Conquest of invisible enemies: a human history of antiviral drugs
It's time to examine the human history of viruses, vaccines, and antiviral drugs.Public response to the COVID-19 pandemic has demonstrated that misinformation about viruses is widespread. Vaccine skepticism is rampant, and many people have been quick to accept bogus claims unsupported by scienc...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Oxford University Press
[2022]
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichni |
| Zusammenfassung: | It's time to examine the human history of viruses, vaccines, and antiviral drugs.Public response to the COVID-19 pandemic has demonstrated that misinformation about viruses is widespread. Vaccine skepticism is rampant, and many people have been quick to accept bogus claims unsupported by science. In his latest book, Jie Jack Li sets the record straight by revealing the science and history behind antiviral drugs. Conquest of Invisible Enemies: A Human History of Antiviral Drugs guides readers through the history of viruses, vaccinations, and treatments. Readers learn about the discovery of viruses and diseases, such as HIV/AIDS, hepatitis, influenza, and SARS-CoV-2 (COVID-19). The first chapter takes an expansive look at how viruses have shaped human history. Subsequent chapters narrow in on specific viruses, diseases, and drug treatments. For example, chapter four, on influenza, looks at the1918 Spanish flu pandemic, the history of vaccination efforts, and influenza drugs and vaccines today. Chapter five, on coronaviruses, considers drug treatments for SARS, MERS, and SARS-CoV-2. It also discusses the development of COVID-19 vaccines and drugs. Conquest of Invisible Enemies: A Human History of Antiviral Drugs focuses on the human drama behind drug discovery. Written in an engaging and accessible style, Li's timely book dispels common misconceptions about viruses and treatments and places the COVID-19 pandemic in historical context |
| Beschreibung: | xii, 262 Seiten Illustrationen 22 cm |
| ISBN: | 9780197609859 9780197609873 9780197609866 9780197609880 |
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| 520 | |a It's time to examine the human history of viruses, vaccines, and antiviral drugs.Public response to the COVID-19 pandemic has demonstrated that misinformation about viruses is widespread. Vaccine skepticism is rampant, and many people have been quick to accept bogus claims unsupported by science. In his latest book, Jie Jack Li sets the record straight by revealing the science and history behind antiviral drugs. Conquest of Invisible Enemies: A Human History of Antiviral Drugs guides readers through the history of viruses, vaccinations, and treatments. Readers learn about the discovery of viruses and diseases, such as HIV/AIDS, hepatitis, influenza, and SARS-CoV-2 (COVID-19). The first chapter takes an expansive look at how viruses have shaped human history. Subsequent chapters narrow in on specific viruses, diseases, and drug treatments. For example, chapter four, on influenza, looks at the1918 Spanish flu pandemic, the history of vaccination efforts, and influenza drugs and vaccines today. Chapter five, on coronaviruses, considers drug treatments for SARS, MERS, and SARS-CoV-2. It also discusses the development of COVID-19 vaccines and drugs. Conquest of Invisible Enemies: A Human History of Antiviral Drugs focuses on the human drama behind drug discovery. Written in an engaging and accessible style, Li's timely book dispels common misconceptions about viruses and treatments and places the COVID-19 pandemic in historical context | ||
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Datensatz im Suchindex
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|---|---|
| adam_text |
CONTENTS
PREFACE XI
1. VIRUSES
SHAPING HISTORY
AND
THE
DISCOVERY
OF
VIRUSES 1
1.1
VIRUSES SHAPING HISTORY
I
1.1.1
TULIPOMANIA: BUBBLES
OF
BULBS 2
1.1.2
THE FALL
OF OLD
MEXICO
AND
PERU
5
1.1.3 SUCCESSION
OF
THE THRONE
10
1.1.4 THE LOUISIANA
PURCHASE
15
1.2 DISCOVERY
OF
VIRUSES
19
1.2.1 THE
GERM
THEORY
19
1.2.2 DISCOVERY
OF VIRUSES
22
1.2.3 CANCER-CAUSING
VIRUSES
25
1.2.4 DISCOVERY
OF RETROVIRUSES
32
2. HIV/AIDS
DRUGS: TRANSFORMING
A
DEATH SENTENCE
INTO
A
CHRONIC DISEASE
37
2.1
DISCOVERY
OF
THE
VIRUS
38
2.1.1
A DEATH
SENTENCE
38
2.1.2
DISCOVERY
OF
HIV
AND
THE
GREAT SCIENTIFIC CONTROVERSY
40
2.1.3
THE NOBEL PRIZE
50
2.2
THE FIRST RAY
OF
HOPE
56
2.2.1 NUCLEOSIDE
ANTIVIRAL
DRUGS 56
2.2.2 NON-NUCLEOSIDE
REVERSE
TRANSCRIPTASE
INHIBITORS
65
2.3 HIV PROTEASE
INHIBITORS
69
2.3.1 HIV
PROTEASE
69
2.3.2 FIRST-GENERATION
HIV
PROTEASE
INHIBITORS
71
2.3.3 SECOND-GENERATION
HIV
PROTEASE
INHIBITORS
77
2.4 HIV INTEGRASE
INHIBITORS
80
2.5 HIV ENTRY INHIBITORS
83
2.5.1
HIV FUSION INHIBITORS
84
2.5.2
CCR5 INHIBITORS
86
2.6 THE ROAD
TO
ERADICATION
89
$
B1IOTHEK
DEUTSCHES
MUSEUM
HLUENCHE'A
VIII
CONTENTS
3. HEPATITIS VIRUSES
91
3.1 HEPATITIS A VIRUS 92
3.1.1 DISCOVERY
OF
THE
HEPATITIS A
VIRUS
93
3.1.2 HEPATITIS A
VACCINES
95
3.2 HEPATITIS B VIRUS 98
3.2.1 DISCOVERY
OF
THE
HEPATITIS B
VIRUS
99
3.2.2
HEPATITIS B
VACCINES
106
3.2.3
HEPATITIS B DRUGS
112
3.3 HEPATITIS C VIRUS
125
3.3.1
DISCOVERY
OF
HEPATITIS C
VIRUS
126
3.3.2
HEPATITIS C
VIRUS
NS3/4A
SERINE
PROTEASE
INHIBITORS 130
3.3.3
HEPATITIS C
VIRUS
NS5A
PROTEIN
INHIBITORS 139
3.3.4
HEPATITIS C
VIRUS
NS5B
POLYMERASE
INHIBITORS 143
3.4 A TRIUMPH
OF
MODERN MEDICINE
151
4.
INFLUENZA: A PERENNIAL KILLER
154
4.1 INFLUENZA, A PERENNIAL KILLER 155
4.2 A VIRUS
THAT
CHANGED
THE
WORLD:
THE 1918 SPANISH FLU PANDEMIC 157
4.3 DISCOVERY
OF
THE
INFLUENZA VIRUS 161
4.4 INFLUENZA VACCINES 165
4.4.1
HISTORY
OF VACCINATION
165
4.4.2
HISTORY
OF
INFLUENZA
VACCINES
168
4.4.3
INFLUENZA
VACCINES
TODAY 170
4.5 INFLUENZA DRUGS 172
4.5.1
M2 INHIBITORS
172
4.5.2
INFLUENZA
VIRUS
NEURAMINIDASE
INHIBITORS 175
4.5.3
CAP-DEPENDENT
ENDONUCLEASE
INHIBITOR 184
5. CORONA-VIRUSES
187
5.1 CORONAVIRUS 188
5.1.1
WHAT IS
A CORONAVIRUS?
188
5.1.2
SARS
AND
MERS
189
5.1.3
SARS-COV-2
190
5.2
COVID-19 VACCINES
192
5.2.1 PFIZER/BIONTECH'S
MRNA VACCINE
193
5.2.2 JOHNSON & JOHNSON'S
VIRAL
VECTOR VACCINE
196
CONTENTS
IX
5.3 COVID-19 DRUGS
5.3.1
REMDESIVIR (VEKLURY)
5.3.2
DEXAMETHASONE (DECADRON)
6. CLOSING REMARKS
APPENDIX: CHEMICAL STRUCTURES
OF
THE
DRUGS
NOTES
INDEX
202
202
211
217
219
235
249 |
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| title | Conquest of invisible enemies a human history of antiviral drugs |
| title_auth | Conquest of invisible enemies a human history of antiviral drugs |
| title_exact_search | Conquest of invisible enemies a human history of antiviral drugs |
| title_exact_search_txtP | Conquest of invisible enemies a human history of antiviral drugs |
| title_full | Conquest of invisible enemies a human history of antiviral drugs Jie Jack Li |
| title_fullStr | Conquest of invisible enemies a human history of antiviral drugs Jie Jack Li |
| title_full_unstemmed | Conquest of invisible enemies a human history of antiviral drugs Jie Jack Li |
| title_short | Conquest of invisible enemies |
| title_sort | conquest of invisible enemies a human history of antiviral drugs |
| title_sub | a human history of antiviral drugs |
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