
56
5.1.2
AUTOMATED
MEASUREMENT
SETUP
.
57
5.1.3
MUCUS
APPLICATION
.
59
5.2
MEASUREMENT
PROCEDURE
.
61
5.3
DATA
ANALYSIS
.
63
5.3.1
AERODYNAMIC
PARAMETERS
.
63
5.3.2
GLOTTAL
DYNAMIC
PARAMETERS
.
65
5.3.3
SUBGLOTTAL
PRESSURE
AND
ACOUSTIC
PARAMETERS
.
66
5.3.4
DATA
EXCLUSION
.
66
6
IMPACT
OF
MUCUS
RHEOLOGY
AND
MUCINS
ON
PHONATION
69
6.1
RESEARCH
ON
THE
PHONATORY
PROCESS
.
70
6.2
STUDY
DESIGN
.
70
6.3
GENERAL
PHONATION
PARAMETERS
.
71
6.4
IMPACT
OF
RHEOLOGY
ON
PHONATORY
PARAMETERS
.
72
6.4.1
AERODYNAMIC
PARAMETERS
.
73
6.4.2
GLOTTAL
DYNAMIC
PARAMETERS
.
75
6.4.3
SUBGLOTTAL
PRESSURE
PARAMETERS
.
80
6.4.4
ACOUSTIC
PARAMETERS
.
83
6.5
IMPACT
OF
MUCINS
ON
PHONATORY
PARAMETERS
.
85
6.6
SUMMARY
OF
THE
IMPACT
OF
RHEOLOGY
AND
MUCINS
.
87
7
CLUSTERING
AND
PAIRWISE
ANALYSIS
OF
THE
MEASUREMENT
DATA
89
7.1
CLUSTERING
OF
THE
MEASUREMENT
DATA
.
89
7.2
GRAPHIC
ANALYSIS
OF
THE
PHONATORY
PARAMETERS
.
90
7.2.1
AERODYNAMIC
PARAMETERS
.
90
7.2.2
GLOTTAL
DYNAMIC
PARAMETERS
.
93
7.2.3
SUBGLOTTAL
PRESSURE
PARAMETERS
.
97
7.2.4
ACOUSTIC
PARAMETERS
.
100
7.3
STATISTICAL
ANALYSIS
BY
PAIRWISE
TESTS
.
103
7.3.1
IMPACT
OF
GLOTTIS
CLOSURE
.
103
7.3.2
GLOTTIS
CLOSURE
DEPENDENT
INFLUENCE
OF
RHEOLOGY
.
106
7.4
SUMMARY
OF
THE
CLUSTERED
DATA
ANALYSIS
.
109
8
CONCLUSION
AND
OUTLOOK
111
8.1
PROJECT
STATUS
.
ILL
8.2
PROJECT
LIMITATIONS
AND
OUTLOOK
.
114
8.2.1
INVESTIGATIONS
ON
HUMAN
LARYNGEAL
MUCUS
.
114
8.2.2
EXPERIMENTAL
ADVANCES
.
115
8.2.3
THERAPEUTICAL
OPTIONS
.
116
8.3
IMPACT
OF
THE
PROJECT
.
116
BIBLIOGRAPHY
117
A
FURTHER
INFORMATION
ON
PARTICLE
TRACKING
MICRORHEOLOGY
133
B
FURTHER
INFORMATION
ON
GAT
AND
THE
GAW
135
C
ADDITIONAL
DATA
141
LIST
OF
FIGURES
142
LIST
OF
TABLES
154 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Peters, Gregor |
| author_GND | (DE-588)128674895X |
| author_facet | Peters, Gregor |
| author_role | aut |
| author_sort | Peters, Gregor |
| author_variant | g p gp |
| building | Verbundindex |
| bvnumber | BV048908310 |
| ctrlnum | (OCoLC)1370941889 (DE-599)DNB1280938447 |
| edition | 1. Auflage |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV048908310 |
| illustrated | Illustrated |
| index_date | 2024-07-03T21:52:43Z |
| indexdate | 2024-08-08T00:04:41Z |
| institution | BVB |
| institution_GND | (DE-588)1064118135 |
| isbn | 9783844089943 3844089942 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034172554 |
| oclc_num | 1370941889 |
| open_access_boolean | |
| owner | DE-29 DE-29T DE-83 |
| owner_facet | DE-29 DE-29T DE-83 |
| physical | xx, 158 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 270 g |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| publisher | Shaker |
| record_format | marc |
| series | Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie |
| series2 | Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie |
| spelling | Peters, Gregor (DE-588)128674895X aut Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Gregor Peters 1. Auflage 202303 Düren Shaker 2023 xx, 158 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 270 g txt rdacontent n rdamedia nc rdacarrier Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie Band 31 Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2022 Schleim (DE-588)4179715-2 gnd rswk-swf Stimmbildung (DE-588)4057583-4 gnd rswk-swf Viskoelastizität (DE-588)4063621-5 gnd rswk-swf Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Kehlkopf (DE-588)4139922-5 gnd rswk-swf Ersatzstoff (DE-588)4131298-3 gnd rswk-swf laryngeal mucus Phoniatrie voice disorders ex vivo experiments viscoelasticity phonation rheology voice vocal folds (DE-588)4113937-9 Hochschulschrift gnd-content Kehlkopf (DE-588)4139922-5 s Schleim (DE-588)4179715-2 s Viskoelastizität (DE-588)4063621-5 s Stimmbildung (DE-588)4057583-4 s DE-604 Ersatzstoff (DE-588)4131298-3 s Chemische Synthese (DE-588)4133806-6 s Shaker Verlag (DE-588)1064118135 pbl Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie Band 31 (DE-604)BV012101616 31 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034172554&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p vlb 20230214 DE-101 https://d-nb.info/provenance/plan#vlb |
| spellingShingle | Peters, Gregor Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Kommunikationsstörungen, Berichte aus Phoniatrie und Pädaudiologie Schleim (DE-588)4179715-2 gnd Stimmbildung (DE-588)4057583-4 gnd Viskoelastizität (DE-588)4063621-5 gnd Chemische Synthese (DE-588)4133806-6 gnd Kehlkopf (DE-588)4139922-5 gnd Ersatzstoff (DE-588)4131298-3 gnd |
| subject_GND | (DE-588)4179715-2 (DE-588)4057583-4 (DE-588)4063621-5 (DE-588)4133806-6 (DE-588)4139922-5 (DE-588)4131298-3 (DE-588)4113937-9 |
| title | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_auth | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_exact_search | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_exact_search_txtP | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_full | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Gregor Peters |
| title_fullStr | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Gregor Peters |
| title_full_unstemmed | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation Gregor Peters |
| title_short | Development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| title_sort | development of synthetic mucus with physiological viscoelasticity and its impact on phonation |
| topic | Schleim (DE-588)4179715-2 gnd Stimmbildung (DE-588)4057583-4 gnd Viskoelastizität (DE-588)4063621-5 gnd Chemische Synthese (DE-588)4133806-6 gnd Kehlkopf (DE-588)4139922-5 gnd Ersatzstoff (DE-588)4131298-3 gnd |
| topic_facet | Schleim Stimmbildung Viskoelastizität Chemische Synthese Kehlkopf Ersatzstoff Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034172554&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV012101616 |
| work_keys_str_mv | AT petersgregor developmentofsyntheticmucuswithphysiologicalviscoelasticityanditsimpactonphonation AT shakerverlag developmentofsyntheticmucuswithphysiologicalviscoelasticityanditsimpactonphonation |