Detection of nanoparticles after intraarticular injection in canine elbow joint:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Gießen
VVB Laufersweiler Verlag
2022
|
| Schriftenreihe: | Edition Scientifique
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VII, 115 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 190 g |
| ISBN: | 9783835970229 3835970224 |
Internformat
MARC
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| 100 | 1 | |a Sobhy Abdelhakam Mohammed, Mohammed |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Detection of nanoparticles after intraarticular injection in canine elbow joint |c eingereicht von Mohammed Sobhy Abdelhakam Mohammed |
| 263 | |a 202203 | ||
| 264 | 1 | |a Gießen |b VVB Laufersweiler Verlag |c 2022 | |
| 300 | |a VII, 115 Seiten |b Illustrationen, Diagramme |c 21 cm x 14.8 cm, 190 g | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Edition Scientifique | |
| 502 | |b Dissertation |c Justus-Liebig-Universität Gießen |d 2022 | ||
| 650 | 7 | |a nanoparticles |2 cabt | |
| 650 | 7 | |a dogs |2 cabt | |
| 650 | 7 | |a elbows |2 cabt | |
| 650 | 7 | |a injection |2 cabt | |
| 650 | 7 | |a stem cells |2 cabt | |
| 650 | 7 | |a stem cell therapy |2 cabt | |
| 650 | 7 | |a ultrasonography |2 cabt | |
| 650 | 7 | |a magnetresonance imaging |2 cabt | |
| 653 | |a Hund | ||
| 653 | |a Gelenke | ||
| 653 | |a Knochen | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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Datensatz im Suchindex
| _version_ | 1804184572998451200 |
|---|---|
| adam_text | CONTENTS
INDEX
OF
FIGURES
........................................................................................................................
III
INDEX
OF
TABLES
..........................................................................................................................
VI
ABBREVIATIONS
.........................................................................................................................
VII
1
.
INTRODUCTION
.......................................................................................................................
1
1.1
GENERAL
CONSIDERATIONS
............................................................................................................................
1
1.2
AIMS
OF
THE
STUDY
......................................................................................................................................
2
2
LITERATURE
REVIEW
....................................................................................................................
3
2.1
ANATOMY
OF
THE
ELBOW
JOINT
IN
DOG
..........................................................................................................
3
2.1.1
BONY
STRUCTURES
.............................................................................................................................
3
2.1.2
MUSCLE
SYSTEM
..............................................................................................................................
4
2.1.3
JOINTS
.............................................................................................................................................
5
2.1.4
LIGAMENTS
.....................................................................................................................................
5
2.1.5
JOINT
CAPSULE
.................................................................................................................................
6
2.2
BIOMECHANICS
OF
ELBOW
JOINT
..................................................................................................................
7
2.3
DEVELOPMENT
OF
ELBOW
JOINT
...................................................................................................................8
2.4
ELBOW
DYSPLASIE
..........................................................................................................................................
9
2.4.1
DEFINITION
AND
ETIOLOGY
................................................................................................................
9
2.4.2
OSTEOCHONDROSIS
DISSECANS
(OCD)
...........................................................................................
10
2.4.3
INCONGRUENCE
OF
ELBOW
JOINT
.........................................................................................................
12
2.4.4
FRAGMENTED
PROCESSUS
CORONOIDEUS
MEDIALIS
ULNAE
.................................................................
13
2.4.5
ISOLATED
PROCESSUS
ANCONAEUS
........................................................................................
16
2.4.6
INCOMPLETE
OSSIFICATION
OF
THE
HUMERAL
CONDYLE
.....................................................................
17
2.4.7
FURTHER
FORMS
OF
ELBOW
JOINT
DISEASE
........................................................................................
17
2.4.8
SYMPTOMS
AND CLINICAL
EXAMINATION
.........................................................................................
18
2.4.9
DIAGNOSTIC
IMAGING
......................................................................................................................
19
2.4.10
THERAPEUTIC
PROCEDURE
................................................................................................................
23
2.4.11
PROGNOSIS
AND
PROPHYLAXIS
.........................................................................................................
26
2.5
NANOPARTICLES
.........................................................................................................................................
27
2.5.1
IRON
OXIDE
NANOPARTICLES
.......................................................................................................................
28
2.5.2
IRON
OXIDE
NANOPARTICLES
IN
HUMAN
MEDICINE
........................................................................................
29
2.5.3
GOLD
NANOPARTICLES
..............................................................................................................................
30
2.5.4
USE
OF
NANOPARTICLES
IN
MEDICINE
..........................................................................................................
30
2.5.5
TOXICITY
OF
NANOPARTICLES
......................................................................................................................
31
2.6
STEM
CELLS
..................................................................................................................................................
32
2.6.1
MESENCHYMAL
STEM
CELLS
.............................................................................................................
34
2.6.2
CANINE
MESENCHYMAL
STEM
CELLS
.................................................................................................
35
2.6.3
THERAPY
OPTIONS
OF
MSCS
IN
DOGS
..............................................................................................
36
2.6.4
DIFFERENTIATION
OF
ADIPOSE
MESENCHYMAL
STEM
CELLS
(ASCS)
....................................................
37
2.6.5
CURRENT
METHODS
TO
TRACK
CELLS
..................................................................................................
38
2.6.5.1
OPTICAL
IMAGING
....................................................................................................................
38
2.6.5.2
POSITRON
EMISSION
TOMOGRAPHY
AND
COMPUTED
TOMOGRAPHY
PET/CT
...............................
39
2.6.5.3
MAGNETIC
RESONANCE
IMAGING
(MRI)
...................................................................................
40
3
MATERIAL
AND
METHODS
...................................................................................................................................
43
3.1
STEM
CELLS
COLLECTION
FROM
FATTY
TISSUE
.....................................................................................................
44
3.1.2
EXTRACTION
OF
ADULT
MESENCHYMAL
STEM
CELLS
(ADMSCS)
....................................................................
44
3.1.3
CULTIVATION
OF
ADMSCS
....................................................................................................................
45
3.1.4
PASSAGE
OF
THE
CULTIVATED
ADMSCS
.....................................................................................................
45
3.1.5
CRYOPRESERVATION
OF
ADMSCS
.............................................................................................................
46
3.1.6
DEFROSTING
THE
ADMSCS
......................................................................................................................
46
I
3.1
NANOPARTICLE
S
PRODUCTION
..................................................................................................................
47
3.1.1
PRODUCTION
OF
IRON
OXIDE
NANOPARTICLES
....................................................................................
47
3.2
STATISTICS
.....................................................................................................................................................
48
3.3
ULTRASOUND
GUIDED
INTRAARTICULAR
INJECTIONS
...........................................................................................
49
3.5
MAGNETIC
RESONANCE
IMAGING
EXAMINATION
(3
TESLA)
..............................................................................
49
3.6
COMPUTER
TOMOGRAPHY
EXAMINATION
......................................................................................................
50
3.7
MEASUREMENT
............................................................................................................................................
50
4
RESULTS
..................................................................................................................................
51
4.1
EFFECT
OF
IRON
LABELLING
ON
MRI
.........................................................................................................
52
4.2
COMPUTED
TOMOGRAPHY
......................................................................................................................
52
4.3
OBJECTIVE
EVALUATION
............................................................................................................................
53
4.4
SUBJECTIVE
EVALUATION
.............................................................................................................................
54
4.5
DILUTION
OF
IRON
NANOPARTICLES
............................................................................................................
56
5.
DISCUSSION
.............................................................................................................................
59
6.
SUMMARY
..............................................................................................................................
65
7.
REFERENCE
...............................................................................................................................
69
8.
ERKLARUNG
............................................................................................................................
114
9.
ACKNOWLEDGMENTS
............................................................................................................
115
II
|
| adam_txt |
CONTENTS
INDEX
OF
FIGURES
.
III
INDEX
OF
TABLES
.
VI
ABBREVIATIONS
.
VII
1
.
INTRODUCTION
.
1
1.1
GENERAL
CONSIDERATIONS
.
1
1.2
AIMS
OF
THE
STUDY
.
2
2
LITERATURE
REVIEW
.
3
2.1
ANATOMY
OF
THE
ELBOW
JOINT
IN
DOG
.
3
2.1.1
BONY
STRUCTURES
.
3
2.1.2
MUSCLE
SYSTEM
.
4
2.1.3
JOINTS
.
5
2.1.4
LIGAMENTS
.
5
2.1.5
JOINT
CAPSULE
.
6
2.2
BIOMECHANICS
OF
ELBOW
JOINT
.
7
2.3
DEVELOPMENT
OF
ELBOW
JOINT
.8
2.4
ELBOW
DYSPLASIE
.
9
2.4.1
DEFINITION
AND
ETIOLOGY
.
9
2.4.2
OSTEOCHONDROSIS
DISSECANS
(OCD)
.
10
2.4.3
INCONGRUENCE
OF
ELBOW
JOINT
.
12
2.4.4
FRAGMENTED
PROCESSUS
CORONOIDEUS
MEDIALIS
ULNAE
.
13
2.4.5
ISOLATED
PROCESSUS
ANCONAEUS
.
16
2.4.6
INCOMPLETE
OSSIFICATION
OF
THE
HUMERAL
CONDYLE
.
17
2.4.7
FURTHER
FORMS
OF
ELBOW
JOINT
DISEASE
.
17
2.4.8
SYMPTOMS
AND CLINICAL
EXAMINATION
.
18
2.4.9
DIAGNOSTIC
IMAGING
.
19
2.4.10
THERAPEUTIC
PROCEDURE
.
23
2.4.11
PROGNOSIS
AND
PROPHYLAXIS
.
26
2.5
NANOPARTICLES
.
27
2.5.1
IRON
OXIDE
NANOPARTICLES
.
28
2.5.2
IRON
OXIDE
NANOPARTICLES
IN
HUMAN
MEDICINE
.
29
2.5.3
GOLD
NANOPARTICLES
.
30
2.5.4
USE
OF
NANOPARTICLES
IN
MEDICINE
.
30
2.5.5
TOXICITY
OF
NANOPARTICLES
.
31
2.6
STEM
CELLS
.
32
2.6.1
MESENCHYMAL
STEM
CELLS
.
34
2.6.2
CANINE
MESENCHYMAL
STEM
CELLS
.
35
2.6.3
THERAPY
OPTIONS
OF
MSCS
IN
DOGS
.
36
2.6.4
DIFFERENTIATION
OF
ADIPOSE
MESENCHYMAL
STEM
CELLS
(ASCS)
.
37
2.6.5
CURRENT
METHODS
TO
TRACK
CELLS
.
38
2.6.5.1
OPTICAL
IMAGING
.
38
2.6.5.2
POSITRON
EMISSION
TOMOGRAPHY
AND
COMPUTED
TOMOGRAPHY
PET/CT
.
39
2.6.5.3
MAGNETIC
RESONANCE
IMAGING
(MRI)
.
40
3
MATERIAL
AND
METHODS
.
43
3.1
STEM
CELLS
COLLECTION
FROM
FATTY
TISSUE
.
44
3.1.2
EXTRACTION
OF
ADULT
MESENCHYMAL
STEM
CELLS
(ADMSCS)
.
44
3.1.3
CULTIVATION
OF
ADMSCS
.
45
3.1.4
PASSAGE
OF
THE
CULTIVATED
ADMSCS
.
45
3.1.5
CRYOPRESERVATION
OF
ADMSCS
.
46
3.1.6
DEFROSTING
THE
ADMSCS
.
46
I
3.1
NANOPARTICLE
'
S
PRODUCTION
.
47
3.1.1
PRODUCTION
OF
IRON
OXIDE
NANOPARTICLES
.
47
3.2
STATISTICS
.
48
3.3
ULTRASOUND
GUIDED
INTRAARTICULAR
INJECTIONS
.
49
3.5
MAGNETIC
RESONANCE
IMAGING
EXAMINATION
(3
TESLA)
.
49
3.6
COMPUTER
TOMOGRAPHY
EXAMINATION
.
50
3.7
MEASUREMENT
.
50
4
RESULTS
.
51
4.1
EFFECT
OF
IRON
LABELLING
ON
MRI
.
52
4.2
COMPUTED
TOMOGRAPHY
.
52
4.3
OBJECTIVE
EVALUATION
.
53
4.4
SUBJECTIVE
EVALUATION
.
54
4.5
DILUTION
OF
IRON
NANOPARTICLES
.
56
5.
DISCUSSION
.
59
6.
SUMMARY
.
65
7.
REFERENCE
.
69
8.
ERKLARUNG
.
114
9.
ACKNOWLEDGMENTS
.
115
II |
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| author | Sobhy Abdelhakam Mohammed, Mohammed |
| author_facet | Sobhy Abdelhakam Mohammed, Mohammed |
| author_role | aut |
| author_sort | Sobhy Abdelhakam Mohammed, Mohammed |
| author_variant | a m m s amm amms |
| building | Verbundindex |
| bvnumber | BV048560002 |
| ctrlnum | (OCoLC)1308973619 (DE-599)DNB1254266011 |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV048560002 |
| illustrated | Illustrated |
| index_date | 2024-07-03T20:59:38Z |
| indexdate | 2024-07-10T09:41:29Z |
| institution | BVB |
| institution_GND | (DE-588)1065553803 |
| isbn | 9783835970229 3835970224 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-033936211 |
| oclc_num | 1308973619 |
| open_access_boolean | |
| owner | DE-188 |
| owner_facet | DE-188 |
| physical | VII, 115 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 190 g |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | VVB Laufersweiler Verlag |
| record_format | marc |
| series2 | Edition Scientifique |
| spelling | Sobhy Abdelhakam Mohammed, Mohammed Verfasser aut Detection of nanoparticles after intraarticular injection in canine elbow joint eingereicht von Mohammed Sobhy Abdelhakam Mohammed 202203 Gießen VVB Laufersweiler Verlag 2022 VII, 115 Seiten Illustrationen, Diagramme 21 cm x 14.8 cm, 190 g txt rdacontent n rdamedia nc rdacarrier Edition Scientifique Dissertation Justus-Liebig-Universität Gießen 2022 nanoparticles cabt dogs cabt elbows cabt injection cabt stem cells cabt stem cell therapy cabt ultrasonography cabt magnetresonance imaging cabt Hund Gelenke Knochen (DE-588)4113937-9 Hochschulschrift gnd-content VVB LAUFERSWEILER Verlag (DE-588)1065553803 pbl DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033936211&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p vlb 20220329 DE-101 https://d-nb.info/provenance/plan#vlb |
| spellingShingle | Sobhy Abdelhakam Mohammed, Mohammed Detection of nanoparticles after intraarticular injection in canine elbow joint nanoparticles cabt dogs cabt elbows cabt injection cabt stem cells cabt stem cell therapy cabt ultrasonography cabt magnetresonance imaging cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Detection of nanoparticles after intraarticular injection in canine elbow joint |
| title_auth | Detection of nanoparticles after intraarticular injection in canine elbow joint |
| title_exact_search | Detection of nanoparticles after intraarticular injection in canine elbow joint |
| title_exact_search_txtP | Detection of nanoparticles after intraarticular injection in canine elbow joint |
| title_full | Detection of nanoparticles after intraarticular injection in canine elbow joint eingereicht von Mohammed Sobhy Abdelhakam Mohammed |
| title_fullStr | Detection of nanoparticles after intraarticular injection in canine elbow joint eingereicht von Mohammed Sobhy Abdelhakam Mohammed |
| title_full_unstemmed | Detection of nanoparticles after intraarticular injection in canine elbow joint eingereicht von Mohammed Sobhy Abdelhakam Mohammed |
| title_short | Detection of nanoparticles after intraarticular injection in canine elbow joint |
| title_sort | detection of nanoparticles after intraarticular injection in canine elbow joint |
| topic | nanoparticles cabt dogs cabt elbows cabt injection cabt stem cells cabt stem cell therapy cabt ultrasonography cabt magnetresonance imaging cabt |
| topic_facet | nanoparticles dogs elbows injection stem cells stem cell therapy ultrasonography magnetresonance imaging Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033936211&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sobhyabdelhakammohammedmohammed detectionofnanoparticlesafterintraarticularinjectionincanineelbowjoint AT vvblaufersweilerverlag detectionofnanoparticlesafterintraarticularinjectionincanineelbowjoint |