Enzyme engineering: selective catalysts for applications in biotechnology, organic chemistry, and life science
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
[2023]
|
| Schlagworte: | |
| Online-Zugang: | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-35033-9/ Inhaltsverzeichnis |
| Beschreibung: | xii, 387 Seiten Illustrationen, Diagramme (teilweise farbig) 24.4 cm x 17 cm |
| ISBN: | 9783527350339 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV048809584 | ||
| 003 | DE-604 | ||
| 005 | 20240425 | ||
| 007 | t | ||
| 008 | 230209s2023 gw a||| |||| 00||| eng d | ||
| 015 | |a 22,N37 |2 dnb | ||
| 016 | 7 | |a 1267778857 |2 DE-101 | |
| 020 | |a 9783527350339 |c hbk. : circa EUR 159.00 (DE) (freier Preis), circa EUR 163.50 (AT) (freier Preis) |9 978-3-527-35033-9 | ||
| 024 | 3 | |a 9783527350339 | |
| 028 | 5 | 2 | |a Bestellnummer: 1135033 000 |
| 035 | |a (OCoLC)1373391471 | ||
| 035 | |a (DE-599)DNB1267778857 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BW | ||
| 049 | |a DE-29T |a DE-91G |a DE-19 |a DE-11 |a DE-20 | ||
| 084 | |a WD 5050 |0 (DE-625)148185: |2 rvk | ||
| 084 | |a CHE 825 |2 stub | ||
| 084 | |a 540 |2 23sdnb | ||
| 100 | 1 | |a Reetz, Manfred T. |d 1943- |e Verfasser |0 (DE-588)111053455 |4 aut | |
| 245 | 1 | 0 | |a Enzyme engineering |b selective catalysts for applications in biotechnology, organic chemistry, and life science |c Manfred T. Reetz, Zhoutong Sun, and Ge Qu |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c [2023] | |
| 264 | 4 | |c © 2023 | |
| 300 | |a xii, 387 Seiten |b Illustrationen, Diagramme (teilweise farbig) |c 24.4 cm x 17 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Enzymkatalyse |0 (DE-588)4152480-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Proteindesign |0 (DE-588)4346801-9 |2 gnd |9 rswk-swf |
| 653 | |a Biotechnologie i. d. Biowissenschaften | ||
| 653 | |a Biotechnology | ||
| 653 | |a Biowissenschaften | ||
| 653 | |a CH81: Organische Chemie / Methoden, Synthesen, Verfahren | ||
| 653 | |a CHB4: Proteine | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a LS35: Biotechnologie i. d. Biowissenschaften | ||
| 653 | |a Life Sciences | ||
| 653 | |a Methods - Synthesis & Techniques | ||
| 653 | |a Organische Chemie / Methoden, Synthesen, Verfahren | ||
| 653 | |a Protein Science | ||
| 653 | |a Proteine | ||
| 689 | 0 | 0 | |a Enzymkatalyse |0 (DE-588)4152480-9 |D s |
| 689 | 0 | 1 | |a Proteindesign |0 (DE-588)4346801-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Sun, Zhoutong |e Verfasser |0 (DE-588)1299382878 |4 aut | |
| 700 | 1 | |a Qu, Ge |e Verfasser |0 (DE-588)1299383300 |4 aut | |
| 710 | 2 | |a Wiley-VCH |0 (DE-588)16179388-5 |4 pbl | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-527-83687-1 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPUB |z 978-3-527-83688-8 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, oBook |z 978-3-527-83689-5 |
| 856 | 4 | 2 | |m X:MVB |u http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-35033-9/ |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034075545&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
Datensatz im Suchindex
| _version_ | 1805069453326548992 |
|---|---|
| adam_text |
V
CONTENTS
PREFACE
IX
ABOUT
THE
AUTHORS
XI
1
INTRODUCTION
TO
DIRECTED
EVOLUTION
AND
RATIONAL
DESIGN
AS
PROTEIN
ENGINEERING
TECHNIQUES
1
1.1
METHODS
AND
AIMS
OF
DIRECTED
ENZYME
EVOLUTION
1
1.2
HISTORY
OF
DIRECTED
ENZYME
EVOLUTION
4
1.3
METHODS
AND
AIMS
OF
RATIONAL
DESIGN
OF
ENZYMES
19
REFERENCES
21
2
SCREENING
AND
SELECTION
TECHNIQUES
29
2.1
INTRODUCTORY
REMARKS
29
2.2
SCREENING
METHODS
29
2.3
SELECTION
METHODS
38
2.4
CONCLUSIONS
AND
PERSPECTIVES
52
REFERENCES
53
3
GENE
MUTAGENESIS
METHODS
IN
DIRECTED
EVOLUTION
AND
RATIONAL
ENZYME
DESIGN
59
3.1
INTRODUCTORY
REMARKS
59
3.2
DIRECTED
EVOLUTION
APPROACHES
59
3.2.1
MUTATOR
STRAINS
59
3.2.2
ERROR-PRONE
POLYMERASE
CHAIN
REACTION
(EPPCR)
60
3.2.3
WHOLE
GENE
INSERTION/DELETION
MUTAGENESIS
66
3.2.4
SATURATION
MUTAGENESIS
AS
A
PRIVILEGED
METHOD:
AWAY
FROM
BLIND
DIRECTED
EVOLUTION
73
3.2.5
DNA
SHUFFLING
AND
RELATED
RECOMBINANT
GENE
MUTAGENESIS
METHODS
89
3.2.6
CIRCULAR
MUTATION
AND
OTHER
DOMAIN
SWAPPING
TECHNIQUES
94
3.2.7
SOLID-PHASE
COMBINATORIAL
GENE
SYNTHESIS
AS
A
PCR-INDEPENDENT
MUTAGENESIS
METHOD
FOR
MUTANT
LIBRARY
CREATION
96
3.2.8
COMPUTATIONAL
TOOLS
AND
THE
ROLE
OF
MACHINE
LEARNING
(ML)
IN
DIRECTED
EVOLUTION
AND
RATIONAL
ENZYME
DESIGN
102
VII
CONTENTS
3.3
3.3.1
3.4
DIVERSE
APPROACHES
TO
RATIONAL
ENZYME
DESIGN
112
INTRODUCTORY
REMARKS
112
MERGING
SEMI-RATIONAL
DIRECTED
EVOLUTION
AND
RATIONAL
ENZYME
DESIGN
BY
FOCUSED
RATIONAL
ITERATIVE
SITE-SPECIFIC
MUTAGENESIS
(FRISM)
114
3.5
CONCLUSIONS
AND
PERSPECTIVES
120
REFERENCES
120
4
GUIDELINES
FOR
APPLYING
GENE
MUTAGENESIS
METHODS
IN
ORGANIC
CHEMISTRY,
PHARMACEUTICAL
APPLICATIONS,
AND
BIOTECHNOLOGY
141
4.1
4.1.1
4.1.2
4.2
4.2.1
4.2.2
SOME
GENERAL
TIPS
141
RATIONAL
DESIGN
141
DIRECTED
EVOLUTION
149
RARE
CASES
OF
COMPARATIVE
DIRECTED
EVOLUTION
STUDIES
152
CONVERTING
A
GALACTOSIDASE
INTO
A
FUCOSIDASE
152
ENHANCING
AND
INVERTING
THE
ENANTIOSELECTIVITY
OF
THE
LIPASE
FROM
PSEUDOMONAS
AERUGINOSA
(PAL)
156
4.3
CHOOSING
THE
BEST
STRATEGY
WHEN
APPLYING
SATURATION
MUTAGENESIS
163
4.3.1
4.3.2
GENERAL
GUIDELINES
163
CHOOSING
OPTIMAL
PATHWAYS
IN
ITERATIVE
SATURATION
MUTAGENESIS
(ISM)
AND
ESCAPING
FROM
LOCAL
MINIMA IN
FITNESS
LANDSCAPES
168
4.3.3
SYSTEMATIZATION
OF
SATURATION
MUTAGENESIS
WITH
FURTHER
PRACTICAL
TIPS
174
4.3.4
SINGLE
CODE
SATURATION
MUTAGENESIS
(SCSM):
USE
OF
A
SINGLE
AMINO
ACID
AS
BUILDING
BLOCK
183
4.3.5
TRIPLE
CODE
SATURATION
MUTAGENESIS
(TCSM):
A
VIABLE
COMPROMISE
WHEN
CHOOSING
OPTIMAL
REDUCED
AMINO
ACID
ALPHABETS
IN
CAST/ISM
185
4.4
4.5
TECHNO-ECONOMICAL
ANALYSIS
OF
SATURATION
MUTAGENESIS
STRATEGIES
187
GENERATING
MUTANT
LIBRARIES
BY
COMBINATORIAL
SOLID-PHASE
GENE
SYNTHESIS:
THE
FUTURE
OF
DIRECTED
EVOLUTION?
190
4.6
FUSING
DIRECTED
EVOLUTION
AND
RATIONAL
DESIGN:
NEW
EXAMPLES
OF
FOCUSED
RATIONAL
ITERATIVE
SITE-SPECIFIC
MUTAGENESIS
(FRISM)
192
REFERENCES
194
5
TABLES
OF
SELECTED
EXAMPLES
OF
DIRECTED
EVOLUTION
AND
RATIONAL
DESIGN
OF
ENZYMES
WITH
EMPHASIS
ON
STEREO
AND
REGIO-SELECTIVITY,
SUBSTRATE
SCOPE
AND/OR
ACTIVITY
203
5.1
INTRODUCTORY
EXPLANATIONS
203
REFERENCES
220
CONTENTS
VII
6
PROTEIN
ENGINEERING
OF
ENZYME
ROBUSTNESS
RELEVANT
TO
ORGANIC
AND
PHARMACEUTICAL
CHEMISTRY
AND
APPLICATIONS
IN
BIOTECHNOLOGY
233
6.1
6.2
INTRODUCTORY
REMARKS
233
RATIONAL
DESIGN
OF
ENZYME
THERMOSTABILITY
AND
RESISTANCE
TO
HOSTILE
ORGANIC
SOLVENTS
234
6.3
ANCESTRAL AND
CONSENSUS
APPROACHES
AND
THEIR
STRUCTURE-GUIDED
EXTENSIONS
241
6.4
FURTHER
COMPUTATIONALLY
GUIDED
METHODS
FOR
PROTEIN
THERMOSTABILIZATION
242
6.4.1
6.4.2
6.4.3
6.4.4
6.4.5
6.5
SCHEMA
APPROACH
243
FRESCO
APPROACH
245
FIREPROT
APPROACH
247
CONSTRAINED
NETWORK
ANALYSIS
(CNA)
APPROACH
249
ALTERNATIVE
APPROACHES
251
DIRECTED
EVOLUTION
OF
ENZYME
THERMOSTABILITY
AND
RESISTANCE
TO
HOSTILE
ORGANIC
SOLVENTS
253
6.6
6.7
6.8
APPLICATION
OF
EPPCR
AND
DNA
SHUFFLING
255
SATURATION
MUTAGENESIS
IN
THE
B-FIT
APPROACH
258
ITERATIVE
SATURATION
MUTAGENESIS
(ISM)
AT
PROTEIN-PROTEIN
INTERFACIAL
SITES
FOR
MULTIMERIC
ENZYMES
263
6.9
CONCLUSIONS
AND
PERSPECTIVES
265
REFERENCES
265
7
ARTIFICIAL
ENZYMES
AS
PROMISCUOUS
CATALYSTS
IN
ORGANIC
AND
PHARMACEUTICAL
CHEMISTRY
279
7.1
7.2
INTRODUCTORY
BACKGROUND
INFORMATION
279
APPLYING
PROTEIN
ENGINEERING
FOR
TUNING
THE
CATALYTIC
PROFILE
OF
PROMISCUOUS
ENZYMES
285
7.3
APPLYING
PROTEIN
ENGINEERING
TO
P450
MONOOXYGENASES
FOR
MANIPULATING
ACTIVITY
AND
STEREOSELECTIVITY
OF
PROMISCUOUS
TRANSFORMATIONS
299
7.4
CONCLUSIONS
AND
PERSPECTIVES
307
REFERENCES
308
8
8.1
8.2
LEARNING
LESSONS
FROM
PROTEIN
ENGINEERING
317
INTRODUCTORY
REMARKS
317
ADDITIVE
VERSUS
NONADDITIVE
MUTATIONAL
EFFECTS
IN
FITNESS
LANDSCAPES
REVEALED
BY
PARTIAL
OR
COMPLETE
DECONVOLUTION
318
8.3
UNEXPLORED
CHIRAL
FLEETING
INTERMEDIATES
AND
THEIR
ROLE
IN
PROTEIN
ENGINEERING
327
8.4
CASE
STUDIES
FEATURING
MECHANISTIC,
STRUCTURAL,
AND/OR
COMPUTATIONAL
ANALYSES
OF
THE
SOURCE
OF
EVOLVED
STEREO
AND/OR
REGIOSELECTIVITY
329
VIIII
CONTENTS
8.4.1
8.4.2
8.4.3
8.4.4
8.4.5
ESTERASE
329
EPOXIDE
HYDROLASE
331
ENE-REDUCTASE
OF
THE
OLD
YELLOW
ENZYME
(OYE)
335
CYTOCHROME
P450
MONOOXYGENASE
343
ANALYSIS
OF
BAEYER-VILLIGER
MONOOXYGENASE
WITH
CONSIDERATION
OF
FLEETING
CHIRAL
INTERMEDIATES
350
8.5
CONCLUSIONS
AND
SUGGESTIONS
FOR
FURTHER
THEORETICAL
WORK
358
REFERENCES
360
9
9.1
9.2
PERSPECTIVES
FOR
FUTURE
WORK
367
INTRODUCTORY
REMARKS
367
EXTENDING
APPLICATIONS
IN
ORGANIC
AND
PHARMACEUTICAL
CHEMISTRY
367
9.3
9.4
9.5
EXTENDING
APPLICATIONS
IN
BIOTECHNOLOGY
372
PATENT
ISSUES
376
FINAL
COMMENTS
376
REFERENCES
377
INDEX
381 |
| adam_txt |
V
CONTENTS
PREFACE
IX
ABOUT
THE
AUTHORS
XI
1
INTRODUCTION
TO
DIRECTED
EVOLUTION
AND
RATIONAL
DESIGN
AS
PROTEIN
ENGINEERING
TECHNIQUES
1
1.1
METHODS
AND
AIMS
OF
DIRECTED
ENZYME
EVOLUTION
1
1.2
HISTORY
OF
DIRECTED
ENZYME
EVOLUTION
4
1.3
METHODS
AND
AIMS
OF
RATIONAL
DESIGN
OF
ENZYMES
19
REFERENCES
21
2
SCREENING
AND
SELECTION
TECHNIQUES
29
2.1
INTRODUCTORY
REMARKS
29
2.2
SCREENING
METHODS
29
2.3
SELECTION
METHODS
38
2.4
CONCLUSIONS
AND
PERSPECTIVES
52
REFERENCES
53
3
GENE
MUTAGENESIS
METHODS
IN
DIRECTED
EVOLUTION
AND
RATIONAL
ENZYME
DESIGN
59
3.1
INTRODUCTORY
REMARKS
59
3.2
DIRECTED
EVOLUTION
APPROACHES
59
3.2.1
MUTATOR
STRAINS
59
3.2.2
ERROR-PRONE
POLYMERASE
CHAIN
REACTION
(EPPCR)
60
3.2.3
WHOLE
GENE
INSERTION/DELETION
MUTAGENESIS
66
3.2.4
SATURATION
MUTAGENESIS
AS
A
PRIVILEGED
METHOD:
AWAY
FROM
BLIND
DIRECTED
EVOLUTION
73
3.2.5
DNA
SHUFFLING
AND
RELATED
RECOMBINANT
GENE
MUTAGENESIS
METHODS
89
3.2.6
CIRCULAR
MUTATION
AND
OTHER
DOMAIN
SWAPPING
TECHNIQUES
94
3.2.7
SOLID-PHASE
COMBINATORIAL
GENE
SYNTHESIS
AS
A
PCR-INDEPENDENT
MUTAGENESIS
METHOD
FOR
MUTANT
LIBRARY
CREATION
96
3.2.8
COMPUTATIONAL
TOOLS
AND
THE
ROLE
OF
MACHINE
LEARNING
(ML)
IN
DIRECTED
EVOLUTION
AND
RATIONAL
ENZYME
DESIGN
102
VII
CONTENTS
3.3
3.3.1
3.4
DIVERSE
APPROACHES
TO
RATIONAL
ENZYME
DESIGN
112
INTRODUCTORY
REMARKS
112
MERGING
SEMI-RATIONAL
DIRECTED
EVOLUTION
AND
RATIONAL
ENZYME
DESIGN
BY
FOCUSED
RATIONAL
ITERATIVE
SITE-SPECIFIC
MUTAGENESIS
(FRISM)
114
3.5
CONCLUSIONS
AND
PERSPECTIVES
120
REFERENCES
120
4
GUIDELINES
FOR
APPLYING
GENE
MUTAGENESIS
METHODS
IN
ORGANIC
CHEMISTRY,
PHARMACEUTICAL
APPLICATIONS,
AND
BIOTECHNOLOGY
141
4.1
4.1.1
4.1.2
4.2
4.2.1
4.2.2
SOME
GENERAL
TIPS
141
RATIONAL
DESIGN
141
DIRECTED
EVOLUTION
149
RARE
CASES
OF
COMPARATIVE
DIRECTED
EVOLUTION
STUDIES
152
CONVERTING
A
GALACTOSIDASE
INTO
A
FUCOSIDASE
152
ENHANCING
AND
INVERTING
THE
ENANTIOSELECTIVITY
OF
THE
LIPASE
FROM
PSEUDOMONAS
AERUGINOSA
(PAL)
156
4.3
CHOOSING
THE
BEST
STRATEGY
WHEN
APPLYING
SATURATION
MUTAGENESIS
163
4.3.1
4.3.2
GENERAL
GUIDELINES
163
CHOOSING
OPTIMAL
PATHWAYS
IN
ITERATIVE
SATURATION
MUTAGENESIS
(ISM)
AND
ESCAPING
FROM
LOCAL
MINIMA IN
FITNESS
LANDSCAPES
168
4.3.3
SYSTEMATIZATION
OF
SATURATION
MUTAGENESIS
WITH
FURTHER
PRACTICAL
TIPS
174
4.3.4
SINGLE
CODE
SATURATION
MUTAGENESIS
(SCSM):
USE
OF
A
SINGLE
AMINO
ACID
AS
BUILDING
BLOCK
183
4.3.5
TRIPLE
CODE
SATURATION
MUTAGENESIS
(TCSM):
A
VIABLE
COMPROMISE
WHEN
CHOOSING
OPTIMAL
REDUCED
AMINO
ACID
ALPHABETS
IN
CAST/ISM
185
4.4
4.5
TECHNO-ECONOMICAL
ANALYSIS
OF
SATURATION
MUTAGENESIS
STRATEGIES
187
GENERATING
MUTANT
LIBRARIES
BY
COMBINATORIAL
SOLID-PHASE
GENE
SYNTHESIS:
THE
FUTURE
OF
DIRECTED
EVOLUTION?
190
4.6
FUSING
DIRECTED
EVOLUTION
AND
RATIONAL
DESIGN:
NEW
EXAMPLES
OF
FOCUSED
RATIONAL
ITERATIVE
SITE-SPECIFIC
MUTAGENESIS
(FRISM)
192
REFERENCES
194
5
TABLES
OF
SELECTED
EXAMPLES
OF
DIRECTED
EVOLUTION
AND
RATIONAL
DESIGN
OF
ENZYMES
WITH
EMPHASIS
ON
STEREO
AND
REGIO-SELECTIVITY,
SUBSTRATE
SCOPE
AND/OR
ACTIVITY
203
5.1
INTRODUCTORY
EXPLANATIONS
203
REFERENCES
220
CONTENTS
VII
6
PROTEIN
ENGINEERING
OF
ENZYME
ROBUSTNESS
RELEVANT
TO
ORGANIC
AND
PHARMACEUTICAL
CHEMISTRY
AND
APPLICATIONS
IN
BIOTECHNOLOGY
233
6.1
6.2
INTRODUCTORY
REMARKS
233
RATIONAL
DESIGN
OF
ENZYME
THERMOSTABILITY
AND
RESISTANCE
TO
HOSTILE
ORGANIC
SOLVENTS
234
6.3
ANCESTRAL AND
CONSENSUS
APPROACHES
AND
THEIR
STRUCTURE-GUIDED
EXTENSIONS
241
6.4
FURTHER
COMPUTATIONALLY
GUIDED
METHODS
FOR
PROTEIN
THERMOSTABILIZATION
242
6.4.1
6.4.2
6.4.3
6.4.4
6.4.5
6.5
SCHEMA
APPROACH
243
FRESCO
APPROACH
245
FIREPROT
APPROACH
247
CONSTRAINED
NETWORK
ANALYSIS
(CNA)
APPROACH
249
ALTERNATIVE
APPROACHES
251
DIRECTED
EVOLUTION
OF
ENZYME
THERMOSTABILITY
AND
RESISTANCE
TO
HOSTILE
ORGANIC
SOLVENTS
253
6.6
6.7
6.8
APPLICATION
OF
EPPCR
AND
DNA
SHUFFLING
255
SATURATION
MUTAGENESIS
IN
THE
B-FIT
APPROACH
258
ITERATIVE
SATURATION
MUTAGENESIS
(ISM)
AT
PROTEIN-PROTEIN
INTERFACIAL
SITES
FOR
MULTIMERIC
ENZYMES
263
6.9
CONCLUSIONS
AND
PERSPECTIVES
265
REFERENCES
265
7
ARTIFICIAL
ENZYMES
AS
PROMISCUOUS
CATALYSTS
IN
ORGANIC
AND
PHARMACEUTICAL
CHEMISTRY
279
7.1
7.2
INTRODUCTORY
BACKGROUND
INFORMATION
279
APPLYING
PROTEIN
ENGINEERING
FOR
TUNING
THE
CATALYTIC
PROFILE
OF
PROMISCUOUS
ENZYMES
285
7.3
APPLYING
PROTEIN
ENGINEERING
TO
P450
MONOOXYGENASES
FOR
MANIPULATING
ACTIVITY
AND
STEREOSELECTIVITY
OF
PROMISCUOUS
TRANSFORMATIONS
299
7.4
CONCLUSIONS
AND
PERSPECTIVES
307
REFERENCES
308
8
8.1
8.2
LEARNING
LESSONS
FROM
PROTEIN
ENGINEERING
317
INTRODUCTORY
REMARKS
317
ADDITIVE
VERSUS
NONADDITIVE
MUTATIONAL
EFFECTS
IN
FITNESS
LANDSCAPES
REVEALED
BY
PARTIAL
OR
COMPLETE
DECONVOLUTION
318
8.3
UNEXPLORED
CHIRAL
FLEETING
INTERMEDIATES
AND
THEIR
ROLE
IN
PROTEIN
ENGINEERING
327
8.4
CASE
STUDIES
FEATURING
MECHANISTIC,
STRUCTURAL,
AND/OR
COMPUTATIONAL
ANALYSES
OF
THE
SOURCE
OF
EVOLVED
STEREO
AND/OR
REGIOSELECTIVITY
329
VIIII
CONTENTS
8.4.1
8.4.2
8.4.3
8.4.4
8.4.5
ESTERASE
329
EPOXIDE
HYDROLASE
331
ENE-REDUCTASE
OF
THE
OLD
YELLOW
ENZYME
(OYE)
335
CYTOCHROME
P450
MONOOXYGENASE
343
ANALYSIS
OF
BAEYER-VILLIGER
MONOOXYGENASE
WITH
CONSIDERATION
OF
FLEETING
CHIRAL
INTERMEDIATES
350
8.5
CONCLUSIONS
AND
SUGGESTIONS
FOR
FURTHER
THEORETICAL
WORK
358
REFERENCES
360
9
9.1
9.2
PERSPECTIVES
FOR
FUTURE
WORK
367
INTRODUCTORY
REMARKS
367
EXTENDING
APPLICATIONS
IN
ORGANIC
AND
PHARMACEUTICAL
CHEMISTRY
367
9.3
9.4
9.5
EXTENDING
APPLICATIONS
IN
BIOTECHNOLOGY
372
PATENT
ISSUES
376
FINAL
COMMENTS
376
REFERENCES
377
INDEX
381 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Reetz, Manfred T. 1943- Sun, Zhoutong Qu, Ge |
| author_GND | (DE-588)111053455 (DE-588)1299382878 (DE-588)1299383300 |
| author_facet | Reetz, Manfred T. 1943- Sun, Zhoutong Qu, Ge |
| author_role | aut aut aut |
| author_sort | Reetz, Manfred T. 1943- |
| author_variant | m t r mt mtr z s zs g q gq |
| building | Verbundindex |
| bvnumber | BV048809584 |
| classification_rvk | WD 5050 |
| classification_tum | CHE 825 |
| ctrlnum | (OCoLC)1373391471 (DE-599)DNB1267778857 |
| discipline | Biologie Chemie |
| discipline_str_mv | Biologie Chemie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV048809584</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20240425</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">230209s2023 gw a||| |||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">22,N37</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1267778857</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527350339</subfield><subfield code="c">hbk. : circa EUR 159.00 (DE) (freier Preis), circa EUR 163.50 (AT) (freier Preis)</subfield><subfield code="9">978-3-527-35033-9</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9783527350339</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">Bestellnummer: 1135033 000</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1373391471</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1267778857</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BW</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29T</subfield><subfield code="a">DE-91G</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-11</subfield><subfield code="a">DE-20</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WD 5050</subfield><subfield code="0">(DE-625)148185:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">CHE 825</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">540</subfield><subfield code="2">23sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Reetz, Manfred T.</subfield><subfield code="d">1943-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)111053455</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Enzyme engineering</subfield><subfield code="b">selective catalysts for applications in biotechnology, organic chemistry, and life science</subfield><subfield code="c">Manfred T. Reetz, Zhoutong Sun, and Ge Qu</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Weinheim</subfield><subfield code="b">Wiley-VCH</subfield><subfield code="c">[2023]</subfield></datafield><datafield tag="264" ind1=" " ind2="4"><subfield code="c">© 2023</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xii, 387 Seiten</subfield><subfield code="b">Illustrationen, Diagramme (teilweise farbig)</subfield><subfield code="c">24.4 cm x 17 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Enzymkatalyse</subfield><subfield code="0">(DE-588)4152480-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Proteindesign</subfield><subfield code="0">(DE-588)4346801-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Biotechnologie i. d. Biowissenschaften</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Biotechnology</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Biowissenschaften</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CH81: Organische Chemie / Methoden, Synthesen, Verfahren</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CHB4: Proteine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Chemie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Chemistry</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">LS35: Biotechnologie i. d. Biowissenschaften</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Life Sciences</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Methods - Synthesis & Techniques</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Organische Chemie / Methoden, Synthesen, Verfahren</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Protein Science</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Proteine</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Enzymkatalyse</subfield><subfield code="0">(DE-588)4152480-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Proteindesign</subfield><subfield code="0">(DE-588)4346801-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sun, Zhoutong</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1299382878</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Qu, Ge</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1299383300</subfield><subfield code="4">aut</subfield></datafield><datafield tag="710" ind1="2" ind2=" "><subfield code="a">Wiley-VCH</subfield><subfield code="0">(DE-588)16179388-5</subfield><subfield code="4">pbl</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, PDF</subfield><subfield code="z">978-3-527-83687-1</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, EPUB</subfield><subfield code="z">978-3-527-83688-8</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, oBook</subfield><subfield code="z">978-3-527-83689-5</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">X:MVB</subfield><subfield code="u">http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-35033-9/</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034075545&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield></record></collection> |
| id | DE-604.BV048809584 |
| illustrated | Illustrated |
| index_date | 2024-07-03T21:29:58Z |
| indexdate | 2024-07-20T04:06:16Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527350339 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034075545 |
| oclc_num | 1373391471 |
| open_access_boolean | |
| owner | DE-29T DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-11 DE-20 |
| owner_facet | DE-29T DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-11 DE-20 |
| physical | xii, 387 Seiten Illustrationen, Diagramme (teilweise farbig) 24.4 cm x 17 cm |
| publishDate | 2023 |
| publishDateSearch | 2023 |
| publishDateSort | 2023 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Reetz, Manfred T. 1943- Verfasser (DE-588)111053455 aut Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science Manfred T. Reetz, Zhoutong Sun, and Ge Qu Weinheim Wiley-VCH [2023] © 2023 xii, 387 Seiten Illustrationen, Diagramme (teilweise farbig) 24.4 cm x 17 cm txt rdacontent n rdamedia nc rdacarrier Enzymkatalyse (DE-588)4152480-9 gnd rswk-swf Proteindesign (DE-588)4346801-9 gnd rswk-swf Biotechnologie i. d. Biowissenschaften Biotechnology Biowissenschaften CH81: Organische Chemie / Methoden, Synthesen, Verfahren CHB4: Proteine Chemie Chemistry LS35: Biotechnologie i. d. Biowissenschaften Life Sciences Methods - Synthesis & Techniques Organische Chemie / Methoden, Synthesen, Verfahren Protein Science Proteine Enzymkatalyse (DE-588)4152480-9 s Proteindesign (DE-588)4346801-9 s DE-604 Sun, Zhoutong Verfasser (DE-588)1299382878 aut Qu, Ge Verfasser (DE-588)1299383300 aut Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, PDF 978-3-527-83687-1 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-83688-8 Erscheint auch als Online-Ausgabe, oBook 978-3-527-83689-5 X:MVB http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-35033-9/ DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034075545&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Reetz, Manfred T. 1943- Sun, Zhoutong Qu, Ge Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science Enzymkatalyse (DE-588)4152480-9 gnd Proteindesign (DE-588)4346801-9 gnd |
| subject_GND | (DE-588)4152480-9 (DE-588)4346801-9 |
| title | Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science |
| title_auth | Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science |
| title_exact_search | Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science |
| title_exact_search_txtP | Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science |
| title_full | Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science Manfred T. Reetz, Zhoutong Sun, and Ge Qu |
| title_fullStr | Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science Manfred T. Reetz, Zhoutong Sun, and Ge Qu |
| title_full_unstemmed | Enzyme engineering selective catalysts for applications in biotechnology, organic chemistry, and life science Manfred T. Reetz, Zhoutong Sun, and Ge Qu |
| title_short | Enzyme engineering |
| title_sort | enzyme engineering selective catalysts for applications in biotechnology organic chemistry and life science |
| title_sub | selective catalysts for applications in biotechnology, organic chemistry, and life science |
| topic | Enzymkatalyse (DE-588)4152480-9 gnd Proteindesign (DE-588)4346801-9 gnd |
| topic_facet | Enzymkatalyse Proteindesign |
| url | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-35033-9/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034075545&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT reetzmanfredt enzymeengineeringselectivecatalystsforapplicationsinbiotechnologyorganicchemistryandlifescience AT sunzhoutong enzymeengineeringselectivecatalystsforapplicationsinbiotechnologyorganicchemistryandlifescience AT quge enzymeengineeringselectivecatalystsforapplicationsinbiotechnologyorganicchemistryandlifescience AT wileyvch enzymeengineeringselectivecatalystsforapplicationsinbiotechnologyorganicchemistryandlifescience |