The human connectome: how the brain works
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| Format: | Buch |
| Sprache: | English |
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[2022]
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| Beschreibung: | xxii, 420 Seiten Illustrationen |
| ISBN: | 9783031103506 |
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Datensatz im Suchindex
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| adam_text | Contents History........................................................................................................ 1.1 Antiquity and the Prescientific Era................................................... 1.2 The Dawn of the Scientific Era......................................................... 1.3 From the Middle Ages to the Renaissance and the Early Modern Era............................................................................... 16 1.4 The Great Revolutions and the Extinction of the Supernatural........ References.................................................................................................... 25 30 2 Gross Anatomy of the Brain..................................................................... 2.1 Gross Functional Anatomy............................................................... 2.2 Connections Among Brain Areas....................................................... 2.3 Brain Blood Flow................................................................................ References.................................................................................................... 33 33 44 47 49 3 Cellular Structure and Histological Architecture of the Brain............ 3.1 Structural Components of the Brain................................................. 3.2 Microtopographic Organization of the Brain..................................... References.................................................................................................... 51 51 58 59 4 The Cell
Membrane................................................................................. 4.1 The Membrane.................................................................................... 4.2 The Resting Potential.......................................................................... 4.3 The Action Potential.......................................................................... 4.4 After the Action Potential Period....................................................... 4.5 Local Potentials.................................................................................. References.................................................................................................... 61 61 62 63 66 67 67 5 Neurotransmitters...................................................................................... 5.1 General Concepts................................................................................ 5.2 Definition of a Neurotransmitter....................................................... 5.3 Classification of Neurotransmitters................................................... 5.3.1 Small-Molecule Neurotransmitters or Biogenic Amines.... 5.3.2 Excitatory Amino Acids and Neuroactive Peptides.............. 5.3.3 Small-Molecule Neurotransmitters...................................... 5.3.4 Excitatory Amino Acids and Neuroactive Peptides.............. 5.3.5 Gliotransmitters..................................................................... 69 69 71 74 74 75 76 85 96 1 1 1 8 xv
xvi Contents 5.4 Cotransmission................................................................................... References................................................................................................... 97 97 6 The Neural Synapse.................................................................................... 107 6.1 Background.......................................................................................... 107 6.2 Chemical Synapses.............................................................................. Ill 6.2.1 Receptors................................................................................. Ill 6.2.2 Neurotransmitter Reuptake..................................................... 132 6.3 Electrical Synapses.............................................................................. 134 6.4 Autapses................................................................................................ 135 References..................................................................................................... 135 7 Functional Significance of Neurotransmitter Systems............................ 147 7.1 The Functional Role of the CholinergicSystem................................... 148 7.2 The Functional Role of the Serotonergic System................................ 150 7.2.1 Pathways and Information Input into the Serotonin System......................................................... 150 7.2.2 Regulation of Serotonin Activity............................................ 151 7.2.3 Projections of Serotonergic
Pathways.................................... 151 7.2.4 The Role of Serotonergic Receptors...................................... 154 7.3 The Functional Role of the Norepinephrine System........................... 155 7.3.1 Pathways and Information Input into the Norepinephrine System............................................... 155 7.3.2 Regulation of Norepinephrine Activity................................... 157 7.4 The Functional Role of the Dopamine System................................... 158 7.4.1 Pathways and Information Input into the Dopaminergic System................................................. 158 7.4.2 Regulation of Dopaminergic Activity..................................... 159 7.4.3 Projections of Dopamine Pathways..........................................159 7.4.4 The Role of Dopamine Receptors........................................... 161 7.5 The Functional Role of the Histamine System................................... 162 7.5.1 The Role of Histamine in the Brain and the Body................... 162 7.5.2 The Role of Histamine Receptors............................................ 164 7.6 The Functional Role of the Glutamatergic System............................. 165 7.6.1 The Role of Ionotropic Glutamate Receptors..........................165 7.6.2 The Role of the Metabotropic Glutamate Receptors............. 167 7.7 The Functional Role of the GABAergic System................................. 169 7.8 The Functional Role of the Neuropeptide System............................... 170 7.8.1 The General FunctionalRole of Neuropeptides.....................
170 7.8.2 The Role of Neuropeptide Receptors...................................... 172 7.9 General Principles of Neurotransmitter Systems Self-Regulation.......................................................................... 174 References..................................................................................................... 177
Contents xvi։ 8 Second Messenger Systems........................................................................ 193 8.1 From the Synapsis to the Second Messenger...................................... 193 8.1.1 G-Protein................................................................................ 194 8.1.2 Effectors................................................................................ 196 8.2 Second Messengers.............................................................................196 8.2.1 Classes of Second Messenger Molecules............................. 196 8.2.2 Second Messenger Pathways andSystems............................ 197 References...................................................................................................... 200 9 Neurotrophic Factors...................................................................................203 9.1 Basics for Neurotrophic Factors......................................................... 203 9.2 Neurotrophic Factor Molecules............................................................ 204 9.3 Neurotrophic Factor Receptors............................................................ 205 9.4 Neurotrophic Factor Actions................................................................ 207 9.5 Other Neurotrophic Mechanisms and Substances................................ 208 References...................................................................................................... 209 10 FunctionalOrganization of the Brain........................................................ 217 10.1 Basic Functional
Anatomy of the Brain............................................. 218 10.2 Perception......................................................................................... 220 10.3 Neuronal Circuits............................................................................... 224 10.4 Internal Representation of theExternal Environment....................... 231 10.5 Decision-Making and Action............................................................. 235 References...................................................................................................... 238 11 Higher Mental Functions........................................................................... 243 11.1 Attention and Concentration..............................................................243 11.1.1 Neuropsychological Models of Attention............................. 243 11.1.2 Neurobiology of Attention................................................... 246 11.2 Memory and Learning........................................................................ 246 11.2.1 Categories of Memory and Learning................................... 248 11.2.2 Neurobiology of Memory and Learning............................... 250 11.3 Visuospatial Function.......................................................................... 251 11.4 Praxis.................................................................................................. 253 11.5 Language............................................................................................ 253 11.6 Arithmetic
Calculations...................................................................... 258 11.7 Abstract Thinking.............................................................................. 258 11.8 Executive Functions and Neurocognitive Control............................. 260 11.8.1 Neuropsychological Definition of Executive Function... . 260 11.8.2 Neurobiology of Executive Functions................................. 261 11.9 Social Cognition and Theory of Mind................................................ 262 References...................................................................................................... 263 12 Thought........................................................................................................ 273 12.1 Basic Characteristics of Human Thinking......................................... 273 12.2 General Intelligence.......................................................................... 276 References...................................................................................................... 279
xviii Contents 13 Mood, Affect, and Emotions..................................................................... 281 13.1 Mood, Affect, and Emotions........................................................... 281 13.2 The Role of Mood, Affect, and Emotions........................................ 282 13.3 Neurobiology of Mood, Affect, and Emotions................................ 283 13.4 Comparison of Rational and Emotional Processing........................ 288 References................................................................................................... 289 14 Sleep............................................................................................................291 14.1 General Comments on Sleep............................................................ 291 14.2 The Structure of Sleep.......................................................................291 14.3 Neurobiology of Sleep....................................................................... 294 14.4 The Role of Sleep in Brain and Body Functions.............................. 295 14.5 Dreaming........................................................................................... 296 References..................................................................................................... 297 15 Consciousness and Free Will...................................................................... 301 15.1 Theoretical Approach of Consciousness........................................... 301 15.2 Neurobiology of Consciousness....................................................... 303
15.3 The Concept of Free Will................................................................... 306 15.4 Determinism Vs. Randomness........................................................... 307 15.5 Physics, Mind, and the Brain............................................................. 311 15.6 Neurobiology and Free Will............................................................... 312 References..................................................................................................... 318 16 Temperament, Personality, and Character................................................ 321 16.1 Basic Concepts and Definitions......................................................... 321 16.2 Models of Human Personality........................................................... 323 16.3 Neurobiology of Human Personality................................................. 326 References..................................................................................................... 328 17 Differences Between Genders in the Organization and the Functioning of the Brain........................................................................... 335 17.1 Differences Between Genders in Observed Behavior...................... 335 17.2 Structural Brain Differences Between Genders.................................339 17.2.1 Basic Biological Differences................................................ 339 17.2.2 Whole Brain Volume............................................................ 341 17.2.3 Regional Differences............................................................
341 17.2.4 Differences in Gray Matter.................................................. 343 17.2.5 Differences in White Matter and Connectivity.................... 343 17.2.6 Relationship to Sexual Orientation...................................... 344 17.3 Differences in Neurobioiogical Function of the Brain Between Genders.....................................................................346 17.4 The Role of Sexual Hormones and Genes in the Development and Functioning of the Brain.................................................. 348 References..................................................................................................... 349
Contents xix 18 Genetics of Brain Structure and Function............................................... 365 18.1 Human Genetics.................................................................................. 365 18.1.1 Basic Human Genetics........................................................... 365 18.1.2 Patterns of Inheritance........................................................... 370 18.1.3 Human Variation and Its Components................................... 372 18.1.4 Methods in Behavior Genetics Research...............................374 18.2 Brain and Behavior Genetics............................................................. 374 18.2.1 The Most Important Genetic Markers Identified So Far......................................................................... 375 18.2.2 Phenotypes and Endophenotypes........................................... 378 18.3 Conclusions from Genetic Studies..................................................... 383 References...................................................................................................... 384 19 Psychoneurobiology, Brain, and Society (Sociobiology)........................ 397 19.1 Evolutionary Social Biopsychology................................................... 397 19.2 Sociobiology...................................................................................... 401 References...................................................................................................... 410 20
Acronyms...................................................................................................... 415 20.1 Acronyms to Full Names................................................................... 415 20.2 Full Names to Acronyms................................................................... 418
Kostas N. Fountoulakis The Human Connectome How the Brain Works This book constitutes the end result of 20 years-long effort that goes beyond a Psychiatrist s standard clinical training and education, even that of a Psychiatrist that follows an academic career. Trying to explain how the human mind works is hard and the heterogeneity of the audience make the attempt even more difficult. There is a conceptual difference between the words ‘brain and ‘mind’and this makes the effort even more difficult since the present book tries to preserve the strict scientific approach concerning all the topics discussed. The work elaborates and tries to answer questions frequently phrased by audiences in teaching classes and in conferences and does not avoid any question. In order to achieve this goal, it is structured in chapters all the way from the molecule and the cell to consciousness and free will. The book targets mainly the mental health care professionals as an audience, and to a lesser extend the other health professionals. It is written according to the author’s view concerning the training and educational needs of Psychiatrists and Psychologists and to a lesser degree of Neurologists and Neuroscientists in general.
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| adam_txt |
Contents History. 1.1 Antiquity and the Prescientific Era. 1.2 The Dawn of the Scientific Era. 1.3 From the Middle Ages to the Renaissance and the Early Modern Era. 16 1.4 The Great Revolutions and the Extinction of the Supernatural. References. 25 30 2 Gross Anatomy of the Brain. 2.1 Gross Functional Anatomy. 2.2 Connections Among Brain Areas. 2.3 Brain Blood Flow. References. 33 33 44 47 49 3 Cellular Structure and Histological Architecture of the Brain. 3.1 Structural Components of the Brain. 3.2 Microtopographic Organization of the Brain. References. 51 51 58 59 4 The Cell
Membrane. 4.1 The Membrane. 4.2 The Resting Potential. 4.3 The Action Potential. 4.4 After the Action Potential Period. 4.5 Local Potentials. References. 61 61 62 63 66 67 67 5 Neurotransmitters. 5.1 General Concepts. 5.2 Definition of a Neurotransmitter. 5.3 Classification of Neurotransmitters. 5.3.1 Small-Molecule Neurotransmitters or Biogenic Amines. 5.3.2 Excitatory Amino Acids and Neuroactive Peptides. 5.3.3 Small-Molecule Neurotransmitters. 5.3.4 Excitatory Amino Acids and Neuroactive Peptides. 5.3.5 Gliotransmitters. 69 69 71 74 74 75 76 85 96 1 1 1 8 xv
xvi Contents 5.4 Cotransmission. References. 97 97 6 The Neural Synapse. 107 6.1 Background. 107 6.2 Chemical Synapses. Ill 6.2.1 Receptors. Ill 6.2.2 Neurotransmitter Reuptake. 132 6.3 Electrical Synapses. 134 6.4 Autapses. 135 References. 135 7 Functional Significance of Neurotransmitter Systems. 147 7.1 The Functional Role of the CholinergicSystem. 148 7.2 The Functional Role of the Serotonergic System. 150 7.2.1 Pathways and Information Input into the Serotonin System. 150 7.2.2 Regulation of Serotonin Activity. 151 7.2.3 Projections of Serotonergic
Pathways. 151 7.2.4 The Role of Serotonergic Receptors. 154 7.3 The Functional Role of the Norepinephrine System. 155 7.3.1 Pathways and Information Input into the Norepinephrine System. 155 7.3.2 Regulation of Norepinephrine Activity. 157 7.4 The Functional Role of the Dopamine System. 158 7.4.1 Pathways and Information Input into the Dopaminergic System. 158 7.4.2 Regulation of Dopaminergic Activity. 159 7.4.3 Projections of Dopamine Pathways.159 7.4.4 The Role of Dopamine Receptors. 161 7.5 The Functional Role of the Histamine System. 162 7.5.1 The Role of Histamine in the Brain and the Body. 162 7.5.2 The Role of Histamine Receptors. 164 7.6 The Functional Role of the Glutamatergic System. 165 7.6.1 The Role of Ionotropic Glutamate Receptors.165 7.6.2 The Role of the Metabotropic Glutamate Receptors. 167 7.7 The Functional Role of the GABAergic System. 169 7.8 The Functional Role of the Neuropeptide System. 170 7.8.1 The General FunctionalRole of Neuropeptides.
170 7.8.2 The Role of Neuropeptide Receptors. 172 7.9 General Principles of Neurotransmitter Systems Self-Regulation. 174 References. 177
Contents xvi։ 8 Second Messenger Systems. 193 8.1 From the Synapsis to the Second Messenger. 193 8.1.1 G-Protein. 194 8.1.2 Effectors. 196 8.2 Second Messengers.196 8.2.1 Classes of Second Messenger Molecules. 196 8.2.2 Second Messenger Pathways andSystems. 197 References. 200 9 Neurotrophic Factors.203 9.1 Basics for Neurotrophic Factors. 203 9.2 Neurotrophic Factor Molecules. 204 9.3 Neurotrophic Factor Receptors. 205 9.4 Neurotrophic Factor Actions. 207 9.5 Other Neurotrophic Mechanisms and Substances. 208 References. 209 10 FunctionalOrganization of the Brain. 217 10.1 Basic Functional
Anatomy of the Brain. 218 10.2 Perception. 220 10.3 Neuronal Circuits. 224 10.4 Internal Representation of theExternal Environment. 231 10.5 Decision-Making and Action. 235 References. 238 11 Higher Mental Functions. 243 11.1 Attention and Concentration.243 11.1.1 Neuropsychological Models of Attention. 243 11.1.2 Neurobiology of Attention. 246 11.2 Memory and Learning. 246 11.2.1 Categories of Memory and Learning. 248 11.2.2 Neurobiology of Memory and Learning. 250 11.3 Visuospatial Function. 251 11.4 Praxis. 253 11.5 Language. 253 11.6 Arithmetic
Calculations. 258 11.7 Abstract Thinking. 258 11.8 Executive Functions and Neurocognitive Control. 260 11.8.1 Neuropsychological Definition of Executive Function. . 260 11.8.2 Neurobiology of Executive Functions. 261 11.9 Social Cognition and Theory of Mind. 262 References. 263 12 Thought. 273 12.1 Basic Characteristics of Human Thinking. 273 12.2 General Intelligence. 276 References. 279
xviii Contents 13 Mood, Affect, and Emotions. 281 13.1 Mood, Affect, and Emotions. 281 13.2 The Role of Mood, Affect, and Emotions. 282 13.3 Neurobiology of Mood, Affect, and Emotions. 283 13.4 Comparison of Rational and Emotional Processing. 288 References. 289 14 Sleep.291 14.1 General Comments on Sleep. 291 14.2 The Structure of Sleep.291 14.3 Neurobiology of Sleep. 294 14.4 The Role of Sleep in Brain and Body Functions. 295 14.5 Dreaming. 296 References. 297 15 Consciousness and Free Will. 301 15.1 Theoretical Approach of Consciousness. 301 15.2 Neurobiology of Consciousness. 303
15.3 The Concept of Free Will. 306 15.4 Determinism Vs. Randomness. 307 15.5 Physics, Mind, and the Brain. 311 15.6 Neurobiology and Free Will. 312 References. 318 16 Temperament, Personality, and Character. 321 16.1 Basic Concepts and Definitions. 321 16.2 Models of Human Personality. 323 16.3 Neurobiology of Human Personality. 326 References. 328 17 Differences Between Genders in the Organization and the Functioning of the Brain. 335 17.1 Differences Between Genders in Observed Behavior. 335 17.2 Structural Brain Differences Between Genders.339 17.2.1 Basic Biological Differences. 339 17.2.2 Whole Brain Volume. 341 17.2.3 Regional Differences.
341 17.2.4 Differences in Gray Matter. 343 17.2.5 Differences in White Matter and Connectivity. 343 17.2.6 Relationship to Sexual Orientation. 344 17.3 Differences in Neurobioiogical Function of the Brain Between Genders.346 17.4 The Role of Sexual Hormones and Genes in the Development and Functioning of the Brain. 348 References. 349
Contents xix 18 Genetics of Brain Structure and Function. 365 18.1 Human Genetics. 365 18.1.1 Basic Human Genetics. 365 18.1.2 Patterns of Inheritance. 370 18.1.3 Human Variation and Its Components. 372 18.1.4 Methods in Behavior Genetics Research.374 18.2 Brain and Behavior Genetics. 374 18.2.1 The Most Important Genetic Markers Identified So Far. 375 18.2.2 Phenotypes and Endophenotypes. 378 18.3 Conclusions from Genetic Studies. 383 References. 384 19 Psychoneurobiology, Brain, and Society (Sociobiology). 397 19.1 Evolutionary Social Biopsychology. 397 19.2 Sociobiology. 401 References. 410 20
Acronyms. 415 20.1 Acronyms to Full Names. 415 20.2 Full Names to Acronyms. 418
Kostas N. Fountoulakis The Human Connectome How the Brain Works This book constitutes the end result of 20 years-long effort that goes beyond a Psychiatrist s standard clinical training and education, even that of a Psychiatrist that follows an academic career. Trying to explain how the human mind works is hard and the heterogeneity of the audience make the attempt even more difficult. There is a conceptual difference between the words ‘brain and ‘mind’and this makes the effort even more difficult since the present book tries to preserve the strict scientific approach concerning all the topics discussed. The work elaborates and tries to answer questions frequently phrased by audiences in teaching classes and in conferences and does not avoid any question. In order to achieve this goal, it is structured in chapters all the way from the molecule and the cell to consciousness and free will. The book targets mainly the mental health care professionals as an audience, and to a lesser extend the other health professionals. It is written according to the author’s view concerning the training and educational needs of Psychiatrists and Psychologists and to a lesser degree of Neurologists and Neuroscientists in general. |
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| index_date | 2024-07-03T21:14:26Z |
| indexdate | 2024-07-10T09:43:18Z |
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| publisher | Springer |
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| spelling | Fountoulakis, Kostas N. 1966- Verfasser (DE-588)1193734177 aut The human connectome how the brain works Kostas N. Fountoulakis Cham Springer [2022] xxii, 420 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Psychiatry Neurology Neuropsychology Neurology Gehirn (DE-588)4019752-9 gnd rswk-swf Neurowissenschaften (DE-588)7555119-6 gnd rswk-swf Neurowissenschaften (DE-588)7555119-6 s Gehirn (DE-588)4019752-9 s DE-604 Erscheint auch als Online-Ausgabe 978-3-031-10351-3 10.1007/978-3-031-10351-3 Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033999570&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033999570&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Fountoulakis, Kostas N. 1966- The human connectome how the brain works Psychiatry Neurology Neuropsychology Neurology Gehirn (DE-588)4019752-9 gnd Neurowissenschaften (DE-588)7555119-6 gnd |
| subject_GND | (DE-588)4019752-9 (DE-588)7555119-6 |
| title | The human connectome how the brain works |
| title_auth | The human connectome how the brain works |
| title_exact_search | The human connectome how the brain works |
| title_exact_search_txtP | The human connectome how the brain works |
| title_full | The human connectome how the brain works Kostas N. Fountoulakis |
| title_fullStr | The human connectome how the brain works Kostas N. Fountoulakis |
| title_full_unstemmed | The human connectome how the brain works Kostas N. Fountoulakis |
| title_short | The human connectome |
| title_sort | the human connectome how the brain works |
| title_sub | how the brain works |
| topic | Psychiatry Neurology Neuropsychology Neurology Gehirn (DE-588)4019752-9 gnd Neurowissenschaften (DE-588)7555119-6 gnd |
| topic_facet | Psychiatry Neurology Neuropsychology Neurology Gehirn Neurowissenschaften |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033999570&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033999570&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT fountoulakiskostasn thehumanconnectomehowthebrainworks |